IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene VLDLR Ensembl ENSG00000147852 Chromosome 9 Start 2611793 End 2644485
Description Very low-density lipoprotein receptor Precursor (VLDL receptor)(VLDL-R) [Source:UniProtKB/Swiss-Prot;Acc:P98155]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12698
     Entrez Gene : 7436
     UCSC : uc003zhk.1
     GeneCards : 12698
     RefSeq : NM_001018056
     CCDS : CCDS6446.1
     Uniprot : P98155
     Interpro : P98155
     OMIM : 192977
     GeneTests : VLDLR
     CGAP : VLDLR
     PMID : 8294473

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36873_at  -1.66  1.48e-8  1.44e-7  -0.51  1.07e-1  1.74e-1
 HG_U133A  209822_s_at  -0.71  3.79e-17  2.41e-16  0.44  2.07e-7  2.48e-7
 HG_U133_Plus2  209822_s_at  -0.79  1.08e-10  8.58e-10  -0.26  5.60e-2  7.94e-2
 Stanford  1470  -0.23  5.86e-1  7.46e-1  0.50  3.08e-1  5.48e-1
 Stanford  18862  -0.46  3.38e-1  5.39e-1  -0.05  9.15e-1  9.62e-1
 Stanford  19853  0.11  7.42e-1  8.54e-1  0.41  3.26e-1  5.66e-1
 Agilent_HS_21.6K  20100  0.13  1.63e-1  3.27e-1  0.19  2.89e-2  8.19e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209822_s_at  0.04  8.36e-1  9.86e-1  0.08  7.10e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36873_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209822_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209822_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1470    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18862    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19853    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20100    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vldlr carcinoma We investigated the expression and regulation of VLDLR in fetal and carcinoma cells. 10629142 Human
vldlr tumors OBJECTIVE: The expression of VLDLR was examined by immunohistochemistry and reverse-transcriptase polymerase chain reaction using several specimens, including a fetus of 12 to 15 weeks' gestation, various tumors, AGS cells, and INT407 cells. 10629142 Human
vldlr gastric adenocarcinoma RESULTS: Immunoreactive VLDLR was abundantly present in human fetal intestinal epithelial and gastric adenocarcinoma cells. 10629142 Human
vldlr gastric adenocarcinoma In addition, the VLDLR that was expressed in INT407 cells, AGS cells, and gastric adenocarcinoma tissue was present mainly in a variant form lacking the O-linked sugar domain. 10629142 Human
vldlr cancer CONCLUSIONS: These data suggest that an important function of VLDLR may be the mediation of cell growth in developing tissues, such as fetal intestinal and cancer cells. 10629142 Human
very low density lipoprotein receptor breast cancer The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro. 10066806 Human
vldlr breast cancer In this study, we characterized the effects of the VLDLr on the internalization, catabolism, and function of the uPA receptor (uPAR) in MCF-7 and MDA-MB-435 breast cancer cells. 10066806 Human
vldlr epithelial cancer By immunohistochemistry, we demonstrate that VLDLR is mainly expressed by the epithelial cancer cells in these carcinomas. 9346319 Human
vldlr carcinomas By immunohistochemistry, we demonstrate that VLDLR is mainly expressed by the epithelial cancer cells in these carcinomas. 9346319 Human
vldlr epithelial cancer The VLDLR variant expressed by epithelial cancer cells could function in the clearance of cell-surface-associated serine proteinase/serpin complexes in breast carcinomas. 9346319 Human
vldlr breast carcinomas The VLDLR variant expressed by epithelial cancer cells could function in the clearance of cell-surface-associated serine proteinase/serpin complexes in breast carcinomas. 9346319 Human
vldlr hepatoma Transduction of cultured Hepa (mouse hepatoma) cells and LDLR-deficient CHO-ldlA7 cells in vitro by the virus led to high-level expression of immunoreactive VLDLR proteins with molecular sizes of 143 kDa and 161 kDa. 8636110 Human
vldlr choriocarcinoma The regulation of VLDLR expression was studied in JEG-3 and BeWo choriocarcinoma cells, two trophoblast-derived cell lines. 7828550 Human
very low density lipoprotein receptor human breast carcinoma Very low density lipoprotein receptor (VLDL-R) was found to be expressed in bovine mammary gland and the human breast carcinoma cell line MCF-7 as an M(r) 105,000 variant, and in Chinese hamster ovary (CHO) cells transfected with human VLDL-R cDNA as an M 7657671 Human
vldlr hl We measured plasma lipids, lipoproteins, and apolipoproteins and analyzed DNA for genotypes of apolipoprotein (apo) B (APOB), paraoxonase (PON), lipoprotein lipase (LPL), VLDL receptor (VLDLR), apo CIII (APOC3), LDL receptor-related protein (LRP), hepatic 7600118 Human
vldlr adenocarcinoma AIM: This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. 15884130 Human
vldlr gastric adenocarcinoma The expression of VLDLR subtypes was detected in gastroenteric carcinoma/adjacent normal tissues and three various differentiated human gastric adenocarcinoma cell lines (MKN28, SGC7901 and MKN45) by reverse transcription polymerase chain reaction (RT-PCR 15884130 Human
vldlr carcinoma The expression of VLDLR subtypes was detected in gastroenteric carcinoma/adjacent normal tissues and three various differentiated human gastric adenocarcinoma cell lines (MKN28, SGC7901 and MKN45) by reverse transcription polymerase chain reaction (RT-PCR 15884130 Human
vldlr gastric adenocarcinoma RESULTS: Two VLDLR subtypes, namely, type II VLDLR and type I VLDLR, were found to express changes in gastroenteric carcinoma tissues, their adjacent normal tissue, and gastric adenocarcinoma cell lines as well. 15884130 Human
vldlr carcinoma RESULTS: Two VLDLR subtypes, namely, type II VLDLR and type I VLDLR, were found to express changes in gastroenteric carcinoma tissues, their adjacent normal tissue, and gastric adenocarcinoma cell lines as well. 15884130 Human
vldlr gastric adenocarcinoma Type II VLDLR is predominantly expressed in poorly- or moderately-differentiated gastroenteric carcinoma tissues and gastric adenocarcinoma cell lines, whereas type I VLDLR is mainly detected in well-differentiated intestinal carcinoma tissues and gastric 15884130 Human
vldlr carcinoma Type II VLDLR is predominantly expressed in poorly- or moderately-differentiated gastroenteric carcinoma tissues and gastric adenocarcinoma cell lines, whereas type I VLDLR is mainly detected in well-differentiated intestinal carcinoma tissues and gastric 15884130 Human
vldlr carcinoma CONCLUSION: The results suggested that the variations of the VLDLR subtype expression might be correlated with the progress and differentiation of gastroenteric carcinoma. 15884130 Human

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