IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PLAA Ensembl ENSG00000137055 Chromosome 9 Start 26894518 End 26937263
Description Phospholipase A-2-activating protein (PLA2P)(PLAP) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y263]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9043
     Entrez Gene : 9373
     UCSC : uc003zqd.2
     GeneCards : 9043
     RefSeq : NM_001031689
     CCDS : CCDS35000.1
     Uniprot : Q9Y263
     Interpro : Q9Y263
     OMIM : 603873
     GeneTests : PLAA
     CGAP : PLAA
     PMID : 9931468

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35196_at  -0.30  2.52e-1  3.52e-1  0.04  9.13e-1  9.41e-1
 HG_U133A  209532_at  -0.11  2.60e-1  3.10e-1  5.26  1.15e-117  1.29e-116
 HG_U133A  209533_s_at  0.06  3.95e-1  4.50e-1  2.46  4.34e-90  2.27e-89
 HG_U133_Plus2  209532_at  -0.60  3.00e-5  1.05e-4  -0.80  1.75e-7  5.67e-7
 HG_U133_Plus2  209533_s_at  0.01  8.89e-1  9.18e-1  -0.19  6.01e-2  8.47e-2
 HG_U133_Plus2  235394_at  -0.58  1.13e-8  6.83e-8  -0.78  3.03e-14  2.18e-13
 Agilent_HS_21.6K  12763  0.01  8.05e-1  8.89e-1  0.01  6.47e-1  7.65e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209532_at  0.08  8.42e-1  9.87e-1  0.18  5.76e-1  1.00e+0
 HG_U133A  209533_s_at  0.55  4.13e-3  6.53e-1  -0.23  2.54e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35196_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209532_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209533_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209532_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209533_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235394_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12763    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
phospholipase a2 activating protein melanoma Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region. 10571045 Human
plap polyposis PLAP was considered a potential candidate to be involved in malignant melanoma because it maps to the critical region for CMM and because the PLA2 gene has been identified as a modifier of the APC gene, responsible for the adenomatous polyposis phenotype 10571045 Mouse
plap malignant melanoma PLAP was considered a potential candidate to be involved in malignant melanoma because it maps to the critical region for CMM and because the PLA2 gene has been identified as a modifier of the APC gene, responsible for the adenomatous polyposis phenotype 10571045 Human
plaa cancers Fluorescence in situ hybridization (FISH) mapping placed PLAA on chromosome 9p21, a region frequently deleted in various cancers. 10644453 Human
plaa neoplasms Yeast artificial chromosome (YAC) mapping localized PLAA proximal to the CDKN2A/CDKN2B genes and to a region flanked by D9S171 and INFA commonly deleted in many neoplasms. 10644453 Human
plaa cutaneous melanoma Two YACs contained both PLAA and D9S259, a marker present in a second more proximal minimal deleted region observed in cutaneous melanoma and squamous cell lung carcinoma. 10644453 Human
plaa squamous-cell lung carcinoma Two YACs contained both PLAA and D9S259, a marker present in a second more proximal minimal deleted region observed in cutaneous melanoma and squamous cell lung carcinoma. 10644453 Human
phospholipase a2 activating protein inflammatory bowel disease Phospholipase A2 activating protein and idiopathic inflammatory bowel disease. 9014769 Human
plap germ cell tumors Immunohistochemical study on AFP, HCG and PLAP in primary intracranial germ cell tumors. 2442798 Human
plap testicular seminomas In this study, we compared staining by IMP using monoclonal antibody (mAb) and polyclonal antibody to PLAP with that seen using a mAb, M2A, which was previously shown to react with testicular seminomas and ITMGC. 1646453 Human
plap gliomas Injection of a 24 amino acid peptide from this phospholipase A2 activating protein (PLAP), resulted in induction of an acute inflammatory response, and a concomitant regression of gliomas in rats. 8603356 Rat
plap testicular germ-cell tumours PATIENTS AND METHODS: A total of 673 serum samples from 116 patients with testicular germ cell tumours (78 seminomas and 38 non-seminomas) were analysed for several markers including PLAP, total alkaline phosphatase (AL-P), alpha fetoprotein (AFP), beta h 8653285 Human
plap seminomas PATIENTS AND METHODS: A total of 673 serum samples from 116 patients with testicular germ cell tumours (78 seminomas and 38 non-seminomas) were analysed for several markers including PLAP, total alkaline phosphatase (AL-P), alpha fetoprotein (AFP), beta h 8653285 Human
plap ibd AIMS: The purpose of this investigation was to discover if PLAP values might be increased in the inflamed intestinal tissue of patients with IBD and in intestinal tissue of mice with colitis. 9014769 Human
plap ibd METHODS: Immunocytochemistry with affinity purified antibodies to PLAP synthetic peptides was used to locate PLAP antigen in sections of intestinal biopsy specimens from IBD patients compared with that of normal intestinal tissue. 9014769 Human
plap ibd RESULTS: PLAP antigen was localised predominantly within monocytes and granulocytes in intestinal tissue sections from IBD patients, and additional deposition of extracellular PLAP antigen was associated with blood vessels and oedema fluid in the inflamed 9014769 Human
plap ibd CONCLUSIONS: As PLAP values were increased in the intestinal mucosa of IBD patients and mice with colitis, as well as in LPS treated cultured HT-29 cells, a role was postulated for PLAP in increasing PLA2 activity, which leads to the increased synthesis o 9014769 Human
plap testicular tumor PATIENTS AND METHODS: The paraffin blocks of two cases who later developed testicular tumor were sliced again and re-examined by H/E staining and immunostaining with PLAP antibody (clone No. 8A9). 14978939 Human
plap cancer Based on knowledge of PLAP as a pro-inflammatory agent, its capacity to modulate the immune response and the role of the inflammatory and immune responses in immune surveillance, the role of PLAP in cancer therapy was explored. 15616658 Human
plap tumor Significant tumor regression was observed 72 hours following a single treatment with PLAP in an animal air pouch model of glioma. 15616658 Mouse
plap glioma Significant tumor regression was observed 72 hours following a single treatment with PLAP in an animal air pouch model of glioma. 15616658 Mouse
plap breast tumors PEG-PLAP treatment increased the life expectancy of animals with Lewis lung cancer, and in preliminary studies in MTVL breast tumors in mice, PLAP treatment resulted in a similar increase in life expectancy. 15616658 Mouse
plap lewis lung cancer PEG-PLAP treatment increased the life expectancy of animals with Lewis lung cancer, and in preliminary studies in MTVL breast tumors in mice, PLAP treatment resulted in a similar increase in life expectancy. 15616658 Mouse
plap cancer These findings suggest that PLAP holds promise as a potential therapy for cancer, and warrants further study. 15616658 Human
phospholipase a2 activating protein gliomas Injection of a 24 amino acid peptide from this phospholipase A2 activating protein (PLAP), resulted in induction of an acute inflammatory response, and a concomitant regression of gliomas in rats. 8603356 Rat
phospholipase a2 activating protein tumor Phospholipase A2 activating protein induces tumor regression. 15616658 Human

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