IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ACO1 Ensembl ENSG00000122729 Chromosome 9 Start 32374618 End 32440834
Description Cytoplasmic aconitate hydratase (Aconitase)(EC 4.2.1.3)(Citrate hydro-lyase)(Iron-responsive element-binding protein 1)(IRE-BP 1)(Iron regulatory protein 1)(IRP1)(Ferritin repressor protein) [Source:UniProtKB/Swiss-Prot;Acc:P21399]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 117
     Entrez Gene : 48
     UCSC : uc003zqw.3
     GeneCards : 117
     RefSeq : NM_002197
     CCDS : CCDS6525.1
     Uniprot : P21399
     Interpro : P21399
     OMIM : 100880
     GeneTests : ACO1
     CGAP : ACO1
     PMID : 2172968

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40077_at  -0.12  2.58e-1  3.59e-1  -0.91  1.77e-10  2.28e-9
 HG_U133A  207071_s_at  -0.08  2.05e-1  2.51e-1  -4.89  1.24e-143  3.26e-142
 HG_U133_Plus2  207071_s_at  0.06  4.69e-1  5.58e-1  -0.22  1.95e-2  3.02e-2
 Stanford  14622  -0.05  8.71e-1  9.30e-1  -0.98  1.16e-3  1.56e-2
 Agilent_HS_21.6K  4363  0.01  7.20e-1  8.34e-1  -0.06  4.32e-2  1.11e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207071_s_at  -0.17  4.49e-1  9.14e-1  -0.26  8.38e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40077_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14622    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4363    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
irp1 hepatoma Given the important relationship between O2 and iron (Fenton chemistry) a study was undertaken to characterize the effects of hypoxia, as well as subsequent reoxygenation, on the iron-regulatory proteins 1 and 2 (IRP1 and IRP2) in a rat hepatoma cell line 9516462 Rat
irp1 hepatoma Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells. 8639920 Rat
irp1 hepatoma The role of NO. in the regulation of IRP1 and IRP2 in rat hepatoma cells was investigated by using the NO.-generating compound S-nitroso-N-acetylpenicillamine (SNAP), or by stimulating cells with multiple cytokines and lipopolysaccharide (LPS) to induce N 8639920 Rat
irp1 hepatoma Our data indicate that IRP1 and IRP2 are differentially regulated by NO. in rat hepatoma cells, suggesting a role for IRP1 in the regulation of iron homeostasis in vivo during hepatic inflammation. 8639920 Rat
aco1 melanoma Since ACO1 is not linked with melanoma severity in X. helleri x X. maculatus Jp 163 A backcross hybrids, these data indicate that homozygosity for the X. helleri TP53 genotype in backcross hybrids of the cross type is not associated with genetically regul 8640724 others
irp1 astrocytoma Two cDNA clones were isolated from a human brain cDNA library with IRP1 cDNA probes, and both of these cDNA probes recognized a single mRNA species (4.0 kb) from human astrocytoma cells. 8764614 Human
irp1 myelogenous leukemia Doxorubicin exposure reversibly inactivated IRP1 in small cell lung carcinoma (GLC(4)) and myelogenous leukemia (K562) cell lines, but was without effect in their derived doxorubicin-resistant sublines. 12581865 Human
irp1 small-cell lung carcinoma Doxorubicin exposure reversibly inactivated IRP1 in small cell lung carcinoma (GLC(4)) and myelogenous leukemia (K562) cell lines, but was without effect in their derived doxorubicin-resistant sublines. 12581865 Human
irp1 mouse lymphoma Here, we show that inhibition of IRP1 aconitase activity and induction of its IRE-binding activity during exposure of L5178Y mouse lymphoma cells to NO are associated with an increase in LIP levels. 15629469 Mouse

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