IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TOPORS Ensembl ENSG00000197579 Chromosome 9 Start 32530545 End 32542601
Description E3 ubiquitin-protein ligase Topors (EC 6.3.2.-)(SUMO1-protein E3 ligase Topors)(Topoisomerase I-binding RING finger protein)(Topoisomerase I-binding arginine/serine-rich protein)(Tumor suppressor p53-binding protein 3)(p53-binding protein 3)(p53BP3) [Source:UniProtKB/Swiss-Prot;Acc:Q9NS56]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 21653
     Entrez Gene : 10210
     UCSC : uc003zrb.2
     GeneCards : 21653
     RefSeq : NM_005802
     CCDS : CCDS6527.1
     Uniprot : Q9NS56
     Interpro : Q9NS56
     OMIM : 609507
     GeneTests : TOPORS
     CGAP : TOPORS
     PMID : 10352183

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38568_at  -0.34  3.88e-4  1.37e-3  -0.16  2.79e-1  3.81e-1
 HG_U133A  204071_s_at  -0.36  1.27e-5  2.92e-5  1.83  1.15e-59  3.08e-59
 HG_U133_Plus2  1564403_at  -0.23  1.95e-1  2.70e-1  0.02  9.18e-1  9.34e-1
 HG_U133_Plus2  204071_s_at  -0.21  3.53e-2  6.22e-2  -0.51  1.85e-5  4.56e-5
 Agilent_HS_21.6K  9708  -0.12  3.75e-2  1.19e-1  -0.15  1.25e-2  4.29e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204071_s_at  0.63  1.69e-1  8.15e-1  -0.04  9.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38568_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1564403_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9708    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
topors tumor The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor. 15107820 Human
topors colon adenocarcinomas By contrast, topors mRNA and protein levels are decreased or undetectable in colon adenocarcinomas relative to normal colon tissue, and expression of the topors protein is not detectable in several colon cancer cell lines. 15107820 Human
topors colon cancer By contrast, topors mRNA and protein levels are decreased or undetectable in colon adenocarcinomas relative to normal colon tissue, and expression of the topors protein is not detectable in several colon cancer cell lines. 15107820 Human
topors colon adenocarcinoma While we were unable to detect loss of heterozygosity of the TOPORS gene in 16 sporadic colon cancer cases, increased methylation of a CpG island in the TOPORS promoter was evident in colon adenocarcinoma specimens relative to matched normal tissues. 15107820 Human
topors sporadic colon cancer While we were unable to detect loss of heterozygosity of the TOPORS gene in 16 sporadic colon cancer cases, increased methylation of a CpG island in the TOPORS promoter was evident in colon adenocarcinoma specimens relative to matched normal tissues. 15107820 Human
topors tumor These results suggest that topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor. 15107820 Human
topors promyelocytic leukemia (pml) We now demonstrate that both the GFP-topors fusion protein and endogenous topors are associated with promyelocytic leukemia (PML) nuclear bodies in exponentially growing HeLa cells. 12083797 Human
lun tumor The LUN gene locus was assigned to chromosome 9p21, which contains candidate tumor suppressor genes associated with loss of heterozygosity in more than 86% of small cell lung cancers. 11278651 Human
lun small-cell lung cancers The LUN gene locus was assigned to chromosome 9p21, which contains candidate tumor suppressor genes associated with loss of heterozygosity in more than 86% of small cell lung cancers. 11278651 Human

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