IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene BAG1 Ensembl ENSG00000107262 Chromosome 9 Start 33244163 End 33254737
Description BAG family molecular chaperone regulator 1 (BAG-1)(Bcl-2-associated athanogene 1)(Glucocorticoid receptor-associated protein RAP46) [Source:UniProtKB/Swiss-Prot;Acc:Q99933]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 937
     Entrez Gene : 573
     UCSC : uc003zsj.2
     GeneCards : 937
     RefSeq : NM_001172415
     CCDS : CCDS35004.1
     Uniprot : Q9Y2V4
     Interpro : Q9Y2V4
     OMIM : 601497
     GeneTests : BAG1
     CGAP : BAG1
     PMID : 7834747

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34798_at  -0.48  3.09e-5  1.43e-4  -0.46  1.72e-3  4.97e-3
 HG_U133A  202387_at  -0.19  1.46e-2  2.23e-2  -0.36  1.34e-8  1.64e-8
 HG_U133A  211475_s_at  -0.10  2.30e-1  2.77e-1  -5.48  5.84e-177  6.38e-175
 HG_U133_Plus2  202387_at  -0.40  1.34e-4  4.13e-4  -0.71  3.71e-10  1.67e-9
 HG_U133_Plus2  211475_s_at  -0.27  5.61e-3  1.22e-2  -0.32  9.91e-4  1.91e-3
 HG_U133_Plus2  229720_at  -0.14  2.65e-1  3.50e-1  -0.33  1.50e-2  2.36e-2
 Agilent_HS_21.6K  14263  -0.05  5.11e-1  6.83e-1  -0.03  6.77e-1  7.88e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202387_at  0.18  4.48e-1  9.14e-1  0.06  7.25e-1  1.00e+0
 HG_U133A  211475_s_at  0.38  1.97e-1  8.28e-1  -0.20  3.42e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34798_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202387_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211475_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202387_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211475_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229720_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14263    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
bag1 human breast cancer Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells. 11912172 Human
bag1 breast cancers Because overexpression of Bag1and Bag1L has been reported in breast cancers, we explored the effects of Bag1 and Bag1L on the growth of ZR-75-1 human breast cancer cells cultured in vitro and in tumor xenograft models using immunocompromised mice. 11912172 Human
bag1 tumor Because overexpression of Bag1and Bag1L has been reported in breast cancers, we explored the effects of Bag1 and Bag1L on the growth of ZR-75-1 human breast cancer cells cultured in vitro and in tumor xenograft models using immunocompromised mice. 11912172 Human
bag1 human breast cancer Because overexpression of Bag1and Bag1L has been reported in breast cancers, we explored the effects of Bag1 and Bag1L on the growth of ZR-75-1 human breast cancer cells cultured in vitro and in tumor xenograft models using immunocompromised mice. 11912172 Human
bag1 tumors In tumor xenograft studies involving injection of ZR-75-1 cells into mammary fat pads of female nu/nu mice, ZR-75-1 cells expressing Bag1 or Bag1L formed 1.4-1.6-fold larger tumors compared with control-transfected cells, whereas tumors formed by Bag1Delt 11912172 Human
bag1 tumor In tumor xenograft studies involving injection of ZR-75-1 cells into mammary fat pads of female nu/nu mice, ZR-75-1 cells expressing Bag1 or Bag1L formed 1.4-1.6-fold larger tumors compared with control-transfected cells, whereas tumors formed by Bag1Delt 11912172 Human
bag1 breast cancer Altogether, these findings demonstrate that Bag1 and Bag1L provoke similar changes in breast cancer cell growth and survival and suggest that interference with Bag1 or Bag1L function might be a useful strategy for opposing breast cancer. 11912172 Human
bag1 cancers Aberrant overexpression of the founding member of this family, BAG1, occurs in human cancers. 11276257 Human
bag-1 human tumour Here we show that BAG-1 inhibits p53- induced apoptosis in the human tumour cell line Saos-2. 14646536 Human
bag-1 pulmonary metastasis Here, we provide evidence that prolonged cell survival introduced by overexpression of Bcl-2 or BAG-1 proteins strongly promotes experimental pulmonary metastasis of melanoma B16-BL6 cells. 9205104 Mouse
bag-1 melanoma Here, we provide evidence that prolonged cell survival introduced by overexpression of Bcl-2 or BAG-1 proteins strongly promotes experimental pulmonary metastasis of melanoma B16-BL6 cells. 9205104 Mouse
bag-1 melanoma In murine melanoma cell line B16-BL6, gene transfer-mediated expression of the Bcl-2 or BAG-1 led to prolonged cell survival against serum-starved apoptosis in vitro. 9205104 Mouse
bag-1 tumors Immunoblot analysis of primary adenocarcinomas revealed expression of the anti-apoptotic proteins Bcl-2, Bcl-X(L), Mcl-1, and BAG-1, as well as the pro-apoptotic proteins Bax, Bak, and CPP32, in at least 2 of the 3 tumors examined. 9497101 Human
bag-1 primary adenocarcinomas Immunoblot analysis of primary adenocarcinomas revealed expression of the anti-apoptotic proteins Bcl-2, Bcl-X(L), Mcl-1, and BAG-1, as well as the pro-apoptotic proteins Bax, Bak, and CPP32, in at least 2 of the 3 tumors examined. 9497101 Human
bag-1 prostate cancer The recently identified BAG-1 long (BAG-1L) protein, an isoform of BAG-1 that arises from translation initiation at a noncanonical CUG codon, was co-immunoprecipitated with androgen receptors (AR) from LNCaP prostate cancer cells and other cell lysates, w 9565586 Human
bag-1 prostate cancer BAG-1L, but not BAG-1 or BAG-1M (RAP46), also markedly enhanced the ability of AR to transactivate reporter gene plasmids containing an androgen response element (ARE) in PC3 prostate cancer and other cell lines. 9565586 Human
bag-1 human gastric cancer Here, we provide evidence that prolonged cell survival introduced by overproduction of Bcl-2 or BAG-1 strongly enhances peritoneal dissemination of human gastric cancer MKN74 cells. 9632144 Human
bag-1 cancer Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. 9642262 Human
bag-1 breast cancer When stably expressed in breast cancer cell lines, BAG-1 inhibited binding of RAR/RXR heterodimer to a number of RAREs and suppressed RA-induced growth inhibition and apoptosis. 9642262 Human
bag-1 cancer These results demonstrate that BAG-1 can regulate retinoid activities through its interaction with RAR and suggest that elevated levels of BAG-1 protein could potentially contribute to retinoid resistance in cancer cells. 9642262 Human
bag-1 tumor Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. 9679980 Human
bag-1 human tumor The BAG-1 protein was found at high levels in several types of human tumor cell lines among the 67 tested, particularly leukemias, breast, prostate, and colon cancers. 9679980 Human
bag-1 colon cancers The BAG-1 protein was found at high levels in several types of human tumor cell lines among the 67 tested, particularly leukemias, breast, prostate, and colon cancers. 9679980 Human
bag-1 tumor In contrast to normal tissues, which only rarely expressed BAG-1L, tumor cell lines commonly contained BAG-1L protein, including most prostate, breast, and leukemia cell lines, suggesting that a change in BAG-1 mRNA translation frequently accompanies mali 9679980 Human
bag-1 invasive breast carcinomas Expression of BAG-1 in invasive breast carcinomas. 10561207 Human
bag-1 invasive breast carcinomas PURPOSE: The purpose of this study was to retrospectively evaluate the expression of BAG-1 in invasive breast carcinomas. 10561207 Human
bag-1 breast tumor Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues. 10561207 Human
bag-1 breast carcinomas RESULTS: Of the 140 breast carcinomas examined, 77.1% were positive for BAG-1 expression. 10561207 Human
bag-1 tumors Patients whose tumors expressed nuclear BAG-1 tended to have a shorter disease-free (63 v 84 months; P = 0.4493) and overall (69 v 99 months, P =.1009) survival. 10561207 Human
bag-1 invasive breast carcinomas CONCLUSION: BAG-1 is overexpressed in the majority of invasive breast carcinomas. 10561207 Human
bag-1 breast cancer Our preliminary data strongly indicate that further investigation is warranted to define the role of BAG-1 as an independent prognostic factor in patients with newly diagnosed breast cancer. 10561207 Human
bag-1 human breast cancer Therefore, analysis of expression of BAG-1 in human breast cancer is of considerable interest. 10576663 Human
bag-1 tumours BAG-1 was readily detected by immunostaining in normal breast epithelial cells and most ER-positive tumours, but was undetectable or weakly expressed in ER-negative tumours. 10576663 Human
bag-1 breast cancer A correlation between ER and BAG-1 was also evident in breast cancer derived cell lines, as all lines examined with functional ER expression also expressed high levels of BAG-1. 10576663 Human
bag-1 breast cancer In addition to the prototypical 36 kDa BAG-1 isoform, breast cancer cells expressed higher molecular weight isoforms and, in contrast to BCL-2, BAG-1 expression was independent of oestrogens. 10576663 Human
bag-1 breast cancer These results demonstrate a close association between BAG-1 and functional ER expression and suggest BAG-1 may be useful as a therapeutic target or prognostic marker in breast cancer. 10576663 Human
bag-1 primary breast cancer In this report, we summarize our attempts thus far to explore the expression of several Bcl-2 family proteins, caspase-3, and BAG-1 in primary breast cancer specimens and breast cancer cell lines. 10732784 Human
bag-1 breast cancer In this report, we summarize our attempts thus far to explore the expression of several Bcl-2 family proteins, caspase-3, and BAG-1 in primary breast cancer specimens and breast cancer cell lines. 10732784 Human
bag-1 malignant glioma Bag-1 and Bcl-2 gene transfer in malignant glioma: modulation of cell cycle regulation and apoptosis. 10764042 Human
bag-1 glioma Here, we report that 11 of 12 human glioma cell lines express Bag-1 protein in vitro. 10764042 Human
bag-1 glioblastomas Moreover, 15 of 19 human glioblastomas expressed Bag-1 as assessed by immunohistochemistry in primary tumor specimens. 10764042 Human
bag-1 malignant glioma To examine the biological effects of Bag-1 in glioma cells, we expressed Bag-1 or Bcl-2 transgenes in 2 human malignant glioma cell lines, LN-18 and LN-229. 10764042 Human
bag-1 glioma To examine the biological effects of Bag-1 in glioma cells, we expressed Bag-1 or Bcl-2 transgenes in 2 human malignant glioma cell lines, LN-18 and LN-229. 10764042 Human
bag-1 glioma Bag-1 significantly slowed glioma cell growth and reduced clonogenicity of both cell lines in vitro. 10764042 Human
bag-1 cervical carcinoma BAG-1 promotes apoptosis induced by N-(4-hydroxyphenyl)retinamide in human cervical carcinoma cells. 10772821 Human
bag-1 other cancers BAG-1 is an antiapoptotic gene that is overexpressed in cervical and other cancers. 10772821 Human
bag-1 cervical carcinoma In this study, we examined whether BAG-1 can inhibit 4-HPR-induced apoptosis in the C33A cervical carcinoma cell line. 10772821 Human
bag-1 cancer These in vitro results suggest that the effectiveness of 4-HPR against the development of malignancy may be due to the overexpression of BAG-1 in cancer cells. 10772821 Human
bag-1 malignancy These in vitro results suggest that the effectiveness of 4-HPR against the development of malignancy may be due to the overexpression of BAG-1 in cancer cells. 10772821 Human
bag-1 oral squamous-cell carcinoma BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. 10964051 Human
bag-1 oral squamous-cell carcinoma In this report we show a possible correlation between BAG-1 expression levels and the probability of oral squamous cell carcinoma (SCC) progression. 10964051 Human
bag-1 cervical cancer Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer. 10047462 Human
bag-1 cervical cancer However, the role of BAG-1 in the oncogenesis of human cervical cancer has yet to be illustrated. 10047462 Human
bag-1 carcinoma In this study, we examined the expression of BAG-1 in cervical normal and carcinoma cultured cells and tissues. 10047462 Human
bag-1 cervical carcinoma BAG-1 was overexpressed in human cervical carcinoma cell lines and tissues. 10047462 Human
bag-1 cervical carcinoma The increased expression of BAG-1 was correlated with enhanced resistance of cervical carcinoma cells to apoptosis induced by a DNA-damaging reagent. 10047462 Human
bag-1 cervical cancer This study provided the first evidence that BAG-1 is upregulated in human cervical cancer and may play an important role in apoptosis and human cervical carcinogenesis. 10047462 Human
bag-1 human gastric cancer BAG-1 accelerates cell motility of human gastric cancer cells. 10359530 Human
bag-1 human gastric cancer Here, we provide evidence that gene transfer-mediated overexpression of BAG-1 markedly enhances the motility of human gastric cancer cells. 10359530 Human
bag-1 human gastric cancer The promotive effect of BAG-1 on cell migration was similarly observed in transfectants of another human gastric cancer MKN45 cell line. 10359530 Human
bag-1 gastric cancer In BAG-1 transfected gastric cancer MKN74 cells, BAG-1 colocalized with cytokeratin as well as actin filaments, and was concentrated at membrane ruffles induced by lysophosphatidic acid (LPA). 10359530 Human
bag-1 human gastric cancer Taken together, these studies demonstrate that BAG-1 has a novel function as promoter of cell migration in human gastric cancer cells, possibly through cooperation with cytoskeletal proteins. 10359530 Human
bag-1 cancer Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues. 10430086 Human
bag-1 human breast cancer Although many apoptosis-associated genes have been linked to oncogenesis of human breast cancer, the role of BAG-1 has not been fully elucidated. 10430086 Human
bag-1 tumor In this study, we examined the expression of BAG-1 RNA or protein isoforms and its interacting antiapoptotic proteins, Bcl-2 and BcI-X(L), in breast normal and tumor cell lines and tissues by Northern or Western blot analysis. 10430086 Human
bag-1 human breast cancer We provide convincing evidence that both BAG-1 RNA and protein are overexpressed in human breast cancer cell lines. 10430086 Human
bag-1 carcinoma The expression of Bcl-2 and Bcl-X(L) correlated with that of BAG-1 in breast normal and carcinoma cell lines but not tissues. 10430086 Human
bag-1 human breast cancer Our study suggests that BAG-1 isoforms may serve as a molecular marker, independent of Bcl-2 and Bcl-X(L), for human breast cancer. 10430086 Human
bag-1 cancer Recently, BAG-1 has been found to be overexpressed in a variety of human cancer cell lines and some tumors. 10467399 Human
bag-1 tumors Recently, BAG-1 has been found to be overexpressed in a variety of human cancer cell lines and some tumors. 10467399 Human
bag-1 human tumors Most importantly, functional characterization of the BAG-1 promoter in vivo demonstrated that gain-of-function p53 mutants derived from human tumors upregulated the transcription of BAG-1 RNA and the expression of a reporter gene from the BAG-1 promoter. 10467399 Human
bag-1 tumors Furthermore, the data suggested that overexpression of BAG-1 in some tumors may be due to upregulation of the human BAG-1 promoter by mutant p53. 10467399 Human
bag-1 sll Statistically significant differences were: (1) a higher level of Bad expression in DLCL compared to FL and MCL; (2) a lower level of Bak expression in FL compared to DLCL, SLL and MCL; and (3) a higher Bag-1 expression level in FL compared to SLL. 10516756 Human
bag-1 early-stage breast cancer BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. 11181661 Human
bag-1 breast tumors We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients. 11181661 Human
bag-1 early-stage breast cancer We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients. 11181661 Human
bag-1 breast cancer PATIENTS AND METHODS: Archival paraffin blocks from 122 women with stages I to II breast cancer treated with lumpectomy and radiation therapy (median follow-up, 12.1 years) were analyzed by immunohistochemical methods using monoclonal antibodies recognizi 11181661 Human
bag-1 invasive breast cancers RESULTS: Cytosolic immunostaining for BAG-1 was upregulated in 79 (65%) of 122 invasive breast cancers (P <.001) compared with normal breast. 11181661 Human
bag-1 early-stage breast cancer CONCLUSION: These findings provide preliminary evidence that BAG-1 represents a potential marker of improved survival in early-stage breast cancer patients, independent of the status of axillary lymph nodes. 11181661 Human
bag-1 laryngeal carcinomas Nuclear BAG-1 localization and the risk of recurrence after radiation therapy in laryngeal carcinomas. 11248425 Human
bag-1 laryngeal carcinoma We attempted to investigate whether BAG-1 expression is correlated with prognosis of laryngeal carcinoma patients after radiotherapy. 11248425 Human
bag-1 laryngeal carcinomas Immunohistochemical analyses revealed BAG-1 expression was present in all laryngeal carcinomas examined, and its expression pattern varied, i.e. cytoplasmic, nuclear and both these staining types. 11248425 Human
bag-1 tumors Patients whose tumors predominantly express nuclear BAG-1 have a significantly poor failure-free survival rate after radiotherapy. 11248425 Human
bag-1 laryngeal carcinoma We thus propose that nuclear BAG-1 localization is a prediction of unfavorable outcome should radiation therapy be undertaken for laryngeal carcinoma patients. 11248425 Human
bag-1 human colon adenocarcinoma In this study, we demonstrated that in addition to depleting c-Raf-1 and inhibiting ERK-1/2 phosphorylation in human colon adenocarcinoma cells, 17AAG also depleted N-ras, Ki-ras, and c-Akt and inhibited phosphorylation of c-AKT: A consequence of these ev 11358818 Human
bag-1 other tumor In this study, we demonstrated that in addition to depleting c-Raf-1 and inhibiting ERK-1/2 phosphorylation in human colon adenocarcinoma cells, 17AAG also depleted N-ras, Ki-ras, and c-Akt and inhibited phosphorylation of c-AKT: A consequence of these ev 11358818 Human
bag-1 nonsmall-cell lung cancer Prognostic significance of BAG-1 expression in nonsmall cell lung cancer. 11494232 Human
bag-1 tumor Univariate Cox regression analysis showed that those patients whose tumor overexpressed BAG-1 had a significant reduction in the risk of death (hazard ratio = 0.53, p = 0.03). 11494232 Human
bag-1 tumor The survival advantage of patients with BAG-1 overexpression tumor was also demonstrated by Kaplan-Meier analysis and log-rank tests (median survival 30.10 months versus 17.04 months, p = 0.05). 11494232 Human
bag-1 nsclc Our preliminary data strongly indicate that further investigation is warranted to better define the role of BAG-1 as an independent prognostic factor in NSCLC. 11494232 Human
bag-1 early breast cancer BAG-1 immunostaining and survival in early breast cancer. 11504752 Human
bag-1 advanced breast cancer The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer. 11895913 Human
bag-1 tumour BAG-1, an anti-apoptotic tumour marker. 12049201 Human
bag-1 cancer BAG-1 is widely overexpressed in a variety of tumour cell lines and cancer tissues. 12049201 Human
bag-1 tumour BAG-1 is widely overexpressed in a variety of tumour cell lines and cancer tissues. 12049201 Human
bag-1 laryngeal carcinomas Pilot clinical studies have demonstrated that overexpression of nuclear BAG-1 may be associated with a shorter survival in breast and laryngeal carcinomas. 12049201 Human
bag-1 non-small cell lung cancer Conversely, overexpression of cytoplasmic BAG-1 may be associated with a better clinical outcome in early stage breast cancer and in non-small cell lung cancer. 12049201 Human
bag-1 early-stage breast cancer Conversely, overexpression of cytoplasmic BAG-1 may be associated with a better clinical outcome in early stage breast cancer and in non-small cell lung cancer. 12049201 Human
bag-1 human breast cancer BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data. 12081204 Human
bag-1 invasive breast cancer Immunohistochemistry was used to examine the expression of BAG-1 and HSC70 in 160 cases of invasive breast cancer. 12081204 Human
bag-1 tumours BAG-1 was expressed in 92% of cases; most tumours exhibited cytoplasmic BAG-1, while a smaller proportion also had nuclear immunostaining. 12081204 Human
bag-1 tumours There was a significant inverse correlation between histological grade and nuclear BAG-1 expression, with higher-grade tumours tending to have reduced nuclear BAG-1 expression, but there was no association with cytoplasmic BAG-1. 12081204 Human
bag-1 tumour The statistically significant correlation between nuclear BAG-1 expression and low tumour grade was strong in pre-menopausal, but not apparent in postmenopausal women. 12081204 Human
bag-1 tumour HSC70 was also detected in the majority (97%) of cases, although expression was not correlated with BAG-1 levels, oestrogen receptor status or tumour grade. 12081204 Human
bag-1 breast cancers These results are consistent with the hypothesis that BAG-1 plays an important but variable role in breast cancers developing in pre-menopausal and post-menopausal women. 12081204 Human
bag-1 oral squamous-cell carcinomas Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases. 12081206 Human
bag-1 lymph-node metastases Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases. 12081206 Human
bag-1 metastasis Bag-1 is an anti-apoptotic protein that promotes metastasis in some tumour cell types. 12081206 Human
bag-1 tumour Bag-1 is an anti-apoptotic protein that promotes metastasis in some tumour cell types. 12081206 Human
bag-1 oral squamous-cell carcinomas To determine whether Bag-1 expression is altered in 64 oral squamous cell carcinomas, tumour samples were compared with 17 samples of normal oral epithelium. 12081206 Human
bag-1 tumour To determine whether Bag-1 expression is altered in 64 oral squamous cell carcinomas, tumour samples were compared with 17 samples of normal oral epithelium. 12081206 Human
bag-1 lymph-node metastases Furthermore, in lymph node metastases, cytoplasmic Bag-1 staining was stronger in 8/13 cases than in corresponding primary tumours (p=0.021). 12081206 Human
bag-1 primary tumours Furthermore, in lymph node metastases, cytoplasmic Bag-1 staining was stronger in 8/13 cases than in corresponding primary tumours (p=0.021). 12081206 Human
bag-1 oral squamous-cell carcinomas Therefore the reduced nuclear staining observed in oral squamous cell carcinomas compared with normal epithelium may reflect changes in the localization of Bag-1 isoforms, rather than decreased expression of Bag-1L. 12081206 Human
bag-1 lymph-node metastasis Overall, the results suggest that Bag-1 deregulation plays a role in oral carcinogenesis at two different stages: during primary carcinoma development and during lymph node metastasis. 12081206 Human
bag-1 primary carcinoma Overall, the results suggest that Bag-1 deregulation plays a role in oral carcinogenesis at two different stages: during primary carcinoma development and during lymph node metastasis. 12081206 Human
bag-1 lung adenomas Interestingly, 19 genes showed differential expression or increased incidence or difference in level of change between lung adenomas and adenocarcinomas, including Stat1, ADAP, IGFBP-6, PDGF-A, TGF-beta2, Int-3, VEGFR2, BAX, BAG-1, c-Jun, FasL, TRAIL, YB- 12173053 Mouse
bag-1 breast cancer The clonogenic growth of breast cancer cell lines was inhibited by a ligand for PPARgamma (troglitazone, TGZ) combined with a ligand for either retinoid X receptor (RXR) (LG10069) (4/8 cell lines), RAR (ATRA) (5/8 cell lines) or RAR/RXR and RXR/RXR (9-cis 12186376 Human
bag-1 cervical carcinoma Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line. 12370827 Human
bag-1 cancer BAG-1 expression and function in human cancer. 12373595 Human
bag-1 metastasis BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. 12373595 Human
bag-1 cancer The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. 12373595 Human
bag-1 early breast cancer There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in e 12373595 Human
bag-1 cancers There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in e 12373595 Human
bag-1 other cancer However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. 12373595 Human
bag-1 breast cancer However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. 12373595 Human
bag-1 cancer This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function. 12373595 Human
bag-1 colorectal carcinomas Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas. 12402153 Human
bag-1 colorectal cancer The aim of our study was to investigate the immunohistochemical staining pattern of BAG-1 protein in patients with colorectal cancer and examine associations of BAG-1 expression with various clinicopathological factors and patient survival. 12402153 Human
bag-1 tumours Overall survival was significantly shorter for patients with tumours exhibiting BAG-1 positive nuclei than those with absent nuclear BAG-1-staining (P=0.011). 12402153 Human
bag-1 metastasis These studies demonstrate that nuclear BAG-1 expression is a useful predictive factor for distant metastasis and a poor prognosis in patients with colorectal cancer. 12402153 Human
bag-1 colorectal cancer These studies demonstrate that nuclear BAG-1 expression is a useful predictive factor for distant metastasis and a poor prognosis in patients with colorectal cancer. 12402153 Human
bag-1 cervical cancer We have obtained human cervical cancer HeLa cells with down-regulated BAG-1 levels by using a highly specific and efficient RNA interference approach. 12565851 Human
bag-1 tumour Of particular relevance to tumour cells, BAG-1 interacts with the anti-apoptotic BCL-2 protein, various nuclear hormone receptors and the 70 kDa heat shock proteins, Hsc70 and Hsp70. 12618309 Human
bag-1 thyroid neoplasm Bag-1 expression in thyroid neoplasm: its correlation with Bcl-2 expression and carcinoma dedifferentiation. 12680148 Human
bag-1 carcinoma Bag-1 expression in thyroid neoplasm: its correlation with Bcl-2 expression and carcinoma dedifferentiation. 12680148 Human
bag-1 carcinomas Bag-1 is a recently identified bcl-2-related protein and is known to be linked to the biological aggressiveness of some carcinomas. 12680148 Human
bag-1 thyroid neoplasms MATERIALS AND METHODS: We immunohistochemically investigated bag-1 and bcl-2 expression in various thyroid neoplasms using monoclonal antibodies. 12680148 Human
bag-1 follicular adenoma RESULTS: High bag-1 expression was observed in 66.7% of follicular adenoma and 75.0% of follicular carcinoma, and no statistical difference was established between them. 12680148 Human
bag-1 follicular carcinoma RESULTS: High bag-1 expression was observed in 66.7% of follicular adenoma and 75.0% of follicular carcinoma, and no statistical difference was established between them. 12680148 Human
bag-1 papillary and follicular carcinomas In papillary carcinoma, 60.7% were classified with high bag-1 expression, whereas only 4.5% of anaplastic (undifferentiated) carcinoma highly expressed bag-1, and the incidence was significantly lower (p < 0.0001) than in papillary and follicular carcinom 12680148 Human
bag-1 papillary carcinoma In papillary carcinoma, 60.7% were classified with high bag-1 expression, whereas only 4.5% of anaplastic (undifferentiated) carcinoma highly expressed bag-1, and the incidence was significantly lower (p < 0.0001) than in papillary and follicular carcinom 12680148 Human
bag-1 carcinoma In papillary carcinoma, 60.7% were classified with high bag-1 expression, whereas only 4.5% of anaplastic (undifferentiated) carcinoma highly expressed bag-1, and the incidence was significantly lower (p < 0.0001) than in papillary and follicular carcinom 12680148 Human
bag-1 thyroid neoplasm Furthermore, in thyroid neoplasm, bag-1 expression was directly linked (p < 0.0001) to bcl-2 expression. 12680148 Human
bag-1 thyroid neoplasm CONCLUSION: These findings suggest that bag-1 may interact with bcl-2 to play an important role in thyroid neoplasm before anaplastic transformation, and the disruption of events mediated by bag-1 and bcl-2 may be a typical characteristic of undifferentia 12680148 Human
bag-1 undifferentiated carcinoma CONCLUSION: These findings suggest that bag-1 may interact with bcl-2 to play an important role in thyroid neoplasm before anaplastic transformation, and the disruption of events mediated by bag-1 and bcl-2 may be a typical characteristic of undifferentia 12680148 Human
bag-1 esophageal squamous-cell carcinoma Nuclear BAG-1 expression is a biomarker of poor prognosis in esophageal squamous cell carcinoma. 12823208 Human
bag-1 esophageal squamous-cell carcinoma (escc) The present study was performed to clarify the clinical implications of BAG-1, a bcl-2 binding protein in esophageal squamous cell carcinoma (ESCC). 12823208 Human
bag-1 tumor BAG-1 expression in the nuclei was related to the depth of tumor invasion (P = 0.0381) but not to any other clinicopathologic parameters. 12823208 Human
bag-1 tumor Our data suggests that BAG-1 expression in the nuclei of ESCC plays an important role in tumor development and may be useful for predicting the prognosis after surgery. 12823208 Human
bag-1 colonic adenoma The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. 12845674 Human
bag-1 carcinoma The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. 12845674 Human
bag-1 breast cancer BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. 12874020 Human
bag-1 breast cancer There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been studied in detail. 12874020 Human
bag-1 breast cancer Here we demonstrate that BAG-1 overexpression completely protected breast cancer cells from apoptosis and long-term growth inhibition induced by heat shock and also partially protected cells from other stresses, including hypoxia, radiation, and chemotoxi 12874020 Human
bag-1 breast cancer Here we have investigated the effects of BAG-1 on function of the oestrogen receptor (ER), a key growth control molecule and target for hormonal therapy in breast cancer. 12902980 Human
bag-1 breast cancers Consistent with an important effect on receptor function, nuclear BAG-1 expression in breast cancers was associated with expression of the progesterone receptor, a transcriptional target of ERalpha, and was associated with improved survival in patients tr 12902980 Human
bag-1 breast cancer Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer. 14607338 Human
bag-1 breast tumour The expression of transcripts for anti-apoptotic (survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-alpha) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, 14607338 Human
bag-1 tumour Overall, survivin, survivin-deltaEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-alpha and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. 14607338 Human
bag-1 breast cancer The results from this study suggest, however, that the expression of survivin, survivin-deltaEx3, survivin-2B, bag-1, galectin-3, bax-alpha and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer. 14607338 Human
bag-1 cancers Elucidating the molecular mechanisms that underlie the cellular functions of BAG-1 becomes an increasingly important task, particularly in light of the growing evidence connecting aberrant BAG-1 expression to certain human cancers. 14984055 Human
bag-1 invasive breast carcinoma BAG-1 expression correlates with Bcl-2, p53, differentiation, estrogen and progesterone receptors in invasive breast carcinoma. 15026618 Human
bag-1 invasive breast carcinomas BAG-1, a recently identified anti-apoptotic protein, is overexpressed in the majority of invasive breast carcinomas. 15026618 Human
bag-1 cancer Overexpression of BAG-1 is important for both multi-step oncogenesis and resistance of cancer cells to apoptosis induced by DNA-damaging alkylating agents. 15026618 Human
bag-1 non-small cell lung cancer BAG-1 protein species are localized differentially; nuclear expression may be associated with a shorter disease-free and overall survival in early stage breast cancer, while cytoplasmic expression has been associated with longer survival in non-small cell 15026618 Human
bag-1 early-stage breast cancer BAG-1 protein species are localized differentially; nuclear expression may be associated with a shorter disease-free and overall survival in early stage breast cancer, while cytoplasmic expression has been associated with longer survival in non-small cell 15026618 Human
bag-1 invasive breast cancer Since BAG-1 interacts with Bcl-2 and is upregulated by mutant p53 in vitro, it would be interesting to determine if their expressions are correlated with each other and with other clinical prognostic factors in invasive breast cancer. 15026618 Human
bag-1 breast cancer To address this question we conducted a large scale retrospective study of BAG-1, Bcl-2 and p53 in 185 breast cancer patients. 15026618 Human
bag-1 breast cancer Our study again showed that BAG-1 is overexpressed in the majority of breast cancer patients. 15026618 Human
bag-1 breast cancer Further experiments to explore the prognostic and therapeutic role of BAG-1 in breast cancer are warranted. 15026618 Human
bag-1 cancer Consistent with this proposal, previous analyses in cancer cells have demonstrated that BAG-1 requires protein domains important for HSC70/HSP70 and proteasome binding in order to interfere with the growth inhibition induced by heat shock (Townsend, P. A. 14978028 Human
bag-1 locally advanced breast cancer Expression of BAG-1 and BcL-2 proteins before and after neoadjuvant chemotherapy of locally advanced breast cancer. 15199607 Human
bag-1 breast cancers All breast cancers expressed BAG-1 protein, and, in individual tumors, 40-100% of neoplastic cells stained positive for this protein. 15199607 Human
bag-1 individual tumors All breast cancers expressed BAG-1 protein, and, in individual tumors, 40-100% of neoplastic cells stained positive for this protein. 15199607 Human
bag-1 residual tumor Paired pre- and posttreatment specimens showed similar levels of BAG-1 expression when residual tumor could be assessed. 15199607 Human
bag-1 breast cancer High levels of BAG-1 have been implicated as a prognostic indicator in breast cancer. 15297164 Human
bag-1 cancers RESULTS: The proportion of "high-grade" cancers with positive cytoplasmic staining for BAG-1 was higher than that of secretory endometrium (P = 0.006). 15297164 Human
bag-1 carcinoma Additionally, the proportion of specimens with positive staining for nuclear BAG-1 expression was significantly higher among high-grade carcinoma specimens compared to secretory specimens (P = 0.009). 15297164 Human
bag-1 cancers High-grade cancers stain more frequently than secretory endometrium for both cytoplasmic and nuclear BAG-1 expression, perhaps indicating an association between expression of BAG-1 and prognosis. 15297164 Human
bag-1 tongue squamous cell carcinomas Bag-1 expression as a prognostic factor in tongue squamous cell carcinomas. 15454773 Human
bag-1 tumors Patients with tumors expressing high Bag-1 values had a shortened disease-specific survival time when compared with those with low Bag-1 values (P =.0017). 15454773 Human
bag-1 tongue scc The expression of Bag-1 protein, particularly in combination with Bax expression or AI, respectively, has prognostic value in oral tongue SCC. 15454773 Human
bag-1 metastasis Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. 15474970 Human
bag-1 breast cancer Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, a 15474970 Human
bag-1 breast cancer Evidence that BAG-1 expression is frequently altered in human cancers, in particular in breast cancer, relative to normal cells has been put forward but the notion that overexpression of BAG-1 contributes to poor prognosis in tumorigenesis remains controv 15560850 Human
bag-1 cancers Evidence that BAG-1 expression is frequently altered in human cancers, in particular in breast cancer, relative to normal cells has been put forward but the notion that overexpression of BAG-1 contributes to poor prognosis in tumorigenesis remains controv 15560850 Human
bag-1 lung adenoma RESULTS: We show that BAG-1 heterozygosity in mice impairs C-Raf oncogene-induced lung adenoma growth. 15560850 Mouse
bag-1 lung tumor Lung tumor initiation was reduced by half in BAG-1 heterozygous SP-C C-Raf BxB mice compared to their littermates. 15560850 Mouse
bag-1 tumor Tumor area was reduced by 75% in 4 month lungs of BAG-1 haploinsufficient mice compared to mice with two BAG-1 copies. 15560850 Mouse
bag-1 adenoma Whereas BAG-1 heterozygosity did not affect the rate of cell proliferation or signaling through the mitogenic cascade in adenoma cells, it increased the rate of apoptosis. 15560850 Mouse
bag-1 tumor CONCLUSION: Reduced BAG-1 expression specifically targets tumor cells to apoptosis and impairs tumorigenesis. 15560850 Mouse
bag-1 cancer Our data implicate BAG-1 as a key player in oncogenic transformation by Raf and identify it as a potential molecular target for cancer treatment. 15560850 Mouse
bag-1 tumor In addition, CT120 might play an important role in tumor progression through modulating the expression of some candidate "Lung Tumor Progression" genes including B-Raf, Rab-2, BAX, BAG-1, YB-1, and Cdc42. 15625016 Mouse
bag-1 lung tumor In addition, CT120 might play an important role in tumor progression through modulating the expression of some candidate "Lung Tumor Progression" genes including B-Raf, Rab-2, BAX, BAG-1, YB-1, and Cdc42. 15625016 Mouse
bag-1 human ovarian cancer BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells. 15707960 Human
bag-1 ovarian cancer To further understand the role of this smaller isoform in ovarian cancer cells, the SKOV3 cell line was transfected with a doxycycline-inducible human BAG-1 p29 isoform or control plasmid. 15707960 Human
bag-1 cultured pheochromocytoma Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding protein are controlled by withdrawal of nicotine from cultured pheochromocytoma PC12 cells. 15785859 Rat
bag-1 colorectal cancer BAG-1 is an anti-apoptotic protein that is frequently deregulated in a variety of malignancies including colorectal cancer. 15843891 Human
bag-1 metastasis In colon cancer, the expression of nuclear BAG-1 is associated with poorer prognosis and is potentially a useful predictive factor for distant metastasis. 15843891 Human
bag-1 colon cancer In colon cancer, the expression of nuclear BAG-1 is associated with poorer prognosis and is potentially a useful predictive factor for distant metastasis. 15843891 Human
bag-1 tumour Having previously shown a predominant nuclear localisation of BAG-1 in adenoma-derived cell lines, we wanted to determine the function of nuclear BAG-1 in these non-tumourigenic cells, to identify whether nuclear BAG-1 was implicated in tumour progression 15843891 Human
bag-1 colorectal tumour The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. 16042572 Human
bag-1 colorectal cancers Interestingly, although reported as deregulated in colorectal cancers, we have found that BAG-1 expression is also altered in small adenomas, where its localization was found to be predominantly nuclear. 16042572 Human
bag-1 adenomas Interestingly, although reported as deregulated in colorectal cancers, we have found that BAG-1 expression is also altered in small adenomas, where its localization was found to be predominantly nuclear. 16042572 Human
bag-1 colorectal tumour We have found predominant nuclear BAG-1 localization in small adenomas, and suggest that BAG-1 may promote colorectal tumour cell survival by making colonic epithelial cells less sensitive to DNA damage. 16042572 Human
bag-1 adenomas We have found predominant nuclear BAG-1 localization in small adenomas, and suggest that BAG-1 may promote colorectal tumour cell survival by making colonic epithelial cells less sensitive to DNA damage. 16042572 Human
bag1 cancers Bcl-2-associated athanogene (BAG1), an anti-apoptotic protein found at high levels in a number of human cancers, was significantly over-expressed in growth hormone-secreting and prolactin-secreting adenomas and NFPAs. 15994756 Human
bag1 adenomas Bcl-2-associated athanogene (BAG1), an anti-apoptotic protein found at high levels in a number of human cancers, was significantly over-expressed in growth hormone-secreting and prolactin-secreting adenomas and NFPAs. 15994756 Human
bag-1 cancer Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. 9747877 Human
bag-1 nhl Expression of Bcl-2 and its homologues, Bcl-xL, Bcl-xS, Bax, Bad, Bak and Bag-1, was detected in all NHL cases, with wide variations between histological subtypes and within each subtype. 10516756 Human
bag-1 mcl Statistically significant differences were: (1) a higher level of Bad expression in DLCL compared to FL and MCL; (2) a lower level of Bak expression in FL compared to DLCL, SLL and MCL; and (3) a higher Bag-1 expression level in FL compared to SLL. 10516756 Human
bag-1 b-cell chronic lymphocytic leukaemia (b-cll) B-cell chronic lymphocytic leukaemia (B-CLL) cells were treated in vitro with CD40-ligand (CD40L) (CD154) or the protein kinase C modulator Bryostatin-1, exploring the effects on: (a) sensitivity to apoptosis induction by chemotherapeutic drugs (fludarabi 10520003 Human
bag-1 cancer Taken together, these results indicate a role for Bag-1/Bcl-2 interactions in providing a survival advantage to cancer cells in a deprived microenvironment that may be characteristic of ischemic/hypoxic tumors such as human glioblastoma multiforme, and su 10764042 Human
bag-1 glioblastoma multiforme Taken together, these results indicate a role for Bag-1/Bcl-2 interactions in providing a survival advantage to cancer cells in a deprived microenvironment that may be characteristic of ischemic/hypoxic tumors such as human glioblastoma multiforme, and su 10764042 Human
bag-1 tumors Taken together, these results indicate a role for Bag-1/Bcl-2 interactions in providing a survival advantage to cancer cells in a deprived microenvironment that may be characteristic of ischemic/hypoxic tumors such as human glioblastoma multiforme, and su 10764042 Human
bag-1 nonsmall cell lung cancer (nsclc) The purpose of this study was to evaluate the expression of BAG-1 in a cohort of patients with nonsmall cell lung cancer (NSCLC). 11494232 Human
bag-1 esophageal squamous cell carcinoma Nuclear BAG-1 expression is a biomarker of poor prognosis in esophageal squamous cell carcinoma. 12823208 Human
bag-1 esophageal squamous cell carcinoma (escc) The present study was performed to clarify the clinical implications of BAG-1, a bcl-2 binding protein in esophageal squamous cell carcinoma (ESCC). 12823208 Human
bag-1 laryngeal squamous cell carcinoma [Expression of BAG-1 and p53 in laryngeal squamous cell carcinoma and their clinical significance] OBJECTIVE: To study the expression of BAG-1 and p53 in laryngeal squamous cell carcinoma (LSCC), and the relation between BAG-1 and p53. 16398049 Human
bag-1 laryngeal squamous cell carcinoma (lscc) [Expression of BAG-1 and p53 in laryngeal squamous cell carcinoma and their clinical significance] OBJECTIVE: To study the expression of BAG-1 and p53 in laryngeal squamous cell carcinoma (LSCC), and the relation between BAG-1 and p53. 16398049 Human
bag-1 polyp METHOD: BAG-1 and p53 protein were examined by using the method of immunohistochemical SP staining method in 40 cases of LSCC, 27 cases of pap- a-cancerous tissues and 20 cases of polyp specimens from vocal cord tissues. 16398049 Human
bag-1 breast cancer The bDLE induced cytotoxic effects and suppressed the p53, bag-1, c-myc, bax, bcl-2, and bad mRNA expression that influences apoptosis in MCF-7 breast cancer cells. 16923617 Human
bag1 tumors Of these 253 differentially expressed genes, pathways up-regulated in sensitive tumors included cell cycle (BUB3, CDKN1B), survival (BCL2, BAG1, BIRC1, STK39), stress response (CYP2B6, MAPK14), and estrogen-related pathways (ER, IRS1). 16322899 Human
bag-i human breast cancer BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data. 12081204 Human
bag-1 receptor-positive human breast cancers High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. 10576663 Human
bag-1 oral squamous cell carcinoma BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. 10964051 Human
bag-1 oral squamous cell carcinoma In this report we show a possible correlation between BAG-1 expression levels and the probability of oral squamous cell carcinoma (SCC) progression. 10964051 Human
bag-1 nonsmall cell lung cancer Prognostic significance of BAG-1 expression in nonsmall cell lung cancer. 11494232 Human
bag-1 early stage breast cancer Conversely, overexpression of cytoplasmic BAG-1 may be associated with a better clinical outcome in early stage breast cancer and in non-small cell lung cancer. 12049201 Human
bag-1 lymph node metastases Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases. 12081206 Human
bag-1 oral squamous cell carcinomas Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases. 12081206 Human
bag-1 oral squamous cell carcinomas To determine whether Bag-1 expression is altered in 64 oral squamous cell carcinomas, tumour samples were compared with 17 samples of normal oral epithelium. 12081206 Human
bag-1 lymph node metastases Furthermore, in lymph node metastases, cytoplasmic Bag-1 staining was stronger in 8/13 cases than in corresponding primary tumours (p=0.021). 12081206 Human
bag-1 oral squamous cell carcinomas Therefore the reduced nuclear staining observed in oral squamous cell carcinomas compared with normal epithelium may reflect changes in the localization of Bag-1 isoforms, rather than decreased expression of Bag-1L. 12081206 Human
bag-1 lymph node metastasis Overall, the results suggest that Bag-1 deregulation plays a role in oral carcinogenesis at two different stages: during primary carcinoma development and during lymph node metastasis. 12081206 Human
bag-1 early stage breast cancer BAG-1 protein species are localized differentially; nuclear expression may be associated with a shorter disease-free and overall survival in early stage breast cancer, while cytoplasmic expression has been associated with longer survival in non-small cell 15026618 Human
bag-1 glial tumours Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours. 16292491 Human
bag-1 neoplasia BAG-1 is a multifunctional protein with an important role in neoplasia and is possibly regulated by estrogen receptors. 16292491 Human
bag-1 astrocytomas ERbeta, BAG-1 and HSP70 protein expression was monitored immunohistochemically in 66 cases of astrocytomas and 20 oligodendrogliomas. 16292491 Human
bag-1 oligodendrogliomas ERbeta, BAG-1 and HSP70 protein expression was monitored immunohistochemically in 66 cases of astrocytomas and 20 oligodendrogliomas. 16292491 Human
bag-1 astrocytic tumours In astrocytic tumours low ERbeta expression correlated significantly with high grade (P < 0.001), higher expression of cytoplasmic BAG-1 (P < 0.001) and worse survival (log rank P = 0.02). 16292491 Human
bag-1 glial neoplasms Our results strengthen the hypothesis that ERbeta, BAG-1 and HSP70 play an important role in the pathogenesis and progression of glial neoplasms. 16292491 Human
bag-1 hyperplastic BAG-1 expression in hyperplastic and neoplastic prostate tissue: is there any relationship with BCL-related proteins and androgen receptor status? 16457154 Human
bag-1 hyperplastic AIMS AND BACKGROUND: To evaluate the function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression 16457154 Human
bag-1 prostatic adenocarcinomas AIMS AND BACKGROUND: To evaluate the function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression 16457154 Human
bag-1 carcinomas There were significant differences in nuclear and cytoplasmic BAG-1 positivity between high and low-grade carcinomas. 16457154 Human
bag-1 carcinomas BAG-1 expression was higher in low-grade carcinomas. 16457154 Human
bag-1 carcinoma In the carcinoma group there was a positive correlation (Pearson) between BCL-2 and cytoplasmic/nuclear BAG-1. 16457154 Human
bag-1 hyperplasias We also detected a positive correlation between AR and nuclear/cytoplasmic BAG-1 and between nuclear and cytoplasmic BAG-1 in hyperplasias. 16457154 Human
bag-1 hyperplastic BAG-1 showed the same specific basal cell localization as BCL-2 in hyperplastic and normal glands. 16457154 Human
bag-1 hyperplastic CONCLUSIONS: The BAG-1 protein showed a distinct distribution pattern in hyperplastic and neoplastic prostate. 16457154 Human
bag-1 prostate cancers Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers. 16482527 Human
bag-1 prostate cancers METHODS: Using immunohistochemical method, we explored BAG-1 expression in prostate cancers and its association with clinicopathological parameters. 16482527 Human
bag-1 prostate cancer RESULTS: BAG-1 immunostaining was elevated in prostate cancer compared to normal prostatic epithelium. 16482527 Human
bag-1 tumors Higher nuclear BAG-1 in hormone-refractory (n = 34) compared to localized untreated tumors (n = 58) (P < 0.0001) suggested that upregulation of the nuclear isoform may contribute to disease progression. 16482527 Human
bag-1 prostate cancer CONCLUSIONS: Increased cytosolic and nuclear BAG-1 expression may denote more aggressive variants of prostate cancer. 16482527 Human
bag-1 chronic lymphocytic leukemia Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins. 16501812 Human
bag-1 b-chronic lymphocytic leukemia (b-cll) The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10(-6) M fludarabine using multiparametric f 16501812 Human
bag-1 cll The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10(-6) M fludarabine using multiparametric f 16501812 Human
bag-1 cll Therefore, we could assume that Bag-1 expression in such situation might identify CLL patients who will need treatment earlier. 16501812 Human
bag-1 prostate hyperplasias AIMS AND BACKGROUND: To evaluate the function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression 16457154 Human
bag-1 metastasis The Bcl-2-expressing B16 cells, B16-Bcl-2 and the BAG-1-expressing B16 cells, B16-BAG-1 strongly enhanced pulmonary metastasis in allogenic BALB/c nude mice and whole lung weights were increased by 2.4-fold and 1.4-fold, respectively, compared with contro 9205104 Mouse
bag-1 pulmonary metastasis The Bcl-2-expressing B16 cells, B16-Bcl-2 and the BAG-1-expressing B16 cells, B16-BAG-1 strongly enhanced pulmonary metastasis in allogenic BALB/c nude mice and whole lung weights were increased by 2.4-fold and 1.4-fold, respectively, compared with contro 9205104 Mouse
bag-1 oncoprotein The Bcl-2 oncoprotein is a key regulator of apoptosis and the Bag-1 protein interacts with Bcl-2 and cooperates with Bcl-2 to suppress apoptosis. 9396724 Human
bag-1 tumor When the viable transfectants were inoculated into the intraperitoneal cavity of BALB/c nude mice, the Bcl-2-expressing MKN74 cells and the BAG-1-expressing MKN74 cells exhibited strongly enhanced peritoneal dissemination in BALB/c nude mice and whole dis 9632144 Human
bag-1 leukemias The BAG-1 protein was found at high levels in several types of human tumor cell lines among the 67 tested, particularly leukemias, breast, prostate, and colon cancers. 9679980 Human
bag-1 leukemia In contrast to normal tissues, which only rarely expressed BAG-1L, tumor cell lines commonly contained BAG-1L protein, including most prostate, breast, and leukemia cell lines, suggesting that a change in BAG-1 mRNA translation frequently accompanies mali 9679980 Human
bag-1 malignant transformation In contrast to normal tissues, which only rarely expressed BAG-1L, tumor cell lines commonly contained BAG-1L protein, including most prostate, breast, and leukemia cell lines, suggesting that a change in BAG-1 mRNA translation frequently accompanies mali 9679980 Human
bag-1 oncoprotein In this context, the induction of anti-apoptotic molecules such as Bcl-2 oncoprotein and BAG-1 protein seems to be a key event for the anti-apoptotic function of cytokines. 9711911 Human
bag-1 carcinogenesis This study provided the first evidence that BAG-1 is upregulated in human cervical cancer and may play an important role in apoptosis and human cervical carcinogenesis. 10047462 Human
bag-1 primary tumors More importantly, we found that the expression of two isoforms of BAG-1, p46 and p33, was also much higher in breast primary tumors. 10430086 Human
bag-1 primary tumor Moreover, 15 of 19 human glioblastomas expressed Bag-1 as assessed by immunohistochemistry in primary tumor specimens. 10764042 Human
bag-1 primary tumors In 126 patients, histological blocks of primary tumors were available for immunohistochemical analysis of bax, bcl-2, bcl-xL, bag-1, fas and fasL. 11895913 Human
bag-1 carcinogenesis Overall, the results suggest that Bag-1 deregulation plays a role in oral carcinogenesis at two different stages: during primary carcinoma development and during lymph node metastasis. 12081206 Human
bag-1 adenocarcinomas Interestingly, 19 genes showed differential expression or increased incidence or difference in level of change between lung adenomas and adenocarcinomas, including Stat1, ADAP, IGFBP-6, PDGF-A, TGF-beta2, Int-3, VEGFR2, BAX, BAG-1, c-Jun, FasL, TRAIL, YB- 12173053 Mouse
bag-1 metastasis The percentage of cases exhibiting nuclear BAG-1 positivity was significantly higher in distant metastasis-positive cases (55.6%) than in distant metastasis-negative cases (20.8%; P=0.036). 12402153 Human
bag-1 oncogene Exogenous expression of BAG-1 was reported to confer cells resistance to several stresses [Chen et al., Oncogene 21 (2002) 7050]. 12565851 Human
bag-1 escc Univariate analysis (P < 0.05), but not multivariate analysis, revealed significantly poor prognosis for ESCC cases exhibiting positive nucleic staining for BAG-1. 12823208 Human
bag-1 escc Our data suggests that BAG-1 expression in the nuclei of ESCC plays an important role in tumor development and may be useful for predicting the prognosis after surgery. 12823208 Human
bag-1 carcinoma In the current study we show that the Retinoblastoma susceptibility protein (Rb) protein interacts with Bag-1, an apoptotic regulator, in human colonic adenoma- and carcinoma-derived cell lines. 12845674 Human
bag-1 carcinoma Coimmunoprecipitation demonstrated that endogenous Rb and Bag-1 interact in both adenoma- and carcinoma-derived cell lines. 12845674 Human
bag-1 oncoprotein The specificity of the interaction was demonstrated by expression of human Papillomavirus E7 oncoprotein, an inhibitor of Rb protein interactions, which disrupted the Rb/Bag-1 complex. 12845674 Human
bag-1 carcinoma We report that Bag-1 is predominantly localised in the nucleus of colorectal adenoma- and carcinoma-derived epithelial cells. 12845674 Human
bag-1 breast cancer BAG-1-mediated resistance to stress-induced growth inhibition is likely to have a major impact on the development and response to therapy of breast cancer. 12874020 Human
bag-1 oncogene [Expression of oncogene proteins Bag-1, p53, and bcl-2 in endometrium adenocarcinoma with different rate of differentiation] 15518275 Human
bag-1 adenocarcinoma [Expression of oncogene proteins Bag-1, p53, and bcl-2 in endometrium adenocarcinoma with different rate of differentiation] 15518275 Human
bag-1 tumorigenesis BAG-1 haplo-insufficiency impairs lung tumorigenesis. 15560850 Mouse
bag-1 tumorigenesis Evidence that BAG-1 expression is frequently altered in human cancers, in particular in breast cancer, relative to normal cells has been put forward but the notion that overexpression of BAG-1 contributes to poor prognosis in tumorigenesis remains controv 15560850 Human
bag-1 tumorigenesis METHODS: We have evaluated the effect of BAG-1 heterozygosity in mice in a model of non-small-cell lung tumorigenesis with histological and molecular methods. 15560850 Human
bag-1 oncogenic We have generated mice heterozygous for BAG-1, carrying a BAG-1 null allele, that in addition express oncogenic, constitutively active C-Raf kinase (SP-C C-Raf BxB) in type II pneumocytes. 15560850 Mouse
bag-1 oncogene RESULTS: We show that BAG-1 heterozygosity in mice impairs C-Raf oncogene-induced lung adenoma growth. 15560850 Mouse
bag-1 tumorigenesis CONCLUSION: Reduced BAG-1 expression specifically targets tumor cells to apoptosis and impairs tumorigenesis. 15560850 Mouse
bag-1 oncogenic Our data implicate BAG-1 as a key player in oncogenic transformation by Raf and identify it as a potential molecular target for cancer treatment. 15560850 Mouse
bag-1 colorectal adenoma Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells. 15843891 Human
bag-1 adenoma Having previously shown a predominant nuclear localisation of BAG-1 in adenoma-derived cell lines, we wanted to determine the function of nuclear BAG-1 in these non-tumourigenic cells, to identify whether nuclear BAG-1 was implicated in tumour progression 15843891 Human
bag-1 colorectal adenoma In the current report we established that nuclear BAG-1 inhibits apoptosis in a colorectal adenoma-derived cell line. 15843891 Human
bag-1 colorectal adenoma We demonstrate that apoptosis induced by gamma-radiation or the vitamin D analogue EB1089 in the non-tumourigenic human colorectal adenoma-derived S/RG/C2 cell line, was preceded by a decrease in nuclear and an increase in cytoplasmic BAG-1 expression. 15843891 Human
bag-1 carcinogenesis This demonstrates that nuclear localisation of the BAG-1 protein confers a survival advantage in colorectal adenoma-derived cells and that nuclear BAG-1 could potentially be an important survival factor in colorectal carcinogenesis. 15843891 Human
bag-1 colorectal adenoma This demonstrates that nuclear localisation of the BAG-1 protein confers a survival advantage in colorectal adenoma-derived cells and that nuclear BAG-1 could potentially be an important survival factor in colorectal carcinogenesis. 15843891 Human
bag-1 oncoprotein We have established that Rb interacts with the anti-apoptotic BAG-1 (Bcl-2 associated athanogene-1) protein, and that a decrease in nuclear localization of BAG-1 is detectable when the interaction between Rb and BAG-1 is disrupted by expression of the E7 16042572 Human
bag-1 adenoma In addition, we have established that maintenance of high nuclear BAG-1 in vitro increases the resistance of adenoma-derived cells to gamma-radiation-induced apoptosis. 16042572 Human
bag-1 oncogenic BAG-1 in association with BCL-2 inhibits apoptosis and may prolong the life of neoplastic cells and give them a chance to gain new oncogenic features in early carcinogenesis. 16457154 Human
bag-1 carcinogenesis BAG-1 in association with BCL-2 inhibits apoptosis and may prolong the life of neoplastic cells and give them a chance to gain new oncogenic features in early carcinogenesis. 16457154 Human
bag1 erythroleukemia [Dynamics of chaperone complex Hdj1-Hsp70-Bag1 as a response of erythroleukemia K562 cells to heat stress] Heat shock protein Hsp70 is known to play an important role in cell protection against a variety of harmful factors. 15473372 Human
bag1 erythroleukemia [Dynamics of chaperone complex Hdj1-Hsp70-Bag1 as a response of erythroleukemia K562 cells to heat stress] Heat shock protein Hsp70 is known to play an important role in cell protection against a variety of harmful factors. 15473372 Human
bag1 lymph node metastasis Expression of BAG1 and TIMP3 was strongly associated with colon carcinoma differentiation, Duke's staging, lymph node metastasis and survival rate (P < 0.05), but not associated with gender and age. 17657847 Human
rap46 prostate cancer BAG-1L, but not BAG-1 or BAG-1M (RAP46), also markedly enhanced the ability of AR to transactivate reporter gene plasmids containing an androgen response element (ARE) in PC3 prostate cancer and other cell lines. 9565586 Human
rap46 thymoma We further show that overexpression of RAP46 in mouse thymoma S49.1 cells inhibits glucocorticoid-induced apoptosis. 9603979 Mouse
rap46 cancer Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. 9747877 Human
bag-1 human breast cancers High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. 10576663 Human
bag-1 metastasis High BAG-1 expression was observed more frequently in cases with nodal metastasis (89%) than in those without nodal metastasis (38%) (P<0. 10964051 Human
bag-1 carcinogenesis BAG-1 in carcinogenesis. BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. 15033003 Human
bag-1 metastasis BAG-1 isoforms interact with a diverse array of molecular targets and regulate a wide range of cellular processes, including proliferation, survival, transcription, apoptosis, metastasis and motility. 15033003 Human
bag-1 cancer The ability of BAG-1 to regulate such a wide variety of cellular processes suggests it might play an important role in many cancer types. 15033003 Human
bag-1 cancer There is also increasing evidence that BAG-1 expression is altered in a variety of human malignancies relative to normal cells, and with further understanding of BAG-1 function it might become a powerful prognostic/predictive marker in human cancer. 15033003 Human
bag-1 tumour This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells. 15033003 Human
bag-1 carcinomas Additionally, gain of the BAG-1 gene was observed in 27.2% of the hormone-refractory tumours and in 18.5% of the untreated carcinomas. 17503439 Human
bag-1 tumours Additionally, gain of the BAG-1 gene was observed in 27.2% of the hormone-refractory tumours and in 18.5% of the untreated carcinomas. 17503439 Human
bag-1 carcinoma Cytoplasmic localization of BAG-1 in leukoplakia and carcinoma of the tongue: correlation with p53 and c-erbB2 in carcinoma. 17549665 Human
bag-1 leukoplakia Cytoplasmic localization of BAG-1 in leukoplakia and carcinoma of the tongue: correlation with p53 and c-erbB2 in carcinoma. 17549665 Human
bag-1 carcinoma of the tongue Cytoplasmic localization of BAG-1 in leukoplakia and carcinoma of the tongue: correlation with p53 and c-erbB2 in carcinoma. 17549665 Human
bag-1 leukoplakia BACKGROUND: The present study evaluated the clinical significance of BAG-1, an antiapoptotic protein, in leukoplakia and carcinoma of the tongue. 17549665 Human
bag-1 carcinoma of the tongue BACKGROUND: The present study evaluated the clinical significance of BAG-1, an antiapoptotic protein, in leukoplakia and carcinoma of the tongue. 17549665 Human
bag-1 leukoplakia METHODS: BAG-1 expression was evaluated by immunohistochemistry in paraffin-embedded tissues of leukoplakia (n=25) and carcinoma of the tongue (n=61). 17549665 Human
bag-1 carcinoma of the tongue METHODS: BAG-1 expression was evaluated by immunohistochemistry in paraffin-embedded tissues of leukoplakia (n=25) and carcinoma of the tongue (n=61). 17549665 Human
bag-1 carcinoma BAG-1 expression in tobacco-using leukoplakia and carcinoma patients was compared by grouping the carcinoma patients according to lymph node status and disease stage. 17549665 Human
bag-1 leukoplakia BAG-1 expression in tobacco-using leukoplakia and carcinoma patients was compared by grouping the carcinoma patients according to lymph node status and disease stage. 17549665 Human
bag-1 carcinoma Carcinoma patients with tumor-positive lymph nodes had significantly lower BAG-1 expression than patients with negative lymph nodes and leukoplakia. 17549665 Human
bag-1 leukoplakia Carcinoma patients with tumor-positive lymph nodes had significantly lower BAG-1 expression than patients with negative lymph nodes and leukoplakia. 17549665 Human
bag-1 tumor Carcinoma patients with tumor-positive lymph nodes had significantly lower BAG-1 expression than patients with negative lymph nodes and leukoplakia. 17549665 Human
bag-1 tongue cancer CONCLUSION: BAG-1 negativity in association with p53 and c-erbB2 positivity identified a subgroup of tongue cancer patients with an aggressive phenotype. 17549665 Human
bag-1 carcinogenesis Hence, an antiapoptotic protein, BAG-1, was found to be down-regulated in chewing-tobacco-mediated tongue carcinogenesis. 17549665 Human
bag-1 neoplasm The expression of BAG-1 and bcl-2 may suggest that anti-apoptotic stimuli are preponderant in this neoplasm. 17645802 Human
bag-1 carcinogenesis Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis. 17662274 Human
bag-1 oral cancers In oral cancers, cytoplasmic BAG-1 overexpression is a marker of poor prognosis. 17662274 Human
bag-1 tumorigenesis By contrast to the cytoplasmic BAG-1 isoforms, BAG-1L may act to suppress tumorigenesis. 17662274 Human
bag1 phaeochromocytoma We have therefore studied the effect of bag1 overexpression in rat phaeochromocytoma (PC12) cells. 17596720 Rat
bag1 colon carcinoma Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma. 17657847 Human
bag1 colon carcinoma AIM: To explore the expression of BAG1 and tissue inhibitor of metalloproteinase 3 (TIMP3) in colon carcinoma and their correlation and clinicopathologic significance. 17657847 Human
bag1 colon carcinoma METHODS: SABC immunohistochemistry was used to detect the expression of BAG1 and TIMP3 in 80 colon carcinoma tissues and 20 normal colonic mucosa. 17657847 Human
bag1 colon carcinoma RESULTS: Positive rate of BAG1 in colon carcinoma tissue (80%) was notably higher compared to normal colonic mucosa (10%) (P < 0.05). 17657847 Human
bag1 colon carcinoma Expression of BAG1 and TIMP3 was strongly associated with colon carcinoma differentiation, Duke's staging, lymph node metastasis and survival rate (P < 0.05), but not associated with gender and age. 17657847 Human
bag1 colon carcinoma CONCLUSION: Our results suggest that over-expression of BAG1 or attenuated expression of TIMP3 may play an important role in genesis and development of colon carcinoma. 17657847 Human
bag1 metastasis The protein expression levels of BAG1 and TIMP3 are related to the malignant degree, infiltration and metastasis of colon carcinoma. 17657847 Human
bag1 colon carcinoma The protein expression levels of BAG1 and TIMP3 are related to the malignant degree, infiltration and metastasis of colon carcinoma. 17657847 Human
bag1 metastasis BAG1 and TIMP3 might be new biological parameters in predicting invasion and metastasis of colon carcinoma. 17657847 Human
bag1 colon carcinoma BAG1 and TIMP3 might be new biological parameters in predicting invasion and metastasis of colon carcinoma. 17657847 Human
bag-1 tumorigenesis There are three major isoforms of BAG-1 in mammalian cells, termed BAG-1L (p50), BAG-1M (p46) and BAG-1S (p36) that function as pro-survival proteins and are associated with tumorigenesis and chemoresistance. 17700523 Human
bag-1 stage iv ovarian cancer EXPERIMENTAL DESIGN: Expression patterns of BAG-1, BAG-3, BAG-4, and Bcl-xL were determined by immunohistochemical analysis of tissue samples obtained at diagnosis from 28 women with stage III or stage IV ovarian cancer treated with cisplatin, paclitaxel, 18006758 Human
bag-1 colorectal tumour BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity. 18204076 Human
bag-1 carcinomas Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we show for the first time that BAG-1 is over-expressed in medium/large-sized colorectal adenomas and ca 18204076 Human
bag-1 colorectal adenomas Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we show for the first time that BAG-1 is over-expressed in medium/large-sized colorectal adenomas and ca 18204076 Human
bag-1 colorectal carcinoma To investigate whether expression of BAG-1 is important for colorectal tumour cell survival, microarray analysis was carried out on the HCT116 colorectal carcinoma cell line following transfection with BAG-1 small interfering RNA (siRNA). 18204076 Human
bag-1 colorectal tumour To investigate whether expression of BAG-1 is important for colorectal tumour cell survival, microarray analysis was carried out on the HCT116 colorectal carcinoma cell line following transfection with BAG-1 small interfering RNA (siRNA). 18204076 Human
bag-1 colorectal carcinoma Of clinical relevance, BAG-1 siRNA sensitized colorectal carcinoma cells to apoptosis induced by potential therapeutic agent TRAIL as well as tumour necrosis factor-alpha, both inducers of NF-kappaB activity. 18204076 Human
bag-1 colorectal cancer It is proposed that, by inhibiting NF-kappaB, suppression of BAG-1 could represent a novel strategy to impede colorectal cancer cell survival and as an adjuvant increase sensitivity to current therapeutic regimes. 18204076 Human
bag-1 breast cancer BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. 18288403 Human
bag-1 breast cancer BAG-1 overexpression in breast cancer is associated with outcome. 18288403 Human
bag-1 prostate cancer BAG-1 modulates the function of various nuclear hormone receptors, including the oestrogen receptor, and BAG-1 can influence the in vitro action of anti-hormonal therapies such as cyproterone acetate in prostate cancer. 18288403 Human
bag-1 breast cancers Thus, BAG-1 is unlikely to directly modulate PPARgamma function, but the overexpression of BAG-1 in some breast cancers may limit the efficacy of PPARgamma agonists as cancer therapies, by suppression of PPARgamma-induced cell death pathways. 18288403 Human
bag-1 cancer Thus, BAG-1 is unlikely to directly modulate PPARgamma function, but the overexpression of BAG-1 in some breast cancers may limit the efficacy of PPARgamma agonists as cancer therapies, by suppression of PPARgamma-induced cell death pathways. 18288403 Human
bag-1 breast cancer Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer. 18430249 Human
bag-1 cancer Bcl-2 and Bag-1 are associated with chemotherapy resistance in cancer cells. 18430249 Human
bag-1 breast tumors The purpose of the present study was to examine expression patterns of Bag-1 in a large cohort of breast tumors and to assess the association with Bcl-2, estrogen receptor, progesterone receptor and Her2/neu, and other clinical/pathological variables. 18430249 Human
bag-1 breast tumors CONCLUSION: Bag-1 and Bcl-2 expression in breast tumors is associated with improved outcome and steroid receptor positivity. 18430249 Human
bag-1 breast cancer Evaluation of Bcl-2 and Bag-1 expression in breast cancer may identify a subset of patients with a favorable prognosis, who might not benefit from chemotherapy or who might benefit from Bcl-2 targeting agents in addition to antihormonal therapy. 18430249 Human
bag-1 dlbcl OBJECTIVE: To investigate the expression level of BAG-1 protein in DLBCL. 18523358 Human
bag-1 dlbcl BAG-1 expression was determined by immunohistochemical staining in both DLBCL and normal lymph node samples. 18523358 Human
bag-1 colon cancer CONCLUSION: Our data indicated that BAG-1 protein was deregulated in this disease similar to some other malignancies such as breast and colon cancer. 18523358 Human
bag-1 dlbcl Overexpression of BAG-1 in DLBCL suggests that this protein probably plays an important role in the pathogenesis of DLBCL. 18523358 Human
bag-1 endometrial hyperplasia BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer. 18704778 Human
bag-1 endometrial cancer BAG-1 expression in normal endometrium, endometrial hyperplasia and endometrial cancer. 18704778 Human
bag-1 carcinogenesis BACKGROUND: BAG-1 (Bcl-2-associated athanogene 1) is a BCL-2 binding anti-apoptotic protein that may play a role in carcinogenesis. 18704778 Human
bag-1 endometrial hyperplasia The purpose of this study is to compare the expression rate of BAG-1 in normal endometrium, endometrial hyperplasia and endometrial cancer, and further to determine a correlation between BAG-1 expression and clinicopathological parameters, and overall sur 18704778 Human
bag-1 endometrial cancer The purpose of this study is to compare the expression rate of BAG-1 in normal endometrium, endometrial hyperplasia and endometrial cancer, and further to determine a correlation between BAG-1 expression and clinicopathological parameters, and overall sur 18704778 Human
bag-1 endometrial hyperplasia RESULTS: Cytoplasmic BAG-1 expression of the normal endometrium, endometrial hyperplasia and endometrial cancer samples was 4/20 (20%), 3/20 (15%) and 27/43 (62%), respectively. 18704778 Human
bag-1 endometrial cancer RESULTS: Cytoplasmic BAG-1 expression of the normal endometrium, endometrial hyperplasia and endometrial cancer samples was 4/20 (20%), 3/20 (15%) and 27/43 (62%), respectively. 18704778 Human
bag-1 cancer Cytoplasmic BAG-1 expression correlated with cancer grade (p=0.02). 18704778 Human
bag-1 endometrial hyperplasia CONCLUSION: Cytoplasmic BAG-1 is more frequently expressed in endometrial cancer tissues than in normal and endometrial hyperplasia tissues (p=0.0007), and its expression correlates with cancer grade. 18704778 Human
bag-1 endometrial cancer CONCLUSION: Cytoplasmic BAG-1 is more frequently expressed in endometrial cancer tissues than in normal and endometrial hyperplasia tissues (p=0.0007), and its expression correlates with cancer grade. 18704778 Human
bag-1 cancer CONCLUSION: Cytoplasmic BAG-1 is more frequently expressed in endometrial cancer tissues than in normal and endometrial hyperplasia tissues (p=0.0007), and its expression correlates with cancer grade. 18704778 Human
bag-1 hyperplasia Nuclear BAG-1 is more frequently expressed in the normal endometrium and hyperplasia tissues than in endometrial cancer tissues (p=0.002). 18704778 Human
bag-1 endometrial cancer Nuclear BAG-1 is more frequently expressed in the normal endometrium and hyperplasia tissues than in endometrial cancer tissues (p=0.002). 18704778 Human
bag-1 colorectal cancers Evaluation of the immunohistochemical stain patterns of survivin, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon. 18795671 Human
bag-1 polyps Evaluation of the immunohistochemical stain patterns of survivin, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon. 18795671 Human
bag-1 tumor Apoptotic markers, such as Bag-1, survivin, and Bak, were used for staining, and relationships between stain features, clinical and prognostic factors, and polyp and tumor staining features were examined. 18795671 Human
bag-1 polyp Apoptotic markers, such as Bag-1, survivin, and Bak, were used for staining, and relationships between stain features, clinical and prognostic factors, and polyp and tumor staining features were examined. 18795671 Human
bag-1 tumor CONCLUSIONS: Cytoplasmic staining of Bag-1 can be considered an indicator of tumor progression. 18795671 Human
bag-1 esophageal squamous cell carcinoma The present study was performed to clarify the clinical implications of BAG-1, a bcl-2 binding protein in esophageal squamous cell carcinoma (ESCC). 12823208 Human
bag-1 b-chronic lymphocytic leukemia The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10(-6) M fludarabine using multiparametric f 16501812 Human

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