IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CHMP5 Ensembl ENSG00000086065 Chromosome 9 Start 33255000 End 33271510
Description Charged multivesicular body protein 5 (Chromatin-modifying protein 5)(Vacuolar protein-sorting-associated protein 60)(Vps60)(hVps60)(SNF7 domain-containing protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZZ3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 26942
     Entrez Gene : 51510
     UCSC : uc003zsm.3
     GeneCards : 26942
     RefSeq : NM_016410
     CCDS : CCDS6537.1
     Uniprot : Q9NZZ3
     Interpro : Q9NZZ3
     OMIM : 610900
     GeneTests : CHMP5
     CGAP : CHMP5
     PMID : 15644320

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218085_at  -0.00  9.53e-1  9.61e-1  -5.16  3.33e-112  3.19e-111
 HG_U133A  219356_s_at  0.25  3.89e-3  6.49e-3  -1.54  2.38e-27  3.84e-27
 HG_U133_Plus2  218085_at  0.09  3.53e-1  4.43e-1  -0.37  9.23e-4  1.79e-3
 HG_U133_Plus2  219356_s_at  -0.10  3.49e-1  4.39e-1  -0.36  2.53e-3  4.56e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218085_at  -0.12  6.71e-1  9.64e-1  0.01  9.77e-1  1.00e+0
 HG_U133A  219356_s_at  0.16  5.46e-1  9.38e-1  -0.02  9.13e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 218085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 219356_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 219356_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pnas-2 apl RT-PCR results showed that the expression ratios of Apaf-1, caspase-9 and PNAS-2 in APL patients pre- and post-remission were 2.31 and 3.21, 0.99 respectively. 16778962 Human
pnas-2 leukemia [Correlation between expression of apoptosis-related gene pnas-2 and leukemia] The study was purposed to explore the correlation between apoptosis-related gene pnas-2 and leukemia. 17708794 Human
pnas-2 acute leukemia The RT-PCR was performed to detect the expression levels of pnas-2 gene in NB4, K562, U937 cells before and after treatment with AS(4)S(4), and to analysis the expression change of pnas-2 gene in bone marrow cells from patients with acute leukemia before 17708794 Human
pnas-2 acute leukemia The positive expression rate of pnas-2 in cells from untreated patients with acute leukemia was 100%, and was significantly higher than that in normal control group. 17708794 Human
pnas-2 apl It is concluded that the pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells, and may consider as a molecular biological remission marker in acute leukemia. 17708794 Human
pnas-2 acute leukemia It is concluded that the pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells, and may consider as a molecular biological remission marker in acute leukemia. 17708794 Human
pnas-2 leukemogenesis PNAS-2: a novel gene probably participating in leukemogenesis. 17855796 Human
pnas-2 leukemogenesis In this study, we tried to clarify the role of PNAS-2 in apoptosis and leukemogenesis. 17855796 Human
pnas-2 acute leukemia PNAS-2 expression is significantly increased in de novo or relapsed acute leukemia, but in patients in complete remission PNAS-2 levels decrease to levels comparable to those found in normal controls. 17855796 Human
pnas-2 carcinomas In carcinomas, PNAS-2 expression was not upregulated, indicating that PNAS-2 overexpression was specific for leukemia. 17855796 Human
pnas-2 leukemia In carcinomas, PNAS-2 expression was not upregulated, indicating that PNAS-2 overexpression was specific for leukemia. 17855796 Human
pnas-2 leukemogenesis CONCLUSION: Based on the preliminary data, we suggest that the PNAS-2 gene functions as an anti-apoptotic gene and probably participates in leukemogenesis. 17855796 Human
pnas-2 acute leukemia (al) [Expression spectra of apoptosis-related gene pnas-2] To explore the expression spectra of apoptosis-related gene pnas-2 in normal tissues and acute leukemia (AL) patient tissues, the expressions of pnas-2 gene in tissues including heart, brain, placenta, 18426649 Human
pnas-2 tumor The expressions of pnas-2 in samples including 44 de novo, 9 non-CR, 27 CR and 12 relapsed AL patients were measured by real-time RT-PCR and Northern blot, and the expression levels of pnas-2 in normal and tumor tissues from 31 patients with malignancies 18426649 Human
pnas-2 tumor The results of real-time PCR indicated that pnas-2 expressions in samples of de novo, non-CR and relapsed patients ware significantly higher than that in CR, tumor tissues and normal tissues. 18426649 Human
pnas-2 oncogene It is concluded that the pnas-2 is specifically up-regulated in acute leukemia patients, which might be an oncogene and participate in leukemogenesis. 18426649 Human
pnas-2 leukemogenesis It is concluded that the pnas-2 is specifically up-regulated in acute leukemia patients, which might be an oncogene and participate in leukemogenesis. 18426649 Human
pnas-2 acute leukemia It is concluded that the pnas-2 is specifically up-regulated in acute leukemia patients, which might be an oncogene and participate in leukemogenesis. 18426649 Human
pnas-2 acute leukemia [Expression spectra of apoptosis-related gene pnas-2] To explore the expression spectra of apoptosis-related gene pnas-2 in normal tissues and acute leukemia (AL) patient tissues, the expressions of pnas-2 gene in tissues including heart, brain, placenta, 18426649 Human

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