IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AQP7 Ensembl ENSG00000165269 Chromosome 9 Start 33374765 End 33392517
Description Aquaporin-7 (AQP-7)(Aquaporin-7-like)(Aquaporin adipose)(AQPap) [Source:UniProtKB/Swiss-Prot;Acc:O14520]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 640
     Entrez Gene : 364
     UCSC : uc003zst.2
     GeneCards : 640
     RefSeq : NM_001170
     CCDS : CCDS6541.1
     Uniprot : O14520
     Interpro : O14520
     OMIM : 602974
     GeneTests : AQP7
     CGAP : AQP7
     PMID : 9252401

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39567_at  0.26  1.67e-1  2.53e-1  0.21  4.12e-1  5.18e-1
 HG_U95  39568_g_at  0.41  3.06e-6  1.79e-5  0.30  4.80e-3  1.21e-2
 HG_U133A  206955_at  0.16  2.18e-1  2.65e-1  -0.50  5.19e-6  6.07e-6
 HG_U133_Plus2  206955_at  0.18  3.03e-1  3.91e-1  -0.49  1.38e-2  2.19e-2
 Stanford  6761  -0.45  3.90e-1  5.87e-1  -0.59  3.76e-1  6.14e-1
 Stanford  11958  0.14  6.39e-1  7.84e-1  -0.28  2.62e-1  5.01e-1
 Stanford  20688  0.06  8.68e-1  9.28e-1  -0.31  3.61e-1  5.98e-1
 Stanford  23403  -0.24  5.67e-1  7.32e-1  -0.87  3.61e-2  1.36e-1
 Agilent_HS_21.6K  14988  -0.04  3.56e-1  5.44e-1  -0.04  3.09e-1  4.67e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206955_at  0.20  4.68e-1  9.21e-1  0.05  8.14e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39567_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39568_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206955_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206955_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6761    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11958    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20688    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23403    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14988    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
aqp7 acute promyelocytic leukemia These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a c 11972053 Human
aqp7 inflammatory bowel disease The expression of AQP4, AQP7 and AQP8 was examined, via reverse transcription/polymerase chain reaction, Western blotting and immunohistochemistry, in a murine model of colitis and in patients with inflammatory bowel disease or infectious colitis. 15338270 Human
aqp9 lymphoid leukemia In 10 of 11 myeloid and lymphoid leukemia lines, quantitative polymerase chain reaction (Q-PCR) and Western blotting showed that AQP9 expression correlated positively with As2O3-induced cytotoxicity. 16968895 Human
aqp9 hepatoma As a proof-of-principle, transfection of EGFP-tagged AQP9 to the hepatoma line Hep3B, not expressing AQP9 and As2O3 insensitive, led to membrane AQP9 expression and increased As2O3-induced cytotoxicity. 16968895 Human
aqp9 chronic myeloid leukemia Similarly, the chronic myeloid leukemia line K562 expressed low levels of AQP9 and was As2O3 insensitive. 16968895 Human
aqp9 myeloid leukemia Pretreatment of the myeloid leukemia line HL-60 with all-trans retinoic acid (ATRA) up-regulated AQP9, leading to a significantly increased arsenic uptake and As2O3-induced cytotoxicity on incubation with As2O3, which might explain the synergism between A 16968895 Human
aqp9 acute myeloid leukemias (amls) Q-PCR showed that primary APL cells expressed AQP9 significantly (2-3 logs) higher than other acute myeloid leukemias (AMLs), which might explain their exquisite As2O3 sensitivity. 16968895 Human
aqp9 apl Q-PCR showed that primary APL cells expressed AQP9 significantly (2-3 logs) higher than other acute myeloid leukemias (AMLs), which might explain their exquisite As2O3 sensitivity. 16968895 Human
aqp9 aml However, APL and AML with maturation expressed comparable AQP9 levels, suggesting that AQP9 expression was related to granulocytic maturation. 16968895 Human
aqp9 apl However, APL and AML with maturation expressed comparable AQP9 levels, suggesting that AQP9 expression was related to granulocytic maturation. 16968895 Human

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