IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PRSS3 Ensembl ENSG00000010438 Chromosome 9 Start 33740515 End 33789228
Description Trypsin-3 Precursor (EC 3.4.21.4)(Trypsin III)(Brain trypsinogen)(Mesotrypsinogen)(Trypsin IV)(Serine protease 3)(Serine protease 4) [Source:UniProtKB/Swiss-Prot;Acc:P35030]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9486
     Entrez Gene : 5646
     UCSC : uc011ksq.1
     GeneCards : 9486
     RefSeq : NM_002771
     CCDS : CCDS6545.1
     Uniprot : P35030
     Interpro : P35030
     GeneTests : PRSS3
     CGAP : PRSS3
     PMID : 2326201

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40043_at  1.35  2.54e-4  9.36e-4  1.37  5.16e-4  1.73e-3
 HG_U133A  207463_x_at  0.46  1.07e-3  1.94e-3  -0.71  1.44e-12  1.88e-12
 HG_U133A  213421_x_at  0.47  1.98e-4  3.96e-4  0.73  2.89e-11  3.70e-11
 HG_U133_Plus2  207463_x_at  1.40  3.95e-9  2.55e-8  1.74  1.34e-17  1.42e-16
 HG_U133_Plus2  213421_x_at  1.09  3.42e-7  1.67e-6  1.42  1.06e-22  2.02e-21
 Agilent_HS_21.6K  1640  0.05  1.87e-1  3.58e-1  0.05  8.27e-3  3.08e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207463_x_at  0.69  8.43e-2  7.56e-1  -0.16  5.68e-1  1.00e+0
 HG_U133A  213421_x_at  0.59  7.31e-2  7.37e-1  -0.00  9.85e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40043_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207463_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213421_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207463_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213421_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1640    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
prss3 tumors In addition, we found S100P, S100A2, trypsinogen C (TRY6), and trypsinogen IVb (PRSS3) to be overexpressed in tumors that metastasized during the course of the disease. 15313892 Human
prss3 nsclc Overexpression of S100A2, S100P, or PRSS3 in NSCLC cell cultures led to increased transendothelial migration, corroborating the role of S100A2, S100P, and PRSS3 in the metastatic process. 15313892 Human

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