IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DCTN3 Ensembl ENSG00000137100 Chromosome 9 Start 34603549 End 34610496
Description Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit)(p22) [Source:UniProtKB/Swiss-Prot;Acc:O75935]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2713
     Entrez Gene : 11258
     UCSC : uc003zux.1
     GeneCards : 2713
     RefSeq : NM_007234
     CCDS : CCDS6560.1
     Uniprot : O75935
     Interpro : O75935
     OMIM : 607387
     GeneTests : DCTN3
     CGAP : DCTN3
     PMID : 9722614

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40410_at  -0.23  7.22e-4  2.35e-3  -0.03  7.53e-1  8.20e-1
 HG_U133A  204246_s_at  -0.31  1.33e-7  3.76e-7  -1.37  1.30e-18  1.86e-18
 HG_U133_Plus2  204246_s_at  -0.07  2.10e-1  2.88e-1  -0.02  8.14e-1  8.45e-1
 Agilent_HS_21.6K  2274  -0.04  3.39e-1  5.27e-1  -0.02  5.63e-1  7.01e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204246_s_at  0.43  1.30e-2  6.83e-1  -0.02  9.14e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40410_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204246_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204246_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2274    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dctn3 breast carcinomas We validated significant overexpression of transcripts for HOXC10 (P=0.001), TPD52L1 (P=0.007), ZFP36L1 (P=0.011), PLINP1 (P=0.013), DCTN3 (P=0.025), DEK (P=0.031), and CSNK1D (P=0.04) in lymph node (+) breast carcinomas. 17855657 Human
dctn3 tumors Moreover, the DCTN3 (P=0.022) and RHBDD2 (P=0.002) transcripts were confirmed to be overexpressed in tumors that recurred within 6 years of follow-up by real-time RT-PCR. 17855657 Human

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