IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IL11RA Ensembl ENSG00000137070 Chromosome 9 Start 34643932 End 34651883
Description Interleukin-11 receptor alpha chain Precursor (IL-11R-alpha)(IL-11RA) [Source:UniProtKB/Swiss-Prot;Acc:Q14626]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5967
     Entrez Gene : 3590
     UCSC : uc011loq.1
     GeneCards : 5967
     RefSeq : NM_001142784
     CCDS : CCDS6567.1
     Uniprot : Q14626
     Interpro : Q14626
     OMIM : 600939
     GeneTests : IL11RA
     CGAP : IL11RA
     PMID : 7670098

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  496_s_at  -0.43  5.11e-6  2.84e-5  -0.48  9.91e-5  3.96e-4
 HG_U133A  204773_at  -1.04  4.02e-40  1.12e-38  -1.70  1.55e-28  2.55e-28
 HG_U133_Plus2  1552646_at  0.12  2.75e-1  3.60e-1  0.57  1.85e-5  4.56e-5
 HG_U133_Plus2  204773_at  -0.83  4.89e-15  6.65e-14  -1.07  1.05e-12  6.35e-12
 Stanford  10493  -0.33  1.12e-1  2.67e-1  -1.01  9.98e-5  2.73e-3
 Stanford  15081  0.21  5.67e-1  7.32e-1  0.28  4.40e-1  6.68e-1
 Stanford  17406  -0.04  8.86e-1  9.39e-1  -0.33  2.63e-1  5.02e-1
 Agilent_HS_21.6K  19483  -0.07  6.30e-7  1.65e-5  -0.09  7.63e-6  8.99e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204773_at  -0.08  8.64e-1  9.89e-1  -0.05  7.28e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 496_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204773_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1552646_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204773_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10493    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15081    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17406    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19483    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
il-11ra lymph node metastasis However, the expression of IL-11Ra was not correlated with the venous invasion and the presence of lymph node metastasis. 16482637 Human
il-11ra adenocarcinomas METHODS: To elucidate the involvement of IL-11 and IL-11Ra in human intestinal adenocarcinomas, we examined 115 cases of surgically resected human colonic adenocarcinoma and 11 cases of adenoma by immunohistochemistry and Western blotting. 16482637 Human
il-11ra adenoma METHODS: To elucidate the involvement of IL-11 and IL-11Ra in human intestinal adenocarcinomas, we examined 115 cases of surgically resected human colonic adenocarcinoma and 11 cases of adenoma by immunohistochemistry and Western blotting. 16482637 Human
il-11ra colonic adenocarcinoma METHODS: To elucidate the involvement of IL-11 and IL-11Ra in human intestinal adenocarcinomas, we examined 115 cases of surgically resected human colonic adenocarcinoma and 11 cases of adenoma by immunohistochemistry and Western blotting. 16482637 Human
il-11ra adenocarcinoma RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. 16482637 Human
il-11ra carcinoma RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. 16482637 Human
il-11ra adenomas Six cases (54.5%) and four cases (36.4%) of 11 adenomas were positive for IL-11 and IL-11Ra, respectively. 16482637 Human
il-11ra tumor The expression of IL-11Ra correlated with the histological differentiation (P = 0.033503), the depth of tumor invasion (P = 0.006395), Dukes'classification (P = 0.015648) and lymphatic invasion (P = 0.003865). 16482637 Human
il-11ra carcinoma In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. 16482637 Human
il-11ra human colorectal carcinoma In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. 16482637 Human
il-11ra colorectal adenocarcinoma CONCLUSION: IL-11 and IL-11Ra are highly expressed in human colorectal adenocarcinoma and the IL-11Ra expression is correlated with clinicopathological factors. 16482637 Human
il-11ra colorectal adenocarcinoma These findings suggest that the expression of IL-11Ra is an important factor for the invasion of human colorectal adenocarcinoma. 16482637 Human
il-11ra tumor Expression levels of interleukin-13 (IL-13), leptin, lymphotoxin beta receptor (LTbR), and macrophage inflammatory protein 1b (MIP1b) were significantly higher (P < 0.04, P < 0.01, P < 0.05, and P < 0.01, respectively), and expression level of IL-11Ra was 17545514 Human
il-11ra metastasis The cytokine profile of tumor-positive SNs; increased expression of IL-13, leptin, LTbR, and MIP1b and decreased expression of IL-11Ra, may provide clues to the local tumor lymph node interaction seen in the earliest steps of melanoma metastasis. 17545514 Human
il-11ra melanoma The cytokine profile of tumor-positive SNs; increased expression of IL-13, leptin, LTbR, and MIP1b and decreased expression of IL-11Ra, may provide clues to the local tumor lymph node interaction seen in the earliest steps of melanoma metastasis. 17545514 Human
il-11ra tumor The cytokine profile of tumor-positive SNs; increased expression of IL-13, leptin, LTbR, and MIP1b and decreased expression of IL-11Ra, may provide clues to the local tumor lymph node interaction seen in the earliest steps of melanoma metastasis. 17545514 Human
il11ra tumors Screening of 20 primary prostate carcinomas by qPCR revealed an IL11-RA copy number gain in 75% of the tumors analyzed. 17712417 Human
il11ra prostate carcinomas Screening of 20 primary prostate carcinomas by qPCR revealed an IL11-RA copy number gain in 75% of the tumors analyzed. 17712417 Human
il11ra tumor Frequent amplification of IL11-RA in prostate cancer is a potential mechanism of IL11-RA overexpression in this tumor type. 17712417 Human
il11ra prostate cancer Frequent amplification of IL11-RA in prostate cancer is a potential mechanism of IL11-RA overexpression in this tumor type. 17712417 Human

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