IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene VCP Ensembl ENSG00000165280 Chromosome 9 Start 35046904 End 35062598
Description Transitional endoplasmic reticulum ATPase (TER ATPase)(15S Mg(2+)-ATPase p97 subunit)(Valosin-containing protein)(VCP) [Source:UniProtKB/Swiss-Prot;Acc:P55072]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12666
     Entrez Gene : 7415
     UCSC : uc003zvy.2
     GeneCards : 12666
     RefSeq : NM_007126
     CCDS : CCDS6573.1
     Uniprot : P55072
     Interpro : P55072
     OMIM : 601023
     GeneTests : VCP
     CGAP : VCP
     PMID : 8595912

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33818_at  0.13  6.83e-2  1.20e-1  0.39  2.20e-3  6.16e-3
 HG_U133A  208648_at  -0.17  5.45e-4  1.03e-3  -2.18  9.60e-40  1.85e-39
 HG_U133A  208649_s_at  0.22  1.67e-4  3.38e-4  -0.44  3.86e-8  4.68e-8
 HG_U133_Plus2  208648_at  0.13  4.93e-2  8.31e-2  0.42  8.74e-7  2.58e-6
 HG_U133_Plus2  208649_s_at  0.12  4.41e-2  7.57e-2  0.48  3.01e-8  1.07e-7
 Agilent_HS_21.6K  15262  -0.08  6.70e-2  1.78e-1  -0.05  2.29e-1  3.78e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208648_at  0.58  2.13e-3  6.34e-1  0.04  8.02e-1  1.00e+0
 HG_U133A  208649_s_at  0.42  6.30e-2  7.26e-1  0.05  8.01e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33818_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208648_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208649_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208648_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208649_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15262    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vcp osteosarcomas New insights from the biology of adolescent osteosarcomas, VCP and SQSTM1 mutations now defined in patients with Paget's disease, and emerging evidence that stromal lesions are present in patients with Paget's disease are changing the way we thi 17229010 Human
vcp paget's disease PURPOSE: Inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia is an adult-onset autosomal dominant illness (IBMPFD) caused by mutations in the valosin-containing protein (VCP) on chromosome 9p21.1-p12. 17224685 Human
p97 paget disease Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD). 16984901 Human
valosin-containing protein paget disease Frontotemporal dementia with inclusion body myopathy and Paget disease of bone is a rare, autosomal-dominant disorder caused by mutations in the gene valosin-containing protein (VCP). 17279000 Human
vcp paget disease Frontotemporal dementia with inclusion body myopathy and Paget disease of bone is a rare, autosomal-dominant disorder caused by mutations in the gene valosin-containing protein (VCP). 17279000 Human
vcp paget's disease New insights from the biology of adolescent osteosarcomas, VCP and SQSTM1 mutations now defined in patients with Paget's disease, and emerging evidence that stromal lesions are present in patients with Paget's disease are changing the way we thi 17229010 Human
valosin-containing protein paget disease Mutations in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 cause a late-onset form of autosomal dominant inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD). 16984901 Human
valosin-containing protein colon cancers PTPN3 is a membrane-associated tyrosine phosphatase with FERM, PDZ, and PTP domains previously implicated in regulating tyrosine phosphorylation of growth factor receptors and p97 VCP (valosin-containing protein, termed Cdc48 in Saccharomyces cerevisiae) 17166906 Human
valosin-containing protein paget's disease PURPOSE: Inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia is an adult-onset autosomal dominant illness (IBMPFD) caused by mutations in the valosin-containing protein (VCP) on chromosome 9p21.1-p12. 17224685 Human
vcp metastasis VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Human
p97 metastasis VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Human
valosin-containing protein lymph-node metastasis Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
p97 lymph-node metastasis Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
valosin-containing protein pancreatic ductal adenocarcinoma Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
p97 pancreatic ductal adenocarcinoma Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
vcp metastasis BACKGROUND: Valosin-containing protein (VCP, also known as p97) exhibits antiapoptotic function and metastasis by activation of nuclear factor kappa-B signaling pathway. 14761919 Human
valosin-containing protein metastasis BACKGROUND: Valosin-containing protein (VCP, also known as p97) exhibits antiapoptotic function and metastasis by activation of nuclear factor kappa-B signaling pathway. 14761919 Human
p97 metastasis BACKGROUND: Valosin-containing protein (VCP, also known as p97) exhibits antiapoptotic function and metastasis by activation of nuclear factor kappa-B signaling pathway. 14761919 Human
vcp gastric carcinoma Our previous study showed that VCP expression level correlated with prognosis of hepatocellular and gastric carcinoma. 14761919 Human
vcp lymph-node metastasis In the present study, association of VCP expression with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma (PDAC) was examined. 14761919 Human
vcp pancreatic ductal adenocarcinoma In the present study, association of VCP expression with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma (PDAC) was examined. 14761919 Human
vcp tumor METHODS: VCP expression in 83 patients (46 males and 37 females) of ages ranging from 43 to 80 (median, 66) years who had undergone curative surgery for primary PDAC was analyzed by immunohistochemistry, in which staining intensity in tumor cells was cate 14761919 Human
vcp lymph-node metastasis VCP expression correlated significantly with lymph node metastasis (P <.01) but not with various clinicopathologic factors, including age, gender, and histologic differentiation. 14761919 Human
vcp lymph-node metastasis Multivariate analysis revealed VCP expression as an independent prognosticator for both disease-free and overall survival, along with histologic differentiation, T stage of pathologic tumor-node-metastasis (pTNM) classification, and lymph node metastasis. 14761919 Human
vcp metastasis CONCLUSIONS: Our results indicate the potential usefulness of VCP expression as a marker of metastasis and overall prognosis of PDAC. 14761919 Human
p97 tumor Six consecutive 12-microm frozen sections of each SN were obtained for the RT-PCR assay to determine expression of mRNA tumor markers C-Met, beta1 --> 4GalNAc-T and P97. 9842976 Human
p97 metastases C-Met, beta1 --> 4GalNAc-T and P97 tumor mRNA markers were expressed in 31 (78%), 21 (53%) and 25 (63%) of 40 SNs without metastases, respectively. 9842976 Human
valosin-containing protein hepatocellular carcinoma Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. 12560433 Human
p97 hepatocellular carcinoma Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. 12560433 Human
valosin-containing protein tumor Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. 12560433 Human
p97 tumor Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. 12560433 Human
vcp metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 12560433 Human
valosin-containing protein metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 12560433 Human
p97 metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 12560433 Human
vcp tumor PATIENTS AND METHODS: VCP expression in 170 patients (139 male and 31 female) with ages ranging from 31 to 81 years (median, 61 years) was analyzed by quantitative reverse-transcription polymerase chain reaction (RT-PCR) and immunohistochemistry, in which 12560433 Human
valosin-containing protein gastric carcinoma Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma. 12829673 Human
p97 metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. 12829673 Human
valosin-containing protein metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. 12829673 Human
vcp metastasis PURPOSE: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. 12829673 Human
vcp tumor PATIENTS AND METHODS: VCP expression in 330 patients with GC (242 males and 88 females) with ages ranging from 26 to 81 years (median, 60 years) was analyzed by immunohistochemistry, in which staining intensity in tumor cells was categorized as weaker (le 12829673 Human
vcp large tumor Patients with level 2 expression showed higher rates of large tumor size (P <.0001), undifferentiated histologic subtype (P <.05), presence of vascular and lymphatic invasion (P <.0001 for both), presence of lymph node metastasis (P <.0001), deep tumor in 12829673 Human
vcp tumor Patients with level 2 expression showed higher rates of large tumor size (P <.0001), undifferentiated histologic subtype (P <.05), presence of vascular and lymphatic invasion (P <.0001 for both), presence of lymph node metastasis (P <.0001), deep tumor in 12829673 Human
vcp lymph-node metastasis Patients with level 2 expression showed higher rates of large tumor size (P <.0001), undifferentiated histologic subtype (P <.05), presence of vascular and lymphatic invasion (P <.0001 for both), presence of lymph node metastasis (P <.0001), deep tumor in 12829673 Human
p97 colon cancers PTPN3 is a membrane-associated tyrosine phosphatase with FERM, PDZ, and PTP domains previously implicated in regulating tyrosine phosphorylation of growth factor receptors and p97 VCP (valosin-containing protein, termed Cdc48 in Saccharomyces cerevisiae) 17166906 Human
valosin-containing protein metastasis BACKGROUND: Valosin-containing protein (VCP) is associated with anti-apoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 15319251 Human
valosin-containing protein metastasis Valosin-containing protein (VCP) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 15328197 Human
valosin-containing protein metastasis A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
valosin-containing protein non-small-cell lung carcinoma Expression Level of Valosin-Containing Protein (p97) Is Correlated With Progression and Prognosis of Non-Small-Cell Lung Carcinoma. 15231524 Human
valosin-containing protein osteosarcoma A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
valosin-containing protein metastasis BACKGROUND: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptosis and metastasis via activation of a nuclear factor-kappaB signaling pathway. 15231524 Human
valosin-containing protein cancers PURPOSE: Valosin-containing protein (VCP) has been shown to be associated with metastasis and prognosis in human cancers. 15131036 Human
valosin-containing protein colorectal carcinomas Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis. 14760088 Human
valosin-containing protein paget's disease Mutations in the valosin-containing protein (VCP) gene on chromosome 9p13-p12 recently have been shown to cause autosomal dominant inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. 15732117 Human
valosin-containing protein paget's disease A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
valosin-containing protein pancreatic endocrine neoplasms Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms. 15452376 Human
p97 metastasis PURPOSE: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 14760088 Human
p97 prostate cancer Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. 15131036 Human
p97 pancreatic endocrine neoplasms Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms. 15452376 Human
p97 non-small-cell lung carcinoma Expression Level of Valosin-Containing Protein (p97) Is Correlated With Progression and Prognosis of Non-Small-Cell Lung Carcinoma. 15231524 Human
p97 metastasis BACKGROUND: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptosis and metastasis via activation of a nuclear factor-kappaB signaling pathway. 15231524 Human
p97 esophageal carcinoma Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma. 15328197 Human
valosin-containing protein squamous-cell carcinoma Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma. 15319251 Human
vcp metastasis PURPOSE: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 14760088 Human
vcp colorectal adenocarcinoma The present study was designed to investigate the prognostic significance of VCP expression in colorectal adenocarcinoma. 14760088 Human
vcp colorectal carcinoma EXPERIMENTAL DESIGN: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35-84 years. 14760088 Human
vcp tumor The staining intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than that in noncancerous colonic mucosa. 14760088 Human
vcp metastatic tumors A low level of VCP expression was noted in all adenomas, whereas a high level was seen in all metastatic tumors. 14760088 Human
vcp adenomas A low level of VCP expression was noted in all adenomas, whereas a high level was seen in all metastatic tumors. 14760088 Human
vcp tumor A significant difference was observed in depth of invasion (T(1-2) versus T(3-4), P < 0.05), presence or absence of venous invasion (P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression 14760088 Human
vcp tumors CONCLUSIONS: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas. 14760088 Human
vcp colorectal carcinomas CONCLUSIONS: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas. 14760088 Human
vcp paget disease Identification of VCP as causing IBMPFD has important implications for other inclusion-body diseases, including myopathies, dementias and Paget disease of bone (PDB), as it may define a new common pathological ubiquitin-based pathway. 15034582 Human
vcp cancers PURPOSE: Valosin-containing protein (VCP) has been shown to be associated with metastasis and prognosis in human cancers. 15131036 Human
vcp metastasis PURPOSE: Valosin-containing protein (VCP) has been shown to be associated with metastasis and prognosis in human cancers. 15131036 Human
vcp prostate cancer In the present study, the correlation of VCP with recurrence and prognosis in patients with prostate cancer (PCA) receiving conservative therapy was examined. 15131036 Human
vcp cancer A significant difference was observed between VCP level 1 and 2 patients in the positive rate for the digital rectal examination (P < 0.01), serum prostate-specific antigen level (P < 0.0001), cancer volume (P < 0.0001), Gleason score (P < 0.0001), stage 15131036 Human
vcp pancreatic endocrine neoplasms OBJECTIVE: To determine the prognostic value of valosin-containing protein (VCP) expression and the Ki-67 labeling index (LI) in pancreatic endocrine neoplasms (PENs), the present analysis was employed. 15452376 Human
vcp tumor VCP staining intensity in tumor cells was categorized as weaker (level 1) or equal to stronger (level 2) compared to nontumorous islet cells. 15452376 Human
vcp tumors All level 1 VCP tumors were benign PENs. 15452376 Human
vcp metastasis BACKGROUND: Valosin-containing protein (VCP; also known as p97) was shown to be associated with antiapoptosis and metastasis via activation of a nuclear factor-kappaB signaling pathway. 15231524 Human
vcp gastric carcinoma Our previous study showed that the VCP expression level correlated with the disease recurrence rate and prognosis of patients with hepatocellular carcinoma and gastric carcinoma. 15231524 Human
vcp hepatocellular carcinoma Our previous study showed that the VCP expression level correlated with the disease recurrence rate and prognosis of patients with hepatocellular carcinoma and gastric carcinoma. 15231524 Human
vcp tumor METHODS: VCP expression in 207 patients with NSCLC (133 men and 74 women) aged 35 to 78 years (median, 62 years) was examined by immunohistochemistry, in which staining intensity in tumor cells was categorized as weaker than (level 1) or equal to or stron 15231524 Human
vcp nsclc METHODS: VCP expression in 207 patients with NSCLC (133 men and 74 women) aged 35 to 78 years (median, 62 years) was examined by immunohistochemistry, in which staining intensity in tumor cells was categorized as weaker than (level 1) or equal to or stron 15231524 Human
vcp nsclc CONCLUSIONS: The prognostic significance of VCP expression in NSCLC was demonstrated. 15231524 Human
vcp squamous-cell carcinoma Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma. 15319251 Human
vcp metastasis BACKGROUND: Valosin-containing protein (VCP) is associated with anti-apoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 15319251 Human
vcp squamous-cell carcinoma In the present study, association of VCP expression with prognosis of gingival squamous cell carcinoma (GSCC) was examined. 15319251 Human
vcp tumor PATIENTS AND METHODS: VCP expression in 74 patients with GSCC (34 males and 40 females) with ages ranging from 42 to 85 (median 66) years was evaluated by immunohistochemistry, in which staining intensity in tumor cells was categorized as either weaker (l 15319251 Human
vcp lymph-node metastasis Multivariate analysis revealed VCP expression level, lymph node metastasis and pT(TNM) to be independent factors for overall survival. 15319251 Human
vcp metastasis Valosin-containing protein (VCP) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 15328197 Human
vcp paget's disease Mutations in the valosin-containing protein (VCP) gene on chromosome 9p13-p12 recently have been shown to cause autosomal dominant inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. 15732117 Human
vcp paget's disease A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
vcp metastasis A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
vcp paget's disease High VCP gene expression is associated with high metastatic potential in osteosarcoma cells, while loss-of-function VCP mutations cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). 15885483 Human
vcp paget's disease Such high levels of VCP protein expression in untransformed osteoblastic cells argue against a major causative role for it in metastasis, while the occurrence of Paget's disease in patients with missense VCP mutations supports a major role for VCP in 15885483 Human
vcp metastasis Such high levels of VCP protein expression in untransformed osteoblastic cells argue against a major causative role for it in metastasis, while the occurrence of Paget's disease in patients with missense VCP mutations supports a major role for VCP in 15885483 Human
valosin-containing protein squamous cell carcinoma Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma. 15319251 Human
p97 osteosarcoma VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Human
vcp osteosarcoma VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Human
vcp hepatocellular carcinoma (hcc) In this study, association of VCP expression with recurrence of hepatocellular carcinoma (HCC) and patient survival was examined. 12560433 Human
vcp gastric carcinoma (gc) In this study, association of VCP expression with recurrence of gastric carcinoma (GC), in which lymphatic vessels are the main route of spread, was examined. 12829673 Human
vcp non-small-cell lung carcinoma (nsclc) This study was designed to evaluate the prognostic significance of VCP expression in non-small-cell lung carcinoma (NSCLC). 15231524 Human
vcp squamous cell carcinoma Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma. 15319251 Human
vcp squamous cell carcinoma In the present study, association of VCP expression with prognosis of gingival squamous cell carcinoma (GSCC) was examined. 15319251 Human
vcp osteosarcoma A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
vcp osteosarcoma High VCP gene expression is associated with high metastatic potential in osteosarcoma cells, while loss-of-function VCP mutations cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). 15885483 Mouse
vcp colon cancers PTPN3 is a membrane-associated tyrosine phosphatase with FERM, PDZ, and PTP domains previously implicated in regulating tyrosine phosphorylation of growth factor receptors and p97 VCP (valosin-containing protein, termed Cdc48 in Saccharomyces cerevisiae) 17166906 Human
valosin-containing protein lymph node metastasis Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
p97 lymph node metastasis Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. 14761919 Human
vcp lymph node metastasis Patients with level 2 expression showed higher rates of large tumor size (P <.0001), undifferentiated histologic subtype (P <.05), presence of vascular and lymphatic invasion (P <.0001 for both), presence of lymph node metastasis (P <.0001), deep tumor in 12829673 Human
vcp lymph node metastasis In the present study, association of VCP expression with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma (PDAC) was examined. 14761919 Human
vcp lymph node metastasis VCP expression correlated significantly with lymph node metastasis (P <.01) but not with various clinicopathologic factors, including age, gender, and histologic differentiation. 14761919 Human
vcp lymph node metastasis Multivariate analysis revealed VCP expression as an independent prognosticator for both disease-free and overall survival, along with histologic differentiation, T stage of pathologic tumor-node-metastasis (pTNM) classification, and lymph node metastasis. 14761919 Human
vcp lymph node metastasis Multivariate analysis revealed VCP expression level, lymph node metastasis and pT(TNM) to be independent factors for overall survival. 15319251 Human
valosin-containing protein follicular thyroid cancer Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. 16189643 Human
valosin-containing protein cancer BACKGROUND: Valosin-containing protein (VCP) is involved in the ubiquitin/proteasome-degradation pathway, which works in proliferation and antiapoptosis in human cancer cells. 16189643 Human
valosin-containing protein paget's disease Evaluation of the role of Valosin-containing protein in the pathogenesis of familial and sporadic Paget's disease of bone. 16199218 Human
valosin-containing protein cancer Valosin-containing protein (p97/VCP) has been proposed as playing crucial roles in a variety of physiological and pathological processes such as cancer and neurodegeneration. 16234241 Human
valosin-containing protein paget disease Mutations in the valosin-containing protein (VCP) on chromosome 9p13-p12 were recently found to be associated with hereditary inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). 16247064 Human
valosin-containing protein paget's disease Mutations in the AAA+ protein (ATPase associated with a variety of cellular activities) p97/VCP (valosin-containing protein) cause a dominantly inherited syndrome of inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementi 16321991 Human
valosin-containing protein paget's disease Similarly, mutations in the valosin-containing protein (VCP) gene have been shown to cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia. 16429324 Human
valosin-containing protein human leukaemia Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance. 16541142 Human
valosin-containing protein all Valosin-containing protein was chosen for validation and quantification by Western blot analysis in a second case-control group of ALL patients. 16541142 Human
valosin-containing protein paget disease Frontotemporal dementia (FTD) with inclusion body myopathy and Paget disease of bone (IBMPFD) is a rare, autosomal-dominant disorder caused by mutations in the valosin-containing protein (VCP) gene, a member of the AAA-ATPase gene superfamily. 16783167 Human
p97 follicular thyroid cancer Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. 16189643 Human
p97 cancer Valosin-containing protein (p97/VCP) has been proposed as playing crucial roles in a variety of physiological and pathological processes such as cancer and neurodegeneration. 16234241 Human
p97 paget's disease Mutations in the AAA+ protein (ATPase associated with a variety of cellular activities) p97/VCP (valosin-containing protein) cause a dominantly inherited syndrome of inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementi 16321991 Human
vcp cancer BACKGROUND: Valosin-containing protein (VCP) is involved in the ubiquitin/proteasome-degradation pathway, which works in proliferation and antiapoptosis in human cancer cells. 16189643 Human
vcp cancers Our previous study showed that VCP expression levels correlated with the recurrence and prognosis of several human cancers, such as hepatocellular carcinoma, gastric carcinoma, and colorectal carcinoma. 16189643 Human
vcp colorectal carcinoma Our previous study showed that VCP expression levels correlated with the recurrence and prognosis of several human cancers, such as hepatocellular carcinoma, gastric carcinoma, and colorectal carcinoma. 16189643 Human
vcp gastric carcinoma Our previous study showed that VCP expression levels correlated with the recurrence and prognosis of several human cancers, such as hepatocellular carcinoma, gastric carcinoma, and colorectal carcinoma. 16189643 Human
vcp hepatocellular carcinoma Our previous study showed that VCP expression levels correlated with the recurrence and prognosis of several human cancers, such as hepatocellular carcinoma, gastric carcinoma, and colorectal carcinoma. 16189643 Human
vcp differentiated thyroid carcinoma In this study, the correlation of VCP expression with the prognosis of differentiated thyroid carcinoma was examined. 16189643 Human
vcp follicular thyroid carcinoma METHODS: VCP expression in 332 patients who underwent operation for differentiated thyroid carcinoma--257 with papillary thyroid carcinoma and 75 with follicular thyroid carcinoma (FTC)--was analyzed by immunohistochemistry. 16189643 Human
vcp papillary thyroid carcinoma METHODS: VCP expression in 332 patients who underwent operation for differentiated thyroid carcinoma--257 with papillary thyroid carcinoma and 75 with follicular thyroid carcinoma (FTC)--was analyzed by immunohistochemistry. 16189643 Human
vcp paget's disease We conducted mutation screening of VCP in 44 kindreds with familial Paget's disease recruited mainly through clinic referrals in the UK, Australia and New Zealand. 16199218 Human
vcp cancer Valosin-containing protein (p97/VCP) has been proposed as playing crucial roles in a variety of physiological and pathological processes such as cancer and neurodegeneration. 16234241 Human
vcp paget disease Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene. 16247064 Human
vcp paget disease Mutations in the valosin-containing protein (VCP) on chromosome 9p13-p12 were recently found to be associated with hereditary inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). 16247064 Human
vcp paget disease We identified a novel missense mutation in the VCP gene (R159H; 688G>A) segregating with this disease in an Austrian family of four affected siblings, who exhibited progressive proximal myopathy and Paget disease of the bone but without clinical signs of 16247064 Human
vcp paget's disease Mutations in the AAA+ protein (ATPase associated with a variety of cellular activities) p97/VCP (valosin-containing protein) cause a dominantly inherited syndrome of inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementi 16321991 Human
vcp paget's disease Similarly, mutations in the valosin-containing protein (VCP) gene have been shown to cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia. 16429324 Human
vcp childhood all We conclude that high VCP expression is associated with poor prednisone response in childhood ALL patients. 16541142 Human
vcp paget disease Frontotemporal dementia (FTD) with inclusion body myopathy and Paget disease of bone (IBMPFD) is a rare, autosomal-dominant disorder caused by mutations in the valosin-containing protein (VCP) gene, a member of the AAA-ATPase gene superfamily. 16783167 Human
vcp lymph node metastasis VCP expression significantly correlated with histological subtype (P < .05) and lymph node metastasis (P < .01). 16189643 Human
vcp lymph node metastasis VCP expression correlated with extrathyroidal extension (P < .05), pT classification (P < .05), and lymph node metastasis (P < .01) in FTC. 16189643 Human
valosin-containing protein esophageal carcinoma Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma. 15328197 Human
valosin-containing protein metastasis PURPOSE: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. 14760088 Human
valosin-containing protein metastasis PURPOSE: Valosin-containing protein (VCP) has been shown to be associated with metastasis and prognosis in human cancers. 15131036 Human
valosin-containing protein paget disease Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. 15034582 Human
valosin-containing protein pancreatic endocrine neoplasms OBJECTIVE: To determine the prognostic value of valosin-containing protein (VCP) expression and the Ki-67 labeling index (LI) in pancreatic endocrine neoplasms (PENs), the present analysis was employed. 15452376 Human
valosin-containing protein prostate cancer Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. 15131036 Human
valosin-containing protein paget's disease No cases with ubiquitinated, valosin-containing protein-immunoreactive intranuclear inclusion bodies of the type seen in inclusion body myopathy with Paget's disease of bone and frontotemporal dementia were seen. 16222525 Human
valosin-containing protein carcinogenesis On the basis of our results, valosin-containing protein, mitochondrial matrix protein P1, T-complex protein 1, enolase alpha, and 14-3-3 beta may play a crucial role in H. pylori-induced gastric carcinogenesis by mediating antiapoptotic and proliferative 16401634 Human
valosin-containing protein cancer Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. 17200190 Human
p97 osteosarcoma VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Mouse
p97 cancers As such, dysfunction of this protein has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative diseases. p97 has a large number of adaptor proteins through which it transmits energy from ATPase activity to 16621604 Human
vcp osteosarcoma VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. 11927012 Mouse
vcp hcc Patients with VCP-level 2 HCC showed higher rate of portal vein invasion in the tumor (P <.01) and poorer disease-free and overall survival (P <.0001 and P <.05, respectively) compared with level 1 patients. 12560433 Human
vcp tumor Patients with VCP-level 2 HCC showed higher rate of portal vein invasion in the tumor (P <.01) and poorer disease-free and overall survival (P <.0001 and P <.05, respectively) compared with level 1 patients. 12560433 Human
vcp hcc CONCLUSION: VCP expression level has prognostic significance for disease-free and overall survival of patients with HCC. 12560433 Human
vcp adenocarcinomas A significant difference was observed in depth of invasion (T(1-2) versus T(3-4), P < 0.05), presence or absence of venous invasion (P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression 14760088 Human
vcp tumors Patients with high VCP-expressing tumors had a higher recurrence rate (P < 0.001) and poorer disease-free and overall survival (P < 0.01 and P < 0.05, respectively) compared with the low expression group. 14760088 Human
vcp escc In the present study, we examined the association of VCP with the recurrence and prognosis of ESCC. 15328197 Human
vcp escc EXPERIMENTAL DESIGN: VCP expression in 156 ESCC patients [139 males and 17 females; age range, 38-82 (median, 60) years] was analyzed by immunohistochemistry. 15328197 Human
vcp escc CONCLUSION: This study demonstrated the prognostic significance of VCP expression in ESCC. 15328197 Human
vcp osteosarcoma A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
vcp osteosarcoma High VCP gene expression is associated with high metastatic potential in osteosarcoma cells, while loss-of-function VCP mutations cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). 15885483 Human
vcp metastasis Our previous studies showed that the enhanced expression of VCP in cancer cells correlated with invasion and metastasis of cancers. 17200190 Human
vcp cancer Our previous studies showed that the enhanced expression of VCP in cancer cells correlated with invasion and metastasis of cancers. 17200190 Human
vcp cancers Our previous studies showed that the enhanced expression of VCP in cancer cells correlated with invasion and metastasis of cancers. 17200190 Human
vcp mammary carcinoma Luciferase reporter constructs containing serially deleted 5'-flanking region of the VCP gene were transfected into MCF7 mammary carcinoma cell line, in which VCP was abundantly expressed. 17200190 Human
valosin-containing protein osteosarcoma A 97-kDa protein called valosin-containing protein (VCP) has been implicated in osteosarcoma metastasis and Paget's disease of bone, two conditions that complicate the course and outcome of orthopaedic surgery. 15885483 Human
valosin-containing protein metastasis Enhanced expression of valosin-containing protein (VCP) correlates with invasion and metastasis of cancers. 17368566 Human
valosin-containing protein cancers Enhanced expression of valosin-containing protein (VCP) correlates with invasion and metastasis of cancers. 17368566 Human
valosin-containing protein paget's disease Inclusion-body myopathy with Paget's disease and frontotemporal dementia (IBMPFD) is a disease of muscle, bone, and brain that results from mutations in the gene encoding valosin-containing protein (VCP). 17626287 Human
p97 paget's disease Mutations in p97/VCP cause the autosomal-dominant, inherited syndrome inclusion body myopathy (IBM) associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD) (Watts, G.D., Wymer, J., Kovach, M.J., Mehta, S.G., Mumm, S., Darvish 17329348 Mouse
vcp paget's disease Mutations in p97/VCP cause the autosomal-dominant, inherited syndrome inclusion body myopathy (IBM) associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD) (Watts, G.D., Wymer, J., Kovach, M.J., Mehta, S.G., Mumm, S., Darvish 17329348 Human
vcp metastasis Enhanced expression of valosin-containing protein (VCP) correlates with invasion and metastasis of cancers. 17368566 Human
vcp cancers Enhanced expression of valosin-containing protein (VCP) correlates with invasion and metastasis of cancers. 17368566 Human
vcp clinical breast cancer Immunohistochemical analysis on clinical breast cancer specimens showed a correlation of nuclear ELF2/NERF expression with VCP expression and proliferative activity of cells shown by Ki-67 immunohistochemistry. 17368566 Human
vcp paget's disease Inclusion-body myopathy with Paget's disease and frontotemporal dementia (IBMPFD) is a disease of muscle, bone, and brain that results from mutations in the gene encoding valosin-containing protein (VCP). 17626287 Human
valosin-containing protein cancer E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth. 18544453 Human
valosin-containing protein cancer Enhanced expression of valosin-containing protein (VCP) correlates with invasiveness and metastatic potential of cancer cells; therefore its transcriptional regulation could be a new target for cancer therapy. 18544453 Human
p97 paget disease Inclusion body myopathy with Paget disease of the bone (PDB) and/or frontotemporal dementia (IBMPFD, OMIM 167320), is a progressive autosomal dominant disorder caused by mutations in the Valousin-containing protein (VCP, p97 or CDC48) gene. 18260132 Human
p97 leukemia The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97. 18279508 Human
p97 myeloid leukemia RESULTS: Separation of autonomously proliferating human U937 myeloid leukemia cells by centrifugal elutriation demonstrated unaltered VCP/p97 expression levels throughout distinct phases of the cell cycle. 18279508 Human
p97 tumor Whereas VCP/p97 was observed predominantly in the cytosol of U937 tumor and retrodifferentiated cells, a significant nuclear accumulation appeared during differentiation and G0/G1 growth arrest. 18279508 Human
p97 leukemia CONCLUSION: The findings demonstrated that monocytic differentiation and G0/G1 growth arrest in human U937 leukemia cells was accompanied by an increase in VCP/p97 expression and a distinct subcellular distribution to be reverted during retrodifferentiati 18279508 Human
vcp paget disease Inclusion body myopathy with Paget disease of the bone (PDB) and/or frontotemporal dementia (IBMPFD, OMIM 167320), is a progressive autosomal dominant disorder caused by mutations in the Valousin-containing protein (VCP, p97 or CDC48) gene. 18260132 Human
vcp leukemia The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97. 18279508 Human
vcp myeloid leukemia RESULTS: Separation of autonomously proliferating human U937 myeloid leukemia cells by centrifugal elutriation demonstrated unaltered VCP/p97 expression levels throughout distinct phases of the cell cycle. 18279508 Human
vcp tumor Whereas VCP/p97 was observed predominantly in the cytosol of U937 tumor and retrodifferentiated cells, a significant nuclear accumulation appeared during differentiation and G0/G1 growth arrest. 18279508 Human
vcp leukemia CONCLUSION: The findings demonstrated that monocytic differentiation and G0/G1 growth arrest in human U937 leukemia cells was accompanied by an increase in VCP/p97 expression and a distinct subcellular distribution to be reverted during retrodifferentiati 18279508 Human
vcp cancer Increased levels of Cdc48/VCP correlate with cancer, whereas Cdc48/VCP at endogenous levels has been proposed to be a pathological effector in protein deposition diseases. 18284922 Human
vcp paget's disease Inclusion body myopathy, Paget's disease of the bone and frontotemporal dementia: recurrence of the VCP R155H mutation in an Italian family and implications for genetic counselling. 18341608 Human
vcp paget's disease The acronym IBMPFD denotes a syndrome including inclusion body myopathy, Paget's disease of the bone (PDB) and frontotemporal dementia (FTD) as cardinal features, which is caused by missense mutations in the VCP gene. 18341608 Human
vcp paget's disease The syndrome of inclusion body myositis, Paget's disease and frontotemporal dementia is caused by mutations in VCP. 18359282 Human
vcp cancer Enhanced expression of valosin-containing protein (VCP) correlates with invasiveness and metastatic potential of cancer cells; therefore its transcriptional regulation could be a new target for cancer therapy. 18544453 Human
valosin-containing protein paget disease (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. p97/VCP is a multi-functional protein with a role in the ubiquitin-proteasome system (UPS) (Wang, Q., Song, C. 17329348 Mouse
valosin-containing protein paget disease Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD, MIM 167320) is a recently identified autosomal dominant disorder due to mutations in the valosin-containing protein (VCP) that affects muscle, bone and brain. 17907600 Human
valosin-containing protein paget disease Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD, OMIM 167320) has recently been attributed to eight missense mutations in valosin-containing protein (VCP). 17935506 Human
p97 paget disease (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. p97/VCP is a multi-functional protein with a role in the ubiquitin-proteasome system (UPS) (Wang, Q., Song, C. 17329348 Human
vcp hepatocellular carcinoma In this study, association of VCP expression with recurrence of hepatocellular carcinoma (HCC) and patient survival was examined. 12560433 Human
vcp gastric carcinoma In this study, association of VCP expression with recurrence of gastric carcinoma (GC), in which lymphatic vessels are the main route of spread, was examined. 12829673 Human
vcp paget disease (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. p97/VCP is a multi-functional protein with a role in the ubiquitin-proteasome system (UPS) (Wang, Q., Song, C. 17329348 Mouse
vcp paget disease Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD, MIM 167320) is a recently identified autosomal dominant disorder due to mutations in the valosin-containing protein (VCP) that affects muscle, bone and brain. 17907600 Human
vcp paget disease Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD, OMIM 167320) has recently been attributed to eight missense mutations in valosin-containing protein (VCP). 17935506 Human
vcp paget disease Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. 18260132 Human

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