IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FANCG Ensembl ENSG00000221829 Chromosome 9 Start 35063837 End 35070013
Description Fanconi anemia group G protein (Protein FACG)(DNA repair protein XRCC9) [Source:UniProtKB/Swiss-Prot;Acc:O15287]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3588
     Entrez Gene : 2189
     UCSC : uc003zwb.1
     GeneCards : 3588
     RefSeq : NM_004629
     CCDS : CCDS6574.1
     Uniprot : O15287
     Interpro : O15287
     OMIM : 602956
     GeneTests : FANCG
     CGAP : FANCG
     PMID : 9256465

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37584_at  0.42  9.56e-7  6.32e-6  0.90  1.40e-10  1.82e-9
 HG_U133A  203564_at  1.05  5.42e-24  5.68e-23  2.02  2.09e-50  4.80e-50
 HG_U133_Plus2  203564_at  1.02  1.73e-31  1.42e-29  1.61  4.87e-39  7.91e-37
 Stanford  8582  1.16  1.06e-4  3.34e-3  1.47  2.36e-5  9.56e-4
 Agilent_HS_21.6K  10989  0.11  2.91e-2  9.93e-2  0.15  1.45e-3  7.39e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203564_at  0.40  2.32e-1  8.46e-1  0.06  8.18e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37584_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203564_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203564_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8582    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10989    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fancg cancer Fanconi anemia (FA) is an inherited cancer susceptibility syndrome caused by mutations in a DNA repair pathway including at least 6 genes (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG). 12351379 Human
fancg breast cancer To investigate whether heterozygous variants in other FA genes are high penetrance breast cancer susceptibility alleles, we screened germ-line DNA from 88 BRCA1/2-negative families, each with at least three cases of breast cancer, for mutations in FANCA, 14695169 Human
fancg hematologic malignancies We are currently screening a pediatric population with hematologic malignancies for mutations in the FANCA, FANCC and FANCG gene, and report here on siblings carrying a heterozygous frameshift mutation in the FANCC Gene. 10994546 Human
fancg jmml PATIENTS AND METHODS: Using PCR based single strand conformational analysis we screened the DNA from pediatric patients suffering from 1 degree or 2 degrees MDS, CMML/JMML or AML for mutations in the FANCA (43 exons), FANCC (14 exons) and FANCG (14 exons) 10994546 Human
xrcc9 tumor XRCC9 is a candidate tumor suppressor gene that might operate in a postreplication repair or a cell cycle checkpoint function. 9256465 Human
fancg pancreatic cancer Here we report inherited and somatic mutations of FANCC and FANCG present in young-onset pancreatic cancer. 12750283 Human
fancg myeloid leukemia Unlike the lymphoblasts, this myeloid leukemia cell line (UoC-M1) was hypersensitive to mitomycin-C (MMC) and diepoxybutane (DEB) and exhibited a marked decrease in nuclear FANCA, FANCG, and FANCD2-L. 12637330 Human
fancg mds PATIENTS AND METHODS: Using PCR based single strand conformational analysis we screened the DNA from pediatric patients suffering from 1 degree or 2 degrees MDS, CMML/JMML or AML for mutations in the FANCA (43 exons), FANCC (14 exons) and FANCG (14 exons) 10994546 Human
fancg cmml PATIENTS AND METHODS: Using PCR based single strand conformational analysis we screened the DNA from pediatric patients suffering from 1 degree or 2 degrees MDS, CMML/JMML or AML for mutations in the FANCA (43 exons), FANCC (14 exons) and FANCG (14 exons) 10994546 NA
fancg t-all PATIENTS AND METHODS: Using PCR based single strand conformational analysis we screened the DNA from pediatric patients suffering from 1 degree or 2 degrees MDS, CMML/JMML or AML for mutations in the FANCA (43 exons), FANCC (14 exons) and FANCG (14 exons) 10994546 NA
fancg aml PATIENTS AND METHODS: Using PCR based single strand conformational analysis we screened the DNA from pediatric patients suffering from 1 degree or 2 degrees MDS, CMML/JMML or AML for mutations in the FANCA (43 exons), FANCC (14 exons) and FANCG (14 exons) 10994546 NA

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