IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CD72 Ensembl ENSG00000137101 Chromosome 9 Start 35599530 End 35609539
Description B-cell differentiation antigen CD72 (Lyb-2)(CD72 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P21854]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1696
     Entrez Gene : 971
     UCSC : uc003zxb.2
     GeneCards : 1696
     RefSeq : NM_001782
     CCDS : CCDS6581.1
     Uniprot : P21854
     Interpro : P21854
     OMIM : 107272
     GeneTests : CD72
     CGAP : CD72
     PMID : 2044654

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37479_at  0.23  2.67e-1  3.69e-1  0.43  1.17e-1  1.87e-1
 HG_U133A  215925_s_at  0.39  2.12e-2  3.15e-2  -0.08  6.29e-1  6.39e-1
 HG_U133_Plus2  215925_s_at  0.36  3.59e-2  6.30e-2  0.06  7.47e-1  7.86e-1
 Stanford  20949  0.84  8.35e-3  5.73e-2  0.50  2.81e-1  5.22e-1
 Agilent_HS_21.6K  6069  -0.30  5.86e-5  7.71e-4  -0.33  8.00e-4  4.51e-3

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  215925_s_at  0.55  3.98e-1  8.99e-1  -0.67  1.46e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37479_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215925_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215925_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20949    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6069    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd72 myeloma Here we demonstrate that, in the BCR-expressing myeloma line J558L mu 3, CD72 expression reduces the BCR ligation-induced phosphorylation of the BCR component Ig alpha/Ig beta and its cytoplasmic effectors Syk and SLP-65. 11356834 Human
cd72 b lymphoma In this paper we demonstrate that expression of CD72 down-modulates both extracellular signal-related kinase (ERK) activation and Ca2+ mobilization induced by BCR ligation in the mouse B lymphoma line K46micromlambda, whereas BCR-mediated ERK activation w 10640734 Mouse
cd72 chronic lymphocytic leukemia The function of the simultaneous expression of CD5 and its ligand CD72 on B cell malignancies like chronic lymphocytic leukemia and mantle cell lymphoma was assessed. 9576009 Human
cd72 mantle-cell lymphoma The function of the simultaneous expression of CD5 and its ligand CD72 on B cell malignancies like chronic lymphocytic leukemia and mantle cell lymphoma was assessed. 9576009 Human
cd72 plasmacytoma In addition, cotransfections with reporter constructs plus different amounts of expression plasmids for BSAP showed that CD72 promoter activity was up-regulated by BSAP in plasmacytoma cells and T cells in a dose-dependent manner. 9794407 Human
cd72 b-cell chronic leukemia Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease prog 9168440 Human
cd72 b-chronic lymphocytic leukemia (b-cll) Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease prog 9168440 Human
cd72 tumor Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease prog 9168440 Human
cd72 chronic lymphocytic leukemia CD5 and/or CD72 engagement delivers critical costimulatory signals in B-1a, B-2, and B cells from patients with chronic lymphocytic leukemia, but with different requirements and patterns. 8757302 Human
lyb-2 lymphomas Coexpression of Lyb-2 and Mac-1 by murine lymphomas and subpopulations of normal spleen and bone marrow cells. 6383728 Mouse
cd72 acute leukemia We used J3-109(anti-CD72) monoclonal antibody to examine primary neoplastic cells from patients with acute leukemia for CD72 expression. 8580813 Human
cd72 b-lineage acute lymphoblastic leukemias CD72 was present at high levels in 70 of 100 B-lineage acute lymphoblastic leukemias (ALL), but it was not expressed on cells from 23 T-lineage ALL patients or 9 acute myeloblastic leukemia patients. 8580813 Human
cd72 acute myeloblastic leukemia CD72 was present at high levels in 70 of 100 B-lineage acute lymphoblastic leukemias (ALL), but it was not expressed on cells from 23 T-lineage ALL patients or 9 acute myeloblastic leukemia patients. 8580813 Human
cd72 chronic lymphocytic leukemia A small subpopulation of normal B cells and chronic lymphocytic leukemia B cells express (analogous to T cells) the transmembrane molecule CD5, a counterstructure of B cell-specific CD72. 7512031 Human
cd72 atypical thymoma The CD5 molecule extracted from an OC tumor showed the same molecular size as that in the spleen, but CD72, a ligand of CD5 on the surface of B cells, was not found in the epithelial cells of OC or atypical thymoma. 7519823 Human
cd72 tumor The CD5 molecule extracted from an OC tumor showed the same molecular size as that in the spleen, but CD72, a ligand of CD5 on the surface of B cells, was not found in the epithelial cells of OC or atypical thymoma. 7519823 Human
cd72 chronic lymphocytic leukemia CD72 is constantly expressed in chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. 8065169 Human
lyb-2 b-cell leukemias Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias. 1384316 Human
cd72 b-cell leukemias Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias. 1384316 Human
cd72 burkitt's lymphomas Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 lymphomas Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 b-cell lymphomas Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 t-cell lymphomas Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 chronic lymphocytic leukemias Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 hairy-cell leukemias Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 non-hodgkin's lymphomas Among 83 malignant non-Hodgkin's lymphomas examined by immunohistochemistry (alkaline phosphatase anti-alkaline phosphatase technique), all 54 B-cell lymphomas, including precursor B-cell lymphomas, Burkitt's lymphomas, germinal center lymphomas 1384316 Human
cd72 leukemias In particular, very early B cells in cytoplasmic Ig (cIg)-negative, CD19-positive pre-pre-B-cell leukemias and hybrid leukemias (mixed myeloid and B-cell type) were consistently positive for CD72 on the cell surface. 1384316 Human
cd72 b-cell leukemias Therefore, CD72 may become an important marker for progenitor B-cell leukemias. 1384316 Human
lyb-2 myeloma Human Lyb-2 mRNA is expressed in normal human tonsils and bone marrow cells, in the pre-B cell line REH, in three Burkitt lymphoma cell lines, and in some EBV-transformed B cell lines, but not in antibody-secreting myeloma cell lines, T cell lines, or a p 2141045 Human
lyb-2 burkitt lymphoma Human Lyb-2 mRNA is expressed in normal human tonsils and bone marrow cells, in the pre-B cell line REH, in three Burkitt lymphoma cell lines, and in some EBV-transformed B cell lines, but not in antibody-secreting myeloma cell lines, T cell lines, or a p 2141045 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.