IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HINT2 Ensembl ENSG00000137133 Chromosome 9 Start 35802957 End 35805042
Description Histidine triad nucleotide-binding protein 2 Precursor (HINT-2)(EC 3.-.-.-)(HINT-3)(HIT-17kDa)(PKCI-1-related HIT protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9BX68]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 18344
     Entrez Gene : 84681
     UCSC : uc003zyh.2
     GeneCards : 18344
     RefSeq : NM_032593
     CCDS : CCDS6594.1
     Uniprot : Q9BX68
     Interpro : Q9BX68
     OMIM : 609997
     GeneTests : HINT2
     CGAP : HINT2

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  224415_s_at  0.14  4.90e-2  8.27e-2  0.16  1.31e-1  1.72e-1
 Agilent_HS_21.6K  8805  -0.01  6.89e-1  8.14e-1  -0.04  2.96e-1  4.53e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 224415_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8805    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hint2 hepatocellular carcinoma Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. 16762638 Human
hint2 tumors Subcutaneous injection of HepG2 cells overexpressing Hint2 in SCID mice resulted in smaller tumors (0.32 +/- 0.13 g vs 0.85 +/- 0.35 g). 16762638 Human
hint2 hepatocellular carcinoma Conclusion: Hint2 defines a novel class of mitochondrial apoptotic sensitizers down-regulated in hepatocellular carcinoma. 16762638 Human
hint2 hepatocellular carcinomas Microarray analyses revealed that HINT2 messenger RNA is downregulated in hepatocellular carcinomas (-0.42 +/- 0.58 log2 vs -0.11 +/- 0.28 log2). 16762638 Human
hint2 tumor To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned. 18596417 Human

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