IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RECK Ensembl ENSG00000122707 Chromosome 9 Start 36026906 End 36114448
Description Reversion-inducing cysteine-rich protein with Kazal motifs Precursor (hRECK)(Suppressor of tumorigenicity 15)(ST15) [Source:UniProtKB/Swiss-Prot;Acc:O95980]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11345
     Entrez Gene : 8434
     UCSC : uc003zyv.2
     GeneCards : 11345
     RefSeq : NM_021111
     CCDS : CCDS6597.1
     Uniprot : O95980
     Interpro : O95980
     OMIM : 605227
     GeneTests : RECK
     CGAP : RECK
     PMID : 9789069

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35234_at  -2.10  9.29e-16  3.34e-14  -2.51  2.66e-13  5.98e-12
 HG_U95  35235_at  0.10  5.76e-1  6.71e-1  0.09  6.69e-1  7.52e-1
 HG_U95  35236_g_at  -0.91  3.66e-5  1.66e-4  -1.20  7.36e-6  3.83e-5
 HG_U133A  205407_at  -2.02  1.73e-52  9.75e-51  -0.65  4.53e-10  5.69e-10
 HG_U133A  216153_x_at  -0.28  2.72e-5  6.02e-5  -2.46  8.43e-84  3.75e-83
 HG_U133A  216156_at  0.07  5.61e-1  6.12e-1  2.19  7.38e-30  1.24e-29
 HG_U133_Plus2  1558115_at  -0.47  3.14e-5  1.10e-4  -0.51  4.06e-5  9.58e-5
 HG_U133_Plus2  1558116_x_at  -0.80  6.47e-7  3.02e-6  -1.53  4.87e-10  2.16e-9
 HG_U133_Plus2  205407_at  -2.07  1.94e-34  2.18e-32  -2.88  5.49e-31  2.84e-29
 HG_U133_Plus2  216153_x_at  0.59  6.82e-4  1.83e-3  1.48  2.17e-12  1.27e-11
 HG_U133_Plus2  216156_at  0.12  5.56e-1  6.39e-1  0.15  5.24e-1  5.82e-1
 Stanford  7683  -0.66  7.12e-2  1.97e-1  -0.40  4.96e-1  7.12e-1
 Stanford  10195  -1.70  1.28e-4  3.84e-3  -1.44  1.22e-3  1.61e-2
 Agilent_HS_21.6K  19080  -0.61  1.46e-7  4.59e-6  -0.77  1.27e-8  3.73e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205407_at  -0.05  8.94e-1  9.93e-1  -0.05  8.88e-1  1.00e+0
 HG_U133A  216153_x_at  -0.24  2.01e-1  8.30e-1  0.06  6.41e-1  1.00e+0
 HG_U133A  216156_at  -0.43  2.57e-1  8.56e-1  0.17  4.93e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35234_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 35235_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 35236_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205407_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216153_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216156_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558115_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558116_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205407_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216153_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216156_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7683    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10195    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19080    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
reck benign prostatic hyperplasia RECK expression in samples of benign prostatic hyperplasia from adenomectomy specimens was higher than in normal adjacent tissue of prostate carcinomas. 16806661 Human
reck prostate carcinomas RECK expression in samples of benign prostatic hyperplasia from adenomectomy specimens was higher than in normal adjacent tissue of prostate carcinomas. 16806661 Human
reck prostatic intraepithelial neoplasia RESULTS: Consistent with lower RECK messenger RNA by 24%, RECK protein expression was decreased in pCA, compared with adjacent normal tissue and prostatic intraepithelial neoplasia. 16806661 Human
reck tumor Multivariate analysis using the Cox proportional hazards model revealed that negative RECK expression was an independent prognostic factor for an increased risk of PSA relapse, especially in patients with higher tumor grades (Gleason score > or =7). 16806661 Human
reck tumor METHODS: RECK messenger RNA levels in 15 microdissected normal/tumor matches were determined by quantitative reverse transcriptase-polymerase chain reaction. 16806661 Human
reck tumor Decreased RECK expression was associated with higher Gleason score (> or =7) and higher tumor stage. 16806661 Human
reck tumor RECK expression was related to preoperative prostate-specific antigen (PSA), tumor stage and grade, surgical margin status, and PSA relapse-free time after radical prostatectomy. 16806661 Human
reck tumor Decreased RECK Expression Indicating Proteolytic Imbalance in Prostate Cancer is Associated with Higher Tumor Aggressiveness and Risk of Prostate-Specific Antigen Relapse after Radical Prostatectomy. 16806661 Human
reck prostate cancer Decreased RECK Expression Indicating Proteolytic Imbalance in Prostate Cancer is Associated with Higher Tumor Aggressiveness and Risk of Prostate-Specific Antigen Relapse after Radical Prostatectomy. 16806661 Human
reversion-inducing-cysteine-rich protein with kazal motifs metastasis In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
the reck gene tumor The RECK gene is widely expressed in normal human tissues but is downregulated in tumor cell lines and oncogenically transformed fibroblasts. 12507228 Human
the reck gene metastasis The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. 10454749 Human
the reck gene tumor The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. 10454749 Human
the reck protein pancreatic cancer CONCLUSIONS: Our findings support the hypothesis that the RECK protein has negative effects on the invasiveness of pancreatic cancer by inhibiting MMP-2 activation and suggest the potential value of RECK as a prognostic molecular marker for pancreatic can 12738734 Human
st-15 human gastric carcinomas This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcino 6088035 Human
st-15 mucinous adenocarcinoma This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcino 6088035 Human
st-15 poorly differentiated adenocarcinoma This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcino 6088035 Human
st-15 colonic carcinoma This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcino 6088035 Human
st-15 adenocarcinoma This study deals with the growth effect of gastrin on two xenotransplantable human gastric carcinomas (SC-6-JCK, poorly differentiated adenocarcinoma; and St-15, mucinous adenocarcinoma) and on one colonic carcinoma (Co-3, well-differentiated adenocarcino 6088035 Human
st-15 human gastric cancer In the in vivo study, the antitumor effects of DDP against human gastric cancer xenografts St-15 and SC-1-NU in BALB/c nu/nu mice were enhanced pretreatment with BSO, which was administered intraperitoneally at a dose of 500 mg/kg according to a schedule 8370654 Human
reversion-inducing-cysteine-rich protein with kazal motifs non-small cell lung cancer In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
reversion-inducing-cysteine-rich protein with kazal motifs tumor In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
reck non-small cell lung cancer Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. 17233834 Human
reck metastasis In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
reck non-small cell lung cancer In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
reck tumor In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lun 17233834 Human
reck prostate carcinoma To evaluate its potential role for prostate carcinoma, we investigated RECK expression in prostate cancer (pCA) samples. 16806661 Human
reck prostate cancer To evaluate its potential role for prostate carcinoma, we investigated RECK expression in prostate cancer (pCA) samples. 16806661 Human
reck cancer OBJECTIVES: Decreased expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) was recently shown in several cancer types. 16806661 Human
reck invasive cervical carcinoma We evaluated the expression and activity of MMPs and their inhibitors RECK and TIMP-2 in 3 human invasive cervical carcinoma cell lines. 17167534 Human
st-15 ca To evaluate the antitumor activity and toxicity of 5-FU and JM-8 in vivo, BALB/cA nu/nu mice bearing human gastric cancer xenografts St-15, St-40 and SC-1-NU were administered 5-FU and JM-8 intraperitoneally. 8017848 Human
the reck gene tumor Studies on the roles and the mechanisms of regulation of the RECK gene during normal development may therefore yield important insights into how the malignant behaviors of tumor cells arise and how they can be controlled. 16007210 Human
the reck gene transitional cell carcinoma In addition, the RECK gene was transfected in the canine transitional cell carcinoma, and its influence on cell proliferation, migration, and invasion was analyzed. 15876788 others
the reck gene benign prostate hyperplasia RESULTS: The mRNA level of the RECK gene in the prostate carcinoma cell strains, such as DU45, LNCaP and PC-3, was lower than that in the benign prostate hyperplasia cell line BPH-1, while MMP-9 had a higher expression. 16281502 Human
the reck gene prostate carcinoma RESULTS: The mRNA level of the RECK gene in the prostate carcinoma cell strains, such as DU45, LNCaP and PC-3, was lower than that in the benign prostate hyperplasia cell line BPH-1, while MMP-9 had a higher expression. 16281502 Human
the reck gene tumor CONCLUSION: The RECK gene is supposed to be a kind of tumor suppressor gene, which may act by inhibiting the activity of MMP-9. 16281502 Human
reck tumor Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. 9789069 Human
reck metastasis Restored expression of RECK in malignant cells resulted in suppression of invasive activity with concomitant decrease in the secretion of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis. 9789069 Human
reck tumor Restored expression of RECK in malignant cells resulted in suppression of invasive activity with concomitant decrease in the secretion of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis. 9789069 Human
reck metastasis Thus, RECK may link oncogenic signals to tumor invasion and metastasis. 9789069 Human
reck tumor Thus, RECK may link oncogenic signals to tumor invasion and metastasis. 9789069 Human
reck metastasis Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene. 10543990 Human
reck hepatocellular carcinoma RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. 11124835 Human
reck hepatocellular carcinoma (hcc) In the present study, we have addressed this issue by analyzing the levels of RECK gene expression in hepatocellular carcinoma (HCC). 11124835 Human
reck tumors Patients with high RECK mRNA expression in tumorous tissues tended to show better survival (P =.02), and such tumors had a tendency to be less invasive. 11124835 Human
reck metastasis We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. 11747814 Human
reck tumor We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. 11747814 Human
reck cancer Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and tha 11747814 Mouse
reck tumor angiogenesis These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis. 11747814 Mouse
reck tumor angiogenesis RECK, a membrane-anchored inhibitor of MMPs was recently characterized for its role in development, tissue homeostasis, and for tumor angiogenesis. 11782309 Human
reck tumor Homozygous loss of RECK results in embryonic lethality and attenuated tumor development in adults - thus providing further support for an efficacious role for protease inhibitors as anticancer therapeutics. 12062160 Human
reck tumor Genomic characterization of the C9orf19 gene identified five exons extending over 27.2 kb of genomic DNA, located 12 kb centromeric to the tumor suppressor RECK gene. 12137952 Human
reck tumor The human RECK gene, mapped at 9p13-->p12, is known as a tumor suppressor gene and as a key regulator of extracellular matrix integrity and angiogenesis. 12438739 Human
reck lung cancer Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells. 12447698 Human
reck metastasis Recent works demonstrated that a membrane-anchored MMP inhibitor RECK may potently suppress MMP-2 and -9 activity to inhibit angiogenesis and metastasis in vitro and in vivo. 12447698 Human
reck human lung cancer RT-PCR analyses showed that NS398 and aspirin up-regulated RECK mRNA level in CL-1 human lung cancer cells. 12447698 Human
reck metastasis Taken together, our results suggest that induction of RECK expression may be one of the mechanisms by which NSAIDs suppress MMP activity to block angiogenesis and metastasis. 12447698 Human
reck metastasis Transcriptional control of the RECK metastasis/angiogenesis suppressor gene. 12507228 Human
reck tumor RECK encodes a membrane-anchored glycoprotein that suppresses tumor invasion and angiogenesis by regulating matrix-metalloproteinases (MMP-2, MMP-9 and MT1-MMP). 12507228 Human
reck cancer Understanding of the mechanisms which control RECK gene transcription may lead to the development of new strategies for cancer prevention and treatment. 12507228 Human
reck pancreatic cancer RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. 12738734 Human
reck metastasis The aim of this study was to examine RECK expression in pancreatic cancer, where intensive invasiveness and metastasis are frequently observed, and investigate its clinical significance. 12738734 Human
reck pancreatic cancer The aim of this study was to examine RECK expression in pancreatic cancer, where intensive invasiveness and metastasis are frequently observed, and investigate its clinical significance. 12738734 Human
reck invasive ductal carcinomas METHODS: (a) RECK expression in surgically resected tissue samples of invasive ductal carcinomas of the pancreas (n = 50) was examined immunohistochemically, and its correlation with clinicopathological factors was analyzed; and (b) gelatin zymography was 12738734 Human
reck ductal carcinoma RESULTS: Among the 50 ductal carcinoma samples, 26 (52%) were stained positive for RECK. 12738734 Human
reck tumors Tumors with positive RECK staining were significantly less invasive as compared with RECK-negative tumors (P = 0.0438). 12738734 Human
reck tumors Importantly, patients who had tumors with high RECK expression showed significantly better prognosis than those who had RECK-negative tumors (P = 0.0463, by Log-rank test). 12738734 Human
reck pancreatic cancer CONCLUSIONS: Our findings support the hypothesis that the RECK protein has negative effects on the invasiveness of pancreatic cancer by inhibiting MMP-2 activation and suggest the potential value of RECK as a prognostic molecular marker for pancreatic can 12738734 Human
reck tumor angiogenesis Down-regulation of RECK has been implicated in tumor angiogenesis and progression. 12767082 Human
reck breast carcinoma METHODS: The authors assessed the prognostic value of RECK expression in tumor tissue specimens from 278 breast carcinoma patients with a median follow-up time of 75 months (range, 2-169 months). 12767082 Human
reck tumor METHODS: The authors assessed the prognostic value of RECK expression in tumor tissue specimens from 278 breast carcinoma patients with a median follow-up time of 75 months (range, 2-169 months). 12767082 Human
reck tumor RESULTS: Expression levels of RECK were lower in tumor tissue specimens than in adjacent normal breast tissue specimens from 10 patients (P = 0.028). 12767082 Human
reck tumors The 100 patients whose tumors exhibited low levels of RECK had a mean RFS time of 80.4 months and a 61.8% 5-year RFS rate, whereas the 178 patients with tumors with high RECK expression had a mean RFS time of 91.2 months and a 73.0% 5-year RFS rate. 12767082 Human
reck breast carcinoma Therefore, the possibility of applying RECK, a pharmaceutical mimetic, or drugs activating endogenous RECK expression, as possible therapeutic or preventive agents for breast carcinoma should be explored. 12767082 Human
reck malignancy RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. 12784995 Human
reck cancer Subsequently, reduced expression of RECK in transformed cells and cancer cells were demonstrated. 12784995 Human
reck tumors Moreover, in several types of tumors, positive correlation between RECK expression and survival of patients have been noted. 12784995 Human
reck cancer Restored expression of RECK in cancer cell lines results in strong suppression of invasion, metastasis, and tumor angiogenesis. 12784995 Human
reck metastasis Restored expression of RECK in cancer cell lines results in strong suppression of invasion, metastasis, and tumor angiogenesis. 12784995 Human
reck tumor angiogenesis Restored expression of RECK in cancer cell lines results in strong suppression of invasion, metastasis, and tumor angiogenesis. 12784995 Human
reck cancer These findings indicate that (i) RECK is an important regulator of extracellular matrix remodeling and that (ii) down-regulation of RECK by oncogenic signaling leads to the excessive activation of MMPs thereby promoting malignant behavior of cancer cells 12784995 Human
reck metastasis These findings indicate that (i) RECK is an important regulator of extracellular matrix remodeling and that (ii) down-regulation of RECK by oncogenic signaling leads to the excessive activation of MMPs thereby promoting malignant behavior of cancer cells 12784995 Human
reck cancer Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. 12810630 Human
reck tumor metastasis RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. 12810630 Human
reck cancer In this study, we test the possibility that HDAC inhibitor may increase RECK expression to inhibit MMP activation and cancer cell invasion. 12810630 Human
reck human lung cancer Our results showed that trichostatin A (TSA) up-regulated RECK via transcriptional activation in CL-1 human lung cancer cells. 12810630 Human
reck metastasis In this study, we investigated the effect of LMP1 on the expression of RECK, a metastasis suppressor gene, in an EBV-negative nasopharyngeal carcinoma (NPC) cell line. 14614450 Human
reck nasopharyngeal carcinoma (npc) In this study, we investigated the effect of LMP1 on the expression of RECK, a metastasis suppressor gene, in an EBV-negative nasopharyngeal carcinoma (NPC) cell line. 14614450 Human
reck tumor metastasis Taken together, these results suggest that LMP1 inhibits RECK expression via the ERK/Sp1 signaling pathway and this inhibition is a critical step for LMP1-induced tumor metastasis. 14614450 Human
reck metastasis Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. 15093608 Human
reck tumor metastasis RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase (MMP) activity and inhibit tumor metastasis. 15093608 Human
reck non-small cell lung cancer Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer. 15196549 Human
reck metastasis Experimental studies have shown that RECK can suppress tumour - invasion, metastasis and angiogenesis. 15196549 Human
reck tumour Experimental studies have shown that RECK can suppress tumour - invasion, metastasis and angiogenesis. 15196549 Human
reck tumour Expression of RECK and vascular endothelial growth factor (VEGF) in tumour tissues was assessed by immunohistochemical staining (IHS). 15196549 Human
reck colorectal cancer The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. 15328199 Human
reck metastasis Studies in mice and cultured cells have shown that restoration of RECK expression inhibits tumor invasion, metastasis, and angiogenesis. 15328199 Mouse
reck tumor Studies in mice and cultured cells have shown that restoration of RECK expression inhibits tumor invasion, metastasis, and angiogenesis. 15328199 Human
reck colorectal cancer Here we examined the expression of RECK and one of its targets, MMP-9, in colorectal cancer tissue. 15328199 Human
reck colorectal cancer EXPERIMENTAL DESIGN: The RECK and MMP-9 expression levels in colorectal cancer samples from 53 patients were determined by immunohistochemical techniques. 15328199 Human
reck tumors Importantly, patients with tumors expressing relatively high levels of RECK (high-RECK group) had a significantly lower risk of recurrence than did patients with tumors expressing relatively low levels of RECK (low-RECK group; P = 0.011). 15328199 Human
reck colorectal cancer CONCLUSIONS: RECK/MMP-9-balance is an informative prognostic indicator for colorectal cancer. 15328199 Human
reck tumor angiogenesis Our data also suggest that RECK suppresses tumor angiogenesis, probably by limiting the availability of VEGF in tumor tissues. 15328199 Human
reck tumor Our data also suggest that RECK suppresses tumor angiogenesis, probably by limiting the availability of VEGF in tumor tissues. 15328199 Human
reck melanoma The effects of TIMP-2 on RECK expression and cell migration were confirmed in A2058 melanoma cells. 15604273 Human
reck malignancy It was reported that decreased RECK expression closely correlated with tumor malignancy. 15876788 Human
reck tumor It was reported that decreased RECK expression closely correlated with tumor malignancy. 15876788 Human
reck tumor RECK mRNA expression was analyzed in various canine tissues and tumor cell lines by quantitative RT-PCR. 15876788 Human
reck tumor The transfected RECK gene suppressed only canine tumor invasion. 15876788 others
reck malignancy These results showed that RECK might play an important role in tumor malignancy in dogs as well as in other mammalians. 15876788 others
reck tumor These results showed that RECK might play an important role in tumor malignancy in dogs as well as in other mammalians. 15876788 others
reck cancer In contrast, there was significantly decreased expression of MMP2 and MMP23, maspin, and the protease inhibitors tissue inhibitor of metalloproteinase 3 (TIMP3), TIMP4 and RECK (reversion-inducing cysteine-rich protein with Kazal motifs) in the cancer spe 15928670 Human
reck human prostate cancer These data provide the first comprehensive and quantitative analysis of the expression and localisation of MMPs and their inhibitors in human prostate cancer, leading to the identification of several genes involved in proteolysis as potential prognostic i 15928670 Human
reck metastasis Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. 16007210 Human
reck tumor Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. 16007210 Human
reck metastasis RECK, a glycosylphosphatidylinositol (GPI)-anchored glycoprotein, negatively regulates matrix metalloproteinases (MMP), such as MMP-9, and inhibits tumor invasion and metastasis. 16103099 Human
reck tumor RECK, a glycosylphosphatidylinositol (GPI)-anchored glycoprotein, negatively regulates matrix metalloproteinases (MMP), such as MMP-9, and inhibits tumor invasion and metastasis. 16103099 Human
reck human tumor In this study, we examined the link between glycosylation and the function of RECK in human tumor cell lines. 16103099 Human
reck tumor Moreover, RECK-suppressed tumor cell invasion was reversed by inhibiting glycosylation at Asn86, Asn297, and Asn352 residues of RECK. 16103099 Human
reck tumor Thus, these findings indicate that glycosylation mediates RECK suppression of tumor cell invasion by multiple mechanisms such as suppressing MMP-9 secretion and inhibiting MMP-2 activation. 16103099 Human
reck tumor BACKGROUND: Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a novel membrane-anchored matrix metalloproteinase inhibitor, and experimental studies have shown that RECK can suppress tumor progression through angiogenesis inhibition. 16132376 Human
reck non-small-cell lung cancer We have already revealed that enhanced RECK expression is significantly correlated with a favorable prognosis in non-small-cell lung cancer (NSCLC). 16132376 Human
reck nsclc We have already revealed that enhanced RECK expression is significantly correlated with a favorable prognosis in non-small-cell lung cancer (NSCLC). 16132376 Human
reck nsclc CONCLUSIONS: RECK status was a novel prognostic factor in pathologic stage IIIA N2 NSCLC. 16132376 Human
reck hilar cholangiocarcinoma Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance. 16463672 Human
reck hilar cholangiocarcinoma In order to study the expression of transformation suppressor gene RECK and MMP-9 in hilar cholangiocarcinomas and its clinical significance, and explore the roles of RECK gene in metastasis and invasion of hilar cholangiocarcinoma, the expression levels 16463672 Human
reck metastasis In order to study the expression of transformation suppressor gene RECK and MMP-9 in hilar cholangiocarcinomas and its clinical significance, and explore the roles of RECK gene in metastasis and invasion of hilar cholangiocarcinoma, the expression levels 16463672 Human
reck hilar cholangiocarcinoma The results showed that in hilar cholangiocarcinoma tissues, the expression of RECK gene was 0.235 +/- 0.062, significantly lower than in normal bile duct tissues (0.533 +/- 0.024, P < 0.05). 16463672 Human
reck hilar cholangiocarcinoma The abnormal expression of RECK gene might be one of the molecular mechanisms of hilar cholangiocarcinoma metastasis. 16463672 Human
reck metastasis The abnormal expression of RECK gene might be one of the molecular mechanisms of hilar cholangiocarcinoma metastasis. 16463672 Human
reck metastasis The tumor and metastasis suppressor RECK protein regulates at least three members of the MMPs family: MMP-2, MMP-9, and MT1-MMP. 16791855 Human
reck tumor The tumor and metastasis suppressor RECK protein regulates at least three members of the MMPs family: MMP-2, MMP-9, and MT1-MMP. 16791855 Human
reck glioblastoma Therefore, we suggest that: (1) RECK downregulation is critical for the invasiveness process displayed by T98G cells; (2) type 1 collagen could be employed to modulate RECK expression in glioblastoma cell lines. 16791855 Human
reck malignant gliomas Since a positive correlation between RECK expression and patients survival has been noted in several types of tumors, our results may contribute to elucidate the complex mechanisms of malignant gliomas invasiveness. 16791855 Human
reck tumors Since a positive correlation between RECK expression and patients survival has been noted in several types of tumors, our results may contribute to elucidate the complex mechanisms of malignant gliomas invasiveness. 16791855 Human
reck metastasis Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation. 16951151 Human
reck metastasis RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase activity to suppress tumor invasion and metastasis. 16951151 Human
reck tumor RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase activity to suppress tumor invasion and metastasis. 16951151 Human
reck human lung cancer Interestingly, human lung cancer cells harboring constitutively activated RAS exhibited lower RECK expression and higher promoter methylation of RECK gene. 16951151 Human
reck metastasis Collectively, our results suggest that RAS oncogene induces RECK gene silencing through DNMT3b-mediated promoter methylation, and DNMT inhibitors may be useful for the treatment of RAS-induced metastasis. 16951151 Human
reck tumors Downregulation of RECK was observed in 60% of the 55 tumors analyzed. 17233834 Human
reck tumor Using methylation-specific polymerase chain reaction analysis methylation of the RECK promoter was detected in 63.6% (35/55) of the tumor tissues. 17233834 Human
reck human lung cancer Promoter methylation was also detected in human lung cancer cell lines, and the DNA methyltransferase inhibitor 5'-azacytidine reversed the expression of RECK and reduced the invasive ability of these cell lines. 17233834 Human
reck metastasis Collectively, our results suggest that downregulation of the metastasis suppressor RECK is caused by promoter methylation in non-small cell lung cancer and is associated with K-ras mutation and lymph node metastasis. 17233834 Human
reck non-small cell lung cancer Collectively, our results suggest that downregulation of the metastasis suppressor RECK is caused by promoter methylation in non-small cell lung cancer and is associated with K-ras mutation and lymph node metastasis. 17233834 Human
reck tumor Moreover, we show that although expression of MMP inhibitor, TIMP, is sufficient to halt developmental invasion, inhibition of proteases by both TIMP and RECK are required to block tumor invasion. 17301221 Fruitfly
reck oncoprotein Tgat oncoprotein functions as a inhibitor of RECK by association of the unique C-terminal region. 17328864 Human
reck oncoprotein We identified RECK, a membrane-anchored glycoprotein negatively regulating the activities of MMPs, as a molecule interacting with Tgat oncoprotein consisting of RhoGEF domain and the unique C-terminal 15 amino acids. 17328864 Human
reck cancer These findings indicate that Tgat is the functional inhibitor of RECK, and the activation of MMPs induced by Tgat is likely to enhance invasive activities of cancer cells expressing Tgat. 17328864 Human
reck tumor The expression of the tumor inhibitory gene RECK was positively related with the invasion ability of trophoblasts, while the invasion gene MMP-2 was negatively related with the ability. 17357505 Human
reck colorectal cancer Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer. mRNA, and latent and active levels MMP-2 and -9 were highe 16046057 Human
reck tumor Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer. mRNA, and latent and active levels MMP-2 and -9 were highe 16046057 Human
reck tumor For active MMP-2, but not for MMP-9, a significant negative partial correlation (R(p)=-0.440, P<0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. 16046057 Human
reck tumor In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P=0.017) association with overall survival. 16046057 Human
reck tumors Matrix metalloproteinase inhibitor RECK expression in canine tumors. 16141662 others
reck tumor The down-regulation of RECK has been implicated in tumor progression. 16141662 Human
reck tumors In this study, the expression levels of the RECK messenger ribonucleic acid (mRNA) in various spontaneously developed canine tumors were investigated by using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and the correlation betwe 16141662 Human
reck tumor Quantitative RT-PCR could detect low levels of expression of RECK mRNA in the tumor samples. 16141662 others
reck tumor The expression levels of RECK mRNA in some tumor tissue samples were significantly lower than those in normal tissue samples. 16141662 others
reck gastric cancer Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer. 16324834 Human
reck gastric cancer In this study the expression levels of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) in gastric cancer cell lines and tissues have been analysed in order to assess their value as a prognostic indicator. 16324834 Human
reck gastric cancer The expressions of RECK, activated matrix metalloproteinase (MMP)-7, and vascular endothelial growth factor (VEGF) in gastric cancer tissues and cell lines were evaluated by Western blot analysis; and MMP-2 and MMP-9 were evaluated by gelatin zymography. 16324834 Human
reck gastric cancer RECK expression in the context of gastric cancer was also compared with various clinicopathologic parameters and compared to the expression of activated MMP-7, MMP-2, and MMP-9. 16324834 Human
reck gastric cancer Fifty-two percent of the 102 gastric cancer tissues and 81.8% of the 11 gastric cancer cell lines exhibited reduced RECK expression. 16324834 Human
reck tumour We also detected a significant inverse correlation between RECK expression and macroscopic tumour growth (P=0.018), lymphatic invasion (P=0.018), lymph node metastasis (P=0.000), stage (P=0.000), and MMP-9 (P=0.039). 16324834 Human
reck gastric cancer Our data strongly supports the hypothesis that RECK is a suppressor of malignancy, and constitutes a good prognostic indicator in gastric cancer. 16324834 Human
reck malignancy Our data strongly supports the hypothesis that RECK is a suppressor of malignancy, and constitutes a good prognostic indicator in gastric cancer. 16324834 Human
reck metastasis HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. 16377629 Human
reck metastasis Restoration of RECK provides a novel strategy for the inhibition of HER-2/neu-induced metastasis. 16377629 Human
reck tumors RECK was the main inhibitor expressed in these 3 tumors, with no significant differences. 16619545 Human
reck tumors Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. 16762015 Human
reck odontogenic tumors Background: To evaluate the roles of matrix-degrading proteinase regulators in progression of odontogenic tumors, expression of membrane-bound matrix metalloproteinase (MMP) MT1-MMP, MMP inhibitor RECK and MMP inducer EMMPRIN was analyzed in ameloblastic 16762015 Human
reck tumors Background: To evaluate the roles of matrix-degrading proteinase regulators in progression of odontogenic tumors, expression of membrane-bound matrix metalloproteinase (MMP) MT1-MMP, MMP inhibitor RECK and MMP inducer EMMPRIN was analyzed in ameloblastic 16762015 Human
reck tumors Methods: Tissue specimens of 11 tooth germs, 40 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against MT1-MMP, RECK, and EMMPRIN. 16762015 Human
reck tumors Results: Immunohistochemical reactivity for MT1-MMP, RECK and EMMPRIN was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastic tumors. 16762015 Human
reck tumor Conclusion: Expression of MT1-MMP, RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control MMP-dependent extracellular matrix (ECM) degradation during tooth development and tumor prog 16762015 Human
reck tumors Conclusion: Expression of MT1-MMP, RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control MMP-dependent extracellular matrix (ECM) degradation during tooth development and tumor prog 16762015 Human
reversion-inducing-cysteine-rich protein with kazal motifs gastric cancer Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer. 16324834 Human
reversion-inducing-cysteine-rich protein with kazal motifs gastric cancer In this study the expression levels of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) in gastric cancer cell lines and tissues have been analysed in order to assess their value as a prognostic indicator. 16324834 Human
reck lymph node metastasis We also detected a significant inverse correlation between RECK expression and macroscopic tumour growth (P=0.018), lymphatic invasion (P=0.018), lymph node metastasis (P=0.000), stage (P=0.000), and MMP-9 (P=0.039). 16324834 Human
reck oncogenic Thus, RECK may link oncogenic signals to tumor invasion and metastasis. 9789069 Human
reck lymph node metastasis Collectively, our results suggest that downregulation of the metastasis suppressor RECK is caused by promoter methylation in non-small cell lung cancer and is associated with K-ras mutation and lymph node metastasis. 17233834 Human
reck lymph node metastasis More importantly, downregulation of RECK significantly correlated with lymph node metastasis (P = 0.038). 17233834 Human
reck lymph node metastasis Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. 17233834 Human
reck oncogene Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene. 10454749 Mouse
reck oncogene One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. 10454749 Mouse
reck oncogene Sp1 transcription factor family is involved in the basal level of promoter activity of many genes, as well as in dynamic regulation of gene expression; in a majority of cases as a positive regulator, or, as exemplified by the oncogene-mediated suppression 10454749 Human
reck oncogene We have isolated and characterized the 5'-flanking region of the mouse RECK gene aiming to understand the mechanism of oncogene-mediated suppression of RECK gene expression. 10543990 Human
reck hcc RECK mRNA was detectable by RNA blot hybridization in all the tumorous and contiguous nontumorous tissues obtained from 64 patients with HCC. 11124835 Human
reck hcc These findings support the hypothesis that RECK has negative effects on the invasiveness of HCC cells and suggest the feasibility of RECK mRNA as a promising prognostic molecular marker for HCC. 11124835 Human
reck fibrosarcoma Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. 11747814 Human
reck tumors Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. 11747814 Human
reck tumorigenesis RECK regulates MMP-induced pericellular signaling cascades during embryogenesis and tumorigenesis. 12062160 Human
reck tumor CONCLUSIONS: These results are in agreement with the notion of RECK being an important tumor-suppressor gene. 12767082 Human
reck oncogenic RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. 12784995 Human
reck oncogene RECK was first isolated as a transformation suppressor gene by cDNA expression cloning in a mouse fibroblast cell line transformed by an activated RAS oncogene. 12784995 Mouse
reck oncogenic These findings indicate that (i) RECK is an important regulator of extracellular matrix remodeling and that (ii) down-regulation of RECK by oncogenic signaling leads to the excessive activation of MMPs thereby promoting malignant behavior of cancer cells 12784995 Human
reck oncogenic Previous study demonstrated that oncogenic ras inhibited RECK expression via an Sp1 binding site in the RECK promoter. 15093608 Human
reck oncogenic By using DNA affinity precipitation assay, we found that induction of oncogenic ras enhanced the binding of HDAC1 to the DNA probe corresponding to the Sp1 site in the RECK promoter. 15093608 Human
reck oncogenic Taken together, our results suggest that oncogenic ras represses RECK expression via a histone deacetylation mechanism. 15093608 Human
reck non-small cell lung cancer To assess the clinical significance of RECK-expression in non-small cell lung cancer (NSCLC), a total of 171 patients with completely resected pathological stage (p-stage) I-IIIA NSCLC were retrospectively examined. 15196549 Human
reck nsclc To assess the clinical significance of RECK-expression in non-small cell lung cancer (NSCLC), a total of 171 patients with completely resected pathological stage (p-stage) I-IIIA NSCLC were retrospectively examined. 15196549 Human
reck tumour A significant inverse correlation between RECK-expression and tumour angiogenesis was documented; the mean IMVD in tumours with strong RECK-expression (157.1) was significantly lower than that observed in tumours with weak RECK-expression (194.5; P = 0.00 15196549 Human
reck tumours A significant inverse correlation between RECK-expression and tumour angiogenesis was documented; the mean IMVD in tumours with strong RECK-expression (157.1) was significantly lower than that observed in tumours with weak RECK-expression (194.5; P = 0.00 15196549 Human
reck tumours The 5-year survival rate for patients with tumours with strong RECK-expression (75.8%) was significantly higher than that for patients with weakly expressing tumours (54.3%; P = 0.016). 15196549 Human
reck adenocarcinoma Subset analyses showed that the prognostic impact of RECK-status was evident in patients with either adenocarcinoma, poorly differentiated tumours, or p-stage IIIA disease. 15196549 Human
reck tumours Subset analyses showed that the prognostic impact of RECK-status was evident in patients with either adenocarcinoma, poorly differentiated tumours, or p-stage IIIA disease. 15196549 Human
reck nsclc In conclusion, RECK-status is a significant prognostic factor correlated with tumour angiogenesis in NSCLC patients. 15196549 Human
reck tumour In conclusion, RECK-status is a significant prognostic factor correlated with tumour angiogenesis in NSCLC patients. 15196549 Human
reck solid tumors The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. 16007210 Human
reck human tumor RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. 16103099 Human
reck tumor RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. 16103099 Human
reck primary tumor RECK expression in the primary tumor, along with involved N2 nodes, was examined immunohistochemically. 16132376 Human
reck primary tumor RESULTS: RECK expression in the primary tumor was strong in 53 patients (44.9%) and was weak in the other 65 patients. 16132376 Human
reck tumor The 5-year survival rate of patients with RECK-strong tumor (42.9%) was significantly higher than that of patients with RECK-weak tumor (23.1%; P = .017). 16132376 Human
reck primary tumors RECK expression in involved N2 nodes was significantly higher than in primary tumors (P < .001). 16132376 Human
reck oncogene In this study, we demonstrate that the HER-2/neu oncogene inhibits the expression of the MMP inhibitor RECK to promote cell invasion. 16377629 Human
reck metastasis Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. 16791855 Human
reck glioma Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. 16791855 Human
reck oncogene Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation. 16951151 Human
reck oncogenic Our previous study indicated that oncogenic RAS inhibited RECK expression via a histone deacetylation mechanism. 16951151 Human
reck oncogenic Oncogenic RAS increased the binding of DNMT3b to the promoter of RECK gene and this binding induced promoter methylation, which could be reversed by 5'-azacytidine and DNMT3b small interfering RNA (siRNA). 16951151 Human
reck oncogene Collectively, our results suggest that RAS oncogene induces RECK gene silencing through DNMT3b-mediated promoter methylation, and DNMT inhibitors may be useful for the treatment of RAS-induced metastasis. 16951151 Human

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