IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC1A1 Ensembl ENSG00000106688 Chromosome 9 Start 4480444 End 4577469
Description Excitatory amino acid transporter 3 (Sodium-dependent glutamate/aspartate transporter 3)(Excitatory amino-acid carrier 1)(Neuronal and epithelial glutamate transporter)(Solute carrier family 1 member 1) [Source:UniProtKB/Swiss-Prot;Acc:P43005]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10939
     Entrez Gene : 6505
     UCSC : uc003zij.1
     GeneCards : 10939
     RefSeq : NM_004170
     CCDS : CCDS6452.1
     Uniprot : P43005
     Interpro : P43005
     OMIM : 133550
     GeneTests : SLC1A1
     CGAP : SLC1A1
     PMID : 8020993

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38267_at  -1.85  3.19e-12  6.29e-11  -2.42  9.26e-13  1.87e-11
 HG_U95  38268_at  -1.72  2.92e-12  5.77e-11  -2.44  1.16e-13  2.78e-12
 HG_U133A  206396_at  -0.91  3.88e-10  1.40e-9  -0.24  8.18e-3  8.91e-3
 HG_U133A  213664_at  -2.01  3.04e-47  1.29e-45  -3.50  5.25e-87  2.53e-86
 HG_U133_Plus2  206396_at  -1.51  6.48e-12  5.99e-11  -2.40  7.98e-23  1.54e-21
 HG_U133_Plus2  213664_at  -2.14  5.58e-29  3.42e-27  -3.07  8.86e-46  5.15e-43
 HG_U133_Plus2  243713_at  1.30  4.50e-11  3.73e-10  0.82  1.02e-3  1.97e-3
 Agilent_HS_21.6K  5862  -0.43  2.17e-5  3.34e-4  -0.54  8.25e-10  3.61e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206396_at  -0.35  3.91e-1  8.96e-1  -0.18  5.35e-1  1.00e+0
 HG_U133A  213664_at  -0.01  9.70e-1  9.98e-1  -0.05  7.73e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38267_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38268_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206396_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213664_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206396_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213664_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243713_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5862    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
eaac1 c6 glioma The possible modulation of the glutamate transporter EAAC1 by a class A G protein-coupled receptor was studied in transfected C6 glioma cells stably expressing the high-affinity neurotensin receptor NTS1. 12123836 Rat
eaac1 c6 glioma In previous studies, we have shown that activation of protein kinase C (PKC) rapidly (within minutes) increases the activity and cell surface expression of the glutamate transporter EAAC1 in two systems that endogenously express this transporter (C6 gliom 12237337 Rat
eaac1 c6 glioma Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells. 12151387 Rat
eaac1 c6 glioma Rat C6 glioma cells were used as a model system to study the biosynthesis, intracellular targeting, and degradation of the EAAC1 transporter, a sodium-dependent glutamate/aspartate transport protein that encodes System X(-)A,G activity. 12151387 Rat
eaac1 c6 glioma PMA also significantly decreased glutamate uptake in a Madin-Darby canine kidney (MDCK) cell line stably transfected with EAAC1 but enhanced EAAC1-mediated glutamate uptake in the rat C6 glioma cells, consistent with previous observations. 11578612 Rat
eaac1 c6 glioma Using C6 glioma, a cell line that endogenously and selectively expresses EAAC1, we report that platelet-derived growth factor (PDGF) increased Na(+)-dependent L-[(3)H]-glutamate transport activity within 30 min. 10671571 Rat
eaac1 c6 glioma Glial glutamate transporter GLT-1 mRNA was selectively induced in C6 glioma cells exposed to hypertonic stress (HS), while the expression of two other subtypes, GLAST and EAAC1, was suppressed. 10548520 Rat
eaat3 astrocytoma In conclusion, the Na(+)-dependent high-affinity L-glutamate transport into human U373 astrocytoma cells appears to be mediated predominantly by the EAAT3 subtype. 10519046 Human
eaac1 hepatoma Na+-dependent aspartate transport in H4 hepatoma cells was mediated by a high-affinity system (Km 5 microM) and was inhibited by D-aspartate and L-glutamate but not by d-glutamate-properties characteristic of the high-affinity glutamate transporter EAAC1. 9461518 Human
eaac1 hepatoma C-terminal antibodies to the EAAC1 protein recognized a single band of 58 kDa in hepatocyte membranes, but an additional strong band of 60 kDa was present in H4 hepatoma cells. 9461518 Human
excitatory amino acid carrier 1 c6 glioma Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. 9502808 Rat
eaac1 c6 glioma In the present study the C6 glioma cell line was used as a model system that endogenously expresses the excitatory amino acid carrier 1 (EAAC1) subtype of neuronal glutamate transporter. 9502808 Rat
excitatory amino acid carrier 1 c6 glioma In the present study the C6 glioma cell line was used as a model system that endogenously expresses the excitatory amino acid carrier 1 (EAAC1) subtype of neuronal glutamate transporter. 9502808 Rat
eaat3 c6 glioma METHODS: Rat cultured C6 glioma cells that express excitatory amino acid transporter type 3 (EAAT3) were exposed to isoflurane at various concentrations (0.5-4.0%) or for different periods (1-24 h) at 37 degrees C. EAAT3 mRNA, proteins, and activity were 14639147 Rat
eaac1 c6 glioma Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1). 8643086 Rat
excitatory amino acid carrier 1 c6 glioma Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1). 8643086 Rat
eaac1 c6 glioma The purpose of the current investigation was to determine whether the pharmacological properties of EAAC1 parallel those observed in cortical or cerebellar synaptosomes, C6 glioma, or primary astrocyte-enriched cultures. 8643086 Rat
eaac1 c6 glioma In contrast, all of the compounds examined inhibit transport observed in C6 glioma wtih potencies similar to that observed in oocytes injected with EAAC1 cRNA. 8643086 Rat
eaac1 c6 glioma These results indicate that (i) EAAC1 but not GLAST or GLT1 transporters are expressed in C6 glioma, (ii) synaptosomes contain a heterogeneous population of transporters, (iii) EAAC1 does not account for the pharmacology previously observed in cortical sy 8643086 Rat
eaat3 brain tumors Several human brain tumors examined, including some astrocytic tumors, expressed the EAAT3 glutamate transporter, which is the human homolog of the rodent EAAC1 transporter. 8738164 Human
eaac1 astrocytic tumors Several human brain tumors examined, including some astrocytic tumors, expressed the EAAT3 glutamate transporter, which is the human homolog of the rodent EAAC1 transporter. 8738164 Human
eaat3 astrocytic tumors Several human brain tumors examined, including some astrocytic tumors, expressed the EAAT3 glutamate transporter, which is the human homolog of the rodent EAAC1 transporter. 8738164 Human
eaat3 glioblastoma A similar opposite effect of (S)-3,5-dihydroxyphenylglycine and (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine was observed for the expression of EAAT3 protein in U373 glioblastoma cell line. 12786977 Human
eaac1 c6 glioma In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1. 12843260 Rat
eaac-1 necrosis The expression of neuron-type glutamate transporters (EAAC-1), AMPA glutamate receptor subunits (GluR1 and GluR2/3), polyadenosine (5'diphosphate-ribose) polymerase (PARP), and transforming growth factor-beta1 was investigated in 20 cases of neonatal 10868778 Human
eaac-1 necrosis PARP could contribute to the pathogenesis of pontosubicular neuron necrosis more than EAAC-1 or GluR1 or GluR2/3. 10868778 Human
eaac1 c6 glioma Biotinylation of cell surface protein under trafficking-permissive conditions (37 degrees C) resulted in a 2-fold increase in the amount of biotinylated EAAC1 within 15 min in C6 glioma and in primary neuronal cultures, suggesting that EAAC1 has a half-li 15197183 Rat
eaac1 c6 glioma Using a reversible biotinylation strategy, a similarly rapid internalization of EAAC1 was observed in C6 glioma. 15197183 Rat
eaac1 c6 glioma In the present study, a brief exposure to ET-1 was found to increase aspartate uptake in C6 glioma cells, which endogenously express the neuronal glutamate transporter EAAC1 (pEC50 of 9.89). 15737330 Rat
eaat3 c6 glioma In this study, we showed that isoflurane induced a time- and concentration-dependent redistribution of EAAT3 to the cell membrane in C6 glioma cells. 15709112 Rat

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