IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene INSL4 Ensembl ENSG00000120211 Chromosome 9 Start 5221443 End 5225304
Description Early placenta insulin-like peptide Precursor (EPIL)(Placentin)(Insulin-like peptide 4) [Contains Early placenta insulin-like peptide B chain;Early placenta insulin-like peptide A chain] [Source:UniProtKB/Swiss-Prot;Acc:Q14641]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6087
     Entrez Gene : 3641
     UCSC : uc003ziy.2
     GeneCards : 6087
     RefSeq : NM_002195
     CCDS : CCDS6459.1
     Uniprot : Q14641
     Interpro : Q14641
     OMIM : 600910
     GeneTests : INSL4
     CGAP : INSL4
     PMID : 8666396

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34219_at  0.65  9.35e-3  2.21e-2  0.16  2.93e-1  3.95e-1
 HG_U133A  206549_at  0.14  3.78e-1  4.33e-1  -1.89  8.30e-18  1.17e-17
 HG_U133_Plus2  206549_at  1.11  2.39e-5  8.55e-5  0.44  1.86e-2  2.89e-2
 Stanford  10589  -0.03  9.72e-1  9.85e-1  -0.87  3.88e-2  1.43e-1
 Agilent_HS_21.6K  21517  0.16  1.93e-1  3.65e-1  0.10  8.85e-2  1.90e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206549_at  0.21  5.24e-1  9.34e-1  0.05  8.06e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34219_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206549_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206549_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10589    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21517    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
epil breast cancer Immunohistochemistry on tissue microarrays revealed a heterogeneous expression of EPIL in breast cancer tissue and no expression in the surrounding stroma cells. 11861376 Human
insl4 metastasis Quantitative PCR was used to measure, in trophoblast cells, the transcriptional expression profiles of four genes, INSL4, BRMS1, KiSS-1 and KiSS-1R, reported to be implicated in tumor invasion and metastasis. 12414911 Human
insl4 tumor Quantitative PCR was used to measure, in trophoblast cells, the transcriptional expression profiles of four genes, INSL4, BRMS1, KiSS-1 and KiSS-1R, reported to be implicated in tumor invasion and metastasis. 12414911 Human
insl4 choriocarcinoma Low levels of expression of BRMS1 were observed in normal pregnancies, in molar pregnancies and in choriocarcinoma cell lines BeWo, JAR and JEG3 while, in striking contrast, the expression levels of INSL4, KiSS-1 and Kiss-1R were increased in both early p 12414911 Human
epil breast cancer Early placenta insulin-like growth factor (EPIL) is expressed by a subpopulation of the Her2-positive SKBR3 breast cancer cell line displaying high motility and transendothelial invasiveness in vitro, as recently shown by our group. 16322324 Human
epil paget's disease of the nipple As an in vivo model for highly motile tumor cells, Paget's disease of the nipple showed simultaneous EPIL and Her2 expression upon immunohistochemical examination using specific antibodies. 16322324 Human
epil tumor As an in vivo model for highly motile tumor cells, Paget's disease of the nipple showed simultaneous EPIL and Her2 expression upon immunohistochemical examination using specific antibodies. 16322324 Human
epil tumors One particular subgroup (7.6% of the cases with full clinical records) that comprised tumors simultaneously expressing EPIL and Her2 represented patients with the poorest 5-year overall survival. 16322324 Human
epil cancer The results suggested that EPIL might be a cancer cell-produced growth factor that influences lateral Her2 signaling. 16322324 Human
epil cancer Moreover, EPIL may be induced by factors apart from Her2 and may independently provide signaling for cancer invasion and motility. 16322324 Human
epil breast cancer In parallel, Her2-positive MDAHer2 breast cancer cells also showed increased invasiveness when induced by EPIL-conditioned medium. 16322324 Human

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