IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RLN2 Ensembl ENSG00000107014 Chromosome 9 Start 5289868 End 5294580
Description Prorelaxin H2 Precursor [Contains Relaxin B chain;Relaxin A chain] [Source:UniProtKB/Swiss-Prot;Acc:P04090]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10027
     Entrez Gene : 6019
     UCSC : uc003zja.1
     GeneCards : 10027
     RefSeq : NM_005059
     CCDS : CCDS6460.1
     Uniprot : P04090
     Interpro : P04090
     OMIM : 179740
     GeneTests : RLN2
     CGAP : RLN2
     PMID : 6548703

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31732_at  0.38  1.78e-1  2.66e-1  0.39  3.59e-1  4.65e-1
 HG_U133A  214519_s_at  -0.02  7.84e-1  8.16e-1  2.01  9.13e-52  2.14e-51
 HG_U133_Plus2  214519_s_at  0.29  1.91e-2  3.63e-2  0.05  7.32e-1  7.73e-1
 Agilent_HS_21.6K  17730  0.19  1.03e-4  1.23e-3  0.19  4.74e-4  2.92e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  214519_s_at  0.34  1.02e-1  7.76e-1  0.01  9.70e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31732_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214519_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214519_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17730    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rln2 anaplastic thyroid carcinoma Here we demonstrate the presence of RLN2 relaxin and relaxin receptor LGR7 in human papillary, follicular, and undifferentiated anaplastic thyroid carcinoma suggesting a specific involvement of relaxin-LGR7 signaling in thyroid carcinoma. 16877360 Human
rln2 thyroid carcinoma Here we demonstrate the presence of RLN2 relaxin and relaxin receptor LGR7 in human papillary, follicular, and undifferentiated anaplastic thyroid carcinoma suggesting a specific involvement of relaxin-LGR7 signaling in thyroid carcinoma. 16877360 Human
rln2 thyroid carcinoma Although RLN2 did not act as a mitogen, it acted as an autocrine/paracrine factor and significantly increased anchorage-independent growth and thyroid carcinoma cell motility and invasiveness through elastin matrices. 16877360 Human
rln2 thyroid carcinoma We found the intracellular distribution of procath-L specifically altered in RLN2 transfectants, providing first evidence for selective actions of relaxin on the powerful elastinolytic cath-L production, storage, and secretion in thyroid carcinoma cells. 16877360 Human
rln2 tumor Suppression of LGR7 expression by LGR7-siRNA abolished the RLN2-mediated accelerated tumor cell motility. 16877360 Human

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