IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CD274 Ensembl ENSG00000120217 Chromosome 9 Start 5440559 End 5471569
Description Programmed cell death 1 ligand 1 Precursor (Programmed death ligand 1)(PD-L1)(PDCD1 ligand 1)(B7 homolog 1)(B7-H1)(CD274 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZQ7]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17635
     Entrez Gene : 29126
     UCSC : uc003zje.2
     GeneCards : 17635
     RefSeq : NM_014143
     CCDS : CCDS6464.1
     Uniprot : Q9NZQ7
     Interpro : Q9NZQ7
     OMIM : 605402
     GeneTests : CD274
     CGAP : CD274
     PMID : 11015443

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  223834_at  -0.17  1.40e-1  2.05e-1  0.03  8.23e-1  8.53e-1

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 223834_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pd-l1 tumor Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. 12218188 Human
pd-l1 tumor Transgenic expression of PD-L1, one of the PD-L, in P815 tumor cells rendered them less susceptible to the specific T cell antigen receptor-mediated lysis by cytotoxic T cells in vitro, and markedly enhanced their tumorigenesis and invasiveness in vivo in 12218188 Human
pd-l1 parental tumor Transgenic expression of PD-L1, one of the PD-L, in P815 tumor cells rendered them less susceptible to the specific T cell antigen receptor-mediated lysis by cytotoxic T cells in vitro, and markedly enhanced their tumorigenesis and invasiveness in vivo in 12218188 Human
pd-l1 tumor Survey of murine tumor lines revealed that all of the myeloma cell lines examined naturally expressed PD-L1. 12218188 Mouse
pd-l1 myeloma Survey of murine tumor lines revealed that all of the myeloma cell lines examined naturally expressed PD-L1. 12218188 Mouse
pd-l1 tumors These results suggest that the expression of PD-L1 can serve as a potent mechanism for potentially immunogenic tumors to escape from host immune responses and that blockade of interaction between PD-1 and PD-L may provide a promising strategy for specific 12218188 Human
pd-l1 tumor These results suggest that the expression of PD-L1 can serve as a potent mechanism for potentially immunogenic tumors to escape from host immune responses and that blockade of interaction between PD-1 and PD-L may provide a promising strategy for specific 12218188 Human
pd-l1 tumor PD-L expression was up-regulated on antigen-presenting cells by interferon gamma treatment and was also present on some normal tissues and tumor cell lines.Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role 11224527 Human
pd-l1 carcinomas PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses. 12538684 Human
b7h1 gastric carcinoma RESULTS: At the site of gastric carcinoma, mRNA expression levels of B7H1, B7H2 and ICOS were much higher than that of B7-1. 12800259 Human
pd-l1 tumor The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, costimulatory molecules PD-L1 (also B7-H1) and PD-L2 (also B7-DC), is involved in the mechanisms of tumor immune evasion. 15470033 Human
pd-l1 tumor RT-PCR and real-time PCR revealed that both PD-L1 and PD-L2 genes were expressed in tumor and vicinal muscle tissues of tumor-bearing mice and the expression level was significantly increased if a higher dosage of pSLC was administered. 15470033 Mouse
pd-l1 tumor The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. 15588223 Human
pd-l1 tumors Previously we and others demonstrated a novel mechanism that allows tumors to escape from the host immune response by expressing PD-L1 which can negatively regulate immune response through the interaction with PD-1, an immunoinhibitory receptor belonging 15611321 Human
pd-l1 tumor After inoculation to spleen, PD-L1 was induced on tumor cells, which did not express PD-L1 in vitro. 15611321 Human
pd-l1 tumor Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. 15599732 Human
pd-l1 cancers In contrast to normal tissues, which show minimal surface expression of PD-L1 protein, PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. 15599732 Human
pd-l1 tumor Thus, PD-L1 might play an important role in tumor immune evasion. 15599732 Human
pd-l1 tumor By using semi-quantitative RT-PCR method, it was found that PD-L1 mRNA but not PD-L2 mRNA was expressed in H22 hepatoma cells and both PD-L1 and PD-L2 mRNAs were expressed in tumor tissues of tumor-bearing mice and upregulated as compared with muscle tiss 15791831 Mouse
pd-l1 hepatoma By using semi-quantitative RT-PCR method, it was found that PD-L1 mRNA but not PD-L2 mRNA was expressed in H22 hepatoma cells and both PD-L1 and PD-L2 mRNAs were expressed in tumor tissues of tumor-bearing mice and upregulated as compared with muscle tiss 15791831 Mouse
pd-l1 human esophageal cancer In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery. 15837746 Human
pd-l1 esophageal cancer CONCLUSIONS: These data suggest that PD-L1 and PD-L2 status may be a new predictor of prognosis for patients with esophageal cancer and provide the rationale for developing novel immunotherapy of targeting PD-1/PD-L pathway. 15837746 Human
pd-l1 tumor [Eukaryotic expression and functional characterization of PD-1 extracellular domain] The negative signal provided by interactions of costimulatory molecules, programmed death-1 (PD-1) and its ligands, PD-L1 (also B7-H1) and PD-L2 (also B7-DC), is involved 15973993 Human
pd-l1 tumor Low level of IFN-gamma upregulates expression of PD-L1, PD-L2, CTLA-4 and Foxp3, which may partly account for the tumor immune evasion promoted by IFN-gamma. 15776283 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.