IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PDCD1LG2 Ensembl ENSG00000197646 Chromosome 9 Start 5500579 End 5565421
Description Programmed cell death 1 ligand 2 Precursor (Programmed death ligand 2)(PD-L2)(PD-1-ligand 2)(PDCD1 ligand 2)(Butyrophilin B7-DC)(B7-DC)(CD273 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQ51]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 18731
     Entrez Gene : 80380
     UCSC : uc003zjg.3
     GeneCards : 18731
     RefSeq : NM_025239
     CCDS : CCDS6465.1
     Uniprot : Q9BQ51
     Interpro : Q9BQ51
     OMIM : 605723
     GeneTests : PDCD1LG2
     CGAP : PDCD1LG2
     PMID : 11224527

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220049_s_at  -0.07  5.83e-1  6.31e-1  3.61  6.25e-96  3.79e-95
 HG_U133_Plus2  220049_s_at  -0.30  2.18e-1  2.97e-1  -0.65  1.95e-2  3.01e-2
 HG_U133_Plus2  224399_at  -0.42  7.71e-2  1.22e-1  -0.78  4.98e-3  8.55e-3
 Agilent_HS_21.6K  15692  0.01  6.92e-1  8.16e-1  -0.00  9.70e-1  9.84e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220049_s_at  0.31  4.23e-1  9.09e-1  0.03  8.99e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 220049_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220049_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224399_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15692    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pd-l2 tumor PD-L expression was up-regulated on antigen-presenting cells by interferon gamma treatment and was also present on some normal tissues and tumor cell lines.Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role 11224527 Human
pdl2 lymphoma PDL2, which encodes a regulator of T cell activation, was the gene that best discriminated PMBL from other DLBCLs and was also highly expressed in Hodgkin lymphoma cells. 12975453 Human
pdl2 lymphoma The genomic loci for PDL2 and several neighboring genes were amplified in over half of the PMBLs and in Hodgkin lymphoma cell lines. 12975453 Human
b7dc tumor Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. 12810690 Human
b7dc tumor Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC. 12810690 Human
pd-l2 tumor The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, costimulatory molecules PD-L1 (also B7-H1) and PD-L2 (also B7-DC), is involved in the mechanisms of tumor immune evasion. 15470033 Human
pd-l2 tumor RT-PCR and real-time PCR revealed that both PD-L1 and PD-L2 genes were expressed in tumor and vicinal muscle tissues of tumor-bearing mice and the expression level was significantly increased if a higher dosage of pSLC was administered. 15470033 Mouse
pd-l2 tumor By using semi-quantitative RT-PCR method, it was found that PD-L1 mRNA but not PD-L2 mRNA was expressed in H22 hepatoma cells and both PD-L1 and PD-L2 mRNAs were expressed in tumor tissues of tumor-bearing mice and upregulated as compared with muscle tiss 15791831 Mouse
pd-l2 hepatoma By using semi-quantitative RT-PCR method, it was found that PD-L1 mRNA but not PD-L2 mRNA was expressed in H22 hepatoma cells and both PD-L1 and PD-L2 mRNAs were expressed in tumor tissues of tumor-bearing mice and upregulated as compared with muscle tiss 15791831 Human
pd-l2 human esophageal cancer In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery. 15837746 Human
pd-l2 esophageal cancer CONCLUSIONS: These data suggest that PD-L1 and PD-L2 status may be a new predictor of prognosis for patients with esophageal cancer and provide the rationale for developing novel immunotherapy of targeting PD-1/PD-L pathway. 15837746 Human
pd-l2 tumor [Eukaryotic expression and functional characterization of PD-1 extracellular domain] The negative signal provided by interactions of costimulatory molecules, programmed death-1 (PD-1) and its ligands, PD-L1 (also B7-H1) and PD-L2 (also B7-DC), is involved 15973993 Human
pd-l2 tumor Low level of IFN-gamma upregulates expression of PD-L1, PD-L2, CTLA-4 and Foxp3, which may partly account for the tumor immune evasion promoted by IFN-gamma. 15776283 Human
pdl2 hodgkin lymphoma PDL2, which encodes a regulator of T cell activation, was the gene that best discriminated PMBL from other DLBCLs and was also highly expressed in Hodgkin lymphoma cells. 12975453 Human
pdl2 hodgkin lymphoma The genomic loci for PDL2 and several neighboring genes were amplified in over half of the PMBLs and in Hodgkin lymphoma cell lines. 12975453 Human

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