IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IL33 Ensembl ENSG00000137033 Chromosome 9 Start 6231678 End 6247982
Description Interleukin-33 Precursor (IL-33)(Interleukin-1 family member 11)(IL-1F11)(Nuclear factor from high endothelial venules)(NF-HEV) [Source:UniProtKB/Swiss-Prot;Acc:O95760]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 16028
     Entrez Gene : 90865
     UCSC : uc003zju.1
     GeneCards : 16028
     RefSeq : NM_033439
     CCDS : CCDS6468.1
     Uniprot : O95760
     Interpro : O95760
     OMIM : 608678
     GeneTests : IL33
     CGAP : IL33
     PMID : 10566975

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35333_r_at  -1.61  9.90e-10  1.23e-8  -1.99  5.43e-9  5.20e-8
 HG_U133A  209821_at  -2.37  1.10e-46  4.54e-45  -0.07  4.32e-1  4.42e-1
 HG_U133_Plus2  209821_at  -2.05  2.34e-21  6.30e-20  -2.62  3.19e-19  4.06e-18

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209821_at  0.28  6.28e-1  9.56e-1  0.02  9.65e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35333_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209821_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209821_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
il-33 crohn's disease Accordingly, in situ hybridization demonstrated that endothelial cells constitute a major source of IL-33 mRNA in chronically inflamed tissues from patients with rheumatoid arthritis and Crohn's disease. 17185418 Human
il-33 crohn's disease IL-33 is associated with endothelial cells in the inflamed tissues of patients with RA and Crohn's disease, where it is a nuclear factor which regulates transcription. 17590166 Human
il-33 thymoma Here we show antagonistic effects of soluble ST2 on IL-33 signaling using a murine thymoma EL-4 cells stably expressing ST2L and a murine model of asthma. 17623648 Human
il-33 mcs In this study we report that IL-33 directly stimulates primary human mast cells (MCs) to produce several proinflammatory cytokines and chemokines and also exerts a permissive effect on the MCs response to thymic stromal lymphopoietin, a recently described 17675461 Human
il-33 thymoma Lack of the IL-1 receptor accessory protein (IL-1RAcP) abrogates responses to IL-33 and IL-1 in the mouse thymoma clone EL-4 D6/76 cells. 18003919 Mouse
il-33 thymoma Blocking of murine IL-1RAcP with the neutralizing antibody 4C5 inhibits response of mouse thymoma cells and BMD mast cells to IL-33. 18003919 Mouse
il-33 mastocytoma IL-33 dose and time-dependently stimulated IL-6 secretion by P815 mastocytoma cells and primary mouse bone marrow-derived mast cells (BMMC). 18023358 Human
il-33 goblet cell hyperplasia IL-33 also acts independently of T cells, altering intestinal pathology in chronically infected SCID mice, leading to an increased crypt length and intestinal epithelial cell proliferation, but reducing goblet cell hyperplasia. 18250453 Mouse
il-33 goblet cell hyperplasia Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. 18448455 Mouse
il-33 goblet cell hyperplasia We finally showed that administration of IL-33 into mice ST2/MyD88 dependently induces airway hyperresponsiveness (AHR) and goblet cell hyperplasia by induction of IL-4, IL-5 and IL-13 in the lungs. 18448455 Mouse
il-33 human tumor Here we show that nuclear IL-33 is expressed in blood vessels of healthy tissues but down-regulated at the earliest onset of angiogenesis during wound healing; in addition, it is almost undetectable in human tumor vessels. 18787100 Human
il-33 tumor However, activation of endothelial cell cultures with either tumor necrosis factor-alpha or vascular endothelial growth factor and subcutaneous injection of these cytokines led to a down-regulation of vascular IL-33, a response consistent with both its ra 18787100 Human
il-33 human tumors We observed abundant nuclear expression of IL-33 in endothelial cells from both large and small blood vessels in most normal human tissues, as well as in human tumors. 18836528 Human

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