IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FXN Ensembl ENSG00000165060 Chromosome 9 Start 70840164 End 70878757
Description Frataxin, mitochondrial Precursor (Friedreich ataxia protein)(Fxn) [Contains Frataxin intermediate form;Frataxin(56-210);Frataxin(81-210)] [Source:UniProtKB/Swiss-Prot;Acc:Q16595]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3951
     Entrez Gene : 2395
     UCSC : uc004aha.2
     GeneCards : 3951
     RefSeq : NM_000144
     CCDS : CCDS6626.1
     Uniprot : Q16595
     Interpro : Q16595
     OMIM : 606829
     GeneTests : FXN
     CGAP : FXN
     PMID : 8596916

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33202_f_at  0.13  3.13e-1  4.19e-1  0.48  1.03e-2  2.38e-2
 HG_U95  38330_at  0.31  1.25e-1  1.98e-1  0.50  8.66e-2  1.46e-1
 HG_U133A  205565_s_at  0.26  1.21e-4  2.49e-4  -0.31  1.14e-2  1.23e-2
 HG_U133_Plus2  205565_s_at  0.15  4.31e-2  7.40e-2  0.32  8.41e-4  1.64e-3
 HG_U133_Plus2  230234_at  -0.04  8.07e-1  8.53e-1  0.28  9.36e-2  1.27e-1
 Agilent_HS_21.6K  11892  -0.00  9.96e-1  9.98e-1  0.04  6.20e-1  7.45e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205565_s_at  0.12  5.19e-1  9.34e-1  0.05  7.64e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33202_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38330_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205565_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205565_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230234_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11892    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
frataxin tumour Here we demonstrate that transgenic overexpression of human frataxin increases cellular antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, thereby reducing the incidence of malignant transformation induced by ROS 11929854 Human
frataxin cancer These findings expand the understanding of antioxidant properties of frataxin, and tentatively suggest a role in the early induction of cancer. 11929854 Human
frataxin embryonic carcinoma In this study we examine the role of frataxin in neuronal differentiation by using the P19 embryonic carcinoma cell line as a model system. 11555630 Human
frataxin human ovarian carcinoma During cDNA microarray analyses of differential gene expression between a cisplatin-resistant A2780CP70 human ovarian carcinoma cell line and its parental A2780 cell line, we discovered that frataxin gene expression was frequently overexpressed in the cis 12928720 Human
frataxin ovarian carcinoma To exploit potential involvement of frataxin gene in the development of resistance to cisplatin, we compared the levels of frataxin gene and protein in the cisplatin-resistant A2780CP70 ovarian carcinoma cell line and its parental A2780 cell line. 12928720 Human
frataxin embryonic carcinoma We also examined the role of frataxin in neuronal differentiation by using stably transfected clones of P19 embryonic carcinoma cells with antisense or sense frataxin constructs. 16120311 Human
frataxin pheochromocytoma In this study we examined the effects of 3-nitropropionic acid (3-NP) on frataxin expression in FRDA patient and control lymphoblasts and in rat pheochromocytoma cell line (PC12) overexpressing human frataxin. 14550925 Rat
frataxin human colon adenocarcinoma Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2. 16091420 Human
frataxin cancer Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. 16263703 Human
frataxin colon cancer We have stably overexpressed the Friedreich ataxia-associated protein frataxin in several colon cancer cell lines. 16263703 Human
frataxin cancer Taken together, these results support the view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals. 16263703 Human
frataxin tumor Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. 16278235 Mouse
frataxin tumor Taken together, these findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals. 16278235 Human
friedreich ataxia colon cancer We have stably overexpressed the Friedreich ataxia-associated protein frataxin in several colon cancer cell lines. 16263703 Human
frataxin malignant transformation Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro. 11929854 Human
frataxin malignant transformation Here we demonstrate that transgenic overexpression of human frataxin increases cellular antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, thereby reducing the incidence of malignant transformation induced by ROS 11929854 Human
frataxin tumor Consistent with Warburg's hypothesis, we found that frataxin-overexpressing cells also have decreased growth rates and increased population doubling times, show inhibited colony formation capacity in soft agar assays, and exhibit a reduced capacity f 16263703 Mouse
frataxin tumors In addition, elevated MtFt in tumors was also associated with a decrease in total aconitase activity and lower frataxin protein level. 16757684 Human

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