IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TJP2 Ensembl ENSG00000119139 Chromosome 9 Start 70956382 End 71059938
Description Tight junction protein ZO-2 (Zonula occludens protein 2)(Zona occludens protein 2)(Tight junction protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9UDY2]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11828
     Entrez Gene : 9414
     UCSC : uc004ahe.2
     GeneCards : 11828
     RefSeq : NM_001170414
     CCDS : CCDS6627.1
     Uniprot : Q9UDY2
     Interpro : Q9UDY2
     OMIM : 607709
     GeneTests : TJP2
     CGAP : TJP2
     PMID : 7951235

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36655_at  -0.99  8.34e-9  8.63e-8  -0.77  3.21e-5  1.44e-4
 HG_U133A  202085_at  -0.88  3.73e-23  3.66e-22  1.65  2.10e-77  7.98e-77
 HG_U133_Plus2  202085_at  -1.07  2.39e-20  5.82e-19  -1.32  1.08e-18  1.29e-17
 HG_U133_Plus2  232017_at  -1.39  8.22e-13  8.55e-12  -1.68  9.90e-13  6.03e-12
 HG_U133_Plus2  237132_at  -0.24  2.11e-1  2.89e-1  -0.36  9.87e-2  1.33e-1
 Stanford  4559  0.12  7.20e-1  8.40e-1  0.02  9.56e-1  9.82e-1
 Agilent_HS_21.6K  1495  -0.09  7.76e-2  1.98e-1  -0.07  2.95e-1  4.52e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202085_at  0.11  6.94e-1  9.67e-1  -0.07  7.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36655_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202085_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232017_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 237132_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4559    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1495    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
zo-2 human colon carcinoma We show that these compounds promote the differentiation of human colon carcinoma SW480 cells expressing vitamin D receptors (VDRs) (SW480-ADH) but not that of a malignant subline (SW480-R) or metastasic derivative (SW620) cells lacking VDR. 1alpha,25(OH) 11470825 Human
zo-2 pancreatic adenocarcinoma In addition to pancreatic adenocarcinoma, ZO-2 was found to be de-regulated in breast adenocarcinoma, but not in colon or prostate adenocarcinoma. 11018256 Human
zo-2 prostate adenocarcinoma In addition to pancreatic adenocarcinoma, ZO-2 was found to be de-regulated in breast adenocarcinoma, but not in colon or prostate adenocarcinoma. 11018256 Human
zo-2 breast adenocarcinoma In addition to pancreatic adenocarcinoma, ZO-2 was found to be de-regulated in breast adenocarcinoma, but not in colon or prostate adenocarcinoma. 11018256 Human
tjp-2 ductal cancer Thus, our data indicate the importance of zo-2 (tjp-2) gene regulation in ductal cancer development and should help to understand the defects of intercellular interactions, critical for suppressing the malignant phenotype. 11018256 Human
zo-2 ductal cancer Thus, our data indicate the importance of zo-2 (tjp-2) gene regulation in ductal cancer development and should help to understand the defects of intercellular interactions, critical for suppressing the malignant phenotype. 11018256 Human
zo-2 human pancreatic adenocarcinoma Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. 10360833 Human
zo-2 pancreatic duct adenocarcinoma We have observed that 2 forms of zonula occludens 2 (ZO-2) protein, ZO-2A and ZO-2C, are expressed in normal human pancreatic duct cells, but only ZO-2C in pancreatic duct adenocarcinoma. 10495427 Human
zo-2 pancreatic duct carcinomas We conclude that the initial down-regulation of zo-2 promoter P(A) activity in pancreatic duct carcinomas is due to the structural or functional alteration(s) in the regulatory elements, localized outside the analyzed promoter region. 10495427 Human
zo-2 large tumor Sequence analysis showed that this protein contains three PSD-95/SAP90, discs-large, ZO-1 (PDZ) domains, a src homology (SH3) domain, and a region similar to guanylate kinase, making it homologous to ZO-1, ZO-2, the discs large tumor suppressor gene produ 9531559 Human
tjp2 pancreatic cancers These genes include UCHL1 (methylated in 100% of 42 pancreatic cancers), NPTX2 (98%), SARP2 (95%), CLDN5 (93%), reprimo (86%), LHX1 (76%), WNT7A (71%), FOXE1 (69%), TJP2 (64%), CDH3 (19%), and ST14 (10%). 12839967 Human
zo-2 primary breast cancer The aim of this study was to investigate the expression of Zonula Occludens (ZO) proteins ZO-1, ZO-2 and ZO-3, and MUPP-1 (multi-PDZ domain protein 1), peripheral/plaque proteins that function in maintaining tight junction integrity and in transducing reg 15571953 Human

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