IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GDA Ensembl ENSG00000119125 Chromosome 9 Start 73954113 End 74058296
Description Guanine deaminase (Guanase)(Guanine aminase)(EC 3.5.4.3)(Guanine aminohydrolase)(GAH)(p51-nedasin) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2T3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4212
     Entrez Gene : 9615
     UCSC : uc004aiq.2
     GeneCards : 4212
     RefSeq : NM_004293
     CCDS : CCDS6641.1
     Uniprot : Q9Y2T3
     Interpro : Q9Y2T3
     OMIM : 139260
     GeneTests : GDA
     CGAP : GDA
     PMID : 10075721

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  1569555_at  0.47  3.31e-3  7.62e-3  1.24  1.39e-10  6.54e-10
 HG_U133_Plus2  224209_s_at  1.13  1.81e-6  7.85e-6  3.47  3.41e-29  1.42e-27
 Stanford  7290  0.96  2.55e-1  4.55e-1  2.68  6.92e-4  1.08e-2
 Stanford  18631  1.15  1.93e-2  9.85e-2  1.95  1.96e-4  4.40e-3
 Stanford  23745  1.51  1.35e-2  7.82e-2  2.37  3.67e-4  6.89e-3
 Agilent_HS_21.6K  7724  0.19  2.40e-5  3.63e-4  0.17  1.11e-4  8.72e-4

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 1569555_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224209_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7290    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18631    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23745    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7724    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
guanase lung cancer To examine the effect of 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid (TEI-6720), an inhibitor of xanthine oxidase, on purine metabolism in the lung cancer cell line A549, the activities of adenosine deaminase, purine nucleoside phosph 10629441 Human
guanase metastatic carcinoma The mean guanase activities for patients with various liver diseases, including acute hepatitis, chronic hepatitis, liver cirrhosis, hepatoma and metastatic carcinoma, were above the upper limit of the reference range. 6499163 Human
guanase hepatoma The mean guanase activities for patients with various liver diseases, including acute hepatitis, chronic hepatitis, liver cirrhosis, hepatoma and metastatic carcinoma, were above the upper limit of the reference range. 6499163 Human
guanase metastatic carcinoma With guanase, the highest validity (1.98) was found in acute hepatitis and metastatic carcinoma. 6499163 Human
guanine deaminase neuroblastoma A deficiency of xanthine oxidase, guanine deaminase and guanosine kinase activities was found in neuroblastoma cells. 718989 Human
guanase hepatocellular carcinoma Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases. 2542677 Human
guanase gastric cancer Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer. 8076377 Human
guanase tumors Uridine kinase, adenylate kinase, and guanase in human lung tumors. 6248202 Human
guanase neoplasms The guanase activities of the different neoplasms, unrelated to their uridine kinase or thymidine kinase content, correlated with the activities in the subjects' noninvolved lung. 6248202 Human
guanase individual tumors Variations in guanase activity thus appear to be "random," whereas observations on the three other enzymes attest to the orderly nature of biochemical differences among individual tumors and between normal and neoplastic lung. 6248202 Human
guanase necrosis This fact, together with other information in the literature, indicated that elevated serum guanase activity following myocardial infarction was consequent upon some degree of sub-clinical hepatic necrosis. 1175293 Human
guanase necrosis Caution must be exercised when serum asparate aminotransferase is used as an index of heart muscle necrosis unless guanase or some other "liver specific" enzyme is known to be normal, or unless creatine phosphokinase or hydroxybutyrate dehydroge 1175293 Human
guanase lung tumors Uridine kinase, adenylate kinase, and guanase in human lung tumors. 6248202 Human
guanase hepatoma Plasma guanine deaminase (guanase; GD) is well established as an indicator of hepatocellular disease, recently being applied in the detection of hepatitis C in donor blood and in the diagnosis of hepatoma. 14690689 Human
guanine deaminase hepatoma Plasma guanine deaminase (guanase; GD) is well established as an indicator of hepatocellular disease, recently being applied in the detection of hepatitis C in donor blood and in the diagnosis of hepatoma. 14690689 Human

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