IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ANXA1 Ensembl ENSG00000135046 Chromosome 9 Start 74956601 End 74975129
Description Annexin A1 (Annexin-1)(Annexin I)(Lipocortin I)(Calpactin II)(Chromobindin-9)(p35)(Phospholipase A2 inhibitory protein) [Source:UniProtKB/Swiss-Prot;Acc:P04083]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 533
     Entrez Gene : 301
     UCSC : uc004ajf.1
     GeneCards : 533
     RefSeq : NM_000700
     CCDS : CCDS6645.1
     Uniprot : P04083
     Interpro : P04083
     OMIM : 151690
     GeneTests : ANXA1
     CGAP : ANXA1
     PMID : 2936963

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37403_at  -1.06  3.28e-7  2.40e-6  -0.64  4.22e-3  1.09e-2
 HG_U133A  201012_at  -1.29  6.06e-19  4.40e-18  -3.57  1.93e-117  2.16e-116
 HG_U133_Plus2  201012_at  -1.18  1.63e-14  2.08e-13  -0.58  3.89e-5  9.19e-5
 HG_U133_Plus2  233011_at  -1.20  2.17e-5  7.81e-5  -1.17  1.37e-4  3.01e-4
 Stanford  804  -0.97  2.60e-2  1.19e-1  -0.21  6.50e-1  8.18e-1
 Agilent_HS_21.6K  8687  -0.09  5.01e-1  6.75e-1  0.09  4.53e-1  6.08e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201012_at  -0.26  5.95e-1  9.52e-1  0.35  2.93e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37403_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201012_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201012_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233011_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 804    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8687    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
annexin-i metastasis Our results showed that enolase-alpha, annexin-I and annexin-II might be important molecules in head and neck cancer invasion and metastasis. 12090472 Human
annexin-i head-and-neck cancer Our results showed that enolase-alpha, annexin-I and annexin-II might be important molecules in head and neck cancer invasion and metastasis. 12090472 Human
annexin i esophageal squamous cell cancer In addition to previously identified down-regulated protein annexin I, tumor rejection antigen (gp96) was found up-regulated in esophageal squamous cell cancer. 12096129 Human
annexin i tumor In contrast, the repressed genes include type I collagen, lysyl oxidase, annexin I, and tissue inhibitor of matrix metalloproteinase 3 (TIMP3) genes that have been implicated in tumor suppression. 12107109 Human
annexin i esophageal squamous-cell carcinomas Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas. 12242662 Human
annexin i esophageal squamous-cell carcinomas Three isoforms of annexin I were detected in normal esophageal mucosa and down-regulated in esophageal squamous cell carcinomas. 12242662 Human
annexin i carcinomas RT-PCR analysis showed annexin I mRNA levels were significantly reduced in 17 out of 24 carcinomas. 12242662 Human
annexin i cancer In cancer tissues, decreased expression of annexin I was observed in 12 out of 16 well differentiated tumors, 16 out of 17 moderately differentiated tumors, and 3 out of 3 poorly differentiated tumors as compared with the corresponding normal esophageal e 12242662 Human
annexin i tumors In cancer tissues, decreased expression of annexin I was observed in 12 out of 16 well differentiated tumors, 16 out of 17 moderately differentiated tumors, and 3 out of 3 poorly differentiated tumors as compared with the corresponding normal esophageal e 12242662 Human
annexin i tumor There was a significant correlation between annexin I expression and the status of tumor differentiation. 12242662 Human
annexin i non-hodgkin's lymphomas Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines. 15070421 Human
annexin i breast cancers Previous studies have shown increased annexin I expression in pancreatic and breast cancers, while it is absent in prostate and esophageal cancers. 15070421 Human
annexin i esophageal cancers Previous studies have shown increased annexin I expression in pancreatic and breast cancers, while it is absent in prostate and esophageal cancers. 15070421 Human
annexin i b-cell lymphoma RESULTS: Data presented here show that annexin I mRNA and protein are undetectable in 10 out of 12 B-cell lymphoma cell lines examined. 15070421 Human
annexin i b-cell lymphoma Southern blot analysis indicates that the annexin I gene is intact in B-cell lymphoma cell lines. 15070421 Human
annexin i lymphoma Annexin I expression was examined in primary lymphoma tissues by immunohistochemistry and presence of annexin I in a subset of normal B-cells and absence of annexin I expression in the lymphoma tissues were observed. 15070421 Human
annexin i primary lymphoma Annexin I expression was examined in primary lymphoma tissues by immunohistochemistry and presence of annexin I in a subset of normal B-cells and absence of annexin I expression in the lymphoma tissues were observed. 15070421 Human
annexin i b-cell lymphomas These results show that annexin I is expressed in normal B-cells, and its expression is lost in all primary B-cell lymphomas and 10 of 12 B-cell lymphoma cell lines. 15070421 Human
annexin i b-cell lymphoma These results show that annexin I is expressed in normal B-cells, and its expression is lost in all primary B-cell lymphomas and 10 of 12 B-cell lymphoma cell lines. 15070421 Human
annexin i b-cell lymphoma CONCLUSIONS: Our results suggest that, similar to prostate and esophageal cancers, annexin I may be an endogenous suppressor of cancer development, and loss of annexin I may contribute to B-cell lymphoma development. 15070421 Human
annexin i cancer CONCLUSIONS: Our results suggest that, similar to prostate and esophageal cancers, annexin I may be an endogenous suppressor of cancer development, and loss of annexin I may contribute to B-cell lymphoma development. 15070421 Human
annexin i esophageal cancers CONCLUSIONS: Our results suggest that, similar to prostate and esophageal cancers, annexin I may be an endogenous suppressor of cancer development, and loss of annexin I may contribute to B-cell lymphoma development. 15070421 Human
annexin i oral cancer Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. 12870656 Human
annexin i tumor Immunohistochemical analysis showed that annexin I was expressed diffusely in neoplastic cells in lung tumor tissues, whereas annexin II was predominant at the cell surface. 11504947 Human
anxa1 acute lymphoblastic leukemia Since this protein modulates the anti-inflammatory actions of the steroid hormones, the purpose of this study was to investigate the effects of the female sex steroid hormone, 17beta-estradiol (E2beta), on the synthesis and secretion of ANXA1 in the human 11759108 Human
anx1 cancer In ASV transgenic mice, an elevated ANX1 level preceded the appearance of the tumor, indicating that it could be a good marker in the diagnosis of cancer. 10655260 Mouse
anx1 tumor In ASV transgenic mice, an elevated ANX1 level preceded the appearance of the tumor, indicating that it could be a good marker in the diagnosis of cancer. 10655260 Mouse
annexin i benign prostatic hyperplasia The EST similar to rat P044, the EST similar to galectin-1, follistatin, annexin I, and the interferon-inducible gene 1-8U were also expressed in benign prostatic hyperplasia tissue. 10950117 Human
anxa1 tumours As a prelude to examining the potential role of ANXA1 in the pathophysiology of pituitary tumours, this study examined the expression, phosphorylation status and distribution of ANXA1 and the closely related protein, annexin 5 (ANXA5), in a series of pitu 14678296 Human
anxa1 pituitary adenomas As a prelude to examining the potential role of ANXA1 in the pathophysiology of pituitary tumours, this study examined the expression, phosphorylation status and distribution of ANXA1 and the closely related protein, annexin 5 (ANXA5), in a series of pitu 14678296 Human
anxa1 carcinomas As a prelude to examining the potential role of ANXA1 in the pathophysiology of pituitary tumours, this study examined the expression, phosphorylation status and distribution of ANXA1 and the closely related protein, annexin 5 (ANXA5), in a series of pitu 14678296 Human
anxa1 adenomas RESULTS: ANXA1 mRNA and protein were detected in all but three adenomas studied; the protein was localized mainly, but not exclusively, to nonendocrine cells. 14678296 Human
anxa1 carcinoma In comparison with the adenomas, the GH-secreting carcinoma showed abundant expression of both ANXA1 and ANXA5, with intense ANXA1 staining in some but not all tumour/endocrine cells. 14678296 Human
anxa1 adenomas In comparison with the adenomas, the GH-secreting carcinoma showed abundant expression of both ANXA1 and ANXA5, with intense ANXA1 staining in some but not all tumour/endocrine cells. 14678296 Human
anxa1 tumour In comparison with the adenomas, the GH-secreting carcinoma showed abundant expression of both ANXA1 and ANXA5, with intense ANXA1 staining in some but not all tumour/endocrine cells. 14678296 Human
anxa1 carcinoma A serine-phosphorylated species of ANXA1 was detected in all pituitary tumours studied; by contrast, tyrosine-phosphorylated ANXA1 was detected in only four adenomas and in the GH carcinoma. 14678296 Human
anxa1 tumours A serine-phosphorylated species of ANXA1 was detected in all pituitary tumours studied; by contrast, tyrosine-phosphorylated ANXA1 was detected in only four adenomas and in the GH carcinoma. 14678296 Human
anxa1 adenomas A serine-phosphorylated species of ANXA1 was detected in all pituitary tumours studied; by contrast, tyrosine-phosphorylated ANXA1 was detected in only four adenomas and in the GH carcinoma. 14678296 Human
anxa1 astrocytoma ANXA1 and ANXA5 were also expressed in abundance in the astrocytoma. 14678296 Human
anxa1 tumours CONCLUSIONS: The results demonstrate expression of both ANXA1 and ANXA5 in human pituitary tumours and thus raise the possibility that these proteins influence the growth and/or functional activity of the tumours. 14678296 Human
annexin-i tumor Annexin-I expression modulates drug resistance in tumor cells. 14733945 Human
anx-i tumor Taken together, these results provide the first direct evidence for the role of Anx-I in MDR of tumor cells. 14733945 Human
annexin a1 polyps No differences in the pattern or the level of expression of annexin A1 were found in the epithelial cells and glands of normal and chronically inflamed (perennial rhinitis or polyps) nasal mucosa. 14967753 Human
annexin i prostatic adenocarcinoma Annexin I protein expression was evaluated in patient-matched longitudinal study sets of laser capture microdissected normal, premalignant, and invasive epithelium from human esophageal squamous cell cancer and prostatic adenocarcinoma. 11103786 Human
annexin i esophageal squamous cell cancer Annexin I protein expression was evaluated in patient-matched longitudinal study sets of laser capture microdissected normal, premalignant, and invasive epithelium from human esophageal squamous cell cancer and prostatic adenocarcinoma. 11103786 Human
annexin i tumor In 25 esophageal cases (20 by Western blot and 5 by immunohistochemistry) and 17 prostate cases (3 by Western blot and 14 by immunohistochemistry), both tumor types showed either complete loss or a dramatic reduction in the level of annexin I protein expr 11103786 Human
annexin i tumor Additional studies investigating the mechanism(s) and functional consequences of annexin I protein loss in tumor cells are warranted. 11103786 Human
annexin a1 head-and-neck cancer Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status. 14695321 Human
anxa1 head and neck squamous cell carcinomas Annexin A1 (ANXA1) protein expression was evaluated by Western blot in a series of 32 head and neck squamous cell carcinomas (HNSCCs) in a search for molecular alterations that could serve as useful diagnostic/prognostic markers. 14695321 Human
annexin a1 head and neck squamous cell carcinomas Annexin A1 (ANXA1) protein expression was evaluated by Western blot in a series of 32 head and neck squamous cell carcinomas (HNSCCs) in a search for molecular alterations that could serve as useful diagnostic/prognostic markers. 14695321 Human
anxa1 lymph-node metastases In relation to clinicopathological variables, ANXA1 down-regulation was significantly associated with advanced T stages (P = 0.029), locoregional lymph node metastases (P = 0.038), advanced disease stage (P = 0.006), hypopharyngeal localization (P = 0.038 14695321 Human
anxa1 tumors Well-differentiated tumors presented a positive ANXA1 signal in highly keratinized areas whereas moderately and poorly differentiated tumors exhibited very weak or negative staining. 14695321 Human
annexin i recurrent prostate cancer Expression of annexin I, II and VII proteins in androgen stimulated and recurrent prostate cancer. 14713853 Human
annexin i prostate cancer PURPOSE: We performed a comprehensive survey of annexin I, II and VII protein expression in patient matched benign prostatic epithelium (BPE), androgen stimulated prostate cancer (AS-CaP) and recurrent prostate cancer (R-CaP). 14713853 NA
annexin i recurrent prostate cancer PURPOSE: We performed a comprehensive survey of annexin I, II and VII protein expression in patient matched benign prostatic epithelium (BPE), androgen stimulated prostate cancer (AS-CaP) and recurrent prostate cancer (R-CaP). 14713853 NA
annexin i high-grade prostatic intraepithelial neoplasia Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. 11801547 Human
annexin i prostate cancer Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. 11801547 Human
lipocortin i high-grade prostatic intraepithelial neoplasia PURPOSE: To determine expression levels of annexin I (lipocortin I) in patient-matched benign prostatic epithelium (BPE), high-grade prostatic intraepithelial neoplasia (HGPIN), and prostate cancer (CaP). 11801547 NA
annexin i high-grade prostatic intraepithelial neoplasia PURPOSE: To determine expression levels of annexin I (lipocortin I) in patient-matched benign prostatic epithelium (BPE), high-grade prostatic intraepithelial neoplasia (HGPIN), and prostate cancer (CaP). 11801547 NA
lipocortin i prostate cancer PURPOSE: To determine expression levels of annexin I (lipocortin I) in patient-matched benign prostatic epithelium (BPE), high-grade prostatic intraepithelial neoplasia (HGPIN), and prostate cancer (CaP). 11801547 NA
annexin i prostate cancer PURPOSE: To determine expression levels of annexin I (lipocortin I) in patient-matched benign prostatic epithelium (BPE), high-grade prostatic intraepithelial neoplasia (HGPIN), and prostate cancer (CaP). 11801547 NA
annexin i mammary adenocarcinoma Elevated levels of annexin I protein in vitro and in vivo in rat and human mammary adenocarcinoma. 9514092 Human
annexin i adenocarcinoma Previous work reported the differential expression of annexin I mRNA among rat adenocarcinoma cell lines of various metastatic potential (MTLn3, MTLn2, MTC.4: highest to lowest, respectively) (Pencil et al. 1993, Breast Cancer Res Treat, 25, 165-74). 9514092 Rat
annexin i metastases Annexin I protein expression was highest in lung metastases of MTLn3, at 8-fold the levels observed in the MTC.4 primary tumors. 9514092 Rat
annexin i primary tumors Annexin I protein expression was highest in lung metastases of MTLn3, at 8-fold the levels observed in the MTC.4 primary tumors. 9514092 Rat
annexin i primary tumor MTLn3 cells in the primary tumor had an annexin I specific optical density 3-fold higher than that of cells in the MTC.4 primary tumor. 9514092 Rat
annexin i primary tumors MTLn2 primary tumors had an annexin I specific optical density 1.5-fold higher than MTC.4. 9514092 Rat
annexin i lymph-node metastases A proportion of human mammary adenocarcinomas also have positive annexin I immunoreactivity, often with more uniform annexin I staining in the lymph node metastases. 9514092 Human
annexin i mammary adenocarcinomas A proportion of human mammary adenocarcinomas also have positive annexin I immunoreactivity, often with more uniform annexin I staining in the lymph node metastases. 9514092 Human
lipocortin i epithelioid cell granuloma BACKGROUND AND AIM OF WORK: Lipocortin I, induced by corticosteroids in vivo is considered to be related to cell activation and differentiation in mononuclear phagocytes, key cells in the process of epithelioid cell granuloma formation in sarcoidosis. 9572000 Human
annexin i human stomach cancer Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. 9870185 Human
annexin i lymphoma Annexin I is thought to be involved in cell proliferation and differentiation and has recently been shown to be expressed on the surfaces of lymphoma cells where it acts as an endothelial cell adhesion molecule. 9062391 Human
annexin i human breast cancer To evaluate the expression of annexin I in relation to human breast cancer development and progression we used breast biopsy tissues. 9062391 Human
annexin i noninvasive ductal carcinoma Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i breast tumors Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i breast cancers Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i ductal adenoma Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i benign tumors Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i human breast cancer The results suggest that annexin I expression might correlate with malignant breast cancer progression but it is most likely involved at an early stage of human breast cancer development. 9062391 Human
annexin i malignant breast cancer The results suggest that annexin I expression might correlate with malignant breast cancer progression but it is most likely involved at an early stage of human breast cancer development. 9062391 Human
annexin i tumor As an example, the annexin I and II genes, implicated in signal transduction, were highly induced in tumor tissue and also in dysplastic lesions isolated from the kidneys of rats treated chronically with TGHQ. 14587099 Rat
annexin i tumor The annexin I and II proteins were also upregulated in tumor tissue, which probably play an important role in TGHQ-induced nephrocarcinogenesis. 14587099 Rat
annexin i metastasis Our results suggest that annexin I and alpha B-crystallin are important cellular proteins that are down regulated through BRMS1 mediated metastasis suppression. 15168732 Mouse
annexin i rat osteosarcoma Growth hormone induces tyrosine phosphorylation of annexin I in rat osteosarcoma cells. 8828496 Rat
annexin i seborrhoeic keratosis Annexin I mRNA expression was detected in the keratinizing squamous cells in keratotic type seborrhoeic keratosis and in keratinocytes at the periphery of the horn pearl in well-differentiated squamous cell carcinoma. 8919037 Human
annexin i squamous-cell carcinoma Annexin I mRNA expression was detected in the keratinizing squamous cells in keratotic type seborrhoeic keratosis and in keratinocytes at the periphery of the horn pearl in well-differentiated squamous cell carcinoma. 8919037 Human
annexin i basal-cell carcinoma By contrast, no annexin I mRNA signals were detected in tumour cells in basal cell carcinoma. 8919037 Human
annexin i tumour By contrast, no annexin I mRNA signals were detected in tumour cells in basal cell carcinoma. 8919037 Human
annexin i cancer Additional mammalian proteins of interest to signal transduction and cancer research exhibit histidine phosphorylation, including P-selectin, annexin I and the 20S proteasome. 12536071 Human
annexin i human promyelocytic leukemia Okadaic acid increased annexin I and induced differentiation of human promyelocytic leukemia cells. 7718618 Human
anxa1 lung adenocarcinoma RT-PCR revealed mRNA and Western blotting demonstrated protein for the ATP binding cassette A1 (ABCA1) transporter in mouse FS, TtT/GF, and A549 lung adenocarcinoma cells from which glucocorticoids also induce externalization of ANXA1. 12586783 Human
lpc-1 myeloma The cellular basis of the antibody-mediated, hapten-specific anti-idiotype antibody response of CBA/J mice to a hapten conjugate of the BALB/c myeloma protein LPC-1 was examined. 1086213 Human
lipocortin i lymphoma These residues could be aligned exactly with the previously published sequence of lipocortin I derived from the cDNA from a human lymphoma. 3032981 Human
lipocortin i rat glioma Effect of recombinant human lipocortin I on brain oedema in a rat glioma model. 2151008 Rat
lipocortin i epidermoid carcinoma Lack of phosphorylation of lipocortin I in A431 epidermoid carcinoma cells treated with phorbol esters. 2524194 Human
lipocortin i tumor Tumor promoter-dependent phosphorylation of a Triton X-100 extractable form of lipocortin I in T51B rat liver cells. 2530098 Rat
annexin i prostate cancer Conventional and 2D SDS-PAGE, together with Western blotting, also revealed reduced or lost expression of annexin I in prostate cancer cells. 12629510 Human
annexin i prostate cancer Since annexins play important roles in maintaining Ca(2+) homeostasis and regulating the cytoskeleton and cell motility, we hypothesized that the reduced or lost expression of annexin I/II might promote certain aggressive phenotypes of prostate cancer cel 12629510 Human
annexin i prostate cancer Hence, our results suggest that annexin II, and, likely, annexin I, may be endogenous suppressors of prostate cancer cell migration and their reduced or lost expression may contribute to prostate cancer development and progression. 12629510 Human
anxa1 hairy-cell leukaemia Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). 15183626 Human
annexin a1 hairy-cell leukaemia Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). 15183626 Human
anxa1 hairy-cell leukaemia Through gene expression profiling, annexin A1 (ANXA1) has been identified as a gene that is upregulated in hairy cell leukaemia. 15183626 Human
annexin a1 hairy-cell leukaemia Through gene expression profiling, annexin A1 (ANXA1) has been identified as a gene that is upregulated in hairy cell leukaemia. 15183626 Human
anxa1 hairy-cell leukaemia We did immunostaining of 500 B-cell tumours with a specific anti-ANXA1 monoclonal antibody and showed that ANXA1 protein expression is specific to hairy cell leukaemia. 15183626 Human
anxa1 tumours We did immunostaining of 500 B-cell tumours with a specific anti-ANXA1 monoclonal antibody and showed that ANXA1 protein expression is specific to hairy cell leukaemia. 15183626 Human
anxa1 hairy-cell leukaemia Immunocytochemical detection of ANXA1 represents a simple, inexpensive, highly sensitive and specific (100%) assay for diagnosis of hairy cell leukaemia. 15183626 Human
lipocortin i melanoma Mass spectrometric and Edman sequencing of lipocortin I isolated by two-dimensional SDS/PAGE of human melanoma lysates. 8446611 Human
lipocortin i melanoma By using this approach, we have isolated and identified, by partial sequencing, a human melanoma protein (34 kDa, pI 6.4) as lipocortin I. 8446611 Human
annexin i esophageal squamous-cell carcinoma Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma. 12679902 Human
annexin i esophageal squamous-cell carcinoma (escc) AIM: To investigate the alteration of the annexin I subcellular localization in esophageal squamous cell carcinoma (ESCC) and the correlation between the translocation and the tumorigenesis of ESCC. 12679902 Human
annexin i esophageal cancer In esophageal cancer annexin I decreased very sharply with scattered disappearance on the cellular membrane, however it translocated and highly expressed on the nuclear membrane, which was never found in normal esophageal epithelia. 12679902 Human
annexin i esophageal cancer In cultured esophageal cancer cell line annexin I protein was also focused on the nuclear membrane, which was consistent with the result from esophageal cancer tissues. 12679902 Human
annexin i esophageal cancer CONCLUSION: This observation suggests that the translocation of annexin I protein in ESCC may correlate with the tumorigenesis of the esophageal cancer. 12679902 Human
annexin i tumor Immunolocalization studies also showed annexin II expression in both normal and tumor stroma while only tumor stromal cells were found to be reactive with the antibody against annexin I. 8387039 Human
annexin i squamous-cell carcinoma Annexin I and involucrin are cross-linked by particulate transglutaminase into the cornified cell envelope of squamous cell carcinoma Y1. 1348694 Human
annexin i squamous carcinoma Further evidence that annexin I and annexin II are glycosylated was provided by the finding that these proteins incorporated D-[2,6-3H]mannose and D-[6-3H]glucose when they were biosynthesized by the human squamous carcinoma cell line SqCC/Y1. 1445299 Human
lipocortin i epidermoid carcinoma Covalently cross-linked multimers of lipocortin I are shown to be present in human epidermoid carcinoma A431 cells treated with epidermal growth factor or the calcium ionophore A23187. 1670773 Human
annexin a1 solid tumours Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively. 15190345 Human
annexin a1 tumours Radio-immunotherapy to annexin A1 destroys tumours and increases animal survival. 15190345 Human
lpc-i seborrheic keratosis To understand the mechanism of the PS lesion formation and the function of LPC-I, its distribution was studied in the epidermis of PS, subacute eczema and normal skin, and in tumor cells of seborrheic keratosis and Bowen's disease. 1836217 Human
lpc-i tumor To understand the mechanism of the PS lesion formation and the function of LPC-I, its distribution was studied in the epidermis of PS, subacute eczema and normal skin, and in tumor cells of seborrheic keratosis and Bowen's disease. 1836217 Human
lpc-i seborrheic keratosis This membrane-binding of LPC-I was also observed in seborrheic keratosis, but not in Bowen's disease. 1836217 Human
annexin-i esophageal cancer The expression level of annexin-I, annexin-II was downregulated in esophageal cancer, whereas cPLA(2), FLAP, COX-2, 5-LOX and 12-LOX were upregulated. 12845669 Human
lipocortin i squamous carcinoma Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma. 2137129 Human
lipocortin-i fibrosarcoma The role of the phospholipase inhibitor proteins, lipocortin-I and -II, in tumor necrosis factor (TNF)-mediated cytotoxicity against L929 fibrosarcoma cells was investigated. 2138568 Human
annexin a1 human breast cancer Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses. 15567174 Human
annexin a1 human colon adenocarcinoma Thus, we have analyzed changes in annexin A1 (AnxA1), annexin A2 (AnxA2), and annexin A5 (AnxA5) levels and localization in human colon adenocarcinoma cells differentiated by butyrate treatment or by culture in glucose-free inosine-containing medium. 15526283 Human
anxa1 pituitary tumours As a prelude to examining the potential role of ANXA1 in the pathophysiology of pituitary tumours, this study examined the expression, phosphorylation status and distribution of ANXA1 and the closely related protein, annexin 5 (ANXA5), in a series of pitu 14678296 Human
anxa1 pituitary tumours A serine-phosphorylated species of ANXA1 was detected in all pituitary tumours studied; by contrast, tyrosine-phosphorylated ANXA1 was detected in only four adenomas and in the GH carcinoma. 14678296 Human
anxa1 pituitary tumours CONCLUSIONS: The results demonstrate expression of both ANXA1 and ANXA5 in human pituitary tumours and thus raise the possibility that these proteins influence the growth and/or functional activity of the tumours. 14678296 Human
anxa1 breast cancer Loss of ANXA1 in breast cancer was further confirmed at mRNA level by Human Breast Cancer Tissue Profiling Array and at protein level by immunohistochemical staining. 15567174 Human
anxa1 human breast cancer Loss of ANXA1 in breast cancer was further confirmed at mRNA level by Human Breast Cancer Tissue Profiling Array and at protein level by immunohistochemical staining. 15567174 Human
anxa1 breast cancer A distinctive loss of ANXA1 in breast cancer suggests its involvement in maintaining normal breast biology. 15567174 Human
anxa1 human colon adenocarcinoma Thus, we have analyzed changes in annexin A1 (AnxA1), annexin A2 (AnxA2), and annexin A5 (AnxA5) levels and localization in human colon adenocarcinoma cells differentiated by butyrate treatment or by culture in glucose-free inosine-containing medium. 15526283 Human
anxa1 human colon adenocarcinoma Human colon adenocarcinoma cell differentiation is associated with an up-regulation of AnxA1, AnxA2, and AnxA5 and with a subcellular relocation of these proteins. 15526283 Human
anxa1 breast cancer Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer. 15647832 Human
annexin-i atypical hyperplasia [Significance on expressions of Annexin-I and its correlative gene proteins in endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma] OBJECTIVE: To investigate expression of Annexin-I in various endometrial lesions and its significance i 11758212 Human
annexin-i endometrial hyperplasia [Significance on expressions of Annexin-I and its correlative gene proteins in endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma] OBJECTIVE: To investigate expression of Annexin-I in various endometrial lesions and its significance i 11758212 Human
annexin-i endometrial carcinoma [Significance on expressions of Annexin-I and its correlative gene proteins in endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma] OBJECTIVE: To investigate expression of Annexin-I in various endometrial lesions and its significance i 11758212 Human
annexin i necrosis Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I. Lipocortin I, also called annexin I, a calcium and phospholipid binding protein, protected rat thymocytes from H2O2-elicited necrosis and facilitat 8607818 Human
annexin i dcis Immunohistochemical analysis of annexin I in paraffin-embedded ductal epithelial cells of various human breast tissues indicated that this annexin was not demonstrable in the ductal luminal cells of normal breast tissues (n = 11) and benign tumors (n = 10 9062391 Human
annexin i lung metastases Annexin I protein expression was highest in lung metastases of MTLn3, at 8-fold the levels observed in the MTC.4 primary tumors. 9514092 Rat
annexin i lung tumor Immunohistochemical analysis showed that annexin I was expressed diffusely in neoplastic cells in lung tumor tissues, whereas annexin II was predominant at the cell surface. 11504947 Human
annexin i esophageal squamous-cell carcinomas Altered expressions of HSP27 and ANNEXIN I were the frequent events in Chinese esophageal squamous cell carcinomas. 12500389 Human
annexin i b-cell non-hodgkin's lymphomas Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines. 15070421 Human
annexin i pancreatic cancer AIM: To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance. 15133855 Human
annexin i pancreatic adenocarcinoma METHODS: Annexin I expression was analyzed by Western blot and immunohistochemical staining in pancreatic adenocarcinoma and multi-tissue microarrays (MTAs). 15133855 NA
annexin i pancreatic ductal adenocarcinomas RESULTS: Western blot analysis showed that annexin I was overexpressed in 84.6% (11/13) pancreatic ductal adenocarcinomas. 15133855 Human
annexin i tumor Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4%(30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4%(7/38) (P<0.01). 15133855 Human
annexin i pancreatic cancer Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4%(30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4%(7/38) (P<0.01). 15133855 Human
annexin i esophageal squamous-cell carcinoma Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma. 15447985 Human
annexin i esophageal squamous-cell carcinoma PURPOSE: The purpose is to characterize alterations of the annexin I gene, its mRNA, and protein expression in esophageal squamous cell carcinoma. 15447985 NA
annexin i esophageal squamous-cell carcinoma EXPERIMENTAL DESIGN: Fifty-six cases of esophageal squamous cell carcinoma were analyzed using four microsatellite markers flanking the annexin I gene (9q11-q21) to identify loss of heterozygosity. 15447985 Human
annexin i tumor Thirty of 37 (81%) esophageal squamous cell carcinoma patients showed reduced annexin I mRNA expression, which was confirmed by in situ hybridization, whereas annexin I protein expression was reduced in 79% of poorly differentiated tumor cell foci but in 15447985 Human
annexin i esophageal squamous-cell carcinoma Thirty of 37 (81%) esophageal squamous cell carcinoma patients showed reduced annexin I mRNA expression, which was confirmed by in situ hybridization, whereas annexin I protein expression was reduced in 79% of poorly differentiated tumor cell foci but in 15447985 Human
annexin i esophageal squamous-cell carcinoma CONCLUSIONS: Allelic loss of annexin I occurs frequently, whereas somatic mutations are rare, suggesting that annexin I is not inactivated in esophageal squamous cell carcinoma via a two-hit mechanism. 15447985 Human
annexin i tumor A decrease in annexin I protein expression was confirmed, consistent with a quantitative decrease in mRNA expression, and appeared to be related to tumor cell differentiation. 15447985 Human
annexin i tumor We conclude that annexin I is not the tumor suppressor gene corresponding to the high levels of loss of heterozygosity observed on chromosome 9 in esophageal squamous cell carcinoma; however, dysregulation of mRNA and protein levels is associated with thi 15447985 Human
annexin i esophageal squamous-cell carcinoma We conclude that annexin I is not the tumor suppressor gene corresponding to the high levels of loss of heterozygosity observed on chromosome 9 in esophageal squamous cell carcinoma; however, dysregulation of mRNA and protein levels is associated with thi 15447985 Human
annexin i metastasis Seventeen significantly different phosphotyrosine proteins in gel were identified by MALDI-TOF-MS/MS, including Annexin I. CONCLUSION: The changed expression of tyrosine-phosphorylated proteins is associated with HCC metastasis and recurrence. 15975278 Human
annexin i hcc Seventeen significantly different phosphotyrosine proteins in gel were identified by MALDI-TOF-MS/MS, including Annexin I. CONCLUSION: The changed expression of tyrosine-phosphorylated proteins is associated with HCC metastasis and recurrence. 15975278 Human
anxi tumor Increased constituents of the pseudopodial proteome in glioma cells, identified in this study as actin, HGF, Met, and isoforms of AnxI, AnxII, and several glycolytic enzymes, represent therapeutic targets to consider for suppression of tumor invasion. 15654357 Human
anxi glioma Increased constituents of the pseudopodial proteome in glioma cells, identified in this study as actin, HGF, Met, and isoforms of AnxI, AnxII, and several glycolytic enzymes, represent therapeutic targets to consider for suppression of tumor invasion. 15654357 Human
lipocortin i apl Thus, Lipocortin I and one locus detected by Lipocortin II cDNA are syntenic on chromosome 9; one Lipocortin II locus is perhaps not far from the genes for EGF and IL-2 on 4q; and another of the Lipocortin II loci is on 15q, perhaps not far from the APL b 2969496 Human
lipocortin i necrosis In the kidney, changes in quantity and distribution of lipocortin I have been seen during recovery from acute tubular necrosis. 8588606 Human
lipocortin i necrosis Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I. Lipocortin I, also called annexin I, a calcium and phospholipid binding protein, protected rat thymocytes from H2O2-elicited necrosis and facilitat 8607818 Rat
lipocortin i necrosis Available evidence suggests that lipocortin I modulates signals for cell death pathways of H2O2-treated rat thymocytes to apoptosis and necrosis by regulating cellular phospholipase A2 activities but not by inhibiting membrane lipid peroxidation. 8607818 Human
lpc-i bowen's disease To understand the mechanism of the PS lesion formation and the function of LPC-I, its distribution was studied in the epidermis of PS, subacute eczema and normal skin, and in tumor cells of seborrheic keratosis and Bowen's disease. 1836217 Human
lpc-i bowen's disease This membrane-binding of LPC-I was also observed in seborrheic keratosis, but not in Bowen's disease. 1836217 Human

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