IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PCSK5 Ensembl ENSG00000099139 Chromosome 9 Start 77695406 End 78163658
Description Proprotein convertase subtilisin/kexin type 5 Precursor (EC 3.4.21.-)(Proprotein convertase PC5)(Subtilisin/kexin-like protease PC5)(hPC6)(PC6) [Source:UniProtKB/Swiss-Prot;Acc:Q92824]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8747
     Entrez Gene : 5125
     UCSC : uc004ajz.2
     GeneCards : 8747
     RefSeq : NM_006200
     CCDS : CCDS6652.1
     Uniprot : Q92824
     Interpro : Q92824
     OMIM : 600488
     GeneTests : PCSK5
     CGAP : PCSK5
     PMID : 7782070

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41032_at  -1.06  2.78e-7  2.07e-6  -0.50  3.40e-2  6.62e-2
 HG_U133A  205559_s_at  -0.63  4.02e-9  1.32e-8  0.24  8.52e-3  9.27e-3
 HG_U133A  205560_at  -0.10  2.35e-1  2.84e-1  2.55  3.51e-57  9.04e-57
 HG_U133A  213652_at  -0.96  4.29e-10  1.54e-9  0.65  1.91e-14  2.56e-14
 HG_U133_Plus2  205559_s_at  -0.87  8.23e-9  5.09e-8  -0.81  6.54e-6  1.72e-5
 HG_U133_Plus2  205560_at  -0.85  4.21e-8  2.36e-7  -1.00  1.52e-6  4.35e-6
 HG_U133_Plus2  213652_at  -1.64  5.43e-16  8.20e-15  -1.91  9.16e-14  6.23e-13
 Stanford  12110  -0.40  3.26e-1  5.28e-1  -0.33  3.06e-1  5.46e-1
 Agilent_HS_21.6K  17574  -0.43  9.71e-5  1.18e-3  -0.46  7.85e-4  4.43e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205559_s_at  0.25  4.95e-1  9.27e-1  -0.06  8.51e-1  1.00e+0
 HG_U133A  205560_at  0.77  2.57e-2  6.98e-1  -0.05  7.71e-1  1.00e+0
 HG_U133A  213652_at  0.56  4.27e-1  9.11e-1  0.01  9.80e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41032_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205559_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205560_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213652_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205559_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205560_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213652_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12110    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17574    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pc5 human teratocarcinoma Human teratocarcinoma Ntera2/c 1.D1 (NT2) cells express very low levels of the prohormone convertase enzyme PC1, moderate levels of PC2 and significant levels of PC5. 11883703 Human
pc5 human neuroblastoma Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC and SK-N-SH (human neuroblastoma) tumor cell lines to study the ability of PC5 to process pro-CCK. 11457520 Human
pc5 tumor Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC and SK-N-SH (human neuroblastoma) tumor cell lines to study the ability of PC5 to process pro-CCK. 11457520 Human
pc5 tumor Several studies using endocrine and neuronal tumor cells in culture and recombinant enzymes and synthetic substrates in vitro have pointed to the subtilisin/kexin-like enzymes prohormone convertase (PC) 1, PC2, and PC5 as potential candidates for these en 14608596 Human
pc5 human colon cancer They also suggest that, in addition to NT, several proNT/NN-derived products, possibly generated by PC5, might exert an autocrine positive effect on human colon cancer growth. 9600085 Human
pc6 tumors As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc5 tumors As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc6 breast cancer As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc5 breast cancer As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc6 human breast cancer As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc5 human breast cancer As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human br 9185698 Human
pc5 tumor PC5 expression was detected in 2/30 tumor tissues. 9185698 Human
pc5 colon carcinoma Cotransfection of the furin-deficient colon carcinoma cell line LoVo with proVEGF-C and different PC members revealed that furin, PC5, and PC7 are candidate VEGF-C convertases. 12782675 Human
pc5 nervous system tumors Four PCs (Furin, PACE4, PC5, and PC7) have been localized to several different tissues and epithelial or nervous system tumors. 16167351 Human
pc5 intestinal tumor STC-1 cells, a mouse intestinal tumor cell line that expresses CCK, PC1, PC2, and PC5 were stably transfected with hairpin loop plasmids encoding siRNA targeting PC5 and clones were selected. 16266771 Human
pc5 tumorigenesis The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. 12782675 Human
pc-5 ovarian tumor We sought to determine if there was an association between the expression of the ubiquitously expressed PCs, furin, PACE-4, PC-5 and PC-7, and ovarian tumor progression. 17641413 Human
pc5 colon carcinoma PC function in the human and murine colon carcinoma cell lines HT-29 and CT-26, respectively, was inhibited using siRNA targeting the PCs furin, PACE4, PC5, and PC7 or by overexpression of the general PC inhibitor alpha1-antitrypsin Portland (alpha1-PDX). 18064302 Human

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