IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GCNT1 Ensembl ENSG00000187210 Chromosome 9 Start 78263888 End 78312150
Description Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102)(Core 2-branching enzyme)(Core2-GlcNAc-transferase)(Core 2 GNT)(C2GNT) [Source:UniProtKB/Swiss-Prot;Acc:Q02742]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4203
     Entrez Gene : 2650
     UCSC : uc004akf.3
     GeneCards : 4203
     RefSeq : NM_001097633
     CCDS : CCDS6653.1
     Uniprot : Q02742
     Interpro : Q02742
     OMIM : 600391
     GeneTests : GCNT1
     CGAP : GCNT1
     PMID : 8449405

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38218_at  -0.20  4.09e-1  5.16e-1  -0.18  5.82e-1  6.75e-1
 HG_U133A  205505_at  0.15  1.10e-1  1.42e-1  -1.64  9.16e-31  1.55e-30
 HG_U133_Plus2  205505_at  0.16  2.36e-1  3.17e-1  -0.08  5.73e-1  6.29e-1
 HG_U133_Plus2  239761_at  0.45  1.48e-5  5.46e-5  0.30  2.23e-3  4.06e-3
 Agilent_HS_21.6K  5242  0.09  2.34e-1  4.16e-1  0.06  4.88e-1  6.38e-1
 Agilent_HS_21.6K  12772  0.03  7.92e-1  8.82e-1  -0.00  9.86e-1  9.93e-1
 Agilent_HS_21.6K  16791  -0.10  5.15e-2  1.48e-1  -0.05  4.24e-1  5.83e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205505_at  0.26  4.68e-1  9.21e-1  0.08  7.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38218_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239761_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5242    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12772    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16791    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
c2gnt human lung cancer To test whether this is also the case in human lung cancer, we have examined the expression pattern of core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) mRNA responsible for the biosynthesis of core 2 branched O-glycans in 41 cases of lung cancer. 11280791 Human
c2gnt lung cancer To test whether this is also the case in human lung cancer, we have examined the expression pattern of core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) mRNA responsible for the biosynthesis of core 2 branched O-glycans in 41 cases of lung cancer. 11280791 Human
c2gnt lung cancer Using in situ hybridization, C2GnT mRNA was detected in 73.2% of the lung cancer cells, irrespective of the histopathological type; whereas in normal lung tissues, its expression was restricted to the basal cells of bronchial mucosa. 11280791 Human
c2gnt lymph-node metastasis Statistical analysis between the C2GnT mRNA expressed in pulmonary adenocarcinoma and clinicopathological variables revealed that the expression of C2GnT was correlated with vessel invasion and lymph node metastasis with significant difference (P < 0.05), 11280791 Human
c2gnt pulmonary adenocarcinoma Statistical analysis between the C2GnT mRNA expressed in pulmonary adenocarcinoma and clinicopathological variables revealed that the expression of C2GnT was correlated with vessel invasion and lymph node metastasis with significant difference (P < 0.05), 11280791 Human
c2gnt lymph-node metastasis These results indicate that C2GnT mRNA detected by in situ hybridization reflects the malignant potentials of pulmonary adenocarcinoma, because lymph node metastasis is the most affecting factor to the patients' prognosis. 11280791 Human
c2gnt pulmonary adenocarcinoma These results indicate that C2GnT mRNA detected by in situ hybridization reflects the malignant potentials of pulmonary adenocarcinoma, because lymph node metastasis is the most affecting factor to the patients' prognosis. 11280791 Human
c2gnt carcinoma We analyzed oral cavity epithelial carcinoma cell lines and showed their expression of RNA transcripts for C2GnT and alpha1,3-FucT, identified alpha1,3-FucT enzyme activities, and analyzed the cell surface sLe(x) expression levels. 11552947 Human
c2gnt metastasis These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas. 11552947 Human
c2gnt oral cavity carcinomas These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas. 11552947 Human
beta-1,6-n-acetylglucosaminyltransferase human pancreatic cancer Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes. 10455130 Human
c2gnt human pancreatic adenocarcinoma In this report we describe the stable transfection of a human pancreatic adenocarcinoma cell line, Panc1-MUC1, with the cDNA for mucin core 2 GlcNAc-transferase (C2GnT), which creates the core 2 beta-1,6 branch in mucin-type glycans. 10455130 Human
beta-1,6-n-acetylglucosaminyltransferase human colorectal cancer Carcinoma-associated expression of core 2 beta-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression. 9393734 Human
c2gnt colorectal cancer To address this problem, we have examined expression of sialyl Le(a) and sialyl Le(x), those oligosaccharides in O-glycans, and core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) transcripts in colorectal cancer specimens from 46 patients and compare 9393734 Human
beta-1,6-n-acetylglucosaminyltransferase colorectal cancer To address this problem, we have examined expression of sialyl Le(a) and sialyl Le(x), those oligosaccharides in O-glycans, and core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) transcripts in colorectal cancer specimens from 46 patients and compare 9393734 Human
c2gnt cancer In addition, C2GnT, which was specifically detected in cancer tissues of 63% of patients, was closely correlated with the vessel invasion, as well as depth of tumor invasion. 9393734 Human
c2gnt cancer These results strongly suggest that sialyl Le(a) and sialyl Le(x) in O-glycans and C2GnT, expressed in cancer cells, may play important roles in tumor progression through vessel or direct invasion. 9393734 Human
beta-1,6-n-acetylglucosaminyltransferase tumor metastasis Transforming growth factor beta up-regulates expression of the N-acetylglucosaminyltransferase V gene in mouse melanoma cells. beta-1,6-N-acetylglucosaminyltransferase V (GnT-V) (EC 2.4.1.155) that catalyzes beta-1,6 branching in asparagine-linked oligosa 7890758 Human

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