IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PRUNE2 Ensembl ENSG00000156035 Chromosome 9 Start 78593130 End 78710823
Description Protein prune homolog 2 [Source:UniProtKB/Swiss-Prot;Acc:Q8WUY3]

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33442_at  -1.08  2.83e-5  1.32e-4  -1.86  1.26e-10  1.67e-9
 HG_U133A  212805_at  -0.63  2.95e-13  1.39e-12  0.22  2.79e-4  3.15e-4
 HG_U133A  212806_at  -0.00  9.92e-1  9.93e-1  4.49  4.18e-109  3.65e-108
 HG_U133_Plus2  1552455_at  0.10  6.69e-1  7.39e-1  0.09  6.87e-1  7.33e-1
 HG_U133_Plus2  212805_at  -0.71  9.65e-8  5.13e-7  -1.12  1.37e-18  1.62e-17
 HG_U133_Plus2  212806_at  -0.04  7.42e-1  8.01e-1  -0.66  7.93e-5  1.80e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212805_at  -0.12  5.90e-1  9.50e-1  -0.33  4.08e-3  1.00e+0
 HG_U133A  212806_at  0.11  7.02e-1  9.68e-1  -0.06  8.52e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33442_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212805_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212806_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1552455_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212805_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212806_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
bmcc1 neuroblastomas Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. 16288218 Human
bmcc1 neuroblastomas Differential screening of the genes obtained from cDNA libraries of primary neuroblastomas (NBLs) between the favorable and unfavorable subsets has identified a novel gene BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1). 16288218 Human
bmcc1 tumor Thus, BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. 16288218 Human
bnipxl neuroblastoma It has been reported that overexpression of BNIP-2 in neuroblastoma cell lines resulted in massive cell death, whereas BNIP-XL was upregulated during NGF-depletion-induced apoptosis in neuroblastoma and was involved in the regulation of differentiation, s 17961507 Human
bnipxl oncogenic Consequently, BNIPXL inhibits Lbc-induced oncogenic transformation. 18445682 Human
bnipxl tumorigenesis Given the importance of RhoA and RhoGEF signaling in tumorigenesis, BNIPXL could suppress cellular transformation by preventing sustained Rho activation in concert with restricting RhoA and Lbc binding via its BCH domain. 18445682 Human
bmcc1 neuroblastoma Increased expression of BCH-motif-containing molecule at the C-terminal region 1 (BMCC1) correlates with a favourable prognosis in neuroblastoma, but the underlying mechanism remains unknown. 18445682 Human
bnipxl tumor It has been reported that overexpression of BNIP-2 in neuroblastoma cell lines resulted in massive cell death, whereas BNIP-XL was upregulated during NGF-depletion-induced apoptosis in neuroblastoma and was involved in the regulation of differentiation, s 17961507 Human

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