IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PSAT1 Ensembl ENSG00000135069 Chromosome 9 Start 80101879 End 80134827
Description Phosphoserine aminotransferase (EC 2.6.1.52)(Phosphohydroxythreonine aminotransferase)(PSAT) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y617]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19129
     Entrez Gene : 29968
     UCSC : uc004ala.2
     GeneCards : 19129
     RefSeq : NM_021154
     CCDS : CCDS6659.1
     Uniprot : Q9Y617
     Interpro : Q9Y617
     OMIM : 610936
     GeneTests : PSAT1
     CGAP : PSAT1
     PMID : 12633500

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220892_s_at  1.07  3.28e-26  3.95e-25  1.21  9.05e-42  1.80e-41
 HG_U133_Plus2  220892_s_at  1.87  1.04e-23  3.64e-22  3.31  5.02e-39  8.10e-37
 HG_U133_Plus2  223062_s_at  2.40  8.35e-35  9.69e-33  3.96  4.76e-52  1.18e-48
 Agilent_HS_21.6K  5144  0.27  3.40e-4  3.22e-3  0.58  4.82e-8  1.17e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220892_s_at  0.69  5.60e-2  7.13e-1  -0.12  5.97e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 220892_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220892_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223062_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5144    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
psat1 recurrent breast cancer Concluding, our work indicates that promoter hypermethylation and mRNA expression of PSAT1 are indicators of response to tamoxifen-based endocrine therapy in steroid hormone receptor-positive patients with recurrent breast cancer. 15899800 Human
the psa gene ca No significant differences could be found in the PSA gene expression between BPH and CA samples. 1691151 Human
the psa gene bph No significant differences could be found in the PSA gene expression between BPH and CA samples. 1691151 Human
the psa gene breast carcinoma Based on data of tissue culture experiments with breast carcinoma cell lines, we speculate that the PSA gene in the tumor of this patient was up-regulated by the therapeutically administered glucocorticoids after liver transplantation. 7536128 Human
the psa gene tumor Based on data of tissue culture experiments with breast carcinoma cell lines, we speculate that the PSA gene in the tumor of this patient was up-regulated by the therapeutically administered glucocorticoids after liver transplantation. 7536128 Human
the psa gene tumors Because PSA protein is present in male blood and thus could contaminate extracts from tumors and tissues from men, we propose that the RT-PCR methods we describe be used to assess nonprostatic expression of the PSA gene in men. 8598096 Human
the psa gene prostate cancer A detailed understanding of the possible differences in the PSA gene sequence is essential as we develop newer techniques that utilize RT-PCR to perform molecular diagnosis and staging of prostate cancer. 8677566 Human
the psa gene bladder cancer The PSA gene was not detected by RT-PCR of FNAB samples in any of the 20 cases of bladder cancer. 8951475 Human
the psa gene prostate cancer Thus RT-PCR for detection of the PSA gene in FNAB samples may be useful as a new diagnostic technique for detection of early lymph node metastasis in prostate cancer and an additional tool for cytological diagnosis of prostate cancer. 8951475 Human
the psa gene lymph-node metastasis Thus RT-PCR for detection of the PSA gene in FNAB samples may be useful as a new diagnostic technique for detection of early lymph node metastasis in prostate cancer and an additional tool for cytological diagnosis of prostate cancer. 8951475 Human
the psa gene breast cancer We have now developed a tissue culture system to study the regulation of the PSA gene in breast cancer. 9052414 Human
the psa gene prostate cancer [The PSA gene: value in detection of circulating prostate cancer cells] There has been a renewed interest in detection of circulating cancer cells due to the simplicity, specificity and sensitivity of a molecular biology technique: RT-PCR. 9490137 Human
the psa gene tumours We also sequenced parts of the 5' flanking region of the PSA gene in five tumours. 9470845 Human
the psa gene prostate cancer These results indicate that polymorphism in the PSA gene promoter influences prostate cancer risk, and that the allelic variation in promoter activity may be androgen-dependent. 10706090 Human
the psa gene prostate cancer Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. 11185746 Human
the psa gene breast cancer Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. 11185746 Human
the psa gene breast tumors The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. 11185746 Human
the psa gene breast cancer In this study, we examined the molecular mechanism underlying the expression of the PSA gene in breast cancer and breast cancer cell lines. 10188912 Human
the psa gene breast tumours To determine abnormalities associated with PSA expression in breast tumours, genomic DNA was extracted and all five exons of the PSA gene were polymerase chain reaction (PCR) amplified and sequenced on both strands. 10188912 Human
the psa gene tumours Within a 5.8-kb promoter/enhancer region of the PSA gene, we detected 16 different mutational hotspots (appearing more than once in the nine tumours). 10188912 Human
the psa gene breast tumours The mutations in the core enhancer and promoter region probably contribute to the aberrant expression of the PSA gene in breast tumours, possibly by altering the regulation of the gene by steroid hormones. 10188912 Human
the psa gene prostatic cancer However, the transcription of the PSA gene is strictly androgen dependent, and its promoter activity is very weak at low concentrations of testosterone, which are generally observed in prostatic cancer patients treated with androgen deprivation. 11245419 Human
the psa gene prostate cancer To test this hypothesis, three AREs of the PSA gene promoter were characterized for 47 prostate cancer cases and 105 controls from the Japanese population. 11299734 Human
the psa gene prostate cancer These results suggest that the novel polymorphisms identified in the PSA gene promoter may affect transcriptional activity of the PSA gene, and an excess of PSA production may enhance rapid progression of prostate cancer. 11299734 Human
the psa gene prostate cancer CONCLUSION: Our results indicate that polymorphism in the PSA gene promoter may be an important biomarker for prostate cancer risk, especially for an earlier onset of PC. 12210484 Human
the psa gene prostate cancer Polymerase chain reaction products were sequenced to identify polymorphisms in the PSA gene promoter and to genotype the men for common single nucleotide polymorphisms (SNPs) and were cloned into luciferase reporter constructs to assay PSA promoter activi 12865450 Human
the psa gene human prostate cancer Western blot analysis, luciferase reporter assay using a variety of promoters of the PSA gene and the isolated androgen receptor response elements (ARE), as well as electrophoretic mobility shift assay (EMSA) were employed to study the effect of PC-SPES o 14532991 Human
the psa gene prostate cancer The presence of short AR alleles and the G allele of the PSA gene may contribute to the development of prostate cancer in a 47,XXY patient. 15350307 Human
the psa gene advanced prostate cancer Still, the molecular mechanism(s) by which the transcription of the PSA gene escapes regulation in advanced prostate cancer has yet to be clearly defined. 15368351 Human
the psa gene prostate cancer Insights into AR activity at the PSA gene could be extended to transcriptional regulation of other AR target genes, which may be crucial in discerning prostate cancer progression. 15368351 Human
the psa gene prostate tumor Treatment with DHT in LAPC-4 prostate tumor cells that express a wild-type AR and both ERbeta and ERalpha greatly increased the PSA gene expression and cell growth. 15955889 Human
the psa mrna bph The hGK-1 mRNA levels in the BPH specimens studied demonstrated greater variance than the PSA mRNA levels in the same samples. 1691151 Human
the psa mrna tumors The PSA mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot hybridization in 24 (68%) of 35 tumors from men, in 9 (53%) of 17 tumors from women, and in 5 (71%) of 7 adjacent normal lung tissue specimens. 9260759 Human
the psa mrna prostatic carcinoma By using cDNA microarray gene expression profiling, we found a fourfold increase in the PSA mRNA level in prostatic carcinoma cell line LNCaP, in which the p53 pathway was suppressed by a dominant negative p53 mutant. 11791186 Human
the psa protein lung tumor The PSA protein was detected more frequently and at higher levels in lung tumor extracts from men. 9260759 Human
the psa protein prostate cancer CONCLUSIONS: The PSA protein catalog may be useful for the analysis of differences among PSA forms in men with and without prostate cancer and for analysis of antibodies used to detect PSA. 12446475 Human
the psa protein prostate cancer CONCLUSION: Although recent reports suggest the PSA protein itself may be antiangiogenic, our results demonstrate that production of PSA protein by prostate cancer cells does not significantly alter growth in vitro or in vivo. 12746846 Human

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