IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TLE1 Ensembl ENSG00000196781 Chromosome 9 Start 83388423 End 83493416
Description Transducin-like enhancer protein 1 (ESG1)(E(Sp1) homolog) [Source:UniProtKB/Swiss-Prot;Acc:Q04724]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11837
     Entrez Gene : 7088
     UCSC : uc004aly.2
     GeneCards : 11837
     RefSeq : NM_005077
     CCDS : CCDS6661.1
     Uniprot : Q04724
     Interpro : Q04724
     OMIM : 600189
     GeneTests : TLE1
     CGAP : TLE1
     PMID : 8365415

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41489_at  -0.10  2.41e-1  3.40e-1  -0.02  8.52e-1  8.94e-1
 HG_U133A  203220_s_at  0.05  6.57e-1  7.00e-1  3.13  2.13e-75  7.75e-75
 HG_U133A  203221_at  -0.33  2.36e-8  7.16e-8  -0.10  1.53e-1  1.60e-1
 HG_U133A  203222_s_at  0.01  9.28e-1  9.39e-1  2.33  4.07e-68  1.27e-67
 HG_U133_Plus2  203220_s_at  0.31  9.22e-2  1.43e-1  0.78  1.39e-4  3.05e-4
 HG_U133_Plus2  203221_at  0.20  4.27e-2  7.34e-2  0.62  2.22e-9  9.08e-9
 HG_U133_Plus2  203222_s_at  -0.26  2.97e-2  5.34e-2  -0.06  6.16e-1  6.68e-1
 HG_U133_Plus2  227130_s_at  0.11  5.03e-1  5.90e-1  -0.20  3.06e-1  3.66e-1
 HG_U133_Plus2  228284_at  0.04  6.79e-1  7.48e-1  -0.08  4.36e-1  4.97e-1
 Stanford  3827  0.31  2.79e-1  4.80e-1  0.03  9.41e-1  9.75e-1
 Agilent_HS_21.6K  9716  -0.11  1.21e-1  2.69e-1  -0.20  2.64e-2  7.62e-2

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203220_s_at  -0.12  7.99e-1  9.82e-1  -0.16  5.77e-1  1.00e+0
 HG_U133A  203221_at  0.03  8.77e-1  9.92e-1  0.09  5.27e-1  1.00e+0
 HG_U133A  203222_s_at  0.04  9.34e-1  9.96e-1  -0.11  7.59e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41489_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203220_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203221_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203222_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203220_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203221_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203222_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227130_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228284_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3827    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9716    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tle1 synovial sarcoma We demonstrate that TLE expression is a consistent feature of synovial sarcoma using both a well-characterized monoclonal antibody recognizing the TLE family of proteins and a commercially available polyclonal antibody raised against TLE1. 17255769 Human
tle1 sarcomas Gene expression profiling studies performed by several independent groups have consistently identified TLE1 as an excellent discriminator of synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve s 17255769 Human
tle1 synovial sarcoma TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. 17255769 Human
tle1 tumors Gene expression profiling studies performed by several independent groups have consistently identified TLE1 as an excellent discriminator of synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve s 17255769 Human
tle1 synovial sarcoma Gene expression profiling studies performed by several independent groups have consistently identified TLE1 as an excellent discriminator of synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve s 17255769 Human
tle1 malignant peripheral nerve sheath tumor Gene expression profiling studies performed by several independent groups have consistently identified TLE1 as an excellent discriminator of synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve s 17255769 Human
tle1 embryonic carcinoma Moreover, we show that the nuclear, more slowly migrating, TLE1 proteins are induced during neural determination of P19 embryonic carcinoma cells. 8713081 Human
tle1 mds By statistical analysis of the profiles from 10 individual additional liver tumors, 5 WDs and 5 MDs, we were able to identify 12 genes, LAMA3, PPIB, ADAR, PSMD4, NDUFS8, D9SVA, CCT3, GBAP, ARD1, RDBP, CSRP2, and TLE1, with significantly elevated expressio 12079511 Human
tle1 liver tumors By statistical analysis of the profiles from 10 individual additional liver tumors, 5 WDs and 5 MDs, we were able to identify 12 genes, LAMA3, PPIB, ADAR, PSMD4, NDUFS8, D9SVA, CCT3, GBAP, ARD1, RDBP, CSRP2, and TLE1, with significantly elevated expressio 12079511 Human
tle1 choriocarcinoma RESULTS: A total of 52 coexpressed candidate genes were identified from the gene expression data derived from the choriocarcinoma specimens, of which 19 genes were selected as choriocarcinoma-related genes by further cluster analysis, such as dynamin (L07 15683985 Human
grg1 lung adenocarcinoma We generated Grg1 and Grg5 transgenic mice and found that Grg1 overexpression induces lung adenocarcinoma, whereas Grg5 overexpression does not. 16452182 Mouse
grg1 tumor Coexpression of Grg5 with Grg1 reduces tumor burden. 16452182 Mouse
grg1 human lung cancer The molecular and biological changes that accompany tumor progression in Grg1 transgenic mice closely reiterate events seen in human lung cancer. 16452182 Human
grg1 tumor The molecular and biological changes that accompany tumor progression in Grg1 transgenic mice closely reiterate events seen in human lung cancer. 16452182 Mouse
grg1 carcinomas We also found that within a human lung tumor tissue array, a significant number of carcinomas overexpress Grg1/TLE1. 16452182 Human
grg1 lung tumor We also found that within a human lung tumor tissue array, a significant number of carcinomas overexpress Grg1/TLE1. 16452182 Human
grg1 human lung cancers Our data suggest that Grg1 overexpression contributes to malignancy in human lung cancers. 16452182 Human
grg1 malignancy Our data suggest that Grg1 overexpression contributes to malignancy in human lung cancers. 16452182 Human
tle1 carcinomas We also found that within a human lung tumor tissue array, a significant number of carcinomas overexpress Grg1/TLE1. 16452182 Human
tle1 lung tumor We also found that within a human lung tumor tissue array, a significant number of carcinomas overexpress Grg1/TLE1. 16452182 Human
tle1 leukemogenesis These results suggest that TLE1 acts as a repressor of AML1 and provide important insights into the mechanism of the negative regulation of the AML1 functions in hematopoiesis and leukemogenesis. 9837750 Human
grg1 oncogene Grg1 acts as a lung-specific oncogene in a transgenic mouse model. 16452182 Mouse

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.