IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FRMD3 Ensembl ENSG00000172159 Chromosome 9 Start 85047725 End 85343281
Description FERM domain-containing protein 3 (Band 4.1-like protein 4O)(Ovary type protein 4.1)(4.1O) [Source:UniProtKB/Swiss-Prot;Acc:A2A2Y4]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 24125
     Entrez Gene : 257019
     UCSC : uc004ams.1
     GeneCards : 24125
     RefSeq : NM_174938
     CCDS : CCDS43840.1
     Uniprot : Q8N3Y5
     Interpro : Q8N3Y5
     OMIM : 607619
     GeneTests : FRMD3
     CGAP : FRMD3
     PMID : 12601556

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  229893_at  -1.74  1.93e-33  1.97e-31  -2.34  3.95e-34  3.03e-32
 HG_U133_Plus2  230645_at  -1.73  5.30e-41  1.23e-38  -2.44  2.70e-34  2.12e-32
 HG_U133_Plus2  242600_at  -1.27  4.35e-12  4.12e-11  -1.76  1.74e-18  2.04e-17
 Agilent_HS_21.6K  1727  -0.11  8.23e-5  1.02e-3  -0.13  2.08e-4  1.47e-3
 Agilent_HS_21.6K  9116  -0.30  3.83e-10  2.51e-8  -0.32  2.78e-9  1.01e-7

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 229893_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230645_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242600_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1727    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9116    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
frmd3 nsclc FRMD3, a novel putative tumour suppressor in NSCLC. 17260017 Human
frmd3 tumour FRMD3, a novel putative tumour suppressor in NSCLC. 17260017 Human
frmd3 nsclc We found that ferm domain containing protein 3 (FRMD3), a member of the protein 4.1 superfamily, is expressed in normal lung tissue but silenced in 54 out of 58 independent primary NSCLC tumours compared to patient-matched normal lung tissue. 17260017 Human
frmd3 tumours We found that ferm domain containing protein 3 (FRMD3), a member of the protein 4.1 superfamily, is expressed in normal lung tissue but silenced in 54 out of 58 independent primary NSCLC tumours compared to patient-matched normal lung tissue. 17260017 Human
frmd3 tumour Our data identify FRMD3 as a novel putative tumour suppressor gene suggesting an important role in the origin and progression of lung cancer. 17260017 Human
frmd3 lung cancer Our data identify FRMD3 as a novel putative tumour suppressor gene suggesting an important role in the origin and progression of lung cancer. 17260017 Human

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