IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene UBQLN1 Ensembl ENSG00000135018 Chromosome 9 Start 85464699 End 85512773
Description Ubiquilin-1 (Protein linking IAP with cytoskeleton 1)(PLIC-1)(hPLIC-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9UMX0]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12508
     Entrez Gene : 29979
     UCSC : uc004amv.2
     GeneCards : 12508
     RefSeq : NM_013438
     CCDS : CCDS6663.1
     Uniprot : Q9UMX0
     Interpro : Q9UMX0
     OMIM : 605046
     GeneTests : UBQLN1
     CGAP : UBQLN1
     PMID : 9303440

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  222989_s_at  0.52  2.97e-8  1.70e-7  1.01  1.31e-21  2.18e-20
 HG_U133_Plus2  222990_at  -0.29  1.43e-7  7.39e-7  -0.23  3.05e-3  5.44e-3
 HG_U133_Plus2  222991_s_at  0.20  4.16e-3  9.35e-3  0.49  2.44e-8  8.75e-8
 Stanford  7331  -0.09  7.80e-1  8.78e-1  0.09  7.20e-1  8.61e-1
 Stanford  16712  0.79  5.66e-3  4.41e-2  1.14  2.92e-4  5.84e-3
 Agilent_HS_21.6K  4331  0.23  8.13e-7  2.05e-5  0.29  6.27e-8  1.46e-6

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 222989_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 222990_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 222991_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7331    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16712    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4331    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
da41 bladder cancer Fluorescence in situ hybridization (FISH) revealed that DA41 was mapped to human chromosome 9q21.2-q21.3, a position overlapping the candidate tumor suppressor locus for bladder cancer. 10807547 Human
da41 tumor Fluorescence in situ hybridization (FISH) revealed that DA41 was mapped to human chromosome 9q21.2-q21.3, a position overlapping the candidate tumor suppressor locus for bladder cancer. 10807547 Human
plic1 tumor In contrast, K7 interaction prevented PLIC1 from forming a dimer and binding to polyubiquitinated proteins, leading to the rapid degradation of I kappa B. Furthermore, K7 expression promoted efficient degradation of the p53 tumor suppressor, resulting in 15082787 Human
da41 human neuroblastoma Using a human neuroblastoma cDNA library and the yeast two-hybrid system to identify novel HASH-1-interacting proteins, we isolated ubiquilin-1 (DA41, hPLIC-1), a gene that contains multiple ubiquitin-related domains. 15492808 Human
ubiquilin-1 human neuroblastoma Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. 15492808 Human
ubiquilin-1 human neuroblastoma Using a human neuroblastoma cDNA library and the yeast two-hybrid system to identify novel HASH-1-interacting proteins, we isolated ubiquilin-1 (DA41, hPLIC-1), a gene that contains multiple ubiquitin-related domains. 15492808 Human

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