IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HNRNPK Ensembl ENSG00000165119 Chromosome 9 Start 85772912 End 85785339
Description Heterogeneous nuclear ribonucleoprotein K (hnRNP K)(Transformation up-regulated nuclear protein)(TUNP) [Source:UniProtKB/Swiss-Prot;Acc:P61978]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5044
     Entrez Gene : 3190
     UCSC : uc004anl.3
     GeneCards : 5044
     RefSeq : NM_002140
     CCDS : CCDS6667.1
     Uniprot : P61978
     Interpro : P61978
     OMIM : 600712
     GeneTests : HNRNPK
     CGAP : HNRNPK
     PMID : 8107114

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39415_at  0.21  4.64e-3  1.20e-2  0.38  1.21e-4  4.73e-4
 HG_U133A  200097_s_at  0.02  5.76e-1  6.25e-1  -2.27  7.30e-119  8.54e-118
 HG_U133A  200775_s_at  0.22  7.16e-7  1.87e-6  -1.81  3.54e-89  1.81e-88
 HG_U133_Plus2  200097_s_at  -0.21  4.62e-5  1.56e-4  -0.31  1.86e-6  5.26e-6
 HG_U133_Plus2  200775_s_at  0.23  6.47e-8  3.53e-7  0.46  4.17e-16  3.71e-15

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200097_s_at  -0.06  7.18e-1  9.71e-1  0.12  3.36e-1  1.00e+0
 HG_U133A  200775_s_at  0.28  6.11e-2  7.25e-1  0.12  2.16e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39415_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200097_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200775_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200097_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200775_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hnrnpk multiple myeloma Interestingly, the mutated version of the c-myc IRES that is prevalent in patients with multiple myeloma bound hnRNPK more efficiently in vitro and was stimulated by hnRNPK to a greater extent in vivo. 12970749 Human
heterogeneous nuclear ribonucleoprotein k blast crisis Here, we report that in BCR/ABL+ cell lines and in patient-derived CML blast crisis mononuclear and CD34+ cells, p210(BCR/ABL) increases expression and activity of the transcriptional-inducer and translational-regulator heterogeneous nuclear ribonucleopro 16293596 Human
heterogeneous nuclear ribonucleoprotein k cml Here, we report that in BCR/ABL+ cell lines and in patient-derived CML blast crisis mononuclear and CD34+ cells, p210(BCR/ABL) increases expression and activity of the transcriptional-inducer and translational-regulator heterogeneous nuclear ribonucleopro 16293596 Human
hnrpk blast crisis Here, we report that in BCR/ABL+ cell lines and in patient-derived CML blast crisis mononuclear and CD34+ cells, p210(BCR/ABL) increases expression and activity of the transcriptional-inducer and translational-regulator heterogeneous nuclear ribonucleopro 16293596 Human
hnrpk cml Here, we report that in BCR/ABL+ cell lines and in patient-derived CML blast crisis mononuclear and CD34+ cells, p210(BCR/ABL) increases expression and activity of the transcriptional-inducer and translational-regulator heterogeneous nuclear ribonucleopro 16293596 Human
hnrpk blast crisis Thus, BCR/ABL-dependent enhancement of HNRPK translation-regulation is important for BCR/ABL leukemogenesis and, perhaps, it might contribute to blast crisis transformation. 16293596 Human
heterogeneous nuclear ribonucleoprotein k colorectal cancer Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. 16953238 Human
hnrpk oncogenic A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation. 16293596 Human
hnrpk cml Furthermore, HNRPK down-regulation and interference with HNRPK translation-but not transcription-regulatory activity impairs cytokine-independent proliferation, clonogenic potential, and in vivo leukemogenic activity of BCR/ABL-expressing myeloid 32Dcl3 a 16293596 Human
hnrpk leukemogenesis Thus, BCR/ABL-dependent enhancement of HNRPK translation-regulation is important for BCR/ABL leukemogenesis and, perhaps, it might contribute to blast crisis transformation. 16293596 Human
heterogeneous nuclear ribonucleoprotein k metastasis Isolation of antibodies from cells with loss of migration phenotype and identification of their target proteins revealed the involvement of the heterogeneous nuclear ribonucleoprotein K (hnRNP-K), a multifunctional signaling protein, in metastasis. 17483488 Human
heterogeneous nuclear ribonucleoprotein k oral squamous cell carcinoma Evidence for heterogeneous nuclear ribonucleoprotein K overexpression in oral squamous cell carcinoma. 17667925 Human
heterogeneous nuclear ribonucleoprotein k human gastric carcinoma Of the 14 proteins, 13 were identified as human gastric carcinoma-associated antigens, including heterogeneous nuclear ribonucleoprotein K (hnRNP K), hnRNP H1, hnRNP H2, cytokeratin 18 (CK18), crystal structure of Fkbp52 C-terminal domain complex with the 17927877 Human

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