IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NTRK2 Ensembl ENSG00000148053 Chromosome 9 Start 86473286 End 86828325
Description BDNF/NT-3 growth factors receptor Precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 2)(TrkB tyrosine kinase)(GP145-TrkB)(Trk-B) [Source:UniProtKB/Swiss-Prot;Acc:Q16620]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8032
     Entrez Gene : 4915
     UCSC : uc004anz.1
     GeneCards : 8032
     RefSeq : NM_001007097
     CCDS : CCDS6671.1
     Uniprot : Q16620
     Interpro : Q16620
     OMIM : 600456
     GeneTests : NTRK2
     CGAP : NTRK2
     PMID : 7789988

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
8 3.56 225 6 3.08 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16668 AD c.781G>A p.G261R Substitution - Missense Heterozygous 9:86529019-8652901918948947
16686 AD c.1967C>A p.A656D Substitution - Missense Heterozygous 9:86760047-8676004718948947
16879 AD c.1677G>C p.E559D Substitution - Missense Heterozygous 9:86738940-8673894018948947
16883 AD c.1997A>G p.Q666R Substitution - Missense Heterozygous 9:86760077-8676007718948947
17210 AD c.134G>T p.C45F Substitution - Missense Heterozygous 9:86475617-8647561718948947
17728 AD c.2008C>A p.L670M Substitution - Missense Heterozygous 9:86760088-8676008818948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1354_at  0.14  3.18e-1  4.24e-1  0.36  1.54e-2  3.35e-2
 HG_U95  1355_g_at  -0.14  2.74e-1  3.76e-1  0.15  4.64e-1  5.68e-1
 HG_U95  33182_at  -1.80  5.61e-10  7.27e-9  0.54  2.25e-1  3.20e-1
 HG_U95  36042_at  -2.05  7.48e-12  1.37e-10  1.53  2.16e-3  6.09e-3
 HG_U95  38280_s_at  -1.46  1.31e-7  1.05e-6  0.53  2.96e-1  3.99e-1
 HG_U133A  207152_at  -0.53  1.09e-16  6.72e-16  -3.93  2.53e-83  1.11e-82
 HG_U133A  214680_at  -1.31  1.63e-23  1.65e-22  1.28  6.75e-23  1.02e-22
 HG_U133A  221795_at  -2.36  4.52e-38  1.12e-36  -2.14  2.34e-33  4.10e-33
 HG_U133A  221796_at  -2.23  2.44e-33  4.72e-32  4.30  1.36e-98  8.89e-98
 HG_U133_Plus2  207152_at  0.16  2.14e-1  2.93e-1  1.09  1.73e-13  1.14e-12
 HG_U133_Plus2  214680_at  -0.99  2.23e-7  1.12e-6  2.70  1.38e-11  7.33e-11
 HG_U133_Plus2  221795_at  -2.57  1.34e-26  6.36e-25  1.82  4.44e-7  1.36e-6
 HG_U133_Plus2  221796_at  -2.56  4.09e-20  9.72e-19  2.38  8.25e-10  3.56e-9
 HG_U133_Plus2  229463_at  -0.66  7.44e-4  1.99e-3  0.85  4.33e-4  8.83e-4
 HG_U133_Plus2  236095_at  -0.43  1.58e-2  3.07e-2  1.36  1.16e-6  3.37e-6
 Stanford  16876  -1.94  1.71e-3  2.07e-2  1.90  1.59e-2  9.53e-2
 Agilent_HS_21.6K  1829  -0.08  9.16e-2  2.22e-1  0.27  3.89e-2  1.02e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207152_at  -0.07  7.10e-1  9.69e-1  -0.01  9.17e-1  1.00e+0
 HG_U133A  214680_at  0.69  2.27e-1  8.46e-1  0.12  8.54e-1  1.00e+0
 HG_U133A  221795_at  1.34  8.31e-2  7.54e-1  0.45  5.44e-1  1.00e+0
 HG_U133A  221796_at  2.06  2.00e-2  6.83e-1  -0.09  8.99e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1354_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 1355_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 33182_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36042_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38280_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207152_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221795_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221796_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207152_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221795_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221796_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229463_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 236095_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16876    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1829    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
trkb tumor TrkA expression inhibits angiogenesis and tumor growth in SY5Y NB cells by down-regulation of angiogenic factors, whereas expression of TrkB does not down-regulate the production of these angiogenic factors. 11912158 Human
trkb tumors Neuroblastoma (NB) tumors expressing high levels of brain-derived neurotrophic factor (BDNF) and TrkB are associated with poor 5-year survival outcomes. 12438277 Human
trkb tumors These results suggest that TrkB and BDNF can contribute to the chemoresistance of poor prognosis tumors, and that suppression of PI3K activity might improve the ability of these agents to induce the death of NB tumors. 12438277 Human
trkb tumors The full-length TRKB was predominantly detected in tumors with unfavorable biologies, and the truncated one in those with favorable biologies. 11166915 Human
trkb tumor These results suggest that an autocrine and/or paracrine mechanism involving BDNF may stimulate signal transduction via TRKB receptors rich in neuroblastomas with unfavorable biologies, resulting in an aberrant survival of tumor cells. 11166915 Human
trkb wilms' tumor Expression of the neurotrophin receptor TrkB is associated with unfavorable outcome in Wilms' tumor. 11157019 Human
trkb tumors RESULTS: Children with WT that expressed high levels of full-length TrkB mRNA (TrkBfull) had a significantly greater risk of death than children whose tumors had little or no TrkBfull expression (hazard ratio, 9.7; P =.02). 11157019 Human
trkb tumors Conversely, children with tumors that expressed high mRNA levels of a functionally inactive truncated TrkB receptor (TrkBtrunc) had a greater chance of survival than children with low levels of TrkBtrunc (hazard ratio, 0.08; P =.005). 11157019 Human
ntrk2 human medullary thyroid carcinoma Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants. 11279608 Human
ntrk2 c-cell hyperplasia Immunostaining has shown that only a subset of normal C cells expresses Trk family receptors, but in C-cell hyperplasia, they consistently express NTRK2, with variable expression of NTRK1 and NTRK3. 11279608 Human
trkb tumor We conclude that the BDNF/trkB pathway plays an important role in neuroblastoma survival and speculate on a possible role in tumor pathogenesis. 11340642 Human
trkb tumors We have examined the immunohistochemical expression of BDNF, full-length TrkB receptor and the NMDAR subunit 1 and subunit 2A/B proteins (NMDAR1 and NMDAR2A/B) in glioneuronal tumors (gangliogliomas, GG, n = 40; dysembryoplastic neuroepithelial tumors, DN 11355310 Human
trkb dysembryoplastic neuroepithelial tumors We have examined the immunohistochemical expression of BDNF, full-length TrkB receptor and the NMDAR subunit 1 and subunit 2A/B proteins (NMDAR1 and NMDAR2A/B) in glioneuronal tumors (gangliogliomas, GG, n = 40; dysembryoplastic neuroepithelial tumors, DN 11355310 Human
trkb tumors BDNF and TrkB immunoreactivity (ir) was mainly observed in the neuronal component of the tumors. 11355310 Human
trkb prostate cancer In contrast, the expression of TrkB was down-regulated and the expression of p75NTR was up-regulated in prostate cancer after hormonal therapy. 11442674 Human
trkb tumors TrkB expression in the resultant tumors was examined by quantitative RT-PCR. 11464878 Human
trkb tumors RT PCR analysis confirmed the expression of TrkB in G8 and G12, but not in SY5Y tumors. 11464878 Human
trkb pancreatic cancer Sections of pancreatic cancer and normal pancreatic tissue were examined by immunohistochemistry for the expression of the neurotrophins NGF, BDNF, NT-3, NT-4, and their receptors TrkA, TrkB, and TrkC, as well as the low-affinity receptor, p75NTR. 11561004 Human
trkb cancer TrkA expression was found in duct, islet, and cancer cells; TrkB was found in the alpha-cells of the islet only. 11561004 Human
trkb human tumors Immunoblots of homogenates from human tumors displayed binding of anti-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and NT-3 antibodies as well as of anti-tyrosine-specific protein kinase (Trk) A, TrkB, and TrkC receptor antibodies 11694449 Human
trkb squamous-cell carcinomas A faint BDNF and TrkB immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. 11694449 Human
trkb small-cell lung cancers A faint BDNF and TrkB immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. 11694449 Human
trkb prostatic tumor These lines had negligible trkA and trkC expression, although trkB was expressed in the three prostatic tumor cell lines examined. 10545017 Human
trkb tumor Therefore, we hypothesized that the neurotrophins (nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3) and their receptors (TrkA, TrkB, and TrkC), which are involved in the proliferation, differentiation, and survival of neuronal c 10549931 Human
trkb human neuroblastoma In this report, we evaluate the biological effects after activation of trkA or trkB by their major ligands in SH-SY5Y human neuroblastoma cells. 10550322 Human
trkb human neuroblastoma BDNF induces phosphorylation of fibroblast growth factor receptor substrate 2 (FRS2) in both fibroblasts engineered to express TrkB and human neuroblastoma (NB) cells that naturally express TrkB. 10196222 Human
trkb c-cell hyperplasia Only a subset of normal C cells expresses trk family receptors, but, in C cell hyperplasia, the affected cells consistently express trkB, with variable expression of trkA and trkC. 10200298 Human
trkb tumors In later stages of gross MTC tumors, trkB expression was substantially reduced, while trkC expression was increased and often intense. 10200298 Human
trkb tumor These results suggest that trk family receptor genes participate in MTC development and progression, and, in particular, that trkB may limit MTC tumor growth by inhibition of angiogenesis. 10200298 Human
trkb paraganglioma METHODS AND RESULTS: Light microscopy immunohistochemistry associated with quantitative image analysis was used to study the expression of neurotrophins (nerve growth factor, brain-derived neurotrophic factor and neurotrophin (NT)-3) and their cognate rec 10217562 Human
trkb ganglioneuroma METHODS AND RESULTS: Light microscopy immunohistochemistry associated with quantitative image analysis was used to study the expression of neurotrophins (nerve growth factor, brain-derived neurotrophic factor and neurotrophin (NT)-3) and their cognate rec 10217562 Human
trkb pituitary adenomas In addition, TrkA and TrkB immunoreactivity was located in normal and neoplastic endocrine cells from human pituitary adenomas. 9535101 Human
trkb tumors While neither TrkA nor TrkB expression was demonstrated in 2 intraventricular neurocytomas, the remaining 6 tumors did show positive immunohistochemical staining for TrkA and/or TrkB proteins; for TrkA protein, ganglionic cells showed membraneous or cytop 9625303 Human
trkb human neuroblastoma The results show that monoamine-activated alpha2M binds to trkB and inhibits brain-derived neurotrophic factor/neurotrophin-4-promoted autophosphorylation of trkB in a dose-dependent manner in both trkB-expressing NIH3T3 (NIH3T3-trkB) and human neuroblast 9648868 Human
trkb glial tumors As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis of human glia, glioma tissues and cell cultures of glial tumors to characterize the expression of Trk family 9797000 Human
trkb glioma As little is known about their expression or potential role in human glial tissues and glial tumors, we undertook an immunohistochemical analysis of human glia, glioma tissues and cell cultures of glial tumors to characterize the expression of Trk family 9797000 Human
trkb malignant astrocytomas In six primary cell cultures, one derived from human astrocytes and five established from malignant astrocytomas, only TrkA immunoreactivity could be detected, while TrkB (both full-length and truncated isoforms) and TrkC were absent. 9797000 Human
trkb human neuroblastoma Functional nerve growth factor (NGF) responsiveness was investigated in human neuroblastoma (NB) cell lines in vitro and retinoic acid (RA) was found to transcriptionally enhance expression of the trkA, but not the trkB gene in GOTO cells, while the rever 9811468 Human
trkb tumors Conversely, truncated TrkB is expressed predominantly in differentiated tumors. 9049830 Human
trkb mast-cell leukemia We now report the identification of mRNA transcripts of full-length tyrosine kinase-containing trkA, trkB, and trkC neurotrophin receptor genes in HMC-1 human mast cell leukemia cells. 9292513 Human
trkb tumors Expression of TrkA correlates with favorable outcome, while expression of full-length TrkB is associated with unfavorable, more aggressive, N-myc amplified tumors. 8552397 Human
trkb tumors Because BDNF and TrkB are expressed in many poor-prognosis neuroblastoma (NB) tumors, we evaluated the role of BDNF in affecting sensitivity to chemotherapeutic agents. 8706017 Human
trkb c6 glioma Here, we report that 1,25-(OH)2D3 does not influence the expression of truncated or full-length forms of trkB and trkC receptors mRNAs in primary cultures of astrocytes and in C6 glioma cells. 8883959 Rat
trkb benign prostatic hyperplasia In this context, a pan-Trk antibody that recognizes all of the members of the Trk receptor family (TrkA, TrkB, and TrkC) specifically localized expression of the Trk receptor to the epithelial component of normal prostate tissue, benign prostatic hyperpla 7828539 Human
trkb tumors A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. 7712490 Human
trkb tumor Immunocytochemistry was utilized to evaluate TrkA, TrkB, and TrkC protein expression at the cellular level in the developing human fetal sympathetic nervous system and in a selection of neuroblastoma tumor specimens. 7604872 Human
trkb tumor TrkB expression was primarily localized to cells within the fibrovascular tumor stroma. 7604872 Human
trkb human neuroblastoma Selective regulation of TrkA and TrkB receptors by retinoic acid and interferon-gamma in human neuroblastoma cell lines. 7559588 Human
trkb human neuroblastoma Human neuroblastoma (NB) cell lines constitutively express low levels of TrkA mRNA, while TrkB mRNA is not readily detectable. 7559588 Human
trkb mouse neuroblastoma In this study, we show that stable expression of the c-erbA proto-oncogene, which encodes the alpha 1-isoform of the nuclear receptor for thyroid hormone (Tr alpha 1) induces the expression of trkB mRNA with a concomitant decrease to undetectable levels o 8134111 Mouse
trkb human neuroblastoma Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. 8394722 Human
trkb c6 glioma Expression of p75NGFR TrkA, and TrkB mRNA in rat C6 glioma and type I astrocyte cultures. 1279189 Rat
trkb rat glioma Using a quantitative reverse transcription-polymerase chain reaction (RT-PCR) we have investigated the expression of the neurotrophin receptors p75NGFR, trkA, and trkB mRNAs in cultures of rat pup type I astrocytes and in the C6 rat glioma cell line. 1279189 Rat
trkb human neuroblastoma Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. 12808116 Human
trkb tumors Expression of full-length trkB can be found in some highly malignant neuroblastoma tumors with an amplified MYCN gene. 12808116 Human
trkb tumors In this study we show that trkB was expressed in two out of five neuroblastoma tumors with amplified MYCN, while no trkB expression was observed when the MYCN gene was overexpressed in a non-MYCN-amplified neuroblastoma cell line. 12808116 Human
ntrk2 hepatocellular carcinomas By using HBV-Alu PCR, we have now isolated, from nine hepatocellular carcinomas, nine HBV-DNA integration sites showing that the viral genome mutates key regulatory cellular genes: neurotropic tyrosin receptor kinase 2 (NTRK2) gene, IL-1R-associated kinas 12813464 Human
trkb tumorigenesis Overexpression of TrkB is often correlated with the tumorigenesis, angiogenesis and drug resistance in these malignancies, contributing significantly to the metastasis and aggressive phenotype of these poor prognosis tumors. 17008023 Human
trkb metastasis Overexpression of TrkB is often correlated with the tumorigenesis, angiogenesis and drug resistance in these malignancies, contributing significantly to the metastasis and aggressive phenotype of these poor prognosis tumors. 17008023 Human
trkb neuroblastoma Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death. 16778834 Human
trkb tumors Chemoresistance and increased expression of TrkB and brain-derived neurotrophic factor (BDNF) are biomarkers of poor prognosis in tumors from patients with neuroblastoma (NB). 16778834 Human
trkb neuroblastoma Chemoresistance and increased expression of TrkB and brain-derived neurotrophic factor (BDNF) are biomarkers of poor prognosis in tumors from patients with neuroblastoma (NB). 16778834 Human
trkb lung adenocarcinoma We showed that human lung adenocarcinomas express TrkA and TrkB, but not TrkC; A549 cells, derived from a human lung adenocarcinoma, express mRNA transcripts encoding nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), TrkA, TrkB, and p75 16862449 Human
trkb lung adenocarcinomas We showed that human lung adenocarcinomas express TrkA and TrkB, but not TrkC; A549 cells, derived from a human lung adenocarcinoma, express mRNA transcripts encoding nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), TrkA, TrkB, and p75 16862449 Human
trkb carcinoma Neurotrophic receptor TrkB: Is it a predictor of poor prognosis for carcinoma patients? 17008023 Human
trkb metastasis However, accumulating evidences implies that TrkB signal pathway may also be involved in a variety of human cancers, in which TrkB is likely to play a role in initiation and metastasis of carcinomas. 17008023 Human
trkb carcinomas However, accumulating evidences implies that TrkB signal pathway may also be involved in a variety of human cancers, in which TrkB is likely to play a role in initiation and metastasis of carcinomas. 17008023 Human
trkb cancers However, accumulating evidences implies that TrkB signal pathway may also be involved in a variety of human cancers, in which TrkB is likely to play a role in initiation and metastasis of carcinomas. 17008023 Human
trkb multiple myeloma The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb tumor The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb tumors Overexpression of TrkB is often correlated with the tumorigenesis, angiogenesis and drug resistance in these malignancies, contributing significantly to the metastasis and aggressive phenotype of these poor prognosis tumors. 17008023 Human
trkb haematological malignancies The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
ntrk2 prostate cancer Bisulfite sequencing revealed that 2 regions of NTRK2 as well as MFPC7 and MFPC8 were aberrantly methylated in prostate cancer cell lines, and COBRA showed that 48 (76.24%), 37 (58.7%) and 14 (22.2%) of 63 prostate cancer tissues were methylated, respecti 15386391 Human
ntrk2 prostate cancer For NTRK2, mRNA expression was negative in prostate cancer cell lines (LNCaP and DU145) but was recovered on a methyltransferase inhibitor (5-Aza-CdR) treatment. 15386391 Human
trkb phaeochromocytoma Cell monolayers of fibroblasts transfected to express either the TrkA or TrkB receptor reduced neurite outgrowth of phaeochromocytoma PC12 cells by 50-60% when compared to mock transfected fibroblasts or fibroblasts transfected with the epidermal growth f 7582119 Human
trkb medulloblastomas As neurotrophins play a role in regulating differentiation, proliferation, and cell death in the normal developing central nervous system, and recent evidence suggests that neurotrophins may influence the behavior of medulloblastomas, we studied 29 PNET b 8774147 Human
trkb pnet As neurotrophins play a role in regulating differentiation, proliferation, and cell death in the normal developing central nervous system, and recent evidence suggests that neurotrophins may influence the behavior of medulloblastomas, we studied 29 PNET b 8774147 Human
trkb pnet Additional immunohistochemical studies of a subset of these PNETs using antibodies to neurotrophins that primarily activate TrkB and TrkC, ie, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, showed that immunoreactive brain-derive 8774147 Human
trkb medulloblastomas TrkA, TrkB, and TrkC were observed in 5 (25%), 8 (40%), and 17 (85%), respectively, of these medulloblastomas while NGF, BDNF, and NT-3 were observed in 6 (30%), 8 (40%), and 3 (15%), respectively, and antibodies to neurofilament (NF) and glial fibrillary 9560008 Human
trkb medulloblastomas Finally, this study also suggests that BDNF and NT-3 may act in a paracrine or autocrine manner through TrkB and TrkC receptors, respectively, to induce neuronal differentiation in medulloblastomas. 9560008 Human
trkb neoplasia The role of the neurotrophins (NTs) and their corresponding receptors (NTRs) TrkA, TrkB, TrkC, and p75NTR in neoplasia has received relatively little attention. 10545017 Human
trkb medulloblastoma BACKGROUND: Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain 10994550 Human
trkb phaeochromocytoma METHODS AND RESULTS: Light microscopy immunohistochemistry associated with quantitative image analysis was used to study the expression of neurotrophins (nerve growth factor, brain-derived neurotrophic factor and neurotrophin (NT)-3) and their cognate rec 10217562 Human
trkb tumor PATIENTS AND METHODS: To study the role of the neurotrophin-receptor TrkB in nephroblastoma/Wilms' Tumor (WT), we determined TrkB mRNA expression by semiquantitative duplex RT-PCR in 39 primary WT. 11528553 Human
trkb necrosis We report that chronic ethanol intake during gestation and lactation enhances natural cell death and induces cell necrosis, decreases BDNF levels, and increases the ratio of the truncated to full-length TrkB mRNA receptors during postnatal developing cere 11948666 Human
trkb necrosis TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture. 13678672 Human
trkb necrosis In contrast, trkB antisense oligonucleotides and inhibitors of Trk tyrosine kinase blocked BDNF-triggered neuronal death as well as BDNF potentiation of iron-induced oxidative neuronal necrosis, suggesting a critical role for TrkB in this phenomenon. 13678672 Human
trkb necrosis These results suggest that TrkB plays an important role in BDNF-mediated neuronal necrosis. 13678672 Human
trkb cutaneous squamous cell carcinomas Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas. 15209791 Human
trkb basal-cell carcinoma OBJECTIVE: The objective was to evaluate neural cell adhesion molecule, nerve growth factor, TrkA, TrkB, TrkC, and p75(NGFR) expression when perineural invasion occurs in basal cell carcinoma and cutaneous squamous cell carcinoma. 15209791 Human
trkb cutaneous squamous cell carcinoma OBJECTIVE: The objective was to evaluate neural cell adhesion molecule, nerve growth factor, TrkA, TrkB, TrkC, and p75(NGFR) expression when perineural invasion occurs in basal cell carcinoma and cutaneous squamous cell carcinoma. 15209791 Human
trkb basal-cell carcinomas METHODS: Four basal cell carcinomas and five cutaneous squamous cell carcinomas that were perineural invasion-positive and four basal cell carcinomas and three cutaneous squamous cell carcinomas that were perineural invasion-negative were evaluated for th 15209791 Human
trkb cutaneous squamous cell carcinomas METHODS: Four basal cell carcinomas and five cutaneous squamous cell carcinomas that were perineural invasion-positive and four basal cell carcinomas and three cutaneous squamous cell carcinomas that were perineural invasion-negative were evaluated for th 15209791 Human
trkb metastasis Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. 15329723 Human
trkb large tumour Consistent with the ability of TrkB to suppress anoikis, metastases--whether small vessel infiltrates or large tumour nodules--contained very few apoptotic cells. 15329723 Human
trkb metastases Consistent with the ability of TrkB to suppress anoikis, metastases--whether small vessel infiltrates or large tumour nodules--contained very few apoptotic cells. 15329723 Human
trkb human tumours These observations demonstrate the potent oncogenic effects of TrkB and uncover a specific pro-survival function that may contribute to its metastatic capacity, providing a possible explanation for the aggressive nature of human tumours that overexpress T 15329723 Human
trkb liver metastasis RESULTS: Our findings showed that TrkB was overexpressed in the highly metastatic Colo357L3.6pl cells, which correlated with perineural invasion (P = 0.026), positive retroperitoneal margin (P = 0.0005), and shorter latency to development of liver metasta 15701826 Human
trkb metastasis CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical f 15701826 Human
trkb pancreatic cancer CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical f 15701826 Human
trkb pancreatic cancer Our results also imply that TrkB receptor may be a novel therapeutic target for pancreatic cancer. 15701826 Human
trkb tumors Patients whose neuroblastoma tumors express high levels of brain-derived neurotrophic factor (BDNF) and TrkB have an unfavorable prognosis. 15781614 Human
trkb tumors Expression levels of TrkA/TrkB are important prognostic factors in a variety of embryonal tumors including neuroblastoma, the most common solid tumor of childhood. 15654083 Human
trkb human neuroblastoma To identify these effectors by analyzing biological effects of TrkA and TrkB activation in a defined model, we performed a proteome study using the human neuroblastoma SY5Y cell line stably transfected with the TrkA or TrkB cDNA. 15654083 Human
trkb tumor Therefore, ShcC seems to be associated with an aggressive tumor phenotype, perhaps by enhancing TrkB signals. 15867224 Human
trkb myeloma A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. 15657181 Human
trkb tumor As BDNF and TrkB are expressed by osteoblasts, stromal cells, and endothelial cells within the BM microenvironment, a BDNF-TrkB axis may be critical to the interactions of MM with bone and stroma that contribute to MM tumor progression. 15657181 Human
trkb metastasis The Neurotrophic Receptor TrkB in Anoikis Resistance and Metastasis: A Perspective. 16103047 Human
trkb cancer Here, we discuss our findings within the context of the proposed role of TrkB in human malignancies and address the question of its feasibility as a target for cancer therapy. 16103047 Human
trkb hodgkin lymphoma The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb metastasis In summary, besides its role in development and function of nervous system, TrkB is likely to also play a role in initiation and metastasis of carcinoma although it still remains to be further investigated and confirmed. 17008023 Human
trkb carcinoma In summary, besides its role in development and function of nervous system, TrkB is likely to also play a role in initiation and metastasis of carcinoma although it still remains to be further investigated and confirmed. 17008023 Human
ntrk2 colorectal cancer To further explore these mutations, we examined all reported mutations of NTRK3, FES, KDR, EPHA3, NTRK2, JAK1, PDGFRA, EPHA7, EPHA8, ERBB4, FGFR1, MLK4 and GUCY2F genes in the 24 colorectal cancer cell lines. 17016444 Human
trkb neuroblastoma We suggest that excess TrkB stimulation of sympathoblasts in vivo may lead to the genesis of neuroblastoma. 17309801 Human
trkb metastatic tumors Emerging data have suggested that TrkB may be a mediator as well as a marker of carcinogenesis and metastasis, therefore TrkB may be used as a valuable target for cancer therapy especially for the metastatic tumors with poor prognosis. 17008023 Human
trkb cancer Emerging data have suggested that TrkB may be a mediator as well as a marker of carcinogenesis and metastasis, therefore TrkB may be used as a valuable target for cancer therapy especially for the metastatic tumors with poor prognosis. 17008023 Human
trkb carcinogenesis Emerging data have suggested that TrkB may be a mediator as well as a marker of carcinogenesis and metastasis, therefore TrkB may be used as a valuable target for cancer therapy especially for the metastatic tumors with poor prognosis. 17008023 Human
trkb metastasis Emerging data have suggested that TrkB may be a mediator as well as a marker of carcinogenesis and metastasis, therefore TrkB may be used as a valuable target for cancer therapy especially for the metastatic tumors with poor prognosis. 17008023 Human
trkb pheochromocytoma PC12 cells, a rat pheochromocytoma cell line, and dissociated rat sympathetic neurons showed both trkA and p75, but not trkB or trkC. 8325866 Rat
trkb pancreas cancer The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb pheochromocytoma A clonal deoxyribonucleic acid (cDNA) clone of mouse trkB was expressed in cells of the rat PC12 pheochromocytoma cell line. 8911685 Mouse
trkb pheochromocytoma A clonal cell line stably expressing trkB (TrkB/ PC12) was established from rat pheochromocytoma PC12 cells. 9048737 Rat
trkb mast cell leukemia We now report the identification of mRNA transcripts of full-length tyrosine kinase-containing trkA, trkB, and trkC neurotrophin receptor genes in HMC-1 human mast cell leukemia cells. 9292513 Human
trkb dnt We have examined the immunohistochemical expression of BDNF, full-length TrkB receptor and the NMDAR subunit 1 and subunit 2A/B proteins (NMDAR1 and NMDAR2A/B) in glioneuronal tumors (gangliogliomas, GG, n = 40; dysembryoplastic neuroepithelial tumors, DN 11355310 Human
trkb tumor Expression of TrkB on aggressive neuroblastomas leads to proliferation and survival of the tumor cells and is associated with an unfavorable prognosis. 11528553 Human
trkb nephroblastoma PATIENTS AND METHODS: To study the role of the neurotrophin-receptor TrkB in nephroblastoma/Wilms' Tumor (WT), we determined TrkB mRNA expression by semiquantitative duplex RT-PCR in 39 primary WT. 11528553 Human
trkb wilms' tumor PATIENTS AND METHODS: To study the role of the neurotrophin-receptor TrkB in nephroblastoma/Wilms' Tumor (WT), we determined TrkB mRNA expression by semiquantitative duplex RT-PCR in 39 primary WT. 11528553 Human
trkb tumors Conversely, children with tumors expressing high mRNA levels of a functionally inactive truncated TrkB receptor (TrkBtrunc) had a significantly higher 5-year overall survival rate in comparison to patients with low levels of TrkBtrunc (100 % versus 68 %, 11528553 Human
trkb small cell lung cancers A faint BDNF and TrkB immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. 11694449 Human
trkb squamous cell carcinomas A faint BDNF and TrkB immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. 11694449 Human
trkb basal cell carcinoma OBJECTIVE: The objective was to evaluate neural cell adhesion molecule, nerve growth factor, TrkA, TrkB, TrkC, and p75(NGFR) expression when perineural invasion occurs in basal cell carcinoma and cutaneous squamous cell carcinoma. 15209791 Human
trkb basal cell carcinomas METHODS: Four basal cell carcinomas and five cutaneous squamous cell carcinomas that were perineural invasion-positive and four basal cell carcinomas and three cutaneous squamous cell carcinomas that were perineural invasion-negative were evaluated for th 15209791 Human
trkb dnt Glial cells with astrocytic morphology showed predominantly IR for trkA in FCD and GG specimens, whereas oligodendroglial-like cells in DNT showed predominently IR for trkB. 15375667 Human
trkb multiple myeloma (mm) In order to explore the molecular mechanism of arsenic trioxide treating multiple myeloma (MM) via inhibition of angiogenesis, the expression of brain derived neurotrophic factor (BDNF) and its specific receptor TrkB in human MM cell line KM3 and endothel 16711005 Human
trkb ovarian cancer Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation. 16964397 Human
trkb ovarian cancer Collectively, our data indicate that EGFR and TrkB crosstalk each other in response to EGF and BDNF, leading to cell survival pathway activation in ovarian cancer cells. 16964397 Human
trkb solid tumors The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb malignancy The evidences to show the significant contribution of TrkB to malignancy not only came from solid tumors such as neoblastoma, pancreas cancer, Wilm's tumor and hepatocarcinoma, but also came from haematological malignancies such as Hodgkin lymphoma a 17008023 Human
trkb c cell hyperplasia Only a subset of normal C cells expresses trk family receptors, but, in C cell hyperplasia, the affected cells consistently express trkB, with variable expression of trkA and trkC. 10200298 Human
trkb primitive neuroectodermal brain tumors (pnet) BACKGROUND: Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain 10994550 Human
trkb tumour Immunostaining and real-time RT-PCR analysis of tumour specimens demonstrated coordinated expression of TrkB and HGF/c-Met in experimental and primary neuroblastomas. 16051641 Human
trkb carcinoid Contrarily to the BDNF/TrkB, expression of the NGF/TrkA signaling may overcome aggressiveness of carcinoid cells. 16338793 Human
trkb myeloma METHODS: Transcription and protein expression of BDNF and its receptors (TrkB and P75(NTR)) in human myeloma cell lines (HMCLs) was determined with RT-PCR and Western blotting. 16409727 Human
trkb myeloma The expression of BDNF and TrkB by myeloma cells was studied with immunohistochemistry in bone marrow biopsy samples from 15 patients with MM. 16409727 Human
trkb myeloma BDNF expression by myeloma cells was demonstrated in 12 of the 15 patients with MM (80%), TrkB expression was demonstrated in all the 15 patients (100%), whereas control bone marrow samples showed weaker expression of BDNF in 2 of 9 (22.2%) and TrkB in 4 16409727 Human
trkb metastasis Increasing evidence implies altered signaling through the neurotrophic receptor tyrosine kinase TrkB in promoting tumor formation and metastasis. 16568244 Human
trkb tumor Increasing evidence implies altered signaling through the neurotrophic receptor tyrosine kinase TrkB in promoting tumor formation and metastasis. 16568244 Human
trkb cancers TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti 16568244 Human
trkb pancreatic ductal adenocarcinomas TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti 16568244 Human
trkb tumor TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti 16568244 Human
trkb metastasis In view of its predicted contribution to tumorigenicity and metastasis in humans, TrkB corresponds to a potential drug target, and preclinical models have already been established. 16568244 Human
trkb tumor The encouraging results of pharmacological Trk inhibitors in tumor xenograft models suggest that TrkB inhibition may represent a promising novel anti-tumor therapeutic strategy. 16568244 Human
trkb cancer Here, we will discuss the latest developments on TrkB in these contexts as well as highlight some critical questions that remain to be addressed for evaluating TrkB as a therapeutic target in cancer. 16568244 Human
trkb multiple myeloma Curcumin interrupts the interaction between multiple myeloma cells and endothelial cells by reducing TrkB expression in endothelial cells and inhibiting BDNF production in multiple myeloma cells, eventually, resulting in inhibition of angiogenesis. 16584595 Human
trkb tumors Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expres 16618748 Human
trkb tumor These data indicate that BDNF plays a role in regulating VEGF levels in neuroblastoma cells and that targeted therapies to BDNF/TrkB, PI3K, mTOR signal transduction pathways, and/or HIF-1alpha have the potential to inhibit VEGF expression and limit neurob 16618748 Human
trkb myeloma Previous study defined a brain-derived neurotrophic factor-tyrosine kinase receptor B (BDNF/TrkB) axis in myeloma and autocrine growth stimulation by BDNF in various tumor cells. 16875931 Human
trkb tumor Previous study defined a brain-derived neurotrophic factor-tyrosine kinase receptor B (BDNF/TrkB) axis in myeloma and autocrine growth stimulation by BDNF in various tumor cells. 16875931 Human
trkb myeloma Together, our data indicate that BDNF is a potent myeloma growth and chemotactic factor and suggest that the BDNF/TrkB pathway is a potential therapeutic target in MM. 16875931 Human
trkb neuroblastoma Immunocytochemistry was utilized to evaluate TrkA, TrkB, and TrkC protein expression at the cellular level in the developing human fetal sympathetic nervous system and in a selection of neuroblastoma tumor specimens. 7604872 Human
trkb neuroblastoma A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. 7712490 Human
trkb neuroma After crush, section or neuroma formation of the sciatic nerve, the proportion of trkB-positive cells was 64.5%, 58% and 61.9%, respectively. 7820673 Rat
trkb adenocarcinoma In this context, a pan-Trk antibody that recognizes all of the members of the Trk receptor family (TrkA, TrkB, and TrkC) specifically localized expression of the Trk receptor to the epithelial component of normal prostate tissue, benign prostatic hyperpla 7828539 Human
trkb neuroblastoma Unliganded c-erbA/thyroid hormone receptor induces trkB expression in neuroblastoma cells. 8134111 Human
trkb neuroblastoma In this study, we show that RA treatment of neuroblastoma cells induces the expression of TrkB, the receptor for the neurotrophins BDNF, NT-3, and NT-4/5. 8394722 Human
trkb neuroblastoma BDNF addition to RA-treated SH-SY5Y neuroblastoma cells stimulated the tyrosine phosphorylation of TrkB and neuronal differentiation. 8394722 Human
trkb neuroblastoma RA treatment of KCNR neuroblastoma cells, which constitutively express BDNF mRNA, resulted in the expression of TrkB and differentiation in the absence of added BDNF. 8394722 Human
trkb neuroblastoma Finally, in 15N neuroblastoma cells, which express BDNF mRNA but do not differentiate in response to RA, RA induced only a truncated form of TrkB. 8394722 Human
trkb neuroblastoma Expression of low-affinity NGF receptor and trkB mRNA in human SH-SY5Y neuroblastoma cells. 8397102 Human
trkb neuroblastomas Human neuroblastomas have been found to express the neurotrophin receptors TrkA and TrkB. 8552397 Human
trkb neuroblastoma Because BDNF and TrkB are expressed in many poor-prognosis neuroblastoma (NB) tumors, we evaluated the role of BDNF in affecting sensitivity to chemotherapeutic agents. 8706017 Human
trkb neuroblastomas Expression of TrkA, TrkB and TrkC in human neuroblastomas. 9049830 Human
trkb leukemia Furthermore, while no expression of trkB and trkC was detected, constitutive expression of nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 could be detected in leukemia cells. 9175086 Human
trkb neuroblastoma To address this issue, we used an in vitro coculture paradigm in which wild-type 3T3 NIH fibroblasts or two different 3T3 cell clones stably expressing trkB-T1 receptors served as monolayer substrates upon which to evaluate the effect of trkB-T1 receptors 9417837 Human
trkb neuroblastoma These results suggest that the inhibitory effect of the trkB-T1 receptors on the nonneuronal cell substrates is selective for neurite outgrowth that is mediated via the trkB-kinase receptors on the neuroblastoma cells. 9417837 Human
trkb oncogenes K252a also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp145trkB and gp145trkC, the products of the other known members of the trk gene family, trkB and trkC. 1312698 Human
trkb oncogene A cDNA for a putative PTK, trkB, was cloned, and its sequence indicates that it is likely to be derived from a gene for a ligand-regulated receptor closely related to the human trk oncogene. 1846020 Human
trkb oncogene These antibodies bind to the extracellular domain of the human trk proto-oncogene product and demonstrate no cross-reactivity to the trk oncogene or murine trkB gene products. 2052359 Human
trkb neuroblastoma Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. 10022810 Mouse
trkb neuroblastoma We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. 10022810 Human
trkb neuroblastoma Up-regulation of insulin-like growth factor-II expression is a feature of TrkA but not TrkB activation in SH-SY5Y neuroblastoma cells. 10550322 Human
trkb neuroblastomas The types of neurotrophin receptors that are expressed in neuroblastomas have different prognostic implications; trkA is a marker of good prognosis, whereas trkB expression is associated with poor prognosis. 10550322 Human
trkb neuroblastoma Although trkA and trkB expression is associated with different prognoses in neuroblastoma, our study indicates that the effects mediated by these receptors in vivo may be quite similar for certain subsets of neuroblastomas. 10550322 Human
trkb neuroblastomas Although trkA and trkB expression is associated with different prognoses in neuroblastoma, our study indicates that the effects mediated by these receptors in vivo may be quite similar for certain subsets of neuroblastomas. 10550322 Human
trkb neuroblastoma We tested whether brain derived neurotrophic factor (BDNF) protects neuroblastoma (NB) cells from cytotoxic agents using a model NB cell line, NB 1643, which expresses functional tropomyosin related kinase B (TRKB) following treatment with all-trans-retin 10728907 Human
trkb neuroblastoma Relative quantitative RT-PCR protocol for TrkB expression in neuroblastoma using GAPD as an internal control. 10769746 Human
trkb burkitt lymphoma In order to define a cellular model suitable for studying, in vitro, the molecular properties and functions of neurotrophin receptors in human lymphocytes, TrkA, TrkB, TrkC and p75(NTR) expression was investigated in a panel of EBV immortalized lymphoblas 10903808 Human
trkb neuroblastoma Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma. 10994551 Human
trkb neuroblastomas High expression of the neurotrophin receptor TrkA in neuroblastomas (NB) is associated with favorable prognosis, whereas TrkB is expressed on aggressive, MYCN-amplified NB. 11107119 Human
trkb neuroblastoma The function of the truncated TrkB isoforms is unclear and to gain insights into their function, we have isolated a protein from 15N neuroblastoma cells that specifically binds the TrkB.T1 isoform. 11162451 Human
trkb primary tumors As previously we had reported, over 80% of the primary tumors expressed either the full-length form of BDNF receptor, TRKB, or a truncated form of TRKB lacking the tyrosine kinase domain. 11166915 Human
trkb neuroblastomas These results suggest that an autocrine and/or paracrine mechanism involving BDNF may stimulate signal transduction via TRKB receptors rich in neuroblastomas with unfavorable biologies, resulting in an aberrant survival of tumor cells. 11166915 Human
trkb neuroblastoma We conclude that the BDNF/trkB pathway plays an important role in neuroblastoma survival and speculate on a possible role in tumor pathogenesis. 11340642 Human
trkb neuroblastoma Effect of CEP-751 (KT-6587) on neuroblastoma xenografts expressing TrkB. 11464878 Human
trkb neuroblastomas CONCLUSIONS: These data suggest that the effect of CEP-751 is due, at least in part, to its inhibition of TrkB kinase, and that CEP-751 may become a useful therapeutic tool for the treatment of aggressive neuroblastomas, which often express TrkB. 11464878 Human
trkb neuroblastoma [Expression of the neurotrophin-receptor TrkB predicts outcome in nephroblastomas: results of a pilot-study] BACKGROUND: The neurotrophin-receptor TrkB plays an important role in pathogenesis, biology and prognosis of neuroblastoma. 11528553 Human
trkb neuroblastomas Expression of TrkB on aggressive neuroblastomas leads to proliferation and survival of the tumor cells and is associated with an unfavorable prognosis. 11528553 Human
trkb tumors RESULTS: The 5-year overall survival was significantly worse for patients with tumors expressing high levels of a functional TrkB-receptor (TrkBfull) in comparison to patients with low levels of TrkBfull (70 % versus 100 %, p=0.005). 11528553 Human
trkb neuroblastoma In this study, we present evidence that brain-derived neurotrophic factor (BDNF) modulates, in a dose- and time-dependent fashion, APP promoter activity in SH-SY5Y neuroblastoma cells transiently expressing the receptor TrkB. 11677255 Human
trkb adenocarcinomas A faint BDNF and TrkB immunoreactivity was documented in adenocarcinomas, squamous cell carcinomas, and small cell lung cancers. 11694449 Human
trkb neuroblastomas High expression of the neurotrophin receptor TrkA in neuroblastomas (NBs) is associated with a favorable prognosis, whereas TrkB is mainly expressed on aggressive, MYCN-amplified NBs. 11912158 Human
trkb neuroblastoma We report here that BDNF regulates the cell surface levels of transfected or endogenously expressed full-length TRKB, depending on the exposure time in neuroblastoma cells and primary hippocampal neurons. 12202482 Human
trkb neuroblastomas Resistance to chemotherapy mediated by TrkB in neuroblastomas. 12438236 Human
trkb neuroblastomas Favorable neuroblastomas usually express TrkA, the receptor for nerve growth factor (NGF), whereas unfavorable, MYCN-amplified neuroblastomas usually express TrkB and its ligand, brain-derived neurotrophic factor (BDNF). 12438236 Human
trkb neuroblastoma Here, we provide evidence that the TrkB-BDNF pathway is associated with enhanced survival and resistance to chemotherapy in neuroblastoma. 12438236 Human
trkb neuroblastoma We transfected the neuroblastoma line SH-SY5Y, which has endogenous expression of BDNF, with a full-length TrkB expression vector, and obtained clones with moderate or high levels of expression. 12438236 Human
trkb neuroblastomas These results show that the TrkB-BDNF pathway provides a survival advantage when exposed to DNA-damaging reagents, and, therefore, this autocrine pathway may play an important role in mediating the drug-resistant phenotype associated with TrkB-expressing 12438236 Human
trkb neuroblastomas Activation of PI3K/AKT survival pathway may contribute to the increased drug resistance in TrkB-expressing neuroblastomas. 12438236 Human
trkb neuroblastoma Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. 12438277 Human
trkb neuroblastoma Neuroblastoma (NB) tumors expressing high levels of brain-derived neurotrophic factor (BDNF) and TrkB are associated with poor 5-year survival outcomes. 12438277 Human
trkb neuroblastoma Cisplatin-induced cytotoxicity is blocked by brain-derived neurotrophic factor activation of TrkB signal transduction path in neuroblastoma. 12691830 Human
trkb neuroblastoma METHOD: We analyzed eight different neuroblastoma cell lines for the expression of BDNF and its receptor trkB. 12700894 Human
trkb neuroblastoma Expression of full-length trkB can be found in some highly malignant neuroblastoma tumors with an amplified MYCN gene. 12808116 Human
trkb neuroblastomas This contrasts sympathetic neuroblasts, from which neuroblastomas are thought to arise, which neither express trkB nor are dependent on the p145(trkB) ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin-4/5, for their normal development. 12808116 Human
trkb neuroblastoma In this study we show that trkB was expressed in two out of five neuroblastoma tumors with amplified MYCN, while no trkB expression was observed when the MYCN gene was overexpressed in a non-MYCN-amplified neuroblastoma cell line. 12808116 Human
trkb neuroblastoma This shows that MYCN overexpression per se is not sufficient to induce trkB expression. trkB expression and BDNF responsiveness in neuroblastoma cells can be induced by all-trans-retinoic acid (RA). 12808116 Human
trkb necrosis Furthermore, BDNF did not potentiate neuronal necrosis in cortical cultures prepared from embryonic TrkB-null mice. 13678672 Mouse
trkb neuroblastoma It is hoped that the quest for molecular markers such as neurotrophin, TrkA, and TrkB will continue to advance the understanding of neuroblastoma. 14680322 Human
trkb neuroblastoma In addition, our studies point towards TrkB-Fc or TrkC-Fc receptor bodies as useful tools to influence the survival of neuroblastoma cells. 15015775 Human
trkb neuroblastoma Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. 15024057 Human
trkb neuroblastoma This observation was validated by the study using a human neuronal cell line expressing inducible TrkB (TB8 neuroblastoma cells). 15145081 Human
trkb oncogenic These observations demonstrate the potent oncogenic effects of TrkB and uncover a specific pro-survival function that may contribute to its metastatic capacity, providing a possible explanation for the aggressive nature of human tumours that overexpress T 15329723 Human
trkb neuroblastomas Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. 15637590 Human
trkb neuroblastoma High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastomas with unfavorable outcome. 15637590 Human
trkb neuroblastomas High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastomas with unfavorable outcome. 15637590 Human
trkb neuroblastoma To gain new insights into the global gene expression program resulting in these divergent biological phenotypes, we stably expressed either TrkA or TrkB in the human SH-SY5Y neuroblastoma cell line. 15637590 Human
trkb neuroblastoma Expression levels of TrkA/TrkB are important prognostic factors in a variety of embryonal tumors including neuroblastoma, the most common solid tumor of childhood. 15654083 Human
trkb solid tumor Expression levels of TrkA/TrkB are important prognostic factors in a variety of embryonal tumors including neuroblastoma, the most common solid tumor of childhood. 15654083 Human
trkb tumor A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. 15657181 Human
trkb neuroblastoma Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. 15781614 Human
trkb neuroblastoma Patients whose neuroblastoma tumors express high levels of brain-derived neurotrophic factor (BDNF) and TrkB have an unfavorable prognosis. 15781614 Human
trkb neuroblastoma In this study, we examined whether Akt is required and sufficient to mediate BDNF/TrkB protection of neuroblastoma cells from chemotherapy. 15781614 Human
trkb neuroblastoma These results indicate that Akt is a key signaling component by which BDNF activation of the TrkB signal transduction pathway protects neuroblastoma cells from chemotherapy-induced cell death. 15781614 Human
trkb neuroblastoma Biological effects of TrkA and TrkB receptor signaling in neuroblastoma. 15921851 Human
trkb neuroblastomas High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. 15921851 Human
trkb neuroblastoma This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma. 15921851 Human
trkb neuroblastoma The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. 16051641 Human
trkb oncogene However, amplification of the oncogene MYCN and expression of the neurotrophin receptor TrkB are known to contribute to a highly malignant phenotype. 16051641 Human
trkb neuroblastoma To define the mechanisms through which TrkB may mediate neuroblastoma progression, we stably expressed this receptor in the neuroblastoma cell lines SH-SY5Y and SK-N-AS. 16051641 Human
trkb neuroblastomas Immunostaining and real-time RT-PCR analysis of tumour specimens demonstrated coordinated expression of TrkB and HGF/c-Met in experimental and primary neuroblastomas. 16051641 Human
trkb neuroblastoma We conclude that TrkB expression in neuroblastoma cells results in an increase in their invasive capability via upregulated expression of HGF/c-Met and enhanced activity of proteolytic networks. 16051641 Human
trkb metastatic tumors Upon s.c. inoculation in mice, TrkB-expressing cells formed highly invasive and metastatic tumors. 16103047 Mouse
trkb neuroblastoma Brain-derived neurotrophic factor (BDNF) has been reported to induce APP promoter activity and RA induces expression of the tyrosine kinase receptor B (TrkB) in neuroblastoma cells. 16150056 Human
trkb neuroblastoma Decreased MIF expression was observed after transfection with AS-MIF in neuroblastoma cells and downregulation of MIF expression significantly correlated with decreased expression of N-Myc, Ras, c-Met and TrkB at protein level. 16449971 Human
trkb glioma TrkB-T1 regulates the RhoA signaling and actin cytoskeleton in glioma cells. 16500620 Human
trkb oncogenes During EB culture in BDNF(+) medium, we detected each immunoreactivity associated with the trk proto-oncogenes (trkB; BDNF receptors) and neural crest marker, proto-oncogene tyrosine-protein kinase receptor ret precursor (c-ret), p75, or sox9. 16527901 Human
trkb neuroblastomas TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti 16568244 Human
trkb neuroblastoma Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. 16618748 Human
trkb neuroblastoma Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expres 16618748 Human
trkb neuroblastoma These data indicate that BDNF plays a role in regulating VEGF levels in neuroblastoma cells and that targeted therapies to BDNF/TrkB, PI3K, mTOR signal transduction pathways, and/or HIF-1alpha have the potential to inhibit VEGF expression and limit neurob 16618748 Human
trkb neuroblastoma To further elucidate the interaction between nicotine and BDNF, we examined the effect of nicotine on the proliferation of the neuroblastoma cell line SH-SY5Y, which, following differentiation with retinoic acid, expresses both nicotinic receptors and the 16790237 Human
trkb neuroblastomas Unlike TrkA and TrkB, Ret has never been implicated as a prognostic marker for neuroblastomas. 16849523 Human
trkb neuroma The role of trkB receptor in the formation of post-traumatic neuroma. 17039418 Mouse
trkb neuroma The aim of this work was to examine the role of trkB in post-traumatic neuroma formation. 17039418 Human
trkb neuroma In the majority of trkB-deficient mice, the post-traumatic neuroma was found at the end of the proximal stump of the transected nerve. 17039418 Mouse
trkb neuroma In the gap injury model, in trkB-deficient animals receiving wild-type graft, there was no neuroma at the join site between the graft and distal stump of the nerve. 17039418 Mouse
trkb tumors The recent studies have shown that the levels of tyrosine kinase receptor B (TrkB) and brain-derived neurotrophic factor (BDNF) are high in NB tumors with poor prognosis. 17044982 Human
trkb neuroblastoma The aim of this research was to explore the effects of TrkB and BDNF levels on the chemotherapeutic sensitivity in neuroblastoma by using the NB cell line SH-SY5Y in vitro. 17044982 Human
trkb tumor We observed the following: i) TrkA and TrkB expression was significantly higher in AR-negative compared to AR-positive cells; ii) TrkA and TrkB expression was related to the invasive capacity/malignancy of PCa cells; iii) p75 NGFR could be considered a tu 17143529 Human
trkb malignancy We observed the following: i) TrkA and TrkB expression was significantly higher in AR-negative compared to AR-positive cells; ii) TrkA and TrkB expression was related to the invasive capacity/malignancy of PCa cells; iii) p75 NGFR could be considered a tu 17143529 Human
trkb metastasis In conclusion, the malignancy of PCa seems to be accompanied by increased TrkA and TrkB signaling (with a reduction of p75 NGFR expression) and CEP-701 could be used to reduce the metastasis formation in advanced PCa. 17143529 Human
trkb malignancy In conclusion, the malignancy of PCa seems to be accompanied by increased TrkA and TrkB signaling (with a reduction of p75 NGFR expression) and CEP-701 could be used to reduce the metastasis formation in advanced PCa. 17143529 Human
ntrk2 neuroblastoma High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastomas with unfavorable outcome. 15637590 Human
ntrk2 neuroblastomas High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastomas with unfavorable outcome. 15637590 Human
trkb lymph node metastasis TrkB abnormal expression rate of nasopharyngeal carcinoma with lymph node metastasis was higher than that of NPC without lymph node metastasis (P < 0.05). 17674765 Human
trkb neuroblastomas High expression levels of the neurotrophin receptor TrkB and its ligands in neuroblastomas are associated with an unfavorable outcome. 17374610 Human
trkb neuroblastoma TrkB mRNA and protein levels were elevated nearly 30-fold in neuroblastoma-derived Kelly cells in hypoxia (1% O(2)) versus normoxia (21% O(2)). 17374610 Human
trkb pheochromocytoma Here, we show that TS targets TrkB receptors on TrkB-expressing pheochromocytoma PC12 cells and colocalizes with TrkB receptor internalization and phosphorylation (pTrkB). 17389653 Human
trkb malignancy Herein we report on the effects of oleic acid and of a specific synthetic PPARbeta agonist on cell growth, expression of differentiation markers and on parameters responsible for the malignancy such as adhesion, migration, invasiveness, BDNF, and TrkB exp 17390299 Human
trkb tumorigenesis Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. 17616679 Human
trkb metastasis Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. 17616679 Human
trkb cancer Because TrkB is overexpressed in several aggressive human cancers, first attempts are being made to target TrkB in cancer therapy. 17616679 Human
trkb cancers Because TrkB is overexpressed in several aggressive human cancers, first attempts are being made to target TrkB in cancer therapy. 17616679 Human
trkb oncogenic Although, to date, most attempts to neutralize TrkB in tumors aim to inactivate its kinase activity, it is unclear whether TrkB kinase activity is required for its oncogenic functions. 17616679 Human
trkb tumors Although, to date, most attempts to neutralize TrkB in tumors aim to inactivate its kinase activity, it is unclear whether TrkB kinase activity is required for its oncogenic functions. 17616679 Human
trkb metastasis On the basis of a structure-function analysis, we report that TrkB kinase activity is required and, unexpectedly, also sufficient for anoikis suppression, tumor formation, and experimental metastasis. 17616679 Human
trkb tumor On the basis of a structure-function analysis, we report that TrkB kinase activity is required and, unexpectedly, also sufficient for anoikis suppression, tumor formation, and experimental metastasis. 17616679 Human
trkb cancer These results suggest that targeting the enzymatic activity of TrkB might be beneficial in cancer therapy. 17616679 Human
trkb nasopharyngeal carcinoma [Expression and significance of tyrosine kinase receptors B in nasopharyngeal carcinoma patients] OBJECTIVE: This study was to explore the expression and clinicopathologic features of Tyrosine kinase receptors B (TrkB) and its ligand brain-derived neurotr 17674765 Human
trkb nasopharyngeal carcinoma (npc) [Expression and significance of tyrosine kinase receptors B in nasopharyngeal carcinoma patients] OBJECTIVE: This study was to explore the expression and clinicopathologic features of Tyrosine kinase receptors B (TrkB) and its ligand brain-derived neurotr 17674765 Human
trkb npc METHOD: Immunohistochemistry was adopted to detect the expression level of TrkB and BDNF in NPC patients. 17674765 Human
trkb npc RESULT: Both TrkB and BDNF were expressed in NPC as well as in chronic inflammation. 17674765 Human
trkb npc The active expression rate of TrkB in NPC was 82.5% (47/57) and BDNF was 52.6% (30/57), both of which were higher than those in chronic inflammation (P < 0.05). 17674765 Human
trkb npc The degree of TrkB expression was more marked in T3 + T4, III + IV stage NPC than that in T1 +T2, I + II stage NPC (P < 0.05). 17674765 Human
trkb nasopharyngeal carcinoma TrkB abnormal expression rate of nasopharyngeal carcinoma with lymph node metastasis was higher than that of NPC without lymph node metastasis (P < 0.05). 17674765 Human
trkb npc TrkB abnormal expression rate of nasopharyngeal carcinoma with lymph node metastasis was higher than that of NPC without lymph node metastasis (P < 0.05). 17674765 Human
trkb npc CONCLUSION: The high expression rate of TrkB and BDNF maybe plays an important role in development of NPC. 17674765 Human
trkb metastasis It is suggested that TrkB and its ligand BDNF may act as an important index for forecasting the development and metastasis of NPC. 17674765 Human
trkb npc It is suggested that TrkB and its ligand BDNF may act as an important index for forecasting the development and metastasis of NPC. 17674765 Human
trkb multiple myeloma CONCLUSION: Multiple myeloma cells activated BDNF/TrkB autocrine loops in co-cultured endothelial cells and resulted in endothelial self-activating angiogenesis. 17877199 Human
trkb myeloma BDNF was expressed by the human myeloma cell line RPMI8226 and primary myeloma cells, and TrkB was expressed by human umbilical vein endothelial cells (HUVEC) at the protein levels. 17889702 Human
trkb head and neck cancer Implications of tropomyosin-related kinase B (TrkB) in head and neck cancer. 17970052 Human
trkb hnscc The aim of the present study was to examine the potential role of TrkB in HNSCC disease. 17970052 Human
trkb hnscc RESULTS: A variable but consistent expression of TrkB could be observed in HNSCC tissues and cell lines, whereas no significant expression was seen in the healthy control tissue (soft palate). 17970052 Human
trkb hnscc Immunohisto- and cytochemical staining further demonstrated pronounced TrkB expression in HNSCC tumor cells. 17970052 Human
trkb hnscc However, the invasive properties of TrkB-expressing HNSCC cells were not significantly altered after treatment with 10 or 100 ng/ml brain-derived neurotrophic factor, the natural ligand of TrkB. 17970052 Human
trkb tumor CONCLUSION: The presented data implicates to a great extent that TrkB plays a significant role in HNSCC disease since it was consistently found to be overexpressed in cells of this tumor entity. 17970052 Human
trkb hnscc CONCLUSION: The presented data implicates to a great extent that TrkB plays a significant role in HNSCC disease since it was consistently found to be overexpressed in cells of this tumor entity. 17970052 Human
trkb head and neck cancer Further studies should investigate possible inhibitors of TrkB and their suitability for the treatment of head and neck cancer. 17970052 Human
trkb tumors MATERIAL AND METHODS: In this article we analyzed the expression of NTRK1 (TrkA), NTRK2 (TrkB), NTRK3 (TrkC), and p75NTR in a 102 patient cohort with clinically localized tumors, which had been surgically treated with radical prostatectomy (RP). 17596848 Human
trkb tumors RESULTS: Moderate to strong, granular cytoplasmic immunoreactivity for TrkA, TrkB and TrkC receptors was detected in greater than or equal to 10% of tumor cells in the majority of tumors independently of grade; on the contrary, p75NTR receptor expression 17971243 Human
trkb tumor The endothelium of tumor capillaries showed conspicuous immunoreactivity for TrkB receptor. 17971243 Human
trkb tumor CONCLUSION: In the context of astrocytomas, Trk receptors (TrkA, TrkB, TrkC) expression may promote tumor growth independently of grade. 17971243 Human
trkb astrocytomas CONCLUSION: In the context of astrocytomas, Trk receptors (TrkA, TrkB, TrkC) expression may promote tumor growth independently of grade. 17971243 Human
trkb retinoblastoma PROCEDURE: We analyzed TrkA, TrkB, TrkC, and p75 expression using semi-quantitative RT-PCR in 23 retinoblastomas and 8 retinoblastoma cell lines. 17973327 Human
trkb retinoblastomas PROCEDURE: We analyzed TrkA, TrkB, TrkC, and p75 expression using semi-quantitative RT-PCR in 23 retinoblastomas and 8 retinoblastoma cell lines. 17973327 Human
trkb retinoblastoma Expression of TrkB and its ligand, BDNF, was most pronounced, suggesting TrkB to be the major Trk receptor involved in retinoblastoma biology. 17973327 Human
trkb tumors Patients with a poor prognosis are often resistant to chemotherapy and have tumors that express the neuronal growth/survival factor brain-derived neurotrophic factor and its tyrosine kinase receptor, TrkB. 18020981 Human
trkb tumors In neuroblastoma tumors, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are associated with poor prognosis. 18089706 Human
trkb neuroblastoma In neuroblastoma tumors, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are associated with poor prognosis. 18089706 Human
trkb human ovarian cancer Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. 18201274 Human
trkb benign ovarian tumors To investigate its role in anoikis suppression in human ovarian cancer, we used reverse transcription-polymerase chain reaction and real-time polymerase chain reaction, immunohistochemistry, and western blotting to compare the expression levels of TrkB an 18201274 Human
trkb epithelial ovarian cancers To investigate its role in anoikis suppression in human ovarian cancer, we used reverse transcription-polymerase chain reaction and real-time polymerase chain reaction, immunohistochemistry, and western blotting to compare the expression levels of TrkB an 18201274 Human
trkb human ovarian cancer To investigate its role in anoikis suppression in human ovarian cancer, we used reverse transcription-polymerase chain reaction and real-time polymerase chain reaction, immunohistochemistry, and western blotting to compare the expression levels of TrkB an 18201274 Human
trkb ovarian cancer To investigate its role in anoikis suppression in human ovarian cancer, we used reverse transcription-polymerase chain reaction and real-time polymerase chain reaction, immunohistochemistry, and western blotting to compare the expression levels of TrkB an 18201274 Human
trkb carcinomas TrkB and brain-derived neurotrophic factor were overexpressed in epithelial ovarian cancers, and full-length TrkB was more often overexpressed in high-grade carcinomas and multicellular spheroids in ascites. 18201274 Human
trkb epithelial ovarian cancers TrkB and brain-derived neurotrophic factor were overexpressed in epithelial ovarian cancers, and full-length TrkB was more often overexpressed in high-grade carcinomas and multicellular spheroids in ascites. 18201274 Human
trkb ovarian cancer Our study suggests that TrkB might mediate anoikis suppression by activating the PI3K-AKT pathway in ovarian cancer cells. 18201274 Human
trkb breast cancer The aims of this study were to measure the effect of dieldrin on survival of breast cancer cells and the expression of tyrosine kinase B (TrkB), a suppressor of anoikis (apoptosis triggered by inappropriate anchorage). 18242054 Human
trkb breast carcinoma TrkB was expressed in a subset of high-grade breast carcinoma specimens. 18242054 Human
trkb human breast cancer Our results demonstrate that dieldrin increases resistance to anoikis and expression of TrkB and show for the first time TrkB protein expression in human breast cancer. 18242054 Human
trkb neuroblastoma Retinoic acid (RA)-treatment of neuroblastoma (NB) cells implicates activation of Ret and TrkB RTKs as critical step to induce cell differentiation. 18286198 Human
trkb neuroblastoma [Blocking TrkB-BDNF signal pathway decreases the livability of neuroblastoma cells] OBJECTIVE: Brain-derived neurotrophic factor (BDNF) and its specific tryrosin kinase receptor-B (TrkB) are highly correlated to the chemoresistance of neuroblastoma (NB) c 18289471 Human
trkb adenomas p75 and TrkC neurotrophin receptors demonstrate a different immunoreactivity profile in comparison to TrkA and TrkB receptors in human normal pituitary gland and adenomas. 18319596 Human
trkb adenomas TrkA and TrkB receptors have been previously detected in numerous endocrine cells in human anterior pituitary and adenomas. 18319596 Human
trkb adenomas Furthermore, in the majority of adenomas, independently of type, sex and age, a high percentage of TrkA- and/or TrkB-positive cells was detected. 18319596 Human
trkb bph We observed a high expression of BDNF and TrkB in PC and BPH, though no immuno-reactivity was found for p75. 18357383 Human
trkb prostate cancer These data suggest a possible predictive role for NTs and NTRs, especially for BDNF and TrkB, in the diagnosis and/or management of prostate cancer. 18357383 Human
trkb met RT-PCR and immunohistochemistry on independent cases validated prognostic significance for several genes including RECQL4, FRRS1, CFH and MET - whose combined expression carried greater prognostic value than tumour grade - and cmet and TRKB proteins. 18382428 Human
trkb tumour RT-PCR and immunohistochemistry on independent cases validated prognostic significance for several genes including RECQL4, FRRS1, CFH and MET - whose combined expression carried greater prognostic value than tumour grade - and cmet and TRKB proteins. 18382428 Human
trkb neuroblastoma In the childhood tumor neuroblastoma, high expression of the TrkA neurotrophin receptor is associated with a favorable prognosis and a lack of structural chromosomal changes, whereas TrkB is expressed in aggressive neuroblastomas demonstrating high genomi 18678285 Human
trkb neuroblastomas In the childhood tumor neuroblastoma, high expression of the TrkA neurotrophin receptor is associated with a favorable prognosis and a lack of structural chromosomal changes, whereas TrkB is expressed in aggressive neuroblastomas demonstrating high genomi 18678285 Human
trkb childhood tumor In the childhood tumor neuroblastoma, high expression of the TrkA neurotrophin receptor is associated with a favorable prognosis and a lack of structural chromosomal changes, whereas TrkB is expressed in aggressive neuroblastomas demonstrating high genomi 18678285 Human
trkb human neuroblastoma Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair. 18678285 Human
trkb cancers OBJECTIVE: Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. 18719350 Human
trkb metastases Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). 18719350 Human
trkb gastric carcinoma (gc) Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). 18719350 Human
trkb metastases Both lymph node metastasis (odds ratio = 10.7) and TrkB expression (odds ratio = 9.3) were independent predictors of distant metastases. 18719350 Human
trkb metastases CONCLUSION: A high level of TrkB expression was observed in well-differentiated GC subtypes and is a predictor for distant metastases and prognosis in GC. 18719350 Human
ntrk2 tumors MATERIAL AND METHODS: In this article we analyzed the expression of NTRK1 (TrkA), NTRK2 (TrkB), NTRK3 (TrkC), and p75NTR in a 102 patient cohort with clinically localized tumors, which had been surgically treated with radical prostatectomy (RP). 17596848 Human
ntrk2 esophageal cancer We also detected significant differences in germline allele frequency between the esophageal cohort of our study and normal control samples from the International HapMap Project for 10 genes (CSF1, KIAA1804, IL2, PMS2, IRF7, FLT3, NTRK2, MAP3K9, ERBB2 and 18241037 Human
ntrk2 lung carcinomas A total of 538 primary lung carcinomas, including 17 typical carcinoids (TCs), 10 atypical carcinoids (ACs), 39 small cell lung carcinomas (SCLCs), 29 large cell neuroendocrine carcinomas (LCNECs), and 443 NSCLCs were evaluated by single-strand conformati 18293376 Human
ntrk2 small cell lung carcinomas (sclcs) A total of 538 primary lung carcinomas, including 17 typical carcinoids (TCs), 10 atypical carcinoids (ACs), 39 small cell lung carcinomas (SCLCs), 29 large cell neuroendocrine carcinomas (LCNECs), and 443 NSCLCs were evaluated by single-strand conformati 18293376 Human
ntrk2 large cell neuroendocrine carcinomas A total of 538 primary lung carcinomas, including 17 typical carcinoids (TCs), 10 atypical carcinoids (ACs), 39 small cell lung carcinomas (SCLCs), 29 large cell neuroendocrine carcinomas (LCNECs), and 443 NSCLCs were evaluated by single-strand conformati 18293376 Human
trkb primitive neuroectodermal brain tumors BACKGROUND: Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain 10994550 Human
trkb multiple myeloma In order to explore the molecular mechanism of arsenic trioxide treating multiple myeloma (MM) via inhibition of angiogenesis, the expression of brain derived neurotrophic factor (BDNF) and its specific receptor TrkB in human MM cell line KM3 and endothel 16711005 Human
trkb neuroblastoma Herein we report on the effects of oleic acid and of a specific synthetic PPARbeta agonist on cell growth, expression of differentiation markers and on parameters responsible for the malignancy such as adhesion, migration, invasiveness, BDNF, and TrkB exp 17390299 Human
trkb neuroblastoma Here, we show that RUNX3 abolished mRNA induction of TRKB expression, and concomitantly altered the neurotrophin response in a differentiating neuroblastoma cell line. 17584746 Human
trkb myeloma This study was aimed to further explore whether BDNF/TrkB pathway is a potential therapeutic target in MM, and to elucidate the advantages and disadvantages of two ways developed for human myeloma xenograft in animal models. 17956671 Human
trkb tumor Immunohisto- and cytochemical staining further demonstrated pronounced TrkB expression in HNSCC tumor cells. 17970052 Human
trkb tumor RESULTS: Moderate to strong, granular cytoplasmic immunoreactivity for TrkA, TrkB and TrkC receptors was detected in greater than or equal to 10% of tumor cells in the majority of tumors independently of grade; on the contrary, p75NTR receptor expression 17971243 Human
trkb neuroblastoma Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway. 18020981 Human
trkb neuroblastoma Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells. 18089706 Human
trkb neuroblastoma Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells. 18678285 Human
trkb gastric carcinoma Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). 18719350 Human
ntrk2 small cell lung carcinomas A total of 538 primary lung carcinomas, including 17 typical carcinoids (TCs), 10 atypical carcinoids (ACs), 39 small cell lung carcinomas (SCLCs), 29 large cell neuroendocrine carcinomas (LCNECs), and 443 NSCLCs were evaluated by single-strand conformati 18293376 Human

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