IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GAS1 Ensembl ENSG00000180447 Chromosome 9 Start 88749098 End 88751924
Description Growth arrest-specific protein 1 Precursor (GAS-1) [Source:UniProtKB/Swiss-Prot;Acc:P54826]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4165
     Entrez Gene : 2619
     UCSC : uc004aox.3
     GeneCards : 4165
     RefSeq : NM_002048
     CCDS : CCDS6674.1
     Uniprot : P54826
     Interpro : P54826
     OMIM : 139185
     GeneTests : GAS1
     CGAP : GAS1
     PMID : 8307588

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41839_at  -0.75  5.93e-6  3.25e-5  -0.41  4.14e-2  7.85e-2
 HG_U95  661_at  -0.93  3.32e-7  2.43e-6  -0.59  5.16e-3  1.30e-2
 HG_U133A  204456_s_at  -0.40  3.51e-3  5.90e-3  4.69  9.09e-104  6.86e-103
 HG_U133A  204457_s_at  -1.30  6.94e-11  2.68e-10  1.50  1.33e-20  1.94e-20
 HG_U133_Plus2  204456_s_at  -0.04  8.11e-1  8.57e-1  -0.04  8.31e-1  8.60e-1
 HG_U133_Plus2  204457_s_at  -0.84  1.12e-5  4.26e-5  -0.54  1.36e-2  2.16e-2
 Stanford  19210  -0.43  4.22e-1  6.17e-1  0.03  9.55e-1  9.81e-1
 Stanford  20193  0.05  9.11e-1  9.53e-1  0.47  2.84e-1  5.24e-1
 Agilent_HS_21.6K  12641  -0.16  5.66e-3  2.99e-2  -0.09  1.79e-1  3.17e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204456_s_at  -0.16  7.46e-1  9.74e-1  -0.09  7.78e-1  1.00e+0
 HG_U133A  204457_s_at  0.09  8.87e-1  9.93e-1  0.02  9.68e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41839_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 661_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204456_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204457_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204456_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204457_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19210    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20193    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12641    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
gas1 human neuroblastoma Overexpression of Gas1 in cultured hippocampal neurons and in human neuroblastoma NB69 cells produced a marked reduction in the number of viable cells. 11906213 Human
gas1 cancer Overexpression of gas1 in normal and some cancer cell lines could inhibit G(0)/G(1) transition. 11356029 Human
growth arrest-specific gene 1 tumors In poorly differentiated and locally invasive CaPs and in tumors with unfavorable prognosis or total prostate-specific antigen (PSA) levels > 10.0 ng/ml at diagnosis, an overall increase in the levels of H3 mRNA and a decrease in growth arrest-specific ge 10646846 Human
gas1 tumor Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo. 15056455 Human
gas1 glioma Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo. 15056455 Human
gas1 glioma We recently reported that the targeted expression of growth arrest specific 1 (Gas1) induces apoptosis in glioma cells. 15056455 Human
gas1 c6 glioma We used a retroviral gene transfer system to transduce C6 glioma cells with a transgene in which the expression of a full-length human gas1 cDNA is under the transcriptional control of a human promoter of the glial fibrillary acidic protein (gfa2). 15056455 Rat
gas1 tumor Furthermore, retroviral-mediated transfer of gas1 to gliomas implanted in nude mice induces a significant inhibition of tumor growth, accompanied by increased caspase-3 activation. 15056455 Human
gas1 glioma In the present experiments, we have taken advantage of the property of retrovirus to transfer transgenes exclusively to proliferating cells, together with the use of a glial specific promoter, to selectively target the expression of gas1, a pro-apoptotic 15056455 Human
gas1 human tumor Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines. 9466658 Human
gas1 human tumor To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. 9466658 Human
gas1 tumor To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. 9466658 Human
gas1 tumors When A549 cells were transfected with a dexamethasone-inducible GAS1 plasmid, expression of GAS1 inhibited growth in vitro, and fewer slow-growing tumors arose in nude mice. 9466658 Human
gas1 human tumor Our results show that GAS1 suppresses the growth and tumorigenicity of human tumor cells and overexpression of MDM2 or p53 mutation inhibits the GAS1-mediated growth-suppressing pathway. 9466658 Human
gas1 bladder cancer Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. 8895761 Human
gas1 tumor Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. 8895761 Human
gas1 tumor The growth arrest-specific gene (GAS1), a candidate tumor suppressor gene, was included within the proximal minimal region. 8895761 Human
gas1 bladder cancer We evaluated the GAS1 gene for its potential role in bladder cancer using single-strand conformational polymorphism to screen for mutations in GAS1 in 10 bladder cancer cell lines and 14 primary bladder tumors. 8895761 Human
gas1 bladder cancer GAS1 and PTC do not seem to be frequently mutated in bladder cancer. 8895761 Human
gas1 glioma Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis. 12503088 Human
gas1 neuroblastoma In neurons, it has been recently reported that mild excitotoxic neuronal death is associated with gas1 induction, and that overexpression of Gas1 induces apoptosis in terminally differentiated neurons or in proliferating neuroblastoma cells. 12503088 Human
gas1 rat glioma In the present study, we have analysed the effects of the transcriptionally mediated targeting of gas1 to C6 rat glioma cells. 12503088 Human
gas1 c6 glioma While the identity of the caspase(s) responsible for Gas1-induced apoptosis in neurons has remained elusive, in C6 glioma cells, overexpression of Gas1 reproducibly activated caspase-3. 12503088 Rat
gas1 nevoid-basal-cell-carcinoma syndrome The human growth-arrest-specific gene GAS1 maps outside the candidate region of the gene for nevoid basal cell carcinoma syndrome. 7956349 Human
gas1 nevoid-basal-cell-carcinoma syndrome (nbccs) The human growth-arrest specific gene GAS1 maps to chromosome bands 9q21.3-->q22, the region known to contain the tumour suppressor gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). 7956349 Human
gas1 tumour The human growth-arrest specific gene GAS1 maps to chromosome bands 9q21.3-->q22, the region known to contain the tumour suppressor gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). 7956349 Human
gas1 tumour Because of its putative action as a tumour suppressor gene, the GAS1 gene was analysed as a candidate for the NBCCS gene. 7956349 Human
gas-1 mouse tumours In five chemically-induced mouse tumours grown in vivo the amounts of gas-1 mRNA were largely different but not related to the proliferating activity (evaluated by both H3 histone expression and 3H-thymidine incorporation into DNA). 1379061 Human
gas-1 tumours The amount of gas-1 mRNA in the tumours was in general higher than in normal tissues. 1379061 Human
gas-1 tumours Expression of c-myc was also evaluated and found to be high in tumours which exhibited low gas-1 expression. 1379061 Human
gas-1 fibrosarcomas Two fibrosarcomas, CA-2 and CB-20, with similar phenotype, similar growth rate, different expression of c-myc and 100-fold difference in gas-1 expression were further investigated and gas-1 expression was found to be correlated with the expression of a di 1379061 Human
gas-1 tumour The higher steady state level of gas-1 mRNA in spite of a shorter mRNA half life suggests that in CB-20 cells the gas-1 gene is transcribed faster than in CA-2 cells indicating that transcriptional regulation is the major determinant of gas-1 gene express 1379061 Human
gas-1 tumour The finding of gas-1 expression in tumour cells suggests that its expression is not sufficient to maintain cells into quiescence, however, as a marker specific for the G0 phase, it could be useful, in conjunction with other growth related genes, to define 1379061 Human
gas-1 tumor The growth arrest-specific gene, Gas-1, is preferentially expressed in quiescent NIH3T3 cells and inhibits DNA synthesis, suggesting that Gas-1 may be a tumor suppressor gene. 9597009 Human
gas1 bladder tumors We evaluated the GAS1 gene for its potential role in bladder cancer using single-strand conformational polymorphism to screen for mutations in GAS1 in 10 bladder cancer cell lines and 14 primary bladder tumors. 8895761 Human
gas1 gliomas Our results support the concept of targeted expression of gas1 as a potentially useful gene therapy strategy in the treatment of human gliomas. 12503088 Human
gas1 gliomas Furthermore, retroviral-mediated transfer of gas1 to gliomas implanted in nude mice induces a significant inhibition of tumor growth, accompanied by increased caspase-3 activation. 15056455 Mouse
gas1 tumors Up-regulation of histone H3 and down-regulation of growth arrest-specific gene 1 (Gas1) mRNAs in CaP-developing TRAMP mice demonstrated a high proliferation rate in tumors, while the opposite occurred in the glands of GTC chemoprevented animals. 15358631 Mouse
gas1 papillary carcinoma Four of the genes (CDC6-related protein, CCNC, GAS1 and TFDP2) were decreased in human papillary carcinoma tissues. 15619007 Human
gas1 thyroid papillary carcinoma Relevance of these genes (especially a decrease in GAS1 in thyroid papillary carcinoma) in various malignant pathologies has already been shown. 15619007 Human
growth arrest-specific gene 1 tumors Up-regulation of histone H3 and down-regulation of growth arrest-specific gene 1 (Gas1) mRNAs in CaP-developing TRAMP mice demonstrated a high proliferation rate in tumors, while the opposite occurred in the glands of GTC chemoprevented animals. 15358631 Mouse

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