IGDB.NSCLC Gene View
 
Gene Information        (help)
Not Matched Gene !
Gene PTEN Ensembl   Chromosome Start End  
Description  
 

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
59 5.34 1105 7 1.47 475 13 6.91 188
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
1302807 AD c.375A>T p.K125N Substitution - Missense Unknown 10:89682871-8968287120018398
1302812 AD c.463T>C p.Y155H Substitution - Missense Unknown 10:89682959-8968295920018398
16600 AD c.29G>A p.S10N Substitution - Missense Heterozygous 10:89614235-8961423518948947
16845 AD c.737C>T p.P246L Substitution - Missense Heterozygous 10:89707692-8970769218948947
17172 AD c.640C>T p.Q214* Substitution - Nonsense Heterozygous 10:89707595-8970759518948947
17194 AD c.331T>C p.W111R Substitution - Missense Heterozygous 10:89682827-8968282718948947
Ma3 AD c.?del? p.?fs Deletion - Frameshift Unknown 9598803
1302805 SCC c.493G>T p.G165* Substitution - Nonsense Unknown 10:89701855-8970185520018398
1302806 SCC c.944_945insCT p.L316fs*2 Insertion - Frameshift Unknown 10:89710773-8971077420018398
1302808 SCC c.388C>T p.R130* Substitution - Nonsense Unknown 10:89682884-8968288420018398
1302809 SCC c.540C>G p.Y180* Substitution - Nonsense Unknown 10:89701902-8970190220018398
1302810 SCC c.686C>G p.S229* Substitution - Nonsense Unknown 10:89707641-8970764120018398
1302811 SCC c.388C>G p.R130G Substitution - Missense Unknown 10:89682884-8968288420018398
HF-11785 SCC c.508_508delA p.S170fs*13 Deletion - Frameshift Heterozygous 10:89701870-8970187019962665
HF-15894-(1) SCC c.176C>T p.S59L Substitution - Missense Heterozygous 10:89675261-8967526119962665
HF-7980-(1) SCC c.797_797delA p.K267fs*9 Deletion - Frameshift Heterozygous 10:89707752-8970775219962665
KNS-62 SCC c.1_79del79 p.? Unknown Homozygous  
NCI-H157 SCC c.751G>T p.G251C Substitution - Missense Unknown 10:89707706-897077069598803
PC-10 SCC c.?del? p.?fs Deletion - Frameshift Unknown 9598803
S64211 SCC c.703G>T p.E235* Substitution - Nonsense Unknown 10:89707658-897076589598803

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
down 30/125(24%) IHC- 12006535 Clin Cancer Res. 2002 May;8(5):1178-84.
down 86/117(74%) IHCTumor differentiation(P=0.002)//Tumor stage (SCC)(P=0.02) 16084946 Hum Pathol. 2005 Jul;36(7):768-76.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1434_at  -0.22  4.62e-2  8.64e-2  -0.18  2.00e-1  2.90e-1
 HG_U95  39552_at  -0.54  4.11e-3  1.09e-2  -0.09  6.20e-1  7.10e-1
 HG_U133A  204053_x_at  0.15  1.09e-2  1.70e-2  0.67  6.68e-32  1.15e-31
 HG_U133A  204054_at  -0.67  1.21e-9  4.16e-9  0.91  9.09e-30  1.52e-29
 HG_U133A  211711_s_at  -0.14  3.34e-2  4.80e-2  -4.45  2.01e-103  1.50e-102
 HG_U133A  217492_s_at  0.24  2.39e-4  4.73e-4  -4.41  5.85e-82  2.48e-81
 HG_U133A  222176_at  0.10  4.69e-1  5.23e-1  1.85  9.55e-21  1.40e-20
 HG_U133_Plus2  204053_x_at  -0.06  4.33e-1  5.23e-1  -0.51  3.33e-5  7.93e-5
 HG_U133_Plus2  204054_at  -0.59  3.09e-6  1.29e-5  -1.12  5.51e-9  2.15e-8
 HG_U133_Plus2  211711_s_at  -0.23  4.30e-3  9.63e-3  -0.31  1.25e-2  2.00e-2
 HG_U133_Plus2  217492_s_at  -0.07  3.69e-1  4.59e-1  -0.58  2.62e-6  7.26e-6
 HG_U133_Plus2  222176_at  -1.16  1.37e-8  8.20e-8  -0.92  3.20e-5  7.64e-5
 HG_U133_Plus2  225363_at  -0.32  1.29e-5  4.83e-5  -0.50  1.21e-8  4.51e-8
 HG_U133_Plus2  233254_x_at  -0.98  4.32e-12  4.09e-11  -1.15  1.65e-14  1.22e-13
 HG_U133_Plus2  233314_at  -0.84  3.14e-5  1.10e-4  -1.81  6.79e-15  5.27e-14
 HG_U133_Plus2  240964_at  -0.69  1.55e-5  5.73e-5  -0.93  8.42e-6  2.18e-5
 HG_U133_Plus2  242622_x_at  -0.81  4.18e-7  2.00e-6  -1.60  1.31e-11  6.97e-11
 Stanford  19911  -0.23  2.88e-1  4.91e-1  -0.18  5.37e-1  7.43e-1
 Agilent_HS_21.6K  16109  -0.17  2.03e-2  7.70e-2  -0.23  2.95e-2  8.30e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204053_x_at  -0.35  1.59e-1  8.12e-1  -0.06  7.64e-1  1.00e+0
 HG_U133A  204054_at  -0.49  3.82e-1  8.96e-1  -0.55  1.73e-1  1.00e+0
 HG_U133A  211711_s_at  0.11  6.60e-1  9.62e-1  0.10  7.26e-1  1.00e+0
 HG_U133A  217492_s_at  -0.54  1.81e-2  6.83e-1  -0.21  3.02e-1  1.00e+0
 HG_U133A  222176_at  -0.41  4.50e-1  9.15e-1  -0.19  4.54e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1434_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39552_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204053_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204054_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211711_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217492_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 222176_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204053_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204054_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211711_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217492_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 222176_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225363_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233254_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233314_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 240964_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242622_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19911    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16109    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pten tumor syndromes PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. 15492213 Human
pten intraepithelial neoplasias The present study has assessed the in situ expression of PTEN mRNA and protein in 26 prostate intraepithelial neoplasias (PINs), 58 primary prostate carcinomas, and 15 metastases. 15095479 Human
pten liver cell adenomas Importantly, the loss of Pten function in the liver led to tumorigenesis, with 47% of AlbCrePten(flox/flox) livers developing liver cell adenomas by 44 weeks of age. 15199412 Mouse
pten prostatic intraepithelial neoplasia Ink4a/Arf deficiency reduced tumor-free survival and shortened the latency of neoplasias associated with Pten heterozygosity, specifically pheochromocytoma, prostatic intraepithelial neoplasia, and endometrial hyperplasia. 11818530 Mouse
pten endometrial hyperplasia Ink4a/Arf deficiency reduced tumor-free survival and shortened the latency of neoplasias associated with Pten heterozygosity, specifically pheochromocytoma, prostatic intraepithelial neoplasia, and endometrial hyperplasia. 11818530 Mouse
pten chondrosarcoma PTEN mutation is rare in chondrosarcoma. 11854598 Human
pten chondrosarcoma The authors examined 40 chondrosarcoma tumors and tumor-derived cell lines for alterations in PTEN. 11854598 Human
pten extraskeletal myxoid chondrosarcoma Only one mutation resulting in a truncated PTEN protein was detected, which was in a metastasized extraskeletal myxoid chondrosarcoma. 11854598 Human
pten chondrosarcoma Thus, mutated PTEN is an uncommon event in the development of chondrosarcoma. 11854598 Human
pten hereditary non-polyposis colon cancer Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. 11854177 Human
pten lipomatosis Originally shown to be a major susceptibility gene for both Cowden syndrome (CS), which is characterized by multiple hamartomas and an increased risk of breast, thyroid, and endometrial cancers, and Bannayan-Riley-Ruvalcaba syndrome, which is characterize 11875759 Human
pten endometrial tumors We have investigated the methylation profiles of the promoter region of PTEN in endometrial, breast, and colon cancer cell lines, as well as in a panel of primary endometrial tumors using a combination of methylation-specific polymerase chain reaction, me 11891178 Human
pten mesothelioma We sought to determine whether PTEN overexpression in mesothelioma cells would engender hypophosphorylation of AKT and apoptosis. 11923140 Human
pten mesothelioma CONCLUSIONS: Overexpression of PTEN engenders apoptosis in mesothelioma by AKT hypophosphorylation. 11923140 Human
pten sarcomas PTEN mutations in uterine sarcomas. 11925138 Human
pten sarcomas Since little is known about the molecular pathobiology, our goal was to investigate the potential role of the PTEN gene in the carcinogenesis of uterine sarcomas. 11925138 Human
pten sarcomas RESULTS: Overall 8.5% (4/47) of uterine sarcomas were found to harbor somatic PTEN mutations. 11925138 Human
pten esophageal carcinoma The prognostic importance of PTEN product protein (PTEN) and its correlation with clinicopathologic characteristics have yet to be delineated in patients with esophageal carcinoma. 11932897 Human
pten islet-cell tumors Taken together with our previous observations in thyroid and islet cell tumors, our data suggest that nuclear-cytoplasmic partitioning of PTEN might also play a role in melanoma progression. 11948493 Human
pten cysts A recent study has shown that somatic mutations in the PTEN gene were identified in 20% of endometrioid carcinomas and 20.6% of solitary endometrial cysts, suggesting that inactivation of the PTEN tumor suppressor gene is an early event in the development 11949955 Human
pten chromophobe renal-cell carcinomas (chrcc) We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
mmac1 chromophobe renal-cell carcinomas (chrcc) We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
pten canine osteosarcoma Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. 12014501 Dog
pten bone metastases We also measured IGF1R, IRS-1, and PTEN expression in 12 paired biopsies of primary prostate cancer and subsequent bone metastases. 12019176 Human
pten neuroendocrine neoplasms Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms. 12051632 Human
pten poorly differentiated neuroendocrine carcinomas The authors also study the PTEN expression in NC/NE neoplasms (N = 37), including 5 melanocytic nevi, 2 melanomas, 9 carcinoids, 2 moderately differentiated neuroendocrine carcinomas, 13 poorly differentiated neuroendocrine carcinomas, 2 paragangliomas, 2 12051632 Human
pten medullary-thyroid carcinomas The authors also study the PTEN expression in NC/NE neoplasms (N = 37), including 5 melanocytic nevi, 2 melanomas, 9 carcinoids, 2 moderately differentiated neuroendocrine carcinomas, 13 poorly differentiated neuroendocrine carcinomas, 2 paragangliomas, 2 12051632 Human
pten neuroendocrine carcinomas The authors also study the PTEN expression in NC/NE neoplasms (N = 37), including 5 melanocytic nevi, 2 melanomas, 9 carcinoids, 2 moderately differentiated neuroendocrine carcinomas, 13 poorly differentiated neuroendocrine carcinomas, 2 paragangliomas, 2 12051632 Human
pten poorly differentiated neuroendocrine carcinomas In contrast, the majority of poorly differentiated neuroendocrine carcinomas (7 of 13) were negative for PTEN (54%); the remainder showed diminished reactivity. 12051632 Human
pten medullary-thyroid carcinomas The paragangliomas, pheochromocytomas, medullary thyroid carcinomas, and neuroblastoma all showed a strong PTEN stain. 12051632 Human
pten invasive cancers Reduced PTEN protein expression was seen in 38% of invasive cancers and in 11% of in situ cancers. 12055674 Human
pten hematological malignancies Initial work on cancer cell lines had suggested that PTEN caused every type of cancer because it was reported that a relatively high frequency of a variety of cancer cell lines, whether derived from solid tumors or hematological malignancies, had homozygo 12060605 Human
pten malignant peripheral-nerve-sheath tumors Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors. 12070601 Human
pten benign meningioma The reported patient, in addition to glioma, had suffered from benign meningioma in the past but did not show any clinical signs of Cowden disease or other hereditary diseases typically associated with PTEN germline mutations. 12085208 Human
pten atypical endometrial hyperplasia PTEN and K-ras mutations and MIN are considered early events, occurring in a subset of atypical endometrial hyperplasia, whereas p53 mutation is considered a late event, during progression of about 10-20% of endometrioid carcinomas. 14747944 Human
pten squamous-cell cancer BACKGROUND: Fifty tumor specimens from primarily untreated patients were analyzed to elucidate the involvement of the tumor suppressor gene PTEN/MMAC1 in the development of oral squamous cell cancer. 12110043 Human
mmac1 squamous-cell cancer BACKGROUND: Fifty tumor specimens from primarily untreated patients were analyzed to elucidate the involvement of the tumor suppressor gene PTEN/MMAC1 in the development of oral squamous cell cancer. 12110043 Human
pten squamous-cell cancers CONCLUSIONS: We conclude that PTEN/MMAC1 gene alterations do not play a key role in tumorigenesis of oral squamous cell cancers. 12110043 Human
mmac1 squamous-cell cancers CONCLUSIONS: We conclude that PTEN/MMAC1 gene alterations do not play a key role in tumorigenesis of oral squamous cell cancers. 12110043 Human
pten mixed tumor Among the five HNPCC or MSI+ sporadic CRCs carrying frameshift somatic mutations with immunohistochemistry data, three had lost all PTEN expression, one showed weak PTEN expression levels, and one had mixed tumor cell populations with weak and moderate ex 12163369 Human
pten biliary tract cancer Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer. 12168833 Human
pten biliary tract cancers Aberrations of the PTEN, Smad4 and DCC genes have not been determined in biliary tract cancers. 12168833 Human
pten ampullary cancers We looked for the presence of allelic imbalance (AI) at the PTEN and Smad4 genes in extrahepatic bile duct (EHBD) and ampullary cancers using polymorphic microsatellite markers. 12168833 Human
pten ampullary cancer AI at the PTEN, Smad4 and DCC genes was detected in 13.3%, 50% and 8.3%, respectively, of ampullary cancer cases. 12168833 Human
pten ampullary cancer Our results suggest that (a) alteration of the Smad4 gene is a major factor in the development of ampullary cancer and (b) PTEN, Smad4 and DCC genes are altered infrequently in EHBD cancers. 12168833 Human
pten primitive neuroectodermal tumours Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood. 12175345 Human
pten anaplastic thyroid cancer Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. 12203792 Human
pten kidney cancer PTEN has also been found to be somatically deleted, mutated, and/or silenced in various sporadically occurring cancers such as glioblastoma, breast cancer, kidney cancer, malignant melanoma, and endometrial cancer. 12203792 Human
pten follicular carcinomas To approach further the frequency and mechanism behind PTEN silencing, we screened a panel of 87 sporadic thyroid tumors for PTEN mRNA expression, including 14 anaplastic carcinomas, 37 follicular carcinomas, 21 atypical adenomas, and 15 ordinary adenomas 12203792 Human
pten adenomas To approach further the frequency and mechanism behind PTEN silencing, we screened a panel of 87 sporadic thyroid tumors for PTEN mRNA expression, including 14 anaplastic carcinomas, 37 follicular carcinomas, 21 atypical adenomas, and 15 ordinary adenomas 12203792 Human
pten atypical adenomas To approach further the frequency and mechanism behind PTEN silencing, we screened a panel of 87 sporadic thyroid tumors for PTEN mRNA expression, including 14 anaplastic carcinomas, 37 follicular carcinomas, 21 atypical adenomas, and 15 ordinary adenomas 12203792 Human
pten anaplastic carcinomas To approach further the frequency and mechanism behind PTEN silencing, we screened a panel of 87 sporadic thyroid tumors for PTEN mRNA expression, including 14 anaplastic carcinomas, 37 follicular carcinomas, 21 atypical adenomas, and 15 ordinary adenomas 12203792 Human
pten adenoma Complete loss of PTEN mRNA expression was evident in six of the tumors, including four anaplastic carcinomas, one widely invasive carcinoma, and one ordinary adenoma. 12203792 Human
pten invasive carcinoma Complete loss of PTEN mRNA expression was evident in six of the tumors, including four anaplastic carcinomas, one widely invasive carcinoma, and one ordinary adenoma. 12203792 Human
pten anaplastic carcinomas Complete loss of PTEN mRNA expression was evident in six of the tumors, including four anaplastic carcinomas, one widely invasive carcinoma, and one ordinary adenoma. 12203792 Human
pten invasive lobular carcinoma CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. 12203362 Human
pten multiple myeloma Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. 12208757 Human
pten myeloma The finding of PTEN mutations in several myeloma cell lines suggests that loss of PTEN function may be one mechanism by which AKT activity is increased in this disease. 12208757 Human
pten myeloma In contrast, myeloma cells expressing wild-type PTEN were >1000-fold more resistant. 12208757 Human
pten myeloma Acute expression of a constitutively active AKT gene in CCI-779-resistant myeloma cells containing wild-type PTEN and quiescent AKT did not convert them to the CCI-779-sensitive phenotype. 12208757 Human
pten metastatic prostate cancer Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. 14522255 Mouse
pten human colon cancer The inhibition of phosphatidylinositol (PI) 3-kinase by specific chemical inhibitors or overexpression of the lipid phosphatase PTEN enhances enterocyte-like differentiation in human colon cancer cell models of intestinal differentiation. 12140294 Human
pten colon tumors METHODS: The expression patterns for Cdx-2 and PTEN along wild-type mouse colon, as well as in colon tumors occurring in Pten(+/-) mice, were examined. 12360479 Human
pten colonic polyps RESULTS: Cdx-2 expression correlates with PTEN along the length of the murine colon and in colonic polyps that develop in Pten(+/-) mice. 12360479 Human
pten oral squamous-cell carcinomas Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. 12370746 Human
pten oral squamous-cell carcinomas To investigate the role of PTEN in human oral squamous cell carcinomas, we screened the entire coding region sequences and examined the expression of the PTEN gene in 81 oral cancers displaying microsatellite stability (MSS) and 5 oral cancers displaying 12370746 Human
pten oral cancers To investigate the role of PTEN in human oral squamous cell carcinomas, we screened the entire coding region sequences and examined the expression of the PTEN gene in 81 oral cancers displaying microsatellite stability (MSS) and 5 oral cancers displaying 12370746 Human
pten oral cancers These findings suggest that the inactivation of PTEN by either mutation or loss of transcript plays a role in the pathogenesis of some oral cancers (8/86; 9.3%). 12370746 Human
pten oral cancers Furthermore, inactivation of PTEN was far more frequent in MSI oral cancers (4/5; 80%) than in MSS oral cancers (4/81; 4.9%). 12370746 Human
pten familial breast cancer Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer. 12372056 Human
pten hereditary breast cancer This study suggests that PTEN does not play a major role in predisposing to hereditary breast cancer in Israeli women, and that detection of PTEN mutations in BRRS patients is more likely in familial cases. 12372056 Human
mmac1 melanocytic nevi Investigating PTEN/MMAC1 expression at mRNA level by semi-quantitative reverse transcription-polymerase chain reaction, we did not find a statistically significant down-regulation in melanoma resection specimens in comparison to acquired melanocytic nevi 12454773 Human
pten melanocytic nevi Investigating PTEN/MMAC1 expression at mRNA level by semi-quantitative reverse transcription-polymerase chain reaction, we did not find a statistically significant down-regulation in melanoma resection specimens in comparison to acquired melanocytic nevi 12454773 Human
mmac1 lung adenocarcinomas Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. 11146227 Rat
pten lung adenocarcinomas Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. 11146227 Rat
mmac1 lung adenocarcinomas Mutations of the phosphatase and tensin homolog deleted on chromosome ten/mutated in multiple advanced cancers 1 (PTEN/MMAC1) gene were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. 11146227 Human
phosphatase and tensin homolog lung adenocarcinomas Mutations of the phosphatase and tensin homolog deleted on chromosome ten/mutated in multiple advanced cancers 1 (PTEN/MMAC1) gene were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. 11146227 Human
mutated in multiple advanced cancers 1 lung adenocarcinomas Mutations of the phosphatase and tensin homolog deleted on chromosome ten/mutated in multiple advanced cancers 1 (PTEN/MMAC1) gene were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. 11146227 Human
pten lung adenocarcinomas Mutations of the phosphatase and tensin homolog deleted on chromosome ten/mutated in multiple advanced cancers 1 (PTEN/MMAC1) gene were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. 11146227 Human
pten myoepithelial tumor Expression of the Wnt-1 protooncogene in mammary glands of transgenic mice expands a population of epithelial cells expressing progenitor cell markers, keratin 6 and Sca-1; subsequent tumors express these markers and contain luminal epithelial and myoepit 14668450 Human
pten papillary thyroid cancer Transient expression of PTEN in seven thyroid cancer cell lines resulted in G(1) arrest in two well differentiated papillary thyroid cancer lines (PTCs) and both G(1) arrest and cell death in the remaining five lines, including three FTCs, one poorly diff 11159944 Human
pten male breast cancer Male breast cancer in Cowden syndrome patients with germline PTEN mutations. 11238682 Human
pten male breast cancer Here we report two cases of male breast cancer occurring in patients with classical CS phenotypes and germline PTEN mutations. 11238682 Human
pten male breast cancer These two cases of male breast cancer associated with germline PTEN mutations and the CS phenotype suggest that CS may be associated with an increased risk of early onset male as well as female breast cancer. 11238682 Human
pten female breast cancer These two cases of male breast cancer associated with germline PTEN mutations and the CS phenotype suggest that CS may be associated with an increased risk of early onset male as well as female breast cancer. 11238682 Human
pten merkel-cell carcinoma Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma. 11291079 Human
pten glioma U87MG glioma cells stably reconstituted with PTEN cDNA were tested for growth in a nude mouse orthotopic brain tumor model. 11274365 Human
pten follicular thyroid carcinomas Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. 11297621 Human
pten sarcomas Mutational analysis of the PTEN gene in human uterine sarcomas. 11349153 Human
pten sarcomas The PTEN gene is located on chromosome 10q23.3, a region that displays frequent loss of heterozygosity in human uterine sarcomas. 11349153 Human
pten sarcomas To determine whether the PTEN gene is involved in the pathogenesis of uterine sarcoma, we analyzed deoxyribonucleic acid from uterine sarcomas and cell lines. 11349153 Human
pten sarcoma To determine whether the PTEN gene is involved in the pathogenesis of uterine sarcoma, we analyzed deoxyribonucleic acid from uterine sarcomas and cell lines. 11349153 Human
pten sarcoma CONCLUSIONS: Mutational inactivation of PTEN does not play a major role in uterine sarcoma tumorigenesis, and another gene or genes on chromosome 10q may be implicated as a cause of these cancers. 11349153 Human
pten gliosarcoma Analysis of tumour samples microdissected from the most aggressive regions, representative of the histopathological diagnosis, revealed PTEN mutations in 4/14 anaplastic astrocytomas, 4/13 glioblastomas and 1 gliosarcoma, but not in 19 low-grade gliomas. 11355303 Human
pten thymic lymphomas Moreover, altered expression of Cd95 and Pten occurred concomitantly in 34 of 68 (50%) thymic lymphomas suggesting a coordinated mechanism of inactivation of these genes. 11360203 Mouse
pten nonendometrioid carcinomas Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mu 11431710 Human
pten anaplastic oligodendroglioma In anaplastic oligodendroglioma, therefore, PTEN is a target of 10q loss, and PTEN alterations are associated with poor prognosis, even in chemosensitive cases. 11438483 Human
pten sporadic colon cancer Allele loss close to the PTEN locus occurs in sporadic colon cancer and germline PTEN mutations cause Cowden disease, an inherited cancer syndrome characterized by an increased incidence of gastrointestinal tract lesions that can progress to colorectal ca 11439367 Human
pten sporadic colon cancer However, although PTEN is a good candidate for involvement in the pathogenesis of sporadic colon cancer, previous analyses have not revealed a high frequency of somatic mutations in colorectal tumours. 11439367 Human
pten sporadic colon cancer This study monitored PTEN mRNA and protein levels in a panel of 50 tumour tissues obtained from 35 patients with sporadic colon cancer. 11439367 Human
pten sporadic colon cancer As with previous deletion and mutation analyses, the present study suggests that loss of PTEN expression is not prevalent in sporadic colon cancer. 11439367 Human
pten mucinous adenocarcinoma Expressions of ER, enzyme c-PDE and 67kDaLN-R in SRC were evidently higher than that in mucinous adenocarcinoma, while expressions of LN, CN-IV, CD44v6, and PTEN protein were obviously lower in SRC than that in mucinous adenocarcinoma (P<0.05). 14991954 Human
pten kidney cancers PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers. 14747659 Human
pten high-grade prostatic intraepithelial neoplasia Abnormalities in Pten mutant skin consisted of mild epidermal hyperplasia, whereas prostates from these mice exhibited high-grade prostatic intraepithelial neoplasia (HGPIN) that frequently progressed to focally invasive cancer. 14747659 Human
pten invasive cancer Abnormalities in Pten mutant skin consisted of mild epidermal hyperplasia, whereas prostates from these mice exhibited high-grade prostatic intraepithelial neoplasia (HGPIN) that frequently progressed to focally invasive cancer. 14747659 Human
pten invasive breast cancer DESIGN: Formalin-fixed paraffin embedded tissues from 151 women (mean age 62 years, range 26-98) with primary diagnosis of invasive breast cancer were evaluated for PTEN protein expression by automated immunohistochemical methods. 11454999 Human
mmac1 chromophobe renal-cell carcinoma Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. 11463457 Human
pten chromophobe renal-cell carcinoma Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. 11463457 Human
pten familial cancer syndromes We have trialled denaturing high-performance liquid chromatography (dHPLC) as a tool for rapid germline mutation scanning of genes implicated in three familial cancer syndromes -- Cowden syndrome (PTEN mutation), multiple endocrine neoplasia type 2 (RET m 11494117 Human
pten lipomatosis Hereditary predisposition to lipomas is observed in familial multiple lipomatosis (OMIM 151900) and benign cervical lipomatosis (OMIM 151800) and can also be associated with mutations in the MEN1 and PTEN genes (OMIM 131100 and 153480, respectively). 11571558 Human
pten lipomas Hereditary predisposition to lipomas is observed in familial multiple lipomatosis (OMIM 151900) and benign cervical lipomatosis (OMIM 151800) and can also be associated with mutations in the MEN1 and PTEN genes (OMIM 131100 and 153480, respectively). 11571558 Human
pten stage i non-small cell lung cancer Using immunohistochemical analysis, we retrospectively analyzed PTEN expression in specimens from 53 patients with completely resected stage I non-small cell lung cancer (NSCLC) for whom clinical follow-up data were available. 14981940 Human
pten metastatic cancers PTEN/MMAC1/TEP1 (PTEN) is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers, strongly suggests that PTEN alteration is possibly involved in the tumor progression and formation of metastases. 11595133 Human
mmac1 malignant mesotheliomas Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas. 11605070 Human
pten malignant mesotheliomas Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas. 11605070 Human
mmac1 malignant mesotheliomas Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. 11605070 Human
pten malignant mesotheliomas Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. 11605070 Human
mmac1 mesothelioma Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not frequently involved in mesothelioma formation. 11605070 Human
pten mesothelioma Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not frequently involved in mesothelioma formation. 11605070 Human
pten meningeal gliomatosis PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis. 11678426 Human
pten tongue cancer Loss of PTEN expression as a prognostic marker for tongue cancer. 11735811 Human
pten lipomatosis Investigation of other clinically distinct syndromes associated with lipomatosis and overgrowth has established germline and germline mosaic PTEN mutations in several patients with Proteus syndrome. 11748304 Human
pten fibroma Loss of heterozygosity analysis of two trichilemmomas, one fibroma, and three acanthomas of the index patient demonstrated loss of heterozygosity at the PTEN locus in four of these lesions. 11886535 Human
mmac1 brain cancer Loss of the tumor suppressor MMAC1 has been shown to be involved in breast, prostate and brain cancer. 10644997 Human
mmac1 laryngeal papillomas Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas. 10728713 Human
pten laryngeal papillomas Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas. 10728713 Human
pten laryngeal papillomas We have found that PTEN protein is overexpressed in laryngeal papillomas when compared with normal laryngeal tissues. 10728713 Human
pten papillomas On the basis of reverse transcription-PCR analysis, PTEN mRNA is more abundant in papillomas, suggesting transcriptional up-regulation. 10728713 Human
pten laryngeal papillomas We postulate that negative regulation of the PI 3-K/Akt pathway by PTEN may modulate the effects of the hyperactive epidermal growth factor receptor/mitogen-activated protein kinase pathway, contributing to the low proliferation and dysfunctional differen 10728713 Human
mmac1 follicular thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten follicular thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
mmac1 thyroid adenomas To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten thyroid adenomas To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
mmac1 papillary thyroid carcinomas To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten papillary thyroid carcinomas To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
mmac1 medullary-thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten medullary-thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten arteriovenous malformations Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. 10749983 Human
pten lipomatosis Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. 10749983 Human
pten lipomas To determine whether other syndromes characterized by overgrowth and lipomas are part of the PTEN syndrome spectrum, we ascertained six individuals with overgrowth and lipomas but who did not meet the diagnostic criteria for CS or BRR. 10749983 Human
pten serous carcinoma Whereas endometrioid carcinoma and endometrial hyperplasia are associated with microsatellite instability and ras and PTEN mutations, serous carcinoma and endometrial intraepithelial carcinoma are associated with p53 mutations and abnormal accumulation of 10757340 Human
mmac1 cutaneous melanoma Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. 10766161 Human
pten cutaneous melanoma Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. 10766161 Human
mmac1 cutaneous melanoma Both inactivation of the tumor suppressor gene, PTEN/MMAC1, and oncogenic activation of RAS have been described in human cutaneous melanoma. 10766161 Human
mmac1 cutaneous melanoma metastasis We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis. 10766161 Human
pten cutaneous melanoma metastasis We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis. 10766161 Human
mmac1 cutaneous melanoma We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis. 10766161 Human
pten cutaneous melanoma We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis. 10766161 Human
mmac1 cutaneous melanoma Ectopic expression of PTEN in several cutaneous melanoma cell lines suppressed colony formation irrespective of PTEN/MMAC1 status; furthermore, PTEN expression in cell lines carrying activated RAS also suppressed colony formation. 10766161 Human
pten cutaneous melanoma Ectopic expression of PTEN in several cutaneous melanoma cell lines suppressed colony formation irrespective of PTEN/MMAC1 status; furthermore, PTEN expression in cell lines carrying activated RAS also suppressed colony formation. 10766161 Human
pten cutaneous t-cell lymphoma Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN. 10779442 Human
pten mycosis fungoides Furthermore, abnormalities of PTEN may be important in the pathogenesis of mycosis fungoides, but our data imply that this gene is rarely inactivated by small deletions or point mutations. 10779442 Human
tep1 familial cancer syndrome Germline mutations in PTEN (MMAC1/TEP1) are found in patients with Cowden syndrome, a familial cancer syndrome which is characterized by a high risk of breast and thyroid neoplasia. 10793080 Human
mmac1 familial cancer syndrome Germline mutations in PTEN (MMAC1/TEP1) are found in patients with Cowden syndrome, a familial cancer syndrome which is characterized by a high risk of breast and thyroid neoplasia. 10793080 Human
pten familial cancer syndrome Germline mutations in PTEN (MMAC1/TEP1) are found in patients with Cowden syndrome, a familial cancer syndrome which is characterized by a high risk of breast and thyroid neoplasia. 10793080 Human
pten follicular thyroid adenomas Although somatic intragenic PTEN mutations have rarely been found in benign and malignant sporadic thyroid tumors, loss of heterozygosity (LOH) has been reported in up to one fourth of follicular thyroid adenomas (FAs) and carcinomas. 10793080 Human
pten follicular thyroid carcinomas In this study, we examined PTEN expression in 139 sporadic nonmedullary thyroid tumors (55 FA, 27 follicular thyroid carcinomas, 35 papillary thyroid carcinomas, and 22 undifferentiated thyroid carcinomas) using immunohistochemistry and correlated this to 10793080 Human
pten papillary thyroid carcinomas In this study, we examined PTEN expression in 139 sporadic nonmedullary thyroid tumors (55 FA, 27 follicular thyroid carcinomas, 35 papillary thyroid carcinomas, and 22 undifferentiated thyroid carcinomas) using immunohistochemistry and correlated this to 10793080 Human
pten undifferentiated thyroid carcinomas In this study, we examined PTEN expression in 139 sporadic nonmedullary thyroid tumors (55 FA, 27 follicular thyroid carcinomas, 35 papillary thyroid carcinomas, and 22 undifferentiated thyroid carcinomas) using immunohistochemistry and correlated this to 10793080 Human
pten familial cancer syndromes Thus, whereas germ-line mutations of PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 are not common events in familial glioma, outside of familial cancer syndromes, point mutations of p53 and hemizygous deletions and other rearrangements of the p16(INK4A)/p14(AR 10797439 Human
pten gynecological cancers Mutations in the p53, BRCA1, DCC, and PTEN genes have been reported in gynecological cancers such as ovarian, cervical, and endometrial cancer. 10818392 Human
pten mouse tumor PTEN-knockout mice develop tumors, suggesting that mouse tumor models are useful in vivo model systems to study PTEN function. 10855797 Mouse
pten mouse tumor In this paper, we demonstrate the absence of any PTEN pseudogene in the mouse and discuss the significance of this observation for the mutational studies of the PTEN gene in mouse tumor models. 10855797 Human
pten uveal melanoma Mutation analysis of the PTEN gene in uveal melanoma cell lines. 10861467 Human
pten follicular adenomas The p53 gene appears to be involved in the process of transformation to the anaplastic phenotype and the PTEN gene in the development of follicular adenomas but not carcinomas. 10865036 Human
pten non-hodgkin lymphomas Allelic losses and genetic instabilities of PTEN and p73 in non-Hodgkin lymphomas. 10914564 Human
pten primary carcinomas Accordingly, in a subset of thyroid primary carcinomas and tumor-derived cell lines, a striking correlation between PTEN expression and the level of p27kip1 protein was observed. 10918569 Human
pten adenocarcinoma of the cervix In this study, we have extended the analysis of PTEN in gynecological cancer to include adenocarcinoma of the cervix and vulvar carcinomas. 10955808 Human
pten gynecological cancer In this study, we have extended the analysis of PTEN in gynecological cancer to include adenocarcinoma of the cervix and vulvar carcinomas. 10955808 Human
pten vulvar carcinomas In this study, we have extended the analysis of PTEN in gynecological cancer to include adenocarcinoma of the cervix and vulvar carcinomas. 10955808 Human
pten cervical adenocarcinoma Only 1 cervical adenocarcinoma displayed a PTEN mutation. 10955808 Human
pten vulvar carcinomas In contrast, five of eight vulvar carcinomas studied harbored PTEN mutations. 10955808 Human
pten vulvar carcinomas These results suggest that PTEN is frequently altered in vulvar carcinomas and can be found associated with early dysplastic changes in vulvar mucosa. 10955808 Human
pten primary carcinomas In cervical cancer, unlike some other human primary carcinomas, e.g., those of the breast and thyroid, biallelic structural PTEN defects seem necessary for carcinogenesis. 10959096 Human
mmac1 acute monocytic leukaemia We identified an intragenic deletion including MMAC1/PTEN exons 2-5 in an acute myelocytic leukaemia cell line, HL-60 blast, and an insertion of four nucleotides in exon 5 in an acute monocytic leukaemia cell line, U937. 10966170 Human
pten acute monocytic leukaemia We identified an intragenic deletion including MMAC1/PTEN exons 2-5 in an acute myelocytic leukaemia cell line, HL-60 blast, and an insertion of four nucleotides in exon 5 in an acute monocytic leukaemia cell line, U937. 10966170 Human
mmac1 myelodysplastic syndromes Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
pten myelodysplastic syndromes Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
mmac1 myeloid leukaemia Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
pten myeloid leukaemia Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
pten skin cancers Cowden disease is an autosomal dominant disorder associated with an elevated risk of breast, thyroid and skin cancers, in which germline mutations of a tumour suppressor gene (PTEN) have been identified. 10982030 Human
mmac1 esophageal cancer The aim of this study was to determine whether there are abnormalities in the expression of PTEN/MMAC1 gene in esophageal cancer. 10995879 Human
pten esophageal cancer The aim of this study was to determine whether there are abnormalities in the expression of PTEN/MMAC1 gene in esophageal cancer. 10995879 Human
mmac1 esophageal squamous-cell carcinomas Immunohistochemical staining was carried out to detect PTEN/MMAC1 expression in surgically resected esophageal squamous cell carcinomas and normal esophageal epithelium. 10995879 Human
pten esophageal squamous-cell carcinomas Immunohistochemical staining was carried out to detect PTEN/MMAC1 expression in surgically resected esophageal squamous cell carcinomas and normal esophageal epithelium. 10995879 Human
mmac1 esophageal cancer All 30 esophageal cancer cell lines (KYSE series) and normal cultured esophageal epithelial cells expressed PTEN/MMAC1 mRNA. 10995879 Human
pten esophageal cancer All 30 esophageal cancer cell lines (KYSE series) and normal cultured esophageal epithelial cells expressed PTEN/MMAC1 mRNA. 10995879 Human
mmac1 esophageal squamous-cell carcinomas Immunohistochemical study showed that the PTEN/MMAC1 protein was localized dominantly in the cytoplasm and strongly stained in all 42 surgically resected esophageal squamous cell carcinomas and normal esophageal epithelium. 10995879 Human
pten familial adenomatous polyposis There are at least nine major cancer susceptibility syndromes that infer an increased risk for colorectal cancer and/or colorectal polyposis; hereditary nonpolyposis colorectal cancer syndrome, Muir-Torre syndrome, Turcot syndrome, the I1307K polymorphism 11005140 Human
pten recurrent ovarian carcinomas Single mutations of the PTEN gene in recurrent ovarian carcinomas. 11035285 Human
pten gastrointestinal tumors Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients. 11052475 Human
pten juvenile polyps METHODS: The entire coding region of PTEN was screened by single strand conformational polymorphism or direct sequencing for somatic mutations in 16 gingival papillomas, 4 juvenile polyps, 10 esophageal papillomas, and 20 colorectal cancers and for germli 11052475 Human
pten endometrioid tumors In endometrioid tumors, we reported an increased frequency of mutations in the PTEN/MMAC tumor suppressor genes that was not seen in clear cell or serous carcinoma, suggesting distinct developmental pathways for these tumors [3]. 11093061 Human
pten serous carcinoma In endometrioid tumors, we reported an increased frequency of mutations in the PTEN/MMAC tumor suppressor genes that was not seen in clear cell or serous carcinoma, suggesting distinct developmental pathways for these tumors [3]. 11093061 Human
pten uterine cancer PTEN is a tumor suppressor frequently inactivated in brain, prostate, and uterine cancer. 11156408 Human
pten endometrioid carcinoma Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten clear-cell carcinoma Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten cyst Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten ovarian endometrioid carcinoma Loss of heterozygosity (LOH) at locus 10q23.3 and mutation of the PTEN tumor suppressor gene occur frequently in both endometrial carcinoma and ovarian endometrioid carcinoma. 11156411 Human
pten clear-cell carcinomas To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten cysts To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten ovarian endometrioid carcinoma To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten clear-cell carcinoma To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten ovarian endometrioid carcinomas To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten cysts Somatic mutations in the PTEN gene were identified in 4 of 20 ovarian endometrioid carcinomas (20.0%), 2 of 24 clear cell carcinomas (8.3%), and 7 of 34 solitary endometrial cysts (20.6%). 11156411 Human
pten ovarian endometrioid carcinoma These results indicate that inactivation of the PTEN tumor suppressor gene is an early event in the development of ovarian endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten clear-cell carcinoma These results indicate that inactivation of the PTEN tumor suppressor gene is an early event in the development of ovarian endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten lipomatosis Interestingly, germline mutations in PTEN have also been found in about 50% of a related but distinct disorder, Bannayan-Ruvalcaba-Riley syndrome (BRR), which is characterised by neonatal-onset macrocephaly, mental retardation, Hashimoto's thyroiditi 10548886 Human
pten granular-cell tumor Granular cell tumor in a PHTS patient with a novel germline PTEN mutation. 12833416 Human
pten human ovarian cancer Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene. 10626791 Human
pten haematological malignancies PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. 9931326 Human
pten haematological malignancies PTEN has been mapped to 10q23.3, a region disrupted in several human tumours including haematological malignancies. 9931326 Human
pten acute leukaemias We have analysed PTEN in a series of primary acute leukaemias and non-Hodgkin's lymphomas (NHLs) as well as in cell lines. 9931326 Human
pten haematological malignancies At the structural level, we found mutations and hemizygous deletions in 40% of these cell lines, while a smaller number of primary haematological malignancies, in particular NHLs, carries PTEN mutations. 9931326 Human
pten haematological malignancies These findings suggest that PTEN plays a role in the pathogenesis of haematological malignancies and that it might be inactivated through a wider range of mechanisms than initially considered. 9931326 Human
pten inherited breast cancer To investigate the role of PTEN in inherited breast cancer in the absence of manifestations of Cowden disease, we screened 177 unrelated subjects with breast cancer who also had a family history of breast cancer in at least one relative. 10051004 Human
pten melanoma Somatic mutation of PTEN has been found in a number of malignancies, including glioblastoma, melanoma, and carcinoma of the prostate and endometrium. 10051603 Human
pten anaplasia The results of this study indicate that mutation in the PTEN gene is present only in histologically more aggressive gliomas, may be associated with the transition from low histological grade to anaplasia, but is absent from the majority of high grade glio 10188904 Human
pten localized cancers Therefore, we wished to determine whether inactivation of PTEN might be associated with increased angiogenesis in prostate cancers, because increased angiogenesis in localized cancers is associated with development of metastatic disease. 10208463 Human
pten endometrioid tumors Type I tumors are associated with distinct molecular changes that are rarely found in type II tumors, such as BRAF and KRAS mutations for serous tumors, KRAS mutations for mucinous tumors, and beta-catenin and PTEN mutations and microsatellite instability 15111296 Human
pten common cancers RESULTS: Evidence is presented that misregulation of the PI3 kinase pathway is a feature of many common cancers, either by loss of the suppressor protein PTEN, or by constitutive activation of PI3 kinase isoforms or downstream elements such as AKT and mTO 15143962 Human
pten gastrointestinal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten gastrointestinal neoplasms Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten colonic polyps Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten neurofibromatosis Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten gastrointestinal cancer Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten colorectal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten bronchogenic adenocarcinomas Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissues from 53 bronchogenic adenocarcinomas and 51 squamous cell carcinomas using monoclonal antibodies against PTEN, nm23H-1, and KAI-1 proteins. 15129904 Human
pten fibroadenoma Genotype-phenotype analyses within the BRR group suggested a number of correlations, including the association of PTEN mutation and cancer or breast fibroadenoma in any given CS, BRR or BRR/CS overlap family ( P = 0.014), and, in particular, truncating mu 10400993 Human
pten lipomas Additionally, the presence of lipomas was correlated with the presence of PTEN mutation in BRR patients ( P = 0.028). 10400993 Human
pten colorectal cancer PTEN mutations are common in sporadic microsatellite stable colorectal cancer. 14724591 Human
pten colorectal cancer While initial studies reported that PTEN gene mutations were rare in colorectal cancer, more recent reports have shown an approximate 18% incidence of somatic PTEN mutations in colorectal tumours exhibiting microsatellite instability (MSI+). 14724591 Human
pten sporadic colorectal cancers To verify the role of this gene in colorectal tumorigenesis, we analysed paired normal and tumour DNA from 41 unselected primary sporadic colorectal cancers for PTEN inactivation by mutation and/or allelic loss. 14724591 Human
pten ependymal tumors To evaluate whether morphological subsets of ependymomas are characterized by specific genetic lesions, we analyzed a series of 62 ependymal tumors, including myxopapillary ependymomas, subependymomas, ependymomas, and anaplastic ependymomas, for allelic 10433955 Human
pten brain metastases Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. 10499615 Human
mmac1 brain metastases Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. 10499615 Human
pten brain metastases We searched for genetic alterations in the PTEN/MMAC1 gene in 56 consecutive brain metastases from various primary tumors by loss of heterozygosity (LOH), direct sequence analysis, and differential PCR analysis. 10499615 Human
mmac1 brain metastases We searched for genetic alterations in the PTEN/MMAC1 gene in 56 consecutive brain metastases from various primary tumors by loss of heterozygosity (LOH), direct sequence analysis, and differential PCR analysis. 10499615 Human
mmac1 brain metastases With the exception of lung carcinomas, our findings indicate that genetic abnormalities of the PTENM/MMAC1 gene are only involved in a relatively small subset of brain metastases. 10499615 Human
pten familial breast cancer Linkage analysis of 56 multiplex families excludes the Cowden disease gene PTEN as a major contributor to familial breast cancer. 10507734 Human
pten ductal adenocarcinomas Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. 10514407 Human
pten endometrial tumor Loss of heterozygosity using three microsatellites (D10S215, D10S541, and D10S564) and the complete sequence analysis of PTEN exons in breast and endometrial tumor samples from the same patient were also carried out in an attempt to identify additional PT 14675182 Human
tep1 hepatocellular carcinoma Hepatocellular carcinoma (20 samples) and non-cancerous liver tissues (19 samples) were examined for telomerase activity and expression of hTRT, the human telomerase RNA component (hTR; encoded by TERC) and the human telomerase-associated protein (hTLP1; 9425903 Human
pten meningiomas Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. 9426052 Human
mmac1 meningiomas Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. 9426052 Human
pten meningiomas Therefore, we have investigated 36 glioblastomas and 34 meningiomas (2 benign, 17 atypical, and 15 anaplastic meningiomas) for loss on 10q, as well as deletion, mutation, and expression of PTEN. 9426052 Human
pten meningiomas Although loss of 10q was detected by comparative genomic hybridization and/or LOH analysis in 14 of the 34 meningiomas investigated (41%), none of these tumors showed evidence of PTEN mutations or homozygous gene deletions. 9426052 Human
pten meningiomas However, the lack of detectable PTEN alterations in a considerable fraction of glioblastomas and all meningiomas with 10q loss strongly supports the hypothesis that at least one additional tumor suppressor gene is located on 10q. 9426052 Human
pten metastatic prostate cancer Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. 9443392 Human
mmac1 metastatic prostate cancer Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. 9443392 Human
pten metastatic prostate cancer To examine the role of PTEN/MMAC1 in the progression of prostate cancer, we screened a unique set of 50 metastatic prostate cancer tissues from 19 cancer-death patients for alterations in the PTEN/MMAC1 gene, using single-strand conformational polymorphis 9443392 Human
mmac1 metastatic prostate cancer To examine the role of PTEN/MMAC1 in the progression of prostate cancer, we screened a unique set of 50 metastatic prostate cancer tissues from 19 cancer-death patients for alterations in the PTEN/MMAC1 gene, using single-strand conformational polymorphis 9443392 Human
pten pulmonary hamartoma LOH involving microsatellite markers within the CD interval, and including PTEN/MMACI, was identified in two fibroadenomas of the breast, a thyroid adenoma, and a pulmonary hamartoma belonging to 3 to 11 (27%) of these patients. 9443042 Human
mmaci pulmonary hamartoma LOH involving microsatellite markers within the CD interval, and including PTEN/MMACI, was identified in two fibroadenomas of the breast, a thyroid adenoma, and a pulmonary hamartoma belonging to 3 to 11 (27%) of these patients. 9443042 Human
pten thyroid adenoma LOH involving microsatellite markers within the CD interval, and including PTEN/MMACI, was identified in two fibroadenomas of the breast, a thyroid adenoma, and a pulmonary hamartoma belonging to 3 to 11 (27%) of these patients. 9443042 Human
mmaci thyroid adenoma LOH involving microsatellite markers within the CD interval, and including PTEN/MMACI, was identified in two fibroadenomas of the breast, a thyroid adenoma, and a pulmonary hamartoma belonging to 3 to 11 (27%) of these patients. 9443042 Human
pten head-and-neck cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
mmac1 head-and-neck cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
pten pancreatic cancer We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
mmac1 pancreatic cancer We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
pten kidney cancer Somatic PTEN deletions and mutations were observed in sporadic breast, brain, prostate and kidney cancer cell lines and in several primary tumours such as endometrial carcinomas, malignant melanoma and thyroid tumours. 9467011 Human
pten prostate adenocarcinomas Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas. 9533551 Human
pten stage b prostate cancers To evaluate the role of inactivation of this gene in primary stage B prostate cancers, 60 cases were analyzed using Southern blotting with PTEN probes and microsatellites on 10q23. 9533551 Human
pten stage b prostate carcinomas Thus, inactivation of the PTEN gene by homozygous deletion occurs in approximately 10-15% of primary stage B prostate carcinomas. 9533551 Human
pten grade i meningiomas No PTEN mutations were seen in the WHO grade I meningiomas. 9549723 Human
pten prostatic adenocarcinomas We have investigated the involvement of PTEN in primary prostatic adenocarcinomas using a panel of 51 matched normal and prostate tumour DNAs. 9582022 Human
pten epithelial ovarian tumors Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. 9605750 Human
pten ovarian tumors We have analyzed 81 ovarian tumors, including 34 endometrioid, 29 serous, 10 mucinous, and 8 clear cell tumors, for loss of heterozygosity (LOH) on 10q23 and for mutations in all 9 coding exons of PTEN. 9605750 Human
pten clear cell tumors We have analyzed 81 ovarian tumors, including 34 endometrioid, 29 serous, 10 mucinous, and 8 clear cell tumors, for loss of heterozygosity (LOH) on 10q23 and for mutations in all 9 coding exons of PTEN. 9605750 Human
pten endometrioid tumors Somatic PTEN mutations were detected in seven (21%) of the endometrioid tumors, and in all informative cases, the mutation was accompanied by loss of the wild-type allele. 9605750 Human
pten clear cell tumors No PTEN mutations were found among the serous or clear cell tumors. 9605750 Human
pten dysembryoplastic neuroepithelial tumor No PTEN mutations were detected in 52 astrocytomas, 37 oligoastrocytomas, three subependymal giant cell astrocytomas, four pleomorphic xanthoastrocytomas, 15 ependymomas, 16 gangliogliomas and one dysembryoplastic neuroepithelial tumor. 9619835 Human
pten endometrial adenocarcinomas The purpose of this study was to determine whether PTEN mutations also are present in endometrial hyperplasias, which are premalignant precursors of invasive endometrial adenocarcinomas. 9635567 Human
pten renal-cell tumors Using these new informative markers, we identified apparent retention at the gene locus indicative of homozygous deletion of PTEN/MMAC1 in four of 65 bladder and 0 of 15 renal cell tumors with LOH through chromosome 10q. 9671402 Human
mmac1 renal-cell tumors Using these new informative markers, we identified apparent retention at the gene locus indicative of homozygous deletion of PTEN/MMAC1 in four of 65 bladder and 0 of 15 renal cell tumors with LOH through chromosome 10q. 9671402 Human
pten renal-cell cancer However, the low frequency of biallelic inactivation suggests that either PTEN/MMAC1 is inactivated by other mechanisms or it is not the only target of chromosome 10q deletion in primary bladder and renal cell cancer. 9671402 Human
mmac1 renal-cell cancer However, the low frequency of biallelic inactivation suggests that either PTEN/MMAC1 is inactivated by other mechanisms or it is not the only target of chromosome 10q deletion in primary bladder and renal cell cancer. 9671402 Human
pten kidney cancers A novel tumor suppressor gene, PTEN/MMAC1, has been recently shown to be mutated in gliomas, breast, prostate, kidney cancers and melanomas. 9692547 Human
mmac1 kidney cancers A novel tumor suppressor gene, PTEN/MMAC1, has been recently shown to be mutated in gliomas, breast, prostate, kidney cancers and melanomas. 9692547 Human
pten melanoma In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. 9689095 Human
mmac1 melanoma In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. 9689095 Human
pten malignant melanoma Thus, this approach identified PTEN/MMAC1 as a target in malignant melanoma and may provide an alternative means to localizing tumor suppressor genes. 9689095 Human
mmac1 malignant melanoma Thus, this approach identified PTEN/MMAC1 as a target in malignant melanoma and may provide an alternative means to localizing tumor suppressor genes. 9689095 Human
pten non-hodgkin's lymphoma Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. 9697884 Human
mmac1 non-hodgkin's lymphoma Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. 9697884 Human
pten recurrent tumor Additional loss of heterozygosity for the 10p15 region, for PTEN, and/or for DMBT1 in the recurrent tumor was noted in 7 of 22 cases (32%), suggesting that additional inactivation of tumor suppressor genes on chromosome 10 is another important feature of 9739018 Human
pten metastatic prostate cancers The PTEN gene is inactivated in a significant proportion of prostate carcinomas, particularly metastatic prostate cancers. 9769364 Human
pten follicular adenomas To determine the involvement of PTEN in sporadic follicular thyroid tumors, we first analyzed sporadic follicular adenomas and carcinomas for deletions of the PTEN gene. 9790504 Human
mmac1 polyps Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. 9797362 NA
mmac1 juvenile polyps BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 NA
pten juvenile polyps BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 Human
mmac1 colonic adenoma BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 NA
pten colonic adenoma BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 Human
mmac1 polyps BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 NA
mmac1 tumor CONCLUSIONS: The germline mutation and alteration of the remaining allele observed in this study strongly support that PTEN/MMAC1 functions as a tumor suppressor in Cowden disease. 9797362 NA
mmac1 gastric hamartoma This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 NA
pten gastric hamartoma This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 Human
mmac1 colonic adenoma This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 NA
pten colonic adenoma This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 Human
mmac1 polyps This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 NA
mmac1 juvenile polyp This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 NA
pten juvenile polyp This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 Human
pten lipomas This finding confirms that Cowden disease, a dominant cancer predisposing syndrome, and Bannayan-Riley-Ruvalcaba syndrome, which includes macrocephaly, multiple lipomas, intestinal hamartomatous polyps, vascular malformations, and pigmented macules of the 9832032 Human
pten skin cancer Cowden disease is an autosomal dominant disorder associated with an increased risk of breast, thyroid, and skin cancer in which germline mutations in a candidate tumour suppressor gene (PTEN) have been identified previously. 10193515 Human
pten ductal carcinoma Mammary ductal carcinoma developed earlier in Wnt-1 TG, Pten+/- mice than in mice bearing either genetic change alone, and showed frequent loss of the remaining wild-type PTEN allele. 11737885 Human
pten mouse lymphoma In most cases, the remaining allele was wild type and expressed, suggesting that Pten is a haploinsufficient tumor suppressor gene for mouse lymphoma development. 14627978 Mouse
pten glioblastoma In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and xenografts, and 17% (3/18) of primary glioblastomas. 9072974 Human
pten metastasis These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions. 9072974 Human
pten thyroid cancer Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. 9140396 Human
pten t-cell leukaemia Previously, PTEN expression in the PTEN-null Jurkat T cell leukaemia line was shown to cause reduced proliferation without cell cycle arrest. 14603260 Human
pten ovarian carcinomas To evaluate the role of PTEN in other common malignancies of the female genital tract, 12 serous ovarian carcinomas and 10 squamous cervical carcinomas were analyzed and were negative for mutations. 9307275 Human
pten thyroid tumors Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. 9354427 Human
pten thyroid neoplasms We sought to determine the PTEN status in a series of epithelial thyroid neoplasms. 9354427 Human
pten follicular adenomas Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten anaplastic carcinoma Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten hurthle cell adenomas Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten follicular carcinoma Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten thyroid tumors We conclude that a subset of thyroid tumors have somatic deletions of the PTEN gene, predominantly the benign forms, and that small intragenic mutations of PTEN are infrequent in thyroid tumors. 9354427 Human
pten glioma Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. 9356475 Human
pten glioma We used a combination of Northern blot analysis, protein truncation assays, and sequence analysis to determine the types and frequency of PTEN mutations in glioma cell lines so that we could define appropriate recipients to assess the growth suppressive f 9356475 Human
pten glioma Introduction of wild-type PTEN into glioma cells containing endogenous mutant alleles caused growth suppression, but was without effect in cells containing endogenous wild-type PTEN. 9356475 Human
pten endometrial tumor For these experimental purposes five main classes of experimental models are available: spontaneous endometrial tumorigenesis models in inbred animals (Donryu rats, DA/Han rats, BDII/Han rats), inoculation tumors from chunks of tumors (rat EnDA-tumor, hum 12653669 Human
pten renal tumors Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors. 12599019 Human
pten renal tumors Using tissue microarray technology, we show that sarcomatoid renal tumors have a distinct protein expression profile for biomarkers Ki67, gelsolin and PTEN, when compared with clear-cell and papillary renal tumors. 12599019 Human
pten metaplasia AIM: To detect the expression of PTEN encoding product in normal mucosa, intestinal metaplasia (IM), dysplasia and carcinoma of the stomach, and to investigate its clinical implication in tumorigenesis and progression of gastric carcinoma. 12508347 Human
pten early gastric cancer Advanced gastric cancers expressed less frequent PTEN than early gastric cancer (42.9 % vs 67.6 %, P<0.01). 12508347 Human
pten signet-ring-cell carcinoma Signet ring cell carcinoma showed the expression of PTEN at the lowest level (25.0 %, 7/28); less than well and moderately differentiated ones (P<0.01). 12508347 Human
mmac1 soft-tissue sarcomas Our study was designed to investigate the frequency of PTEN/MMAC1 gene mutation and to evaluate the role of the PTEN/MMAC1 gene in the tumorigenesis of soft tissue sarcomas without specific balanced translocations. 12569572 Human
pten soft-tissue sarcomas Our study was designed to investigate the frequency of PTEN/MMAC1 gene mutation and to evaluate the role of the PTEN/MMAC1 gene in the tumorigenesis of soft tissue sarcomas without specific balanced translocations. 12569572 Human
mmac1 soft-tissue sarcomas We analyzed 51 cases of soft tissue sarcomas without specific balanced translocations for PTEN/MMAC1 mutations by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. 12569572 Human
pten primary carcinomas Expression of PTEN transcript was abnormally low in 5 of 15 (33%) cell lines and 20 of 55 (36%) primary carcinomas, whereas 0 of 71 noncancerous tissues including 16 benign tumors showed altered expression. 12569555 Human
pten primary carcinomas Collectively, our data reveal that 13 of 15 (87%) gastric cell lines and 31 of 55 (56%) primary carcinomas harbored either amplification of PIK3CA or abnormal reduction of PTEN. 12569555 Human
pten primary malignancies Several mechanisms of PTEN inactivation occur in primary malignancies derived from different tissues, but a favored mechanism appears to occur in a tissue-specific manner. 12938083 Human
pten testicular teratoma Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. 12620992 Mouse
pten testicular teratoma Male mice that lacked PTEN exhibited bilateral testicular teratoma, which resulted from impaired mitotic arrest and outgrowth of cells with immature characters. 12620992 Mouse
pten testicular germ-cell tumor PTEN appears to be essential for germ cell differentiation and an important factor in testicular germ cell tumor formation. 12620992 Mouse
pten colorectal adenoma Expression and significance of PTEN, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma. 12632503 Human
pten colorectal adenoma METHODS: Total 71 cases colorectal neoplasms (9 cases of colorectal adenoma and 62 colorectal adenocarcinoma) were formalin fixed and paraffin-embedded, and all specimens were evaluated for PTEN mRNA, HIF-1alpha mRNA and VEGF protein expression. 12632503 Human
pten colorectal neoplasms METHODS: Total 71 cases colorectal neoplasms (9 cases of colorectal adenoma and 62 colorectal adenocarcinoma) were formalin fixed and paraffin-embedded, and all specimens were evaluated for PTEN mRNA, HIF-1alpha mRNA and VEGF protein expression. 12632503 Human
pten colorectal adenocarcinoma METHODS: Total 71 cases colorectal neoplasms (9 cases of colorectal adenoma and 62 colorectal adenocarcinoma) were formalin fixed and paraffin-embedded, and all specimens were evaluated for PTEN mRNA, HIF-1alpha mRNA and VEGF protein expression. 12632503 Human
pten colorectal adenomas RESULTS: There were significant differences in PTEN, HIF-1alpha and VEGF expression between colorectal adenomas and colorectal adenocarcinoma (P<0.05). 12632503 Human
pten colorectal adenocarcinoma RESULTS: There were significant differences in PTEN, HIF-1alpha and VEGF expression between colorectal adenomas and colorectal adenocarcinoma (P<0.05). 12632503 Human
pten colorectal adenocarcinoma CONCLUSION: Loss of PTEN expression and increased levels of HIF-1alpha and VEGF may play an important role in carcinogenesis and progression of colorectal adenocarcinoma. 12632503 Human
pten lung cancer Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. 12649203 Human
pten sporadic colorectal cancers Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. 15126336 Human
pten sporadic colorectal cancers Allelic losses in the proximity of the PTEN locus (10q23) also occur in sporadic colorectal cancers (CRCs), but biallelic inactivation of this site has not been frequently demonstrated. 15126336 Human
pten gliomatosis cerebri Analysis of TP53 and PTEN in gliomatosis cerebri. 12734658 Human
mmac1 gastric adenocarcinoma To clarify the participation of the PTEN/MMAC1 gene in advanced gastric carcinogenesis, we screened their frequency of mutations in primary advanced gastric adenocarcinoma tissues. 12695913 Human
pten gastric adenocarcinoma To clarify the participation of the PTEN/MMAC1 gene in advanced gastric carcinogenesis, we screened their frequency of mutations in primary advanced gastric adenocarcinoma tissues. 12695913 Human
pten prostate adenocarcinoma Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. 12873978 Mouse
pten lymph-node metastases Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. 12873978 Mouse
mmac1 extrapulmonary small cell cancers One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell cancers) were analysed for PTEN/MMAC1 homozygous deletions and five (8%) SCL 9794233 Human
mmac1 hereditary breast cancer Since we could not find any relevant alterations, although further investigations are necessary, PTEN/MMAC1 seems not to play a relevant role in the genesis of hereditary breast cancer. 14518258 Human
mmac1 kidney tumor A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence alterations observed in several glioma, breast, prostate, and kidney tumor specimens or cell lines. 9393738 Human
mmac1 bladder tumors Identification of the second inactivation event in six bladder tumors with LOH of 10q implies that the PTEN/MMAC1 gene is occasionally involved in bladder tumorigenesis. 9671402 Human
mmac1 mesotheliomas One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell cancers) were analysed for PTEN/MMAC1 homozygous deletions and five (8%) SCL 9794233 Human
mmac1 gastrointestinal polyps Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. 9797362 NA
mmac1 gastrointestinal polyps BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 NA
mmac1 hamartomas BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 NA
mmac1 gastrointestinal polyps This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 NA
mmac1 type i endometrial carcinomas Mutations of the human putative protein tyrosine phosphatase (PTEN/MMAC1) gene at chromosome 10q23 have been found frequently in type I endometrial carcinomas. 9829719 Human
mmac1 cerebellar tumor A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor. 9852626 Human
mmac1 cerebellar tumor A monoallelic expression of the mutated PTEN/MMAC1 gene may have been responsible for the development of a cerebellar tumor in the patient. 9852626 Human
mmac1 prostate tumors Finally, higher levels of Akt activation are observed in human prostate cancer cell lines and xenografts lacking PTEN/MMAC1 expression when compared with PTEN/MMAC1-positive prostate tumors or normal prostate tissue. 9861013 Human
mmac1 metastatic tumors The high rate of mutation of MMAC1 in late stage metastatic tumors suggests that effects of MMAC1 on motility, cell - cell and cell - matrix interactions are due to its tumor suppressor activity. 10644997 Human
mmac1 advanced cancers PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway. 11070083 Human
mmac1 anaplastic oligodendrogliomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
mmac1 ependymomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
mmac1 ependymal tumours METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
mmac1 anaplastic ependymomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
mmac1 cancers of the brain The candidate tumor suppressor gene PTEN (also called MMAC1) has recently been shown to be somatically altered in several common malignancies, including cancers of the brain, kidney, skin, thyroid, endometrium, breast, and prostate. 10389923 Human
mmac1 secondary glioblastomas We recently reported that PTEN (MMAC1) on 10q23.3 is mutated in approximately 30% of primary (de novo) glioblastomas but rarely in secondary glioblastomas that progressed from low-grade or anaplastic astrocytomas. 10433932 Human
mmac1 chondrosarcomas Mutations in the exons of p16, alterations of the putative tumor suppressor gene MMAC1/PTEN on chromosome 10q, or an amplification of the cyclin D1 gene (CCND1) on 11q13, which were found to be changed in other studies of chondrosarcomas, could not be dem 11859213 Human
mmac1 leiomyosarcomas Both tumors with PTEN/MMAC1 mutation were leiomyosarcomas arising from the retroperitoneum and inferior vena cava, respectively. 12569572 Human
mmac1 leiomyosarcomas This result suggests that leiomyosarcomas derived from the intra-abdominal cavity might have different tumorigenesis from those of an extremity or the trunk, from the viewpoint of PTEN/MMAC1 mutation, although PTEN/MMAC1 gene mutations are rare event in t 12569572 Human
pten hereditary breast cancer Since we could not find any relevant alterations, although further investigations are necessary, PTEN/MMAC1 seems not to play a relevant role in the genesis of hereditary breast cancer. 14518258 Human
pten primary glioblastomas In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and xenografts, and 17% (3/18) of primary glioblastomas. 9072974 Human
pten adult glioblastomas Mutations in the PTEN gene were found in 13 of 42 adult glioblastomas and 3 of 13 adult anaplastic astrocytomas, whereas none of the 21 low-grade adult gliomas or the 22 childhood gliomas of all grades showed mutations. 9331072 Human
pten anaplastic astrocytomas Mutations in the PTEN gene were found in 13 of 42 adult glioblastomas and 3 of 13 adult anaplastic astrocytomas, whereas none of the 21 low-grade adult gliomas or the 22 childhood gliomas of all grades showed mutations. 9331072 Human
pten benign tumors Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten kidney tumor A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence alterations observed in several glioma, breast, prostate, and kidney tumor specimens or cell lines. 9393738 Human
pten anaplastic meningiomas Therefore, we have investigated 36 glioblastomas and 34 meningiomas (2 benign, 17 atypical, and 15 anaplastic meningiomas) for loss on 10q, as well as deletion, mutation, and expression of PTEN. 9426052 Human
pten who grade i meningiomas No PTEN mutations were seen in the WHO grade I meningiomas. 9549723 Human
pten anaplastic meningiomas Our data suggest that mutations in PTEN are not involved in the formation of low grade meningiomas, but may contribute to malignant progression in a fraction of anaplastic meningiomas. 9549723 Human
pten mucinous tumor One mucinous tumor without 10q23 LOH was shown to harbor two somatic PTEN mutations. 9605750 Human
pten pilocytic astrocytomas PTEN mutations were detected in 20/142 glioblastomas, 1/7 giant cell glioblastomas, 1/2 gliosarcomas, 1/30 pilocytic astrocytomas and 2/22 oligodendrogliomas. 9619835 Human
pten oligodendrogliomas PTEN mutations were detected in 20/142 glioblastomas, 1/7 giant cell glioblastomas, 1/2 gliosarcomas, 1/30 pilocytic astrocytomas and 2/22 oligodendrogliomas. 9619835 Human
pten ependymomas No PTEN mutations were detected in 52 astrocytomas, 37 oligoastrocytomas, three subependymal giant cell astrocytomas, four pleomorphic xanthoastrocytomas, 15 ependymomas, 16 gangliogliomas and one dysembryoplastic neuroepithelial tumor. 9619835 Human
pten bladder tumors Identification of the second inactivation event in six bladder tumors with LOH of 10q implies that the PTEN/MMAC1 gene is occasionally involved in bladder tumorigenesis. 9671402 Human
pten lymphoid neoplasms PTEN gene alterations in lymphoid neoplasms. 9787181 Human
pten lymphoid neoplasms The present study was designed to evaluate the potential involvement of PTEN in the pathogenesis of lymphoid neoplasms. 9787181 Human
pten mesotheliomas One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell cancers) were analysed for PTEN/MMAC1 homozygous deletions and five (8%) SCL 9794233 Human
pten anaplastic oligodendrogliomas At the MMAC/PTEN locus, patients with GM exhibited a significantly increased frequency of LOH (72%) compared with patients with anaplastic astrocytomas (29%) or anaplastic oligodendrogliomas (31%) (P < 0.0001). 9796977 Human
pten gastrointestinal polyps Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. 9797362 Human
pten gastrointestinal polyps BACKGROUND & AIMS: To understand the molecular etiology of Cowden disease-associated gastrointestinal polyps, we analyzed the mutational status of PTEN/MMAC1, a recently identified Cowden disease gene located at 10q23, in gastric hamartomas, colonic adeno 9797362 Human
pten gastrointestinal polyps This study is the first to show that the mutational abrogation of PTEN/MMAC1 plays a causal role in the genesis of gastrointestinal polyps in Cowden disease, providing molecular genetic evidence that colonic adenoma, juvenile polyp, and gastric hamartoma 9797362 Human
pten type i endometrial carcinomas Mutations of the human putative protein tyrosine phosphatase (PTEN/MMAC1) gene at chromosome 10q23 have been found frequently in type I endometrial carcinomas. 9829719 Human
pten cerebellar tumor A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor. 9852626 Human
pten cerebellar tumor A monoallelic expression of the mutated PTEN/MMAC1 gene may have been responsible for the development of a cerebellar tumor in the patient. 9852626 Human
pten prostate tumors Finally, higher levels of Akt activation are observed in human prostate cancer cell lines and xenografts lacking PTEN/MMAC1 expression when compared with PTEN/MMAC1-positive prostate tumors or normal prostate tissue. 9861013 Human
pten malignant tumors of the breast A novel tumor suppressor gene, PTEN, has been mapped to 10q23.3 and is the susceptibility gene for Cowden syndrome, an autosomal dominant disorder characterized by multiple hamartomas and a risk of benign and malignant tumors of the breast and thyroid. 10534767 Human
pten colorectal tumours So far, somatic mutations of the PTEN gene have been found in several different neoplasms but not in colorectal tumours. 10607839 Human
pten colorectal tumours As exons 7 and 8 of the PTEN coding sequence contain an (A)(6)repeat and mononucleotide repeat sequences are targets for mutations in tumours with microsatellite instability (MI), we screened a panel of sporadic colorectal tumours exhibiting MI to test wh 10607839 Human
pten laryngeal tumours PTEN and LKB1 genes in laryngeal tumours. 10636746 Human
pten adult astrocytomas In total, our data suggest at least one significant distinction between the genetic etiology of pediatric and adult astrocytomas and additionally reveal that analysis of PTEN mutations in PMA patients may be useful in the differential diagnosis of these t 10632344 Human
pten secondary glioblastomas Primary (de novo) glioblastomas develop in older patients and are characterized by epidermal growth factor (EGF) receptor amplification/overexpression, p16 deletion, and PTEN mutations, whereas secondary glioblastomas that progressed from low-grade or ana 10666371 Human
pten uterine tumors PTEN mutations have been reported in the endometrioid type of uterine tumors which are associated with frequent activations of the Ras oncogenes. 10698513 Human
pten vulvar cancer Somatic mutation of PTEN in vulvar cancer. 10955808 Human
pten bladder tumors The tumor suppressor gene PTEN, which is mutated or homozygously deleted in numerous cancers, maps to a region of 10q within the reported region of minimal loss in bladder tumors. 11058880 Human
pten bladder tumors In two recent studies alterations in the PTEN gene occur at a low frequency in bladder tumors displaying 10q LOH. 11058880 Human
pten bladder tumors We have screened 35 late-stage bladder tumors for mutations in PTEN and MXI1, both genes mapping to chromosome 10q. 11058880 Human
pten bladder tumor Of 16 bladder tumor cell lines analyzed, 2 showed homozygous deletion of PTEN and 3 harbored point mutations resulting in an amino acid change. 11058880 Human
pten advanced cancers PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway. 11070083 Human
pten pilocytic astrocytomas METHODS AND RESULTS: By using molecular genetic and immunohistochemical techniques, we evaluated p16, p53, CDK4 and PTEN genes in 29 pilocytic astrocytomas. 11119125 Human
pten pilocytic astrocytomas However, altered expression of PTEN may be important in the genesis of pilocytic astrocytomas. 11119125 Human
pten cyst of the ovary Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten cysts of the ovary To investigate the potential role of the PTEN gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovarian endometrioid carcinomas, 24 clear cell carcinomas, and 34 solitary endometrial 11156411 Human
pten benign tumor Mutations of various tumor suppressor genes, e.g., PTEN, TSC1, and TSC2, are known to be responsible for different inherited diseases presenting with multiple hamartomas, a benign tumor resembling neoplasia that results from faulty organ development. 11173847 Human
pten hereditary breast cancer Current advances in molecular biology have shown that hereditary breast cancer may arise as the result of mutations of several specific gene loci including BRCA1, BRCA2, ATM gene, PTEN and p53. 14732174 Human
pten b-cell non-hodgkin's lymphomas Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas. 10092130 Human
pten anaplastic oligodendrogliomas We investigated 47 glioblastomas (GBM), 14 anaplastic astrocytomas (AA), 6 non-pilocytic low-grade astrocytomas (LGA), 21 low-grade and anaplastic oligodendrogliomas (O) and oligoastrocytomas (OA), and 3 ependymomas (E) for mutation of the PTEN gene using 10096247 Human
pten ependymomas We investigated 47 glioblastomas (GBM), 14 anaplastic astrocytomas (AA), 6 non-pilocytic low-grade astrocytomas (LGA), 21 low-grade and anaplastic oligodendrogliomas (O) and oligoastrocytomas (OA), and 3 ependymomas (E) for mutation of the PTEN gene using 10096247 Human
pten hamartomas In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. 10200246 Human
pten anaplastic oligodendrogliomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
pten ependymomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
pten ependymal tumours METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
pten anaplastic ependymomas METHODS AND RESULTS: Sixty-one formalin-fixed, paraffin-embedded oligodendroglial and ependymal tumours (16 oligodendrogliomas, 12 anaplastic oligodendrogliomas, seven oligoastrocytomas, 24 ependymomas and two anaplastic ependymomas) were examined for all 10231401 Human
pten bladder tumours We screened 123 bladder tumours for LOH in the region of PTEN. 10360673 Human
pten bladder tumour Of 15 bladder tumour cell lines analysed, three showed homozygous deletion of all or part of the PTEN gene, but none had mutations detectable by SSCP analysis. 10360673 Human
pten bladder tumours Our results indicate that PTEN is involved in the development of some bladder tumours. 10360673 Human
pten cancers of the brain The candidate tumor suppressor gene PTEN (also called MMAC1) has recently been shown to be somatically altered in several common malignancies, including cancers of the brain, kidney, skin, thyroid, endometrium, breast, and prostate. 10389923 Human
pten breast fibroadenoma Genotype-phenotype analyses within the BRR group suggested a number of correlations, including the association of PTEN mutation and cancer or breast fibroadenoma in any given CS, BRR or BRR/CS overlap family ( P = 0.014), and, in particular, truncating mu 10400993 Human
pten secondary glioblastomas We recently reported that PTEN (MMAC1) on 10q23.3 is mutated in approximately 30% of primary (de novo) glioblastomas but rarely in secondary glioblastomas that progressed from low-grade or anaplastic astrocytomas. 10433932 Human
pten ependymomas To evaluate whether morphological subsets of ependymomas are characterized by specific genetic lesions, we analyzed a series of 62 ependymal tumors, including myxopapillary ependymomas, subependymomas, ependymomas, and anaplastic ependymomas, for allelic 10433955 Human
pten anaplastic ependymomas To evaluate whether morphological subsets of ependymomas are characterized by specific genetic lesions, we analyzed a series of 62 ependymal tumors, including myxopapillary ependymomas, subependymomas, ependymomas, and anaplastic ependymomas, for allelic 10433955 Human
pten ependymomas Six ependymomas carried somatic NF2 mutations, whereas no mutations were detected in the PTEN gene. 10433955 Human
pten ductal hyperplasia Ductal hyperplasia with and without atypia exhibited higher PTEN protein levels than normal mammary epithelial cells. 10514407 Human
pten cancers of the brain Mutations in PTEN have been identified in numerous human malignancies, including cancers of the brain, endometrium, ovary, and prostate. 11259087 Human
pten gliomas These data provide evidence that PTEN regulates tumor-induced angiogenesis and the progression of gliomas to a malignant phenotype via the regulation of phosphoinositide-dependent signals. 11274365 Mouse
pten astrocytomas The transgenic astrocytomas exhibit additional molecular alterations associated with human astrocytomas, including a decreased or absent expression of p16, p19, and PTEN as well as overexpression of EGFR, MDM2, and CDK4. 11325859 Mouse
pten uterine sarcomas Mutational analysis of the PTEN gene in human uterine sarcomas. 11349153 Human
pten uterine sarcomas The PTEN gene is located on chromosome 10q23.3, a region that displays frequent loss of heterozygosity in human uterine sarcomas. 11349153 Human
pten uterine sarcoma To determine whether the PTEN gene is involved in the pathogenesis of uterine sarcoma, we analyzed deoxyribonucleic acid from uterine sarcomas and cell lines. 11349153 Human
pten uterine sarcomas To determine whether the PTEN gene is involved in the pathogenesis of uterine sarcoma, we analyzed deoxyribonucleic acid from uterine sarcomas and cell lines. 11349153 Human
pten uterine sarcoma CONCLUSIONS: Mutational inactivation of PTEN does not play a major role in uterine sarcoma tumorigenesis, and another gene or genes on chromosome 10q may be implicated as a cause of these cancers. 11349153 Human
pten endometrioid adenocarcinomas of the endometrium Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mu 11431710 Human
pten endometrioid adenocarcinomas of the endometrium Mutations in the PTEN and k-RAS genes are also frequent in endometrioid adenocarcinomas of the endometrium, particularly in the tumors that exhibit microsatellite instability, whereas beta-catenin mutations do not seem to be associated with such a phenome 11431710 Human
pten anaplastic oligodendrogliomas PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. 11438483 Human
pten colorectal tumours PTEN expression is maintained in sporadic colorectal tumours. 11439367 Human
pten colorectal tumours However, although PTEN is a good candidate for involvement in the pathogenesis of sporadic colon cancer, previous analyses have not revealed a high frequency of somatic mutations in colorectal tumours. 11439367 Human
pten skin tumors Enhanced activation of Akt occurs in Cowden's disease, an inherited syndrome of follicular thyroid, breast, colon, and skin tumors, via inactivation of its regulatory protein, PTEN. 11507060 Human
pten bph LOH associated with the PTEN locus was recorded in morphologically normal foci, BPH and adenocarcinoma. 11586263 Human
pten bph PTEN mutations in microdissected morphologically normal and BPH tissue showed alterations in nontumor tissue surrounding adenocarcinoma. 11586263 Human
pten squamous cell carcinoma of the tongue OBJECTIVES: To investigate the expression of PTEN and its clinical implication in squamous cell carcinoma of the tongue. 11735811 Human
pten tongue tumor DESIGN: Retrospective analysis of PTEN protein expression in archived primary oral tongue tumor samples. 11735811 Human
pten squamous cell carcinoma of the tongue SETTING: Academic center. PATIENTS AND METHODS: PTEN expression was determined by immunohistochemical analysis in tissue samples from 41 patients with stage II, III, and IV squamous cell carcinoma of the tongue. 11735811 Human
pten squamous cell carcinoma of the tongue CONCLUSIONS: Although genetic alterations of the PTEN gene are rare in head and neck squamous cell carcinoma, loss of PTEN is not an uncommon event in squamous cell carcinoma of the tongue. 11735811 Human
pten soft-tissue tumors [Mutation analysis of tumor suppressor gene PTEN in bone and soft tissue tumors] OBJECTIVE: To study tumor suppressor gene PTEN's role in the tumorigenesis of bone and soft tissue tumors. 11798952 Human
pten soft-tissue tumors METHODS: Exon 4 approximately 9 of PTEN were amplified by polymerase chain reaction (PCR) for homozygous deletions in 110 tumor samples of patients with bone and soft tissue tumors, 3 tumor cell lines. 11798952 Human
pten soft-tissue tumors CONCLUSIONS: At the level of DNA, PTEN mutations do not play major roles in the tumorigenesis of bone and soft tissue tumors. 11798952 Human
pten chondrosarcomas The tumor suppressor gene PTEN is located on chromosome 10q, specifically 10q23, raising the possibility that the loss of PTEN function is responsible for some chondrosarcomas. 11854598 Human
pten chondrosarcomas Mutations in the exons of p16, alterations of the putative tumor suppressor gene MMAC1/PTEN on chromosome 10q, or an amplification of the cyclin D1 gene (CCND1) on 11q13, which were found to be changed in other studies of chondrosarcomas, could not be dem 11859213 Human
pten uterine sarcomas PTEN mutations in uterine sarcomas. 11925138 Human
pten uterine sarcomas Since little is known about the molecular pathobiology, our goal was to investigate the potential role of the PTEN gene in the carcinogenesis of uterine sarcomas. 11925138 Human
pten uterine sarcomas RESULTS: Overall 8.5% (4/47) of uterine sarcomas were found to harbor somatic PTEN mutations. 11925138 Human
pten leiomyosarcomas CONCLUSIONS: These data suggest that intragenic PTEN mutations are involved in the genesis of uterine carcinosarcomas with endometrioid-type carcinoma components but rarely contribute to the pathobiology of uterine leiomyosarcomas. 11925138 Human
pten necrosis Parameters assessed were age at diagnosis, survival, cell type, proliferation, necrosis, microvascular proliferation, sarcomatous growth, lymphocytic infiltration, thromboses, calcifications, GFAP expression, MIB-1 index, loss of heterozygosity (LOH) of t 11939587 Human
pten familial cancer PTEN is mutated at high frequency in many primary human cancers and several familial cancer predisposition disorders. 11997518 Human
pten schwannomas PTEN is not altered in sporadic vestibular schwannomas. 12047763 Human
pten schwannomas AIMS: To investigate the role of the tumour suppressor gene PTEN in the tumorigenesis and growth of sporadic vestibular schwannomas, and to characterize the cellular distribution of the PTEN protein in relation to the MIB-1 proliferation index in these tu 12047763 Human
pten schwannomas METHODS AND RESULTS: Immunoexpression of the PTEN protein was observed within the neoplastic Schwann cells in 21 out of 30 sporadic schwannomas examined (70%). 12047763 Human
pten schwannomas High levels of PTEN immmunoexpression in schwannomas were associated with an increased MIB-1 labelling index. 12047763 Human
pten schwannomas CONCLUSIONS: The PTEN tumour suppressor gene is expressed in the majority of sporadic schwannomas. 12047763 Human
pten schwannomas The maintained expression of the PTEN protein, together with the lack of detectable mutations in this gene, suggests that the function of the PTEN tumour suppressor gene is not altered in sporadic vestibular schwannomas. 12047763 Human
pten paragangliomas The authors also study the PTEN expression in NC/NE neoplasms (N = 37), including 5 melanocytic nevi, 2 melanomas, 9 carcinoids, 2 moderately differentiated neuroendocrine carcinomas, 13 poorly differentiated neuroendocrine carcinomas, 2 paragangliomas, 2 12051632 Human
pten carcinoid tumors All carcinoid tumors and melanocytic nevi showed moderate or strong immunostaining for PTEN. 12051632 Human
pten paragangliomas The paragangliomas, pheochromocytomas, medullary thyroid carcinomas, and neuroblastoma all showed a strong PTEN stain. 12051632 Human
pten in situ breast cancers We analyzed a series of 34 invasive and 18 in situ breast cancers with known molecular status of the PTEN genotype using immunohistochemistry. 12055674 Human
pten in situ cancers Reduced PTEN protein expression was seen in 38% of invasive cancers and in 11% of in situ cancers. 12055674 Human
pten malignant peripheral nerve sheath tumors Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors. 12070601 Human
pten anaplastic oligodendrogliomas Besides the wealth of data elucidating the functional roles of Pten, recent studies suggest a diagnostic significance of PTEN gene alterations as a molecular marker for poor prognosis in anaplastic astrocytomas and anaplastic oligodendrogliomas. 12084351 Human
pten leiomyosarcomas PTEN mutation analysis in uterine leiomyosarcomas and mixed mullerian sarcomas. 12114928 Human
pten pilocytic astrocytomas In 39 astrocytic tumor specimens (6 pilocytic astrocytomas, 14 fibrillary astrocytomas, 9 anaplastic astrocytomas, and 10 glioblastomas), we determined the MIB-1 labeling index, the apoptotic ratio according to nick end labeling with morphologic confirmat 12125970 Human
pten supratentorial primitive neuroectodermal tumours Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhood. 12175345 Human
pten invasive lobular carcinoma of the breast CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. 12203362 Human
pten ductal carcinomas RESULTS: To better understand the role of PTEN in breast tumor development, we have crossed Pten heterozygous mice to MMTV-Wnt-1 transgenic mice that routinely develop ductal carcinomas in the mammary gland. 11178110 Human
pten mammary tumors Female Wnt-1 transgenics heterozygous for Pten developed mammary tumors earlier than Wnt-1 transgenics that were wild type for Pten. 11178110 Mouse
pten ductal carcinoma CONCLUSIONS: An animal model has been developed in which the absence of Pten collaborates with Wnt-1 to induce ductal carcinoma in the mammary gland. 11178110 Mouse
pten leiomyosarcomas Both tumors with PTEN/MMAC1 mutation were leiomyosarcomas arising from the retroperitoneum and inferior vena cava, respectively. 12569572 Human
pten leiomyosarcomas This result suggests that leiomyosarcomas derived from the intra-abdominal cavity might have different tumorigenesis from those of an extremity or the trunk, from the viewpoint of PTEN/MMAC1 mutation, although PTEN/MMAC1 gene mutations are rare event in t 12569572 Human
pten benign tumors Expression of PTEN transcript was abnormally low in 5 of 15 (33%) cell lines and 20 of 55 (36%) primary carcinomas, whereas 0 of 71 noncancerous tissues including 16 benign tumors showed altered expression. 12569555 Human
pten gastric tumor Mutually exclusive alterations of PTEN and PIK3CA also suggest that mutations of either gene could activate the PI3-kinase/AKT signaling pathway, which is directly linked to the malignant progression of gastric tumor cells. 12569555 Human
pten refractory tumours PTEN expression was investigated in terms of each patient's progression-free interval to indicate the role of PTEN in the generation of platinum refractory tumours. 12641545 Human
pten signet-ring-cell carcinoma Signet ring cell carcinoma expressed PTEN stood the lowest (25.0%, 7/28), which was less than well and moderately differentiated ones (61.8%, 21/34) (P < 0.01). 12678979 Human
pten gastrointestinal stromal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
pten relapsed cancers We performed mutation analysis and determined PTEN gene expression in tissue from both primary and relapsed cancers and in the corresponding occult metastases. 14534684 Human
pten gangliocytoma Immunohistochemistry revealed that 75% of the LDD samples had complete or partial loss of PTEN expression accompanied by elevated phosphorylated Akt, specifically in the dysplastic gangliocytoma cells. 14566704 Human
pten dysplastic nevi We found uniformly strong PTEN expression in the cytoplasm of almost all benign and dysplastic nevi. 14576666 Human
pten rhabdomyosarcomas Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells. 14603261 Human
pten human osteosarcoma The chromosome arm on which PTEN is located is deleted in a subset of human osteosarcoma tumors. 14624456 Human
pten human osteosarcoma Immunoblot analyses of several human osteosarcoma cell lines and normal osteoblasts revealed relatively abundant levels of PTEN. 14624456 Human
pten hodgkin's disease Young women who are at a potential high-risk of developing breast cancer such as those with germline mutations of BRCA1, BRCA2, TP53, PTEN or who have previously received mantle irradiation for Hodgkin's disease need close follow-up and are candidate 14642925 Human
pten germ cell tumors Finally, we show that estrogen stimulation of gonadal somatic cells in culture, in combination with PTEN down-regulation in PGCs and the presence of leukemia inhibitory factor in the culture medium, result in high frequency of PGC transformation in tumori 14525951 Human
pten bladder tumour Restoration of the PTEN gene to invasive UM-UC-3 bladder tumour cells or expression of a dominant-negative version of the PI-3 kinase target, Akt, also potently inhibited invasion, indicating a central role for the PI-3 kinase/Akt pathway in this process. 14678387 Human
pten laryngeal squamous-cell carcinoma [Expression of p73 and PTEN in laryngeal squamous cell carcinoma and their clinical significance] BACKGROUND & OBJECTIVE: There are few ideal predictors used to evaluate the prognosis of laryngeal squamous cell carcinoma (LSCC). 14720383 Human
pten colorectal tumours While initial studies reported that PTEN gene mutations were rare in colorectal cancer, more recent reports have shown an approximate 18% incidence of somatic PTEN mutations in colorectal tumours exhibiting microsatellite instability (MSI+). 14724591 Human
pten prostate tumors Consistent with high PTEN mutation rates in human prostate tumors, these data indicate that PTEN is a critical tumor suppressor in this organ. 14747659 Mouse
pten stage i nsclc Loss of PTEN expression is not uncommon, but lacks prognostic value in stage I NSCLC. 14981940 Human
pten gastrointestinal stromal tumor Role of PTEN in gastrointestinal stromal tumor progression. 15043466 Human
pten gist CONCLUSIONS: PTEN downregulation is implied in GIST progression. 15043466 Human
pten gist The immunohistochemical assessment of PTEN status appears to be a promising method of GIST prognostication. 15043466 Human
pten benign hemangiomas Indeed, a constitutively active Akt was sufficient to induce benign hemangiomas in mice, whereas heterozyogosity for PTEN (the phosphatase and tension homologue deleted on chromosome 10), modestly enhancing basal Akt activity, dramatically enhanced vGPCR 15047889 Human
pten oligodendroglial neoplasms We characterized 138 of 189 (73%) available primary and recurrent oligodendroglial neoplasms from 80 patients, utilizing paired FISH probes for 1p32/1q42, 19p13/19q13, CEP7/EGFR, CEP9/p16, and PTEN/DMBT1. 15099021 Human
pten gastric lymphoma The expression of PTEN was negatively correlated with invasion and lymph node metastasis of gastric lymphoma (P < 0.05), while the Caspase-3 expression was negatively associated with the latter one (P < 0.05). 15104220 Human
pten gastric lymphoma CONCLUSIONS: The down-regulated expression of PTEN and Caspase-3 played an important role in progression of primary malignant gastric lymphoma. 15104220 Human
pten ovarian cyst METHODS: Mutated exon 5 of PTEN gene was examined in normal ovary (n=5), ovarian cyst (n=5), ovarian borderline tumor (n=9), epithelial ovarian cancer (n=60), and ovarian cancer cell line (n=1) by polymerase chain reaction-single strand conformation polym 15104221 Human
pten type ii endometrial carcinoma Microsatellite instability and mutations in the PTEN gene have been widely associated with type I (endometrioid) endometrial carcinoma, while p53 mutations have been identified in the majority of type II endometrial carcinoma, of which uterine serous carc 14976538 Human
pten mucinous tumors Type I tumors are associated with distinct molecular changes that are rarely found in type II tumors, such as BRAF and KRAS mutations for serous tumors, KRAS mutations for mucinous tumors, and beta-catenin and PTEN mutations and microsatellite instability 15111296 Human
pten tumors of breast Loss of PTEN tumor suppressor function is observed in tumors of breast, prostate, thyroid, and endometrial origin. 15126336 Human
pten laryngeal squamous-cell carcinoma [Detection of mutation in exon 5 and exon 8 of PTEN in laryngeal squamous cell carcinoma] OBJECTIVE: To detect mutations of exon 5 and exon 8 of phosphatase and tensin homology deleted on chromosome10/mutated in multiple advanced cancer1/TGF-beta regulate 15127561 Human
pten adenocarcinoma of the uterine cervix Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix. 15172121 Human
pten endometrioid adenocarcinomas of the endometrium Although the mutation of PTEN, a tumor suppressor, is known to be involved in tumorigenesis of endometrioid adenocarcinomas of the endometrium and ovary, the role of PTEN alteration in endometrioid adenocarcinoma of the cervix remains to be investigated. 15172121 Human
pten endometrioid adenocarcinoma of the cervix Although the mutation of PTEN, a tumor suppressor, is known to be involved in tumorigenesis of endometrioid adenocarcinomas of the endometrium and ovary, the role of PTEN alteration in endometrioid adenocarcinoma of the cervix remains to be investigated. 15172121 Human
pten cervical adenocarcinoma To elucidate the molecular pathogenesis of cervical adenocarcinoma and adenosquamous carcinoma, and in particular to examine the potential role of PTEN mutation in endometrioid-type cancer of the cervix, we analyzed 32 cervical adeno- or adenosquamous car 15172121 Human
pten adenosquamous carcinoma To elucidate the molecular pathogenesis of cervical adenocarcinoma and adenosquamous carcinoma, and in particular to examine the potential role of PTEN mutation in endometrioid-type cancer of the cervix, we analyzed 32 cervical adeno- or adenosquamous car 15172121 Human
pten mucinous adenocarcinomas To elucidate the molecular pathogenesis of cervical adenocarcinoma and adenosquamous carcinoma, and in particular to examine the potential role of PTEN mutation in endometrioid-type cancer of the cervix, we analyzed 32 cervical adeno- or adenosquamous car 15172121 Human
pten adenosquamous carcinomas To elucidate the molecular pathogenesis of cervical adenocarcinoma and adenosquamous carcinoma, and in particular to examine the potential role of PTEN mutation in endometrioid-type cancer of the cervix, we analyzed 32 cervical adeno- or adenosquamous car 15172121 Human
pten adenosquamous carcinomas HPV DNA was detected in 11 out of 18 (61.1%) PTEN wild-type adenocarcinomas and 8 out of 10 (80.0%) adenosquamous carcinomas. 15172121 Human
pten adenosquamous carcinomas Among 11 HPV-negative adenocarcinomas, 40.0% (2/5) endometrioid cases and 33.3% (2/6) mucinous cases were shown to be PTEN mutated, while no cases (0/21) were PTEN-mutant in the remainder (i.e. adenosquamous carcinomas and HPV-positive adenocarcinomas). 15172121 Human
pten adenocarcinomas of the cervix The current observations suggest that PTEN mutation is frequently detected in HPV-negative adenocarcinomas of the cervix and the most prevalent occurrence of PTEN mutation in endometrioid subtype is keeping with endometrial and ovarian carcinomas. 15172121 Human
pten cervical neoplasm Epigenetic and genetic alternation of PTEN in cervical neoplasm. 15196854 Human
pten cervical cancer CONCLUSIONS: PTEN methylation and loss of PTEN expression are early events in the development of cervical cancer and may have prognostic significance. 15196854 Human
pten breast and ovarian cancer INTRODUCTION: Mutations in BRCA1, BRCA2, ATM, TP53, CHK2 and PTEN account for many, but not all, multiple-case breast and ovarian cancer families. 15217503 Human
pten t-all Sensitivity or resistance to pharmacological inhibitors of PI3'-kinase correlated with tumor suppressor PTEN gene expression, as sensitive T-ALL cells do not express PTEN and have high level of activated AKT, in contrast to HUT-78 cells. 15240138 Human
pten skin tumor Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. 15289454 Human
pten skin tumors H-ras mutation is normally a hallmark of DMBA-TPA-induced skin tumors, but 70% of carcinomas from Pten+/- mice do not exhibit this mutation, and in all cases have lost the wild-type Pten allele. 15289454 Human
pten skin carcinomas Tumors that retain the Pten wild-type allele also have H-ras mutations, indicating that activation of H-ras and complete loss of Pten are mutually exclusive events in skin carcinomas. 15289454 Human
pten skin papilloma Although the conventional protocol requires serial exposures to DMBA and TPA, mice deficient for Pten developed skin papilloma within 6 weeks after a single exposure to DMBA, indicating that loss of Pten has a tumor-promoting effect. 15298725 Mouse
pten inherited cancer syndromes Whilst PTEN mutations are frequent in a variety of sporadic cancers and inherited cancer syndromes, it is not clear how frequently PTEN mutations and immunohistochemical loss of PTEN expression occur in sporadic breast cancer. 15307142 Human
pten mammary tumors Furthermore, two genetic models, one deficient in epithelial structure (Pten conditional tissue specific knockout) and one with hyperplastic epithelium and mammary tumors (MMTV-PyMT), were used to examine radiographic density. 15318935 Human
pten juvenile intestinal polyposis In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. 15378062 Human
pten endometrioid carcinomas of the endometrium PTEN: and beta-catenin mutations constitute the predominant genetic alterations in endometrioid carcinomas of the endometrium. 15492994 Human
pten malignant tumors of the breast INTRODUCTION: Cowden's disease (CD) and Bannayan-Ruvalcaba-Riley syndrome (BRRS) are allelic disorders characterized by multiple hamartomatous overgrowths of the thyroid, breast, skin, and gastrointestinal tract, and an increased risk of developing b 15067177 Human
pten synovial sarcoma PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma. 15069540 Human
pten adenoid-cystic carcinoma METHODS: ABC immunohistochemical staining was applied for detecting expression of PTEN protein in 8 kinds of cancer cell lines, including tongue cancer cell lines Tca8113 and HSC-3,oral bottom cancer cell line HSC-2, buccal cancer cell line BcaCD885, muco 15132901 Human
pten endometrial polyps Enhanced detection of atypical hyperplasia in endometrial polyps by PTEN expression. 15163017 Human
pten endometrial polyps Using immunohistochemical staining for the PTEN protein, we studied 12 endometrial polyps that were noted to contain foci of complex hyperplasia or glandular crowding. 15163017 Human
pten liver cancer Recently, we have found that HBx causes the progression of liver cancer through down-expression of PTEN, known as a tumor suppressor gene (1). 15132991 Human
pten bph But much lower PTEN expression was detected in prostate of APCa patients compared to patients with BPH or OCPCa. 15283888 Human
pten aml EXPERIMENTAL DESIGN: We examined the clinical and biological significance of Skp2 expression in AML and evaluated the relationship between Skp2 and p27Kip1 expression and phosphatase and tensin homologue (PTEN) phosphorylation. 15297415 Human
pten aml The presence of a positive correlation between Skp2 and phosphorylated PTEN suggests that an aberration in the PTEN/Skp2 signaling pathway might be operating in AML. 15297415 Human
pten ameloblastic carcinoma There were 12 ameloblastomas (two peripheral, eight solid, and two unicystic) and three ameloblastic carcinoma studied for loss of heterozygosity of tumor suppressor genes on chromosomes 1p, 3p, 9p,10q, and 17p (L-myc, hOGG1, p16, pten, and p53). 15133474 Human
pten hereditary breast cancer Hereditary breast cancer is characterized by an inherited susceptibility to breast cancer on basis of an identified germline mutation in one allele of a high penetrance susceptibility gene (such as BRCA1, BRCA2, CHEK 2, TP53 or PTEN). 15351094 Human
pten breast cancer Inactivating mutations or deletions of the PTEN gene, which result in hyper-activation of the PI3K/Akt signaling pathway, are increasingly being reported in human malignancies, including breast cancer, and have been related to features of poor prognosis a 15367412 Human
pten invasive breast cancers PTEN promoter is methylated in a proportion of invasive breast cancers. 15382065 Human
pten invasive breast carcinomas Our study was therefore designed to determine if differential methylation of the PTEN promoter region has a role in the transcriptional inactivation of the gene in invasive breast carcinomas. 15382065 Human
pten invasive human breast cancer A total of 44 samples of invasive human breast cancer, 5 breast cancer cell lines and 16 samples of normal human breast tissue from young and elderly women were studied for methylation of the PTEN promoter by methylation-specific PCR and PTEN protein expr 15382065 Human
pten hematological malignancies Initial studies performed on cancer cell lines suggested that PTEN may be responsible for almost all types of cancer, both solid tumors and hematological malignancies. 15448614 Human
pten invasive ductal carcinoma of the breast Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast. 15551732 Human
pten invasive ductal carcinoma Formalin-fixed, paraffin-embedded tissues from 99 women with a primary diagnosis of invasive ductal carcinoma were evaluated for PTEN expression by immunohistochemical methods. 15551732 Human
pten invasive ductal carcinoma Reduced PTEN expression was seen in 27.3% of invasive ductal carcinoma. 15551732 Human
pten invasive ductal carcinoma Our results suggest that reduced PTEN expression may be an independent prognostic indicator in patients with invasive ductal carcinoma. 15551732 Human
pten tumor angiogenesis PTEN loss may be associated with increased tumor angiogenesis. 15551732 Human
pten endometrial carcinoma Thus, PTEN mutations are frequent in sporadic endometrial carcinoma and define a prognostically favourable subgroup, whereas the relationship with PTEN protein expression is complex. 15547698 Human
pten supratentorial primitive neuroectodermal tumors PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors. 15547761 Human
pten pnet The aim of this study was to compare the status of homozygous deletion and expression of PTEN and DMBT1 genes in PNET primary tumor samples and cell lines. 15547761 Human
pten supratentorial pnet Homozygous deletions of PTEN and DMBT1 were studied in 32 paraffin-embedded PNET samples (23 medulloblastomas and 9 supratentorial PNET) and in 7 PNET cell lines, by differential PCR and by FISH. 15547761 Human
pten pnet Homozygous deletions of PTEN and DMBT1 were studied in 32 paraffin-embedded PNET samples (23 medulloblastomas and 9 supratentorial PNET) and in 7 PNET cell lines, by differential PCR and by FISH. 15547761 Human
pten supratentorial pnet PTEN homozygous losses were demonstrated in 7 medulloblastomas (32%) and in no supratentorial PNET, while homozygous deletions of DMBT1 appeared in 1 supratentorial PNET (20%) and in 7 medulloblastomas (33%). 15547761 Human
pten pnet No homozygous deletion of PTEN or DMBT1 was detected in any of the PNET cell lines either by differential PCR or by FISH. 15547761 Human
pten pnet One PNET cell line lacked PTEN and DMBT1 expression, while 2 medulloblastoma cell lines did not express DMBT1. 15547761 Human
pten familial polyposis These findings provide novel functional links between the TSC genes and other tumor suppressors responsible for Cowden's disease (PTEN), Peutz-Jeghers syndrome (LKB1), and familial polyposis (APC). 15565817 Human
pten non-endometrioid carcinomas A strong positive PTEN immunoreaction was observed in all 45 normal proliferative endometria, 2/30 endometrioid carcinomas, and 23/25 non endometrioid carcinomas. 15584653 Human
pten in-situ carcinoma Thus (i) PTEN immunoexpression in endometrial paraffin sections is a new diagnostic tool, distinguishing PTEN-positive cyclic abnormal monoclonal proliferative endometrium (anovulatory, non atypical, simple and complex hyperplasia) from PTEN-negative (or 15584653 Human
pten tumor Promising approaches and molecular markers include gene expression profiles, DNA ploidy, loss of heterozygosity and chromosomal aberrations as detected by CGH and FISH (1q, 17p, 17q), as well as oncogenes/ tumor suppressor genes and their proteins (TP53, 15624758 Human
pten smooth muscle tumors Differential Diagnosis of Smooth Muscle Tumors Utilizing p53, pTEN and Ki-67 Expression with Estrogen and Progesterone Receptors. 15377824 Human
pten smooth muscle tumors Background/Aim: To investigate the expression and value for diagnosis of the genes, p53 and pTEN, the protein, Ki-67, and the receptors, estrogen and progesterone, in differentiating smooth muscle tumors of the uterus. 15377824 Human
pten metaplasia METHODS: Thirty cases of normal gastric mucosa, advanced and early stage gastric cancer, intestinal metaplasia, atrophic gastritis, and atypical hyperplasia were analyzed for PTEN LOH and mutations within the entire coding region of PTEN gene by PCR-SSCP 15633233 Human
pten metaplasia RESULTS: LOH rate found in respectively atrophic gastritis was 10% (3/30), intestinal metaplasia 10% (3/30), atypical hyperplasia 13.3% (4/30), early stage gastric cancer 20% (6/30), and advanced stage gastric cancer 33.3% (9/30), None of the precancerous 15633233 Human
pten papillary thyroid cancer Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens. 15680400 Human
pten anaplastic ependymoma Two cases of glioblastoma multiforme, three cases of anaplastic astrocytoma, one case of anaplastic pleomorphic xanthoastrocytoma, and one case of anaplastic ependymoma showed SSCP band shifts in PTEN mutational analyses. 15679305 Human
pten pleomorphic xanthoastrocytoma Two cases of glioblastoma multiforme, three cases of anaplastic astrocytoma, one case of anaplastic pleomorphic xanthoastrocytoma, and one case of anaplastic ependymoma showed SSCP band shifts in PTEN mutational analyses. 15679305 Human
pten nasopharyngeal carcinoma [Expression and significance of PTEN in nasopharyngeal carcinoma] OBJECTIVE: To investigate the expression of tumor suppressor gene PTEN in nasopharyngeal carcinomas and the relationship between PTEN and the progression of nasopharyngeal cancer. 15715408 Human
pten astrocytomas We hypothesized that PTEN loss and tumor hypoxia, which characterize glioblastoma but not lower grade astrocytomas, could up-regulate TF expression and cause intravascular thrombotic occlusion. 15735028 Human
pten serous carcinoma Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations: high-grade serous and possibly endometrioid carcinomas most probably arise from surface epithelial inclusion glands wit 15761464 Human
pten borderline tumors Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations: high-grade serous and possibly endometrioid carcinomas most probably arise from surface epithelial inclusion glands wit 15761464 Human
pten mucinous carcinomas Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations: high-grade serous and possibly endometrioid carcinomas most probably arise from surface epithelial inclusion glands wit 15761464 Human
pten serous carcinomas Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations: high-grade serous and possibly endometrioid carcinomas most probably arise from surface epithelial inclusion glands wit 15761464 Human
pten germ cell tumors Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. 15674339 Mouse
pten intratubular germ cell neoplasias Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. 15674339 Human
pten embryonal carcinomas We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32 seminomas, 22 embryonal carcinomas and six teratomas) and 22 intratubular germ cell neoplasias (ITGCN) adjacent to the tumors for PTEN protein and mRNA expression. 15674339 Human
pten germ cell tumors We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32 seminomas, 22 embryonal carcinomas and six teratomas) and 22 intratubular germ cell neoplasias (ITGCN) adjacent to the tumors for PTEN protein and mRNA expression. 15674339 Human
pten intratubular germ cell neoplasias We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32 seminomas, 22 embryonal carcinomas and six teratomas) and 22 intratubular germ cell neoplasias (ITGCN) adjacent to the tumors for PTEN protein and mRNA expression. 15674339 Human
pten teratomas We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32 seminomas, 22 embryonal carcinomas and six teratomas) and 22 intratubular germ cell neoplasias (ITGCN) adjacent to the tumors for PTEN protein and mRNA expression. 15674339 Human
pten seminomas We have investigated PTEN expression in 60 bioptic specimens of germ cell tumors (32 seminomas, 22 embryonal carcinomas and six teratomas) and 22 intratubular germ cell neoplasias (ITGCN) adjacent to the tumors for PTEN protein and mRNA expression. 15674339 Human
pten embryonal carcinomas In the testis, PTEN was abundantly expressed in germ cells whereas it was virtually absent from 56% of seminomas as well as from 86% of embryonal carcinomas and virtually all teratomas. 15674339 Mouse
pten teratomas In the testis, PTEN was abundantly expressed in germ cells whereas it was virtually absent from 56% of seminomas as well as from 86% of embryonal carcinomas and virtually all teratomas. 15674339 Mouse
pten seminomas In the testis, PTEN was abundantly expressed in germ cells whereas it was virtually absent from 56% of seminomas as well as from 86% of embryonal carcinomas and virtually all teratomas. 15674339 Mouse
pten testicular tumor On the contrary, ITGCN intensely expressed PTEN, indicating that loss of PTEN expression is not an early event in testicular tumor development. 15674339 Mouse
pten seminoma Analysis of microsatellites D10S551, D10S541 and D10S1765 in GCTs (n=22) showed LOH at the PTEN locus at 10q23 in at least 36% of GCTs (three embryonal carcinoma, three seminoma, two teratoma); one seminoma and one embryonal (9%) carcinoma presented an in 15674339 Mouse
pten embryonal carcinoma Analysis of microsatellites D10S551, D10S541 and D10S1765 in GCTs (n=22) showed LOH at the PTEN locus at 10q23 in at least 36% of GCTs (three embryonal carcinoma, three seminoma, two teratoma); one seminoma and one embryonal (9%) carcinoma presented an in 15674339 Mouse
pten teratoma Analysis of microsatellites D10S551, D10S541 and D10S1765 in GCTs (n=22) showed LOH at the PTEN locus at 10q23 in at least 36% of GCTs (three embryonal carcinoma, three seminoma, two teratoma); one seminoma and one embryonal (9%) carcinoma presented an in 15674339 Mouse
pten embryonal carcinoma Finally, we demonstrated that the phosphatidylinositol 3'-kinase/AKT pathway, which is regulated by the PTEN phosphatase, is crucial in regulating the proliferation of the NT2/D1 embryonal carcinoma cells, and that the cyclin-dependent kinase inhibit 15674339 Human
pten gastric adenocarcinoma Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. 15809062 Human
pten gastric adenocarcinoma To characterize the impact of PTEN on the IGF-IGFR-IGFBP axis in gastric cancer, we overexpressed PTEN using an adenovirus gene transfer system in human gastric adenocarcinoma cells, SNU-484 and SNU-663, which lack PTEN. 15809062 Human
pten cerebellar tumor Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene. 15835270 Human
pten gallbladder cancer [Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer] OBJECTIVE: To explore the relationship between the expressions of PTEN and the metastasis of the gallbladder cancer. 15875318 Human
pten gallbladder cancer METHODS: The expression of PTEN and nm23 were detected by immunohistochemical staining in 32 cases of gallbladder cancer with metastasis and the staining intensity was scored semi-quantitatively, compared with the cases without metastasis. 15875318 Human
pten gallbladder cancer RESULTS: The intensity score of PTEN and nm23 in gallbladder cancer with metastasis was 8.9947+/-4.5590 and 10.2003+/-3.9031, respectively, which was lower than that in those without metastasis (12.9433+/-4.7618 and 15.8436+/-5.6917 respectively, P < 0.01 15875318 Human
pten leiomyosarcoma To investigate the potential role and the alteration of the PTEN gene in soft tissue sarcomas (STSs), we searched for homozygous deletion and promoter hypermethylation in a series of 48 STSs that was composed of malignant fibrous histiocytoma, leiomyosarc 15891996 Human
pten malignant fibrous histiocytoma To investigate the potential role and the alteration of the PTEN gene in soft tissue sarcomas (STSs), we searched for homozygous deletion and promoter hypermethylation in a series of 48 STSs that was composed of malignant fibrous histiocytoma, leiomyosarc 15891996 Human
pten malignant peripheral nerve sheath tumor To investigate the potential role and the alteration of the PTEN gene in soft tissue sarcomas (STSs), we searched for homozygous deletion and promoter hypermethylation in a series of 48 STSs that was composed of malignant fibrous histiocytoma, leiomyosarc 15891996 Human
pten malignant peripheral nerve sheath tumor Of 6 cases with promoter methylation of PTEN gene, 5 were malignant peripheral nerve sheath tumor. 15891996 Human
pten hydatidiform moles PTEN promoter methylation and protein expression in normal early placentas and hydatidiform moles. 15784509 Human
pten hydatidiform moles OBJECTIVE: To investigate the relationship between PTEN promoter methylation and protein expression, and the possible involvement of the PTEN gene in development of gestational trophoblasts and the pathogenesis of hydatidiform moles. 15784509 Human
pten complete hydatidiform moles RESULTS: In partial and complete hydatidiform moles, the PTEN promoter methylation rate was significantly higher than in early placentas (72%, 59.4%, 14.3%; P = .000, .002, respectively), and the PTEN protein expression rate was significantly lower than i 15784509 Human
pten complete hydatidiform moles However, partial hydatidiform moles, complete hydatidiform moles, and invasive moles were not significant different in terms of PTEN promoter methylation and protein expression. 15784509 Human
pten partial hydatidiform moles However, partial hydatidiform moles, complete hydatidiform moles, and invasive moles were not significant different in terms of PTEN promoter methylation and protein expression. 15784509 Human
pten invasive moles However, partial hydatidiform moles, complete hydatidiform moles, and invasive moles were not significant different in terms of PTEN promoter methylation and protein expression. 15784509 Human
pten t-cell leukemia AKAP121 and G3BP expression was reduced, while dihydrofolate reductase (DHFR), Rap1 and RCC1 expression was elevated in response to PTEN expression in a PTEN-null T-cell leukemia line. 15782128 Human
pten endometrial intraepithelial neoplasia Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. 15948123 Human
pten ein When PTEN expression pattern was combined with EIN, the prognostic power was greatly increased (specificity from 63% for PTEN and 85% for EIN to 93% when combined; positive predictive value from 16% and 33% to 50%). 15948123 Human
pten ein We conclude that loss of PTEN expression is the first biomarker in EIN that increases the accuracy of the prognostic DS to predict cancer progression risk. 15948123 Human
pten astrocytoma Somatic induction of pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. 15958561 Human
pten astrocytoma Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. 15958561 Human
pten low-grade astrocytoma Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. 15958561 Human
pten astrocytoma However, the Pten astrocytoma suppression mechanisms are unknown. 15958561 Human
pten adult astrocytoma Depletion of Pten function in adult astrocytoma cells alleviated the apoptosis evoked by pRb family protein inactivation and also induced tumor cell invasion. 15958561 Mouse
pten astrocytoma Thus, we show that Pten deficiency in pRb-deficient astrocytoma cells contributes to tumor progression via multiple mechanisms, including suppression of apoptosis, increased cell invasion, and angiogenesis, all of which are hallmarks of high-grade astrocy 15958561 Mouse
pten pituitary adenomas In pituitary adenomas Akt1 and Akt2 mRNA were found to be over-expressed compared with normal pituitary, while PTEN transcripts showed similar levels between the two tissue types. 15947113 Human
pten adenomas Immunohistochemical expression of phospho-Akt was found to be higher in the tumours than normal pituitaries, while the protein expression of nuclear p27 and PTEN was lower in the adenomas. 15947113 Human
pten pituitary adenomas PTEN sequencing revealed no mutation in the coding region of the gene in pituitary adenomas, and thus we did not locate a cause for the increased phosphorylation of Akt. 15947113 Human
pten prostatic adenocarcinoma We found that bone morphogenetic protein (BMP) 7, a member of the BMP family, was strikingly up-regulated during the development of primary prostatic adenocarcinoma in the conditional Pten deletion mouse model. 15994952 Human
pten uterine tumors We identified a frequency of molecular alterations in both independent and metastatic tumors, including microsatellite instability (uterine tumors, 50% and 67%, respectively; ovarian tumors, 33% and 67%) and PTEN mutations (uterine tumors, 38% and 100%; o 16021566 Human
pten arteriovenous malformations A family is described with a clinical diagnosis of Cowden syndrome, a familial frameshift mutation in the PTEN gene, and large visceral arteriovenous malformations. 16061556 Human
pten arteriovenous malformations The association of these pleomorphic syndromes with arteriovenous malformations can be explained by the putative role of the PTEN gene in suppressing angiogenesis. 16061556 Human
pten prostate adenocarcinoma We further show that progression to prostate adenocarcinoma, as occurs in compound mutant mice lacking Nkx3.1 as well as the Pten tumor suppressor, is correlated with a further deregulation of antioxidants, including superoxide dismutase enzymes, and more 16061659 Human
pten lung tumors Mutations of this gene are common in brain, prostate, endometrial, and gastric cancers but occur rarely in non-small-cell lung cancer (NSCLC), although the PTEN protein is often lost in lung tumors. 16084946 Human
pten invasive ductal carcinoma of the breast Reduced Expression of PTEN Protein and Its Prognostic Implications in Invasive Ductal Carcinoma of the Breast. 16020969 Human
pten ductal carcinoma of the breast Methods: Paraffin-embedded sections ofinvasive ductal carcinoma of the breast were immunohistochemically stained for PTEN protein expression in 236 breast cancers. 16020969 Human
pten hemangiomas The syndrome is associated with mutations of the PTEN gene and is closely related to Bannayan's syndrome in which macrocephaly and benign tumors, especially lipomas and hemangiomas are pathognomic. 15920539 Human
pten lipomas The syndrome is associated with mutations of the PTEN gene and is closely related to Bannayan's syndrome in which macrocephaly and benign tumors, especially lipomas and hemangiomas are pathognomic. 15920539 Human
pten benign tumors The syndrome is associated with mutations of the PTEN gene and is closely related to Bannayan's syndrome in which macrocephaly and benign tumors, especially lipomas and hemangiomas are pathognomic. 15920539 Human
pten testicular tumors In PTEN knockout mice testicular tumors have been reported and for this reason we felt it prudent to examine the testes of our patients with genetically proven Cowden's syndrome. 15920539 Human
pten papillary transitional cell carcinoma The objective of this study was to investigate the PTEN expression profile in superficial noninvasive papillary transitional cell carcinoma (TCC) versus invasive TCC and compared the results with pathological and clinical parameters. 16123561 Human
pten familial adenomatous polyposis We analyzed the DNA of various organs and lesions in Korean patients with Cowden syndrome, their family members, and patients with familial adenomatous polyposis for germline or somatic PTEN mutations. 16007494 Human
pten colonic polyps Deletions and mutations in exons 1 to 9 of the PTEN gene were evaluated by polymerase chain reaction-single strand conformation polymorphism and sequencing analysis in esophageal acanthosis, gastric polyps, colonic polyps, skin lesions, and peripheral blo 16007494 Human
pten gastric polyps Deletions and mutations in exons 1 to 9 of the PTEN gene were evaluated by polymerase chain reaction-single strand conformation polymorphism and sequencing analysis in esophageal acanthosis, gastric polyps, colonic polyps, skin lesions, and peripheral blo 16007494 Human
pten familial adenomatous polyposis No PTEN mutations were found in their family members or in any patient with familial adenomatous polyposis. 16007494 Human
pten tumor angiogenesis The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. 16107612 Human
pten tumor angiogenesis Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis. 16107612 Mouse
pten hemangiosarcoma We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). 16145208 Human
pten hemangiosarcoma Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. 16145208 Dog
tep1 advanced cancers PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway. 11070083 Human
phosphatase and tensin homolog hemangiosarcoma Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. 16145208 Human
phosphatase and tensin homolog hemangiosarcoma We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). 16145208 Human
mmaci primary brain lymphomas With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. 11908870 Human
phosphatase and tensin homolog mds RESULTS: 95 genes, such as the genes of thrombospondin 1 (THBS1), phosphatase and tensin homolog (PTEN), MAX dimerization protein (MAD), DNA-damage-inducible transcript 3 (DDIT3), ets variant gene 1 (ETV1), G1 to S phase transition 1 (GSPT1), were shown t 15387962 Human
phosphatase and tensin homolog mds Ninety-five genes were shown to be abnormally expressed in at least five MDS patients compared to normal controls, involving cell growth and differentiation regulation, cell cycle control, signaling and redox; such as thrombospondin 1, phosphatase and ten 16211284 Human
pten head and neck cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
pten prostate cancer PTEN/MMAC1 mRNA expression was restored in nonexpressing prostate cancer cells by in vitro treatment with the demethylating agent 5-azadeoxycytidine. 9560261 Human
pten hnpcc Additional genes, PTEN (Cowden disease), MSH1 or MLH2 (HNPCC), and p53 (Li-Fraumeni syndrome) are responsible for other breast cancer syndromes but have not yet entered the clinical arena on a large scale. 9579377 Human
pten lung tumors All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles. 9598803 Human
pten renal cell carcinoma PTEN/MMAC1 was also identified as the gene predisposing to Cowden disease, an autosomal dominant cancer predisposition syndrome associated with an increased risk of breast, skin and thyroid tumors and occasional cases of other cancers including bladder an 9671402 Human
pten renal cell cancer However, the low frequency of biallelic inactivation suggests that either PTEN/MMAC1 is inactivated by other mechanisms or it is not the only target of chromosome 10q deletion in primary bladder and renal cell cancer. 9671402 Human
pten nhl These findings suggest that alterations in the PTEN/MMAC1 gene play a role in the pathogenesis of NHL. 9697884 Human
pten ependymoma No mutations of PTEN/MMAC1 were found. p53 mutations were detected in three oligoastrocytomas and one ependymoma; three out of five mutations were found in exon 4. 10231401 Human
pten ependymal tumours Mutations of PTEN/MMAC1 and p53, amplification of the MDM2 gene and allelic loss on chromosome 10q do not play a major part in the pathogenesis or anaplastic transformation of oligodendrogliomas and ependymal tumours. 10231401 Human
pten medullary thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
pten chronic myeloid leukaemia (cml) Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
pten mds Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
pten esophageal squamous cell carcinoma PTEN/MMAC1 is rarely associated with esophageal squamous cell carcinoma carcinogenesis. 10995879 Human
pten renal carcinoma PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines. 11146448 Human
pten clear cell carcinoma These results indicate that inactivation of the PTEN tumor suppressor gene is an early event in the development of ovarian endometrioid carcinoma and clear cell carcinoma of the ovary. 11156411 Human
pten cysts of the ovary [An approach to early genetic alterations in precancerous cells] To investigate the potential role of the PTEN tumor-suppressor gene in the carcinogenesis of ovarian endometrioid carcinoma and its related subtype, clear cell carcinoma, we examined 20 ovar 11197771 Human
pten cysts Somatic mutations in the PTEN gene were identified in 4 of 20 ovarian endometrioid carcinomas (20.0%), 2 of 24 clear cell carcinomas (8.3%) and 7 of 34 solitary endometrial cysts (20.6%). 11197771 Human
pten merkel cell carcinoma Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma. 11291079 Human
pten gliosarcoma Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma w 11355303 Human
pten grade ii astrocytoma Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma w 11355303 Human
pten juvenile pilocytic astrocytoma Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma w 11355303 Human
pten chromophobe renal cell carcinoma Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. 11463457 Human
pten meningeal gliomatosis To identify the role of PTEN gene in malignant gliomas. we used PCR-SSCP and direct sequencing methods to examine 44 malignant gliomas comprising 29 cases without and 15 cases with meningeal gliomatosis. 11678426 Human
pten meningeal gliomatosis In malignant gliomas without meningeal gliomatosis, 2/29 (7%) of the cases showed alteration of the PTEN gene. 11678426 Human
pten soft tissue tumors [Mutation analysis of tumor suppressor gene PTEN in bone and soft tissue tumors] OBJECTIVE: To study tumor suppressor gene PTEN's role in the tumorigenesis of bone and soft tissue tumors. 11798952 Human
pten soft tissue tumors METHODS: Exon 4 approximately 9 of PTEN were amplified by polymerase chain reaction (PCR) for homozygous deletions in 110 tumor samples of patients with bone and soft tissue tumors, 3 tumor cell lines. 11798952 Human
pten soft tissue tumors CONCLUSIONS: At the level of DNA, PTEN mutations do not play major roles in the tumorigenesis of bone and soft tissue tumors. 11798952 Human
pten pheochromocytoma Ink4a/Arf deficiency reduced tumor-free survival and shortened the latency of neoplasias associated with Pten heterozygosity, specifically pheochromocytoma, prostatic intraepithelial neoplasia, and endometrial hyperplasia. 11818530 Mouse
pten pheochromocytoma Functional synergy between Ink4a/Arf and Pten manifested most prominently in the development of pheochromocytoma, prompting an analysis of genes and loci implicated in this rare human neoplasm. 11818530 Human
pten pheochromocytoma The classical pheochromocytoma genes Ret, Vhl, and Nf-1 remained intact, a finding consistent with the intersection of these genes with pathways engaged by Pten and Ink4a/Arf. 11818530 Human
pten hnpcc To determine whether PTEN is involved in the pathogenesis of EC arising in HNPCC cases, and whether PTEN inactivation precedes MMR deficiency, we obtained 41 ECs from 29 MLH1 or MSH2 mutation positive HNPCC families and subjected them to PTEN expression a 11854177 Human
pten hnpcc These results suggest that PTEN plays a significant pathogenic role in both HNPCC and sporadic endometrial carcinogenesis, unlike the scenarios for colorectal cancer. 11854177 Human
pten serous carcinomas In contrast, serous carcinomas show a high frequency of p53 mutations and often loss of p16 expression whereas MIN and PTEN and K-ras mutations are uncommon. 11873308 Human
pten atypical endometrial hyperplasia During the progression of endometrioid carcinoma PTEN mutations and MIN are considered early changes since they are present in a high frequency in atypical endometrial hyperplasia whereas p53 mutations, loss of p16 expression and her2/neu amplification ar 11873308 Human
pten islet cell tumors Taken together with our previous observations in thyroid and islet cell tumors, our data suggest that nuclear-cytoplasmic partitioning of PTEN might also play a role in melanoma progression. 11948493 Human
pten chromophobe renal cell carcinomas We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
pten papillary renal cell carcinomas (prcc) We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
pten medullary thyroid carcinomas The authors also study the PTEN expression in NC/NE neoplasms (N = 37), including 5 melanocytic nevi, 2 melanomas, 9 carcinoids, 2 moderately differentiated neuroendocrine carcinomas, 13 poorly differentiated neuroendocrine carcinomas, 2 paragangliomas, 2 12051632 Human
pten medullary thyroid carcinomas The paragangliomas, pheochromocytomas, medullary thyroid carcinomas, and neuroblastoma all showed a strong PTEN stain. 12051632 Human
pten squamous cell cancer BACKGROUND: Fifty tumor specimens from primarily untreated patients were analyzed to elucidate the involvement of the tumor suppressor gene PTEN/MMAC1 in the development of oral squamous cell cancer. 12110043 Human
pten squamous cell cancers CONCLUSIONS: We conclude that PTEN/MMAC1 gene alterations do not play a key role in tumorigenesis of oral squamous cell cancers. 12110043 Human
pten plasma cell tumor (pct) In contrast, mouse plasma cell tumor (PCT) lines, expressing wild type PTEN, did not respond to IGF-I for Akt activation. 12149650 Mouse
pten hnpcc Immunohistochemical analysis revealed 31% (14 of 45) of the HNPCC CRCs and 41% (9 of 22) of the MSI+ sporadic tumors with absent or depressed PTEN expression. 12163369 Human
pten hnpcc Among the five HNPCC or MSI+ sporadic CRCs carrying frameshift somatic mutations with immunohistochemistry data, three had lost all PTEN expression, one showed weak PTEN expression levels, and one had mixed tumor cell populations with weak and moderate ex 12163369 Human
pten hnpcc These results suggest that PTEN frameshift mutations in HNPCC and sporadic MSI+ tumors are a consequence of mismatch repair deficiency. 12163369 Human
pten signet ring cell carcinoma Signet ring cell carcinoma showed the expression of PTEN at the lowest level (25.0 %, 7/28); less than well and moderately differentiated ones (P<0.01). 12508347 Human
pten mucoepidermoid carcinoma [Transfection of the exogenous PTEN-induced growth inhibition of the highly metastatic mucoepidermoid carcinoma cell line M3SP2 in vitro] OBJECTIVE: The purpose of this study was to evaluate the effects of the exogenous phosphatase and tensin homology del 12607368 Human
pten mucoepidermoid carcinoma CONCLUSION: These data provide evidence that the exogenous wild-type PTEN have remarkably inhibitory effects on in vitro proliferation of the highly metastatic mucoepidermoid carcinoma cell line M3SP2. 12607368 Human
pten testicular germ cell tumor PTEN appears to be essential for germ cell differentiation and an important factor in testicular germ cell tumor formation. 12620992 Mouse
pten b-cell chronic lymphocytic leukaemia (b-cll) Disparate expression of the PTEN gene: a novel finding in B-cell chronic lymphocytic leukaemia (B-CLL). 12670337 Human
pten b-cell chronic lymphocytic leukaemia (b-cll) One fifth of B-cell chronic lymphocytic leukaemia (B-CLL) patients exhibit loss of heterozygosity (LOH) at 10q23.3, the site of the tumour suppressor PTEN. 12670337 Human
pten metaplasia [Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma] OBJECTIVE: To illustrate the significance of expression of phosphatase and tensin homologue derived from chromosome ten (PTEN) encoding produc 12678979 Human
pten signet ring cell carcinoma Signet ring cell carcinoma expressed PTEN stood the lowest (25.0%, 7/28), which was less than well and moderately differentiated ones (61.8%, 21/34) (P < 0.01). 12678979 Human
pten gynecologic tumors PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors. 12712134 Human
pten idiopathic pulmonary fibrosis Furthermore, this study implicates a loss of PTEN function in the pathophysiology of idiopathic pulmonary fibrosis. 12791582 Human
pten granular cell tumor Granular cell tumor in a PHTS patient with a novel germline PTEN mutation. 12833416 Human
pten lhermitte-duclos disease Thus, mTor is required for neuronal hypertrophy downstream of Pten deficiency, but is not required for maintenance of normal neuronal soma size. mTOR inhibitors may be useful therapeutic agents for diseases in brain resulting from PTEN deficiency such as 14534328 Human
pten osteosarcoma Therefore, we predicted that the loss of PTEN expression was contributing to increased Akt activation and the subsequent growth and survival of osteosarcoma tumor cells. 14624456 Human
pten osteosarcoma Furthermore, stimulation of cell growth or induction of apoptosis in osteosarcoma cells failed to affect PTEN expression or activity. 14624456 Human
pten osteosarcoma Therefore, routine regulation of osteosarcoma cell growth and survival appears to be independent of changes in PTEN. 14624456 Human
pten laryngeal squamous cell carcinoma [Expression of p73 and PTEN in laryngeal squamous cell carcinoma and their clinical significance] BACKGROUND & OBJECTIVE: There are few ideal predictors used to evaluate the prognosis of laryngeal squamous cell carcinoma (LSCC). 14720383 Human
pten ovarian cyst RESULTS: Mutated exon 5 of PTEN gene was detected only in 5 (7.1%) cases of epithelial ovarian cancer. mRNA expression level of PTEN gene in ovarian borderline tumor or ovarian cancer was lower than that in normal ovary or ovarian cyst (P < 0.05). 15104221 Human
pten intrahepatic metastasis CONCLUSION: The aberrant expression of PTEN, Cx43, and VEGF may play a role in occurrence, progression, and intrahepatic metastasis of the hepatocellular carcinoma. 15191666 Human
pten mds RESULTS: 95 genes, such as the genes of thrombospondin 1 (THBS1), phosphatase and tensin homolog (PTEN), MAX dimerization protein (MAD), DNA-damage-inducible transcript 3 (DDIT3), ets variant gene 1 (ETV1), G1 to S phase transition 1 (GSPT1), were shown t 15387962 Human
pten carcinoma Thus (i) PTEN immunoexpression in endometrial paraffin sections is a new diagnostic tool, distinguishing PTEN-positive cyclic abnormal monoclonal proliferative endometrium (anovulatory, non atypical, simple and complex hyperplasia) from PTEN-negative (or 15584653 Human
pten complex hyperplasia Thus (i) PTEN immunoexpression in endometrial paraffin sections is a new diagnostic tool, distinguishing PTEN-positive cyclic abnormal monoclonal proliferative endometrium (anovulatory, non atypical, simple and complex hyperplasia) from PTEN-negative (or 15584653 Human
pten prostate adenocarcinoma This review notably summarizes the present knowledge of the (de)regulation of the effects of androgens, p53, Bcl-2, Bcl-xL, Bax, Akt, PTEN, Par-4, clusterine, caspases and NF-kappaB in prostate adenocarcinoma cell lines and provides an appraisal of their 15658057 Human
pten salivary gland carcinomas (sgcs) As combinations of genetic and/or epigenetic alterations occurring during salivary gland carcinogenesis are largely unknown, we here analyzed 36 salivary gland carcinomas (SGCs) for changes in INK4a/ARF, RB1, p21, p27, PTEN, p53, MDM2 and O6-MGMT genes us 15695118 Human
pten hydatidiform mole CONCLUSIONS: These findings suggest that the regulation of PTEN expression may play an important role in the development of the early gestational trophoblast and in the pathogenesis of hydatidiform mole, but not in its malignant transformation. 15784509 Human
pten mammary cancer This study identifies the PTEN as a therapeutic target for the treatment of mammary cancer and presumably other types of cancer. 16061670 Mouse
pten tumor angiogenesis CONCLUSIONS: These results suggest that loss of PTEN expression may play a critical role in tumor progression and metastasis by stimulating tumor angiogenesis in human gastric cancer. 16179839 Human
pten t-all PATIENTS AND METHODS: Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1, ASPP-1, CDH1, CDH13, DAPK, DIABLO, DKK-3, LATS-1, LATS-2, NES-1, p14, p15, p16, p57, p73, PARK-2, PTEN, sFRP1/2/4/5, SH 16192589 Human
pten mature t-cell and nk-cell neoplasms PTEN and p27 expression in mature T-cell and NK-cell neoplasms. 16194892 Human
pten hematological malignancies Recently the importance of the Pten and AKT pathway in the regulation of the immune system and development of hematological malignancies has been shown. 16194892 Human
pten alcl Partial or complete loss of Pten was detected in 66.7% of the cases of anaplastic large cell lymphoma (ALCL) compared to only 12.5% of all other mature T-/NK-cell lymphomas combined. 16194892 Human
pten anaplastic large cell lymphoma Partial or complete loss of Pten was detected in 66.7% of the cases of anaplastic large cell lymphoma (ALCL) compared to only 12.5% of all other mature T-/NK-cell lymphomas combined. 16194892 Human
pten alcl In this study, we showed that loss of Pten is more frequent in ALCL as compared to other mature T-/NK-cell lymphomas, which strongly correlates with the loss of p27 expression. 16194892 Human
pten atll We also show that PTEN and/or SHIP-1, which are PIP3 inositol phosphatases that inhibit the activation of downstream effectors of the PI3-kinase cascade, are disrupted in both ATLL neoplasias and in multilobulated nuclei-forming Jurkat cells. 16217039 Human
pten ovarian epithelial tumors Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth. 16220831 Human
pten ovarian adenocarcinomas OBJECTIVE: To evaluate the expression of tumor suppressor gene phosphatase and tensin homologue on chromosome 10 (PTEN) in ovarian epithelial tumors and its correlation with tumor growth and clinicopathologic features in ovarian adenocarcinomas. 16220831 Human
pten ovarian epithelial tumors OBJECTIVE: To evaluate the expression of tumor suppressor gene phosphatase and tensin homologue on chromosome 10 (PTEN) in ovarian epithelial tumors and its correlation with tumor growth and clinicopathologic features in ovarian adenocarcinomas. 16220831 Human
pten borderline tumors RESULTS: Reduced PTEN expression was significantly higher among the adenocarcinomas than the borderline tumors (p < 0.001). 16220831 Human
pten ovarian adenocarcinomas Tumors with reduced PTEN expression in ovarian adenocarcinomas had a significantly higher KI than those with normal PTEN expression (p < 0.01). 16220831 Human
pten ovarian epithelial tumors CONCLUSION: Our results suggest that alteration of the PTEN gene may be associated with malignant transformation of ovarian epithelial tumors. 16220831 Human
pten ovarian adenocarcinomas The PTEN gene seems to be a negative regulator of cell proliferation in ovarian adenocarcinomas. 16220831 Human
pten metastatic cancers PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. 16264263 Human
pten gastric adenocarcinoma To evaluate effect of PTEN on cell growth and IGF system in gastric cancer, human gastric adenocarcinoma cells (SNU-5 & -216) were transfected with human PTEN cDNA. 16264263 Human
pten gastric adenocarcinoma Molecular study of the tumour suppressor gene PTEN in gastric adenocarcinoma in Brazil. 16284736 Human
pten gastric adenocarcinoma In our study, DNA was obtained from 48 gastric adenocarcinoma samples, amplified, screened for all exons of the PTEN gene by PCR-SSCP and then confirmed by sequencing. 16284736 Human
pten metastatic prostate cancer Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably common in metastatic prostate cancer and the resulting activation of phosphoinostide 3-kinase, AKT and mTOR provides a major therapeutic opportunity in this disease 16288293 Human
pten acute leukemia [Expression of PTEN mRNA in acute leukemia and its clinical significance] OBJECTIVE: To explore PTEN gene expression and its clinical significance in acute leukemia. 16383243 Human
pten acute leukemias (al) METHODS: The expression levels of PTEN mRNA in 5 leukemia cell lines, 87 patients with acute leukemias (AL), including 59 acute myeloid leukemia (AML), 26 acute lymphoblastic leukemia (ALL), and 2 acute hybrid leukemia, 21 AL in complete remission (AL-CR) 16383243 Human
pten chronic myelogenous leukemia (cml) METHODS: The expression levels of PTEN mRNA in 5 leukemia cell lines, 87 patients with acute leukemias (AL), including 59 acute myeloid leukemia (AML), 26 acute lymphoblastic leukemia (ALL), and 2 acute hybrid leukemia, 21 AL in complete remission (AL-CR) 16383243 Human
pten cml The expression ratio of PTEN mRNA between CML (61.29%) and normal control (78.57%) had no statistical difference (P > 0.05). 16383243 Human
pten benign prostatic hyperplasia (bph) METHODS: The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH). 16683571 Human
pten bph The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive. 16683571 Human
pten laryngeal cancers The hypermethylation rate of PTEN gene promoter in the low mRNA expression laryngeal cancers was 70.0% (7/10), the hypermethylation rate of PTEN gene promoter in the high mRNA expression laryngeal cancers was 23.5% (4/17). 16739377 Human
pten laryngeal cancers The hypermethylation rate of PTEN gene promoter in the low mRNA expression laryngeal cancers was higher than that in the high mRNA expression laryngeal cancers (P < 0.05). 16739377 Human
pten laryngeal squamous cell carcinoma CONCLUSION: Hypermethylation of PTEN gene promoter is associated with loss of its transcription in laryngeal squamous cell carcinoma, the decreasing of PTEN mRNA expression may be related to lymph node metastasis and low differentiation of laryngeal squam 16739377 Human
pten endometrial tumors Pten was down regulated in the majority of the DES-promoted carcinomas, which is analogous to the frequent loss of PTEN expression in human endometrial tumors. 16804899 Human
pten benign ovarian tumors A PCR analysis of the minimal promoter region of the tumor suppressor PTEN in the presence of 2-pyrrolidone in 101 patients from Moscow clinics revealed changes in it in patients with endometrial (56%) or ovarian (29%) cancer, as well as in patients with 16909866 Human
pten bilateral breast carcinoma Clinical significance of CK5/6 and PTEN protein expression in patients with bilateral breast carcinoma. 16918971 Human
pten bilateral breast carcinomas CONCLUSIONS: Analysis of expression of CK5/6 and PTEN protein in bilateral breast carcinomas may be of value in clinical practice and warrant further studies. 16918971 Human
pten low-grade pin PTEN deletions were not found in 3/3 of stroma, 6/6 samples of benign glandular epithelium, and 12/12 samples of low-grade PIN. 16938570 Human
pten high-grade pin However, PTEN deletions were found in 3/13 (23%) of high-grade PIN and 24/35 (68%) of CaP. 16938570 Human
pten human bladder cancer Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients. 16951148 Human
pten carcinoma in situ (cis) In early bladder cancers, PTEN expression was repressed in 42% of superficial papillary TCC but in only 8% of cases of carcinoma in situ (CIS). 16951148 Human
pten bladder cancer Thus, PTEN deficiency may contribute to bladder cancer both by initiating superficial papillary TCC and by promoting the progression of CIS to advanced invasive and metastatic forms. 16951148 Human
pten cis Thus, PTEN deficiency may contribute to bladder cancer both by initiating superficial papillary TCC and by promoting the progression of CIS to advanced invasive and metastatic forms. 16951148 Human
mmac1 head and neck cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
mmac1 prostate cancer PTEN/MMAC1 mRNA expression was restored in nonexpressing prostate cancer cells by in vitro treatment with the demethylating agent 5-azadeoxycytidine. 9560261 Human
mmac1 renal cell carcinoma PTEN/MMAC1 was also identified as the gene predisposing to Cowden disease, an autosomal dominant cancer predisposition syndrome associated with an increased risk of breast, skin and thyroid tumors and occasional cases of other cancers including bladder an 9671402 Human
mmac1 nhl These findings suggest that alterations in the PTEN/MMAC1 gene play a role in the pathogenesis of NHL. 9697884 Human
mmac1 ependymoma No mutations of PTEN/MMAC1 were found. p53 mutations were detected in three oligoastrocytomas and one ependymoma; three out of five mutations were found in exon 4. 10231401 Human
mmac1 ependymal tumours Mutations of PTEN/MMAC1 and p53, amplification of the MDM2 gene and allelic loss on chromosome 10q do not play a major part in the pathogenesis or anaplastic transformation of oligodendrogliomas and ependymal tumours. 10231401 Human
mmac1 medullary thyroid carcinoma To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas 10741010 Human
mmac1 chronic myeloid leukaemia (cml) Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
mmac1 mds Analysis of 59 patients with acute myeloid leukaemia (AML), 26 patients with myelodysplastic syndromes (MDS) and 10 patients with chronic myeloid leukaemia (CML) only revealed a polymorphic base substitution in codon 44 in one AML patient, suggesting that 10966170 Human
mmac1 esophageal squamous cell carcinoma PTEN/MMAC1 is rarely associated with esophageal squamous cell carcinoma carcinogenesis. 10995879 Human
mmac1 chromophobe renal cell carcinoma Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. 11463457 Human
mmac1 chromophobe renal cell carcinomas We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
mmac1 papillary renal cell carcinomas (prcc) We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16 chromophobe renal cell carcinomas (chRCC) for loss of heterozygosity (LOH) at and around the PTEN/MMAC1 12011252 Human
mmac1 squamous cell cancer BACKGROUND: Fifty tumor specimens from primarily untreated patients were analyzed to elucidate the involvement of the tumor suppressor gene PTEN/MMAC1 in the development of oral squamous cell cancer. 12110043 Human
mmac1 squamous cell cancers CONCLUSIONS: We conclude that PTEN/MMAC1 gene alterations do not play a key role in tumorigenesis of oral squamous cell cancers. 12110043 Human
mmac1 gynecologic tumors PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors. 12712134 Human
mmac1 metastatic cancers PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. 16264263 Human
pten borderline ovarian tumors METHODS: We examined the promoter methylation status of 9 tumor suppressor genes (RARbeta2, TMS1, RIZ1, P15, P16, PTEN, MINT31, APC and HIC1) in 89 ovarian cancers, 16 borderline ovarian tumors, 19 benign ovarian tumors, 16 normal ovarian tissue and 5 ova 17177027 Human
pten dysplastic nevi Loss of PTEN expression from benign and dysplastic nevi to melanoma was statistically significant (p=0.001). 17302605 Human
pten squamous cervical carcinomas To evaluate the role of PTEN in other common malignancies of the female genital tract, 12 serous ovarian carcinomas and 10 squamous cervical carcinomas were analyzed and were negative for mutations. 9307275 Human
pten serous ovarian cancers The PTEN/MMAC gene on chromosome 10q23 is a tumor suppressor implicated in the pathogenesis of a wide variety of malignancies, but to date, somatic mutations in PTEN have not been identified in studies of predominantly serous ovarian cancers. 9605750 Human
pten metastatic human prostate cancers We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary and nine metastatic human prostate cancers. 9661880 Human
pten renal cell tumors Using these new informative markers, we identified apparent retention at the gene locus indicative of homozygous deletion of PTEN/MMAC1 in four of 65 bladder and 0 of 15 renal cell tumors with LOH through chromosome 10q. 9671402 Human
pten familial cancer syndromes The PTEN/MMAC1/TEP1 gene, located at 10q23.3, is a tumor suppressor gene responsible for the familial cancer syndromes Cowden disease and Bannayan-Zonana syndrome, and is commonly somatically mutated in several types of cancers. 9671408 Human
pten complex atypical hyperplasia PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. 9699651 Human
pten complex atypical hyperplasia (cah) To determine whether PTEN inactivation is a relatively early event in endometrial tumorigenesis, we evaluated complex atypical hyperplasia (CAH), the direct precursor to UEC, for the presence of PTEN mutations. 9699651 Human
pten sporadic colon cancers PTEN and LKB1 are candidate genes for mutations in sporadic colon cancers, either as initiating events in tumorigenesis or providing a selective advantage during tumor growth. 9708796 Human
pten sporadic colon cancers Using single-strand conformational polymorphism analysis, we have screened a set of sporadic colon cancers for somatic mutations in PTEN and LKB1. 9708796 Human
pten sporadic colon cancers It remains possible that PTEN and LKB1 are inactivated in other sporadic colon cancers by means such as deletion or promoter methylation. 9708796 Human
pten inherited cancer syndrome Germline mutations in PTEN have been found in the majority of cases of sporadic and familial Cowden syndrome (CS), an autosomal dominant inherited cancer syndrome characterised by multiple hamartomas and benign and malignant disease of the thyroid and bre 10548886 Human
pten hereditary cancer predisposition syndromes The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. 10555148 Human
pten ovarian borderline tumors We examined 33 primary ovarian cancers and 3 ovarian borderline tumors for allelic imbalance (AI) of the 10q23.3 region using 5 polymorphic markers, including an insertion/deletion-type polymorphic marker identified in intron 4 of the PTEN gene. 10629071 Human
pten nonendometrioid carcinomas (neec) PTEN mutations were detected in 17 tumors (44.7%), and they were more frequent in endometrioid (EEC) (17 of 33, 51.5%) than in nonendometrioid carcinomas (NEEC) (0 of 5, 0%). 10746673 Human
pten high-grade oligodendroglial tumors PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. 10812170 Human
pten low-grade oligodendroglial tumors (lg-ot) In this study, we screened for PTEN mutations in six low-grade oligodendroglial tumors (LG-OT), five 1p-/19q- HG-OT, seven +7/-10 HG-OT, and nine xenografted GBM. 10812170 Human
pten endometrioid endometrial adenocarcinomas RESULTS: The PTEN mutation rate was 83% (25 of 30) in endometrioid endometrial adenocarcinomas and 55% (16 of 29) in precancers, and the difference in number of mutations was statistically significant (two-sided P =.025). 10841828 Human
pten endometrioid endometrial adenocarcinomas Although most precancers and cancers had a mutation in only one PTEN allele, endometrioid endometrial adenocarcinomas showed complete loss of PTEN protein expression in 61% (20 of 33) of cases, and 97% (32 of 33) showed at least some diminution in express 10841828 Human
pten endocrine pancreatic tumors Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. 11021813 Human
pten low grade astrocytoma For example, p53 mutations are frequent in low grade astrocytoma, anaplastic astrocytoma and secondary glioblastoma suggesting that it takes place at an early stage of development of astrocytic tumors, whereas inactivation of PTEN arises mainly in gliobla 11048299 Human
pten mucinous cancer One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. 11093060 Human
pten undifferentiated thyroid cancer Transient expression of PTEN in seven thyroid cancer cell lines resulted in G(1) arrest in two well differentiated papillary thyroid cancer lines (PTCs) and both G(1) arrest and cell death in the remaining five lines, including three FTCs, one poorly diff 11159944 Human
pten inherited cancer syndrome Allele loss close to the PTEN locus occurs in sporadic colon cancer and germline PTEN mutations cause Cowden disease, an inherited cancer syndrome characterized by an increased incidence of gastrointestinal tract lesions that can progress to colorectal ca 11439367 Human
pten inherited cancer syndrome [Cowden disease and the PTEN gene: a successfully clinical and biological combined approach] Cowden disease is an autosomal dominant inherited cancer syndrome characterized by the occurrence of multiple hamartomas, tumors or hyperplastic lesions that may 11792608 Human
pten clear cell renal cell carcinomas (ccrcc) PTEN protein levels were examined in 42 clear cell renal cell carcinomas (ccRCC) and oncocytomas as well as in the corresponding normal renal tissue of the same patients using Western blot analysis. 11948491 Human
pten inherited cancer syndrome In the 5 years since the discovery of PTEN, encoding a dual specificity phosphatase tumor suppressor on 10q23, it has been shown to be a susceptibility gene for an inherited cancer syndrome, Cowden syndrome, and for several developmental disorders; it has 12060605 Human
pten mixed mullerian sarcomas PTEN mutation analysis in uterine leiomyosarcomas and mixed mullerian sarcomas. 12114928 Human
pten oral squamous cell carcinomas Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. 12370746 Human
pten oral squamous cell carcinomas To investigate the role of PTEN in human oral squamous cell carcinomas, we screened the entire coding region sequences and examined the expression of the PTEN gene in 81 oral cancers displaying microsatellite stability (MSS) and 5 oral cancers displaying 12370746 Human
pten benign epithelial ovarian tumors PTEN protein expression deletion in epithelial ovarian cancers (23%) was higher than those of normal ovarian tissues (0) and benign epithelial ovarian tumors (0, P < 0.05). 12487936 Human
pten hereditary cancer syndromes PTEN is a tumor suppressor gene mutated in many human sporadic cancers and in hereditary cancer syndromes such as Cowden disease, Bannayan-Zonana syndrome and Lhermitte-Duclos disease. 12655146 Human
pten primary liver cancer Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. 12767263 Human
pten lymph node metastases Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. 12873978 Mouse
pten tumor thrombus The positive rate of PTEN protein in HCC tissues were relative to the histological gading and the presence of tumor thrombus. 12939185 Human
pten sporadic colorectal cancer Intratumoral heterogeneity in microsatellite alterations in BRCA1 and PTEN regions in sporadic colorectal cancer. 14527905 Human
pten cervical lymph node metastasis PTEN protein positive expression was stronger in stage I-II of LSCC than that in stage III-IV (P< 0.05); PTEN protein positive expression appears less frequently in poor differentiation of LSCC, compared to well/moderate differentiation (P< 0.05); PTEN po 14720383 Human
pten sporadic colorectal cancer This work therefore establishes the importance of PTEN in primary sporadic colorectal cancer. 14724591 Human
pten common cancer In human endometrial cancer, the fourth most common cancer in women, tumor suppressor phosphatase tensin homologue (PTEN) is frequently mutated. 15067356 Human
pten primary gastric malignant lymphoma Expression of PTEN and Caspase-3 and their clinicopathological significance in primary gastric malignant lymphoma. 15104220 Human
pten primary gastric malignant lymphoma OBJECTIVE: To investigate the expression of PTEN and Caspase-3 in malignant lymphoma of the stomach and explore their role in progression of primary gastric malignant lymphoma. 15104220 Human
pten primary gastric malignant lymphoma METHODS: Formalin-fixed paraffin embedded tissues from 56 cases of primary gastric malignant lymphoma and their adjacent non-tumor mucosa were evaluated for PTEN and Caspase-3 protein expression by streptavidin-biotin-complex (SABC) immunohistochemistry. 15104220 Human
pten primary gastric lymphomas RESULTS: The positive rate of PTEN expression in primary gastric lymphomas (50.0%, 28/56) was significantly lower than that in adjacent non-tumor gastric mucosa (96.4%, 27/28) (P < 0.05). 15104220 Human
pten primary gastric malignant lymphoma Additionally, the PTEN expression was positively correlated with Caspase-3 expression in the primary gastric malignant lymphoma (P < 0.05). 15104220 Human
pten ovarian borderline tumor METHODS: Mutated exon 5 of PTEN gene was examined in normal ovary (n=5), ovarian cyst (n=5), ovarian borderline tumor (n=9), epithelial ovarian cancer (n=60), and ovarian cancer cell line (n=1) by polymerase chain reaction-single strand conformation polym 15104221 Human
pten ovarian borderline tumor RESULTS: Mutated exon 5 of PTEN gene was detected only in 5 (7.1%) cases of epithelial ovarian cancer. mRNA expression level of PTEN gene in ovarian borderline tumor or ovarian cancer was lower than that in normal ovary or ovarian cyst (P < 0.05). 15104221 Human
pten mucinous cancer The level of PTEN gene mRNA expression was negatively correlated with clinicopathological staging of ovarian cancer, whereas positively correlated with histological differentiation (P < 0.05). mRNA expression level of PTEN gene in ovarian endometrioid can 15104221 Human
pten hereditary cancer syndromes Pten, a tumor suppressor gene, is mutated in various human cancers and in hereditary cancer syndromes, such as Cowden disease. 15298725 Human
pten in situ carcinoma Thus (i) PTEN immunoexpression in endometrial paraffin sections is a new diagnostic tool, distinguishing PTEN-positive cyclic abnormal monoclonal proliferative endometrium (anovulatory, non atypical, simple and complex hyperplasia) from PTEN-negative (or 15584653 Human
pten salivary adenoid cystic carcinoma (sacc) [The expression of PTEN and PKB in salivary adenoid cystic carcinoma and its clinical significance] PURPOSE: To investigate the expression of PTEN and PKB in salivary adenoid cystic carcinoma (SACC) and its clinical significance. 15886842 Human
pten salivary adenoid cystic carcinoma [The expression of PTEN and PKB in salivary adenoid cystic carcinoma and its clinical significance] PURPOSE: To investigate the expression of PTEN and PKB in salivary adenoid cystic carcinoma (SACC) and its clinical significance. 15886842 Human
pten salivary adenoid cystic carcinoma CONCLUSIONS: The expression of PTEN and PKB may be related to the occurrence and progress of salivary adenoid cystic carcinoma,PTEN and PKB may have effect on metastasis. 15886842 Human
pten intrahepatic cholangiocellular carcinoma Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. 16767220 Mouse
pten primary bladder cancer In humans, 53% of primary bladder cancer patients exhibited decreased or absent expression of PTEN protein in either the cytoplasm or nucleus of tumor cells. 16951148 Human
pten early bladder cancers In early bladder cancers, PTEN expression was repressed in 42% of superficial papillary TCC but in only 8% of cases of carcinoma in situ (CIS). 16951148 Human
pten advanced bladder cancers In advanced bladder cancers, PTEN protein was significantly reduced (particularly in the nucleus) in 94% of cases, and this decrease in PTEN correlated with disease stage and grade. 16951148 Human
mmac1 renal cell tumors Using these new informative markers, we identified apparent retention at the gene locus indicative of homozygous deletion of PTEN/MMAC1 in four of 65 bladder and 0 of 15 renal cell tumors with LOH through chromosome 10q. 9671402 Human
pten metastatic cancer [Expression of PTEN protein in oromaxillofacial tumor cell lines] AIM: To investigate expression of PTEN protein in oromaxillofacial tumor cell lines and to compare the difference of PTEN protein expression between highly metastatic cancer cell lines and 15132901 Human
pten adenoid cystic carcinoma METHODS: ABC immunohistochemical staining was applied for detecting expression of PTEN protein in 8 kinds of cancer cell lines, including tongue cancer cell lines Tca8113 and HSC-3,oral bottom cancer cell line HSC-2, buccal cancer cell line BcaCD885, muco 15132901 Human
pten mucoepidermoid carcinoma METHODS: ABC immunohistochemical staining was applied for detecting expression of PTEN protein in 8 kinds of cancer cell lines, including tongue cancer cell lines Tca8113 and HSC-3,oral bottom cancer cell line HSC-2, buccal cancer cell line BcaCD885, muco 15132901 Human
pten tongue cancer METHODS: ABC immunohistochemical staining was applied for detecting expression of PTEN protein in 8 kinds of cancer cell lines, including tongue cancer cell lines Tca8113 and HSC-3,oral bottom cancer cell line HSC-2, buccal cancer cell line BcaCD885, muco 15132901 Human
pten nasopharyngeal cancer [Expression and significance of PTEN in nasopharyngeal carcinoma] OBJECTIVE: To investigate the expression of tumor suppressor gene PTEN in nasopharyngeal carcinomas and the relationship between PTEN and the progression of nasopharyngeal cancer. 15715408 Human
pten nasopharyngeal carcinomas [Expression and significance of PTEN in nasopharyngeal carcinoma] OBJECTIVE: To investigate the expression of tumor suppressor gene PTEN in nasopharyngeal carcinomas and the relationship between PTEN and the progression of nasopharyngeal cancer. 15715408 Human
pten nasopharyngeal carcinoma METHOD: The SABC immunohistochemistry method was employed to detect the expression of PTEN in paraffin-embedded nasopharyngeal carcinoma tissues. 15715408 Human
pten nasopharyngeal carcinoma RESULT: Loss of PTEN expression in normal cases (13.3%) was lower than that in nasopharyngeal carcinoma cases (47.8%). 15715408 Human
pten nasopharyngeal cancer Of nasopharyngeal cancer cases, loss of PTEN expression in squama cell nasopharyngeal (58.1%) was higher than that in others tissue type (30.8%); loss of PTEN expression in squama cell nasopharyngeal had correlation with pathological stage, which increase 15715408 Human
pten nasopharyngeal carcinoma CONCLUSION: It is presumed that PTEN gene deletion may be involved in carcinogenesis and progression of nasopharyngeal carcinoma, and relates to the tissue type, the pathological grade and clinical stage. 15715408 Human
pten gallbladder cancer CONCLUSION: The lower expressions of PTEN and nm23 are related to the metastasis of gallbladder cancer. 15875318 Human
pten carney complex The molecular pathways involved in the aetiology of these syndromes have recently been more clearly defined and several major cellular signalling pathways are probably involved: the protein kinase A (PKA) pathway in Carney complex (CNC), the Ras/Erk MAP k 15958502 Human
pten plasma cell leukemia (pcl) Clonal plasma cells from patients with multiple myeloma (MM), plasma cell leukemia (PCL) and human myeloma cell lines (HMCLs) were analyzed for deletions/mutations of the tumor suppressor gene PTEN. 16112193 Human
pten skin tumors Skin tumors induced by the classical two stage carcinogenesis protocols show consistent activating mutations of the H-ras gene, but in tumors from Pten heterozygous mice, the frequency of these mutations is markedly decreased, suggesting some redundancy b 16123588 Human
pten skin tumor These observations revealed the essential functions of Smad4-mediated signals in repressing skin tumor formation through the TGFbeta/BMP pathway, which interacts with the Pten signaling pathway. 16170355 Human
pten endometrioid tumour Moreover, in a model of genetically engineered mice harbouring an oncogenic allele of K-ras resulting in benign lesions reminiscent of endometriosis, a conditional deletion of PTEN caused the progression towards the endometrioid tumour. 16172112 Mouse
pten skin tumor Interestingly, coordinated deletion of the Smad4 and PTEN genes resulted in accelerated hair loss and skin tumor formation, suggesting that Smad4 and PTEN act synergistically to regulate epidermal proliferation and differentiation. 16204035 Mouse
pten invasive ductal carcinomas of the breast METHODS: The immunohistochemic expression of p27 and PTEN protein expression was evaluated in a series of 228 invasive ductal carcinomas of the breast. 16208702 Human
pten lung adenocarcinomas PATIENTS AND METHODS: Using immunohistochemical analysis, we retrospectively analyzed EGFR, pAKT, PTEN, Ki-67, p27 and hTERT expression in specimens from 190 patients with completely resected lung adenocarcinomas (43 never-smokers and 147 smokers). 16219624 Human
pten familial breast cancer Mutations in TP53 (Li-Fraumeni syndrome) and PTEN (Cowden's disease), associated with increased risk of breast cancer, are responsible for a smaller portion of familial breast cancer.The risk of inheritance and disease can be identified and defined b 16237564 Human
pten malignant gliomas METHODS: We sequenced kinase domains in the EGFR and human EGFR type 2 (Her2/neu) genes and analyzed the expression of EGFR, EGFR deletion mutant variant III (EGFRvIII), and the tumor-suppressor protein PTEN in recurrent malignant gliomas from patients wh 16282176 Human
pten polyp Germline analysis of PTEN, BMPR1A, STK11 (sequence, deletion), SMAD4, and ENG (sequence), specific exon screening of BRAF, MYH, and BHD, and rereview of polyp histology results were performed. 16287957 Human
pten juvenile polyposis Of 14 patients with juvenile polyposis, 2 with early-onset disease had mutations in ENG, encoding endoglin, previously only associated with hereditary hemorrhagic telangiectasia; 1 had hemizygous deletion encompassing PTEN and BMPR1A; and 1 had an SMAD4 m 16287957 Human
pten polyposis Of the 23 patients with hyperplastic/mixed polyposis, 2 had PTEN mutations. 16287957 Human
pten metaplasia Recent analysis of mice with pancreas-specific deletion of the PTEN tumor suppressor gene has provided new insight into the mechanism of metaplasia and focuses attention on pancreatic centroacinar cells as candidates for the cellular origin of PDAC. 16322695 Human
pten mds Furthermore, all high-risk MDS patients also demonstrated high expression of the Class I PI3K p110delta catalytic subunit and a decreased expression of PTEN. 16341040 Human
pten ductal carcinomas Expression levels of PTEN, phosphorylated forms of the constituent proteins (Akt, FKHR, mTOR, and S6) and cyclin D1 were evaluated by immunohistochemistry, on consecutive sections from a tissue microarray containing 145 invasive breast cancers and 140 pur 16341149 Human
pten invasive breast cancers Expression levels of PTEN, phosphorylated forms of the constituent proteins (Akt, FKHR, mTOR, and S6) and cyclin D1 were evaluated by immunohistochemistry, on consecutive sections from a tissue microarray containing 145 invasive breast cancers and 140 pur 16341149 Human
pten invasive cancers Expression levels of PTEN and S6 were significantly different in in-situ and invasive cancers, indicating association with disease progression. 16341149 Human
pten invasive cancers Loss of PTEN was noted in 11% of in-situ as compared to 26% of invasive cancers, while S6 overexpression was seen in 47% in-situ and in 72% invasive cancers. 16341149 Human
pten uveal melanoma High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. 16344319 Human
pten uveal melanoma PURPOSE: Although cytogenetic aberrations at 10q have been reported in up to 27% of uveal melanomas, the role of PTEN in the pathogenesis of uveal melanoma is largely unknown. 16344319 Human
pten uveal melanomas PURPOSE: Although cytogenetic aberrations at 10q have been reported in up to 27% of uveal melanomas, the role of PTEN in the pathogenesis of uveal melanoma is largely unknown. 16344319 Human
pten uveal melanomas Our aim was to determine the frequency and clinical significance of PTEN alterations in uveal melanomas. 16344319 Human
pten uveal melanomas PATIENTS AND METHODS: We examined PTEN expression using immunohistochemistry in 75 sporadic uveal melanomas, with an average follow-up of 89 months. 16344319 Human
pten uveal melanoma CONCLUSION: This is the first demonstration that PTEN is a tumor suppressor involved in uveal melanoma pathogenesis and may be associated with clinical outcome. 16344319 Human
pten uveal melanomas Our data also suggest that submicroscopic deletion, but not large deletions, is the major mechanism of loss of PTEN expression in uveal melanomas. 16344319 Human
pten prostate cancer This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. 16375758 Human
pten venous malformations These genes include AGGF1 for Klippel-Trenaunay syndrome, RASA1 for capillary malformations, KRIT1, MGC4607, PDCD10 for cerebral cavernous malformations, glomulin for glomuvenous malformations, TIE2 for multiple cutaneous and mucosal venous malformations, 16379592 Human
pten metaplasia METHODS: The expression of Skp2 in 138 specimens of gastric cancer and their paired adjacent mucosa, 102 specimens of paired metastatic lymph nodes, 30 specimens of dysplasia, 30 specimens of intestinal metaplasia, 10 specimens of chronic superficial gast 16405750 Human
pten mammary gland tumors Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs. 16426222 Human
pten endometrioid tumours To determine the molecular mechanisms involved in the initiation of endometrioid carcinoma, the present study investigated whether the genetic alterations reported in these tumours (mutations in PTEN, KRAS, and beta-catenin genes, and microsatellite insta 16429393 Human
pten endometrioid tumours In conclusion, the present study identifies beta-catenin mutation as a nearly constant molecular alteration in borderline endometrioid tumours, whereas PTEN and KRAS mutations and microsatellite instability are very infrequent. 16429393 Human
pten sporadic breast cancers Our observations suggest that differential expression of PTEN and its SVs could play a role in the pathogenesis of sporadic breast cancers and CS, and may lend a novel way of making a rapid molecular diagnosis of CS without mutation analysis. 16436456 Human
pten renal tumor These results indicate that Pax2 is involved in renal tumor angiogenesis and its expression may antagonize that of the PTEN tumor suppressor gene, affecting the Akt-survival pathway and promoting angiogenesis. 16436683 Human
pten papillomas PTEN inactivation in K14.cre/PTEN(flx/flx) keratinocytes resulted in epidermal hyperplasia/hyperkeratosis and novel 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted papillomas, whereas HK1.ras/K14.cre/PTEN(flx/flx) cohorts displayed a rapid onset of pa 16452183 Human
pten gastric adenocarcinoma The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185(HER2) with loss of PTEN expression in gastric adenocarcinoma patients. 16457151 Human
pten gastric adenocarcinoma METHODS: The protein expression of p185(HER2) and PTEN was examined by immunohistochemical stain in paraffin-embedded tissues of 94 (M:F, 52:42) gastric adenocarcinoma patients by using monoclonal antibody, and the results were related to clinicopathologi 16457151 Human
pten gastric adenocarcinoma CONCLUSIONS: Our observations suggest potential prognostic significance of p185(HER2) overexpression with PTEN loss in gastric adenocarcinoma patients. 16457151 Human
pten squamous cell carcinoma of the uterine cervix The purpose of this study was to evaluate PTEN expression in the successive steps of progression in cervical neoplasia and to determine its correlation with tumor angiogenesis and clinicopathologic features in squamous cell carcinoma of the uterine cervix 16482604 Human
pten tumor angiogenesis The purpose of this study was to evaluate PTEN expression in the successive steps of progression in cervical neoplasia and to determine its correlation with tumor angiogenesis and clinicopathologic features in squamous cell carcinoma of the uterine cervix 16482604 Human
pten squamous cell carcinoma of the uterine cervix Reduced PTEN expression is not associated with tumor angiogenesis of squamous cell carcinoma of the uterine cervix. 16482604 Human
pten tumor angiogenesis Reduced PTEN expression is not associated with tumor angiogenesis of squamous cell carcinoma of the uterine cervix. 16482604 Human
pten undifferentiated carcinomas Hypermethylation of tumor suppressor and tumor-related genes, including APC, CHFR, DAP-kinase, DCC, E-cadherin, GSTP1, hMLH1, p16, PTEN, RASSF1A, RUNX3, and TSLC1, can be detected in both differentiated and undifferentiated carcinomas at varying frequenci 16482617 Human
pten tumors of the endometrium PTEN somatic mutations occur in sporadic tumors of the endometrium, brain, prostate, or melanomas, while germline mutations predispose to development of the multiple hamartoma syndromes (i.e., Cowden's disease and Bannayan-Zonana syndrome). 16487009 Human
pten follicular adenomas PTEN promoter hypermethylation was detected in 21 of 46 (45.7%) papillary carcinomas, 6 of 7 follicular carcinomas, and 5 of 6 follicular adenomas. 16487009 Human
pten follicular carcinomas PTEN promoter hypermethylation was detected in 21 of 46 (45.7%) papillary carcinomas, 6 of 7 follicular carcinomas, and 5 of 6 follicular adenomas. 16487009 Human
pten papillary carcinomas PTEN promoter hypermethylation was detected in 21 of 46 (45.7%) papillary carcinomas, 6 of 7 follicular carcinomas, and 5 of 6 follicular adenomas. 16487009 Human
pten prostatic adenocarcinoma This model harboring the Fgf8b transgene and haploinsufficiency in Pten, both in a prostate epithelium-specific manner, yielded prostatic adenocarcinoma with readily detectable lymph node metastases, whereas single models with each of the defects were sho 16489020 Human
pten invasive cancer Here, we identified loss of heterozygosity at the Pten gene leading to bialleic loss, as a necessary secondary event, indicating that a complete loss of PTEN function is required in the development of invasive cancer in the model. 16489020 Mouse
pten multiple myeloma Sensitization was achieved in multiple myeloma cells irrespective of their PTEN or p53 status, enhanced by activation of AKT, and associated with stimulation of both intrinsic and extrinsic pathways of apoptosis. 16489035 Human
pten mammary tumors Expression of a heparin binding growth factor, pleiotrophin (Ptn), was found to be up-regulated in Pten-/- MEFs as well as Pten null mammary tumors. 16507572 Human
pten serous carcinoma These markers did not show association with volume or stage of the tumor. p53 is associated with serous carcinoma, loss of differentiation, and older patients, whereas PTEN inactivation is an early event in carcinogenesis of the endometrioid subtype, as o 16515600 Human
pten type i endometrial carcinoma These markers did not show association with volume or stage of the tumor. p53 is associated with serous carcinoma, loss of differentiation, and older patients, whereas PTEN inactivation is an early event in carcinogenesis of the endometrioid subtype, as o 16515600 Human
pten invasive ductal carcinomas of the breast Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters. 16517411 Human
pten benign tumour Loss of heterozygosity (LOH) analysis showed loss of PTEN in four malignant tumours (40%) and in one benign tumour (14%). 16538614 Human
pten ovarian cancer DESIGN, SETTING, AND PARTICIPANTS: Between 2002-2005, probands from 300 US families with 4 or more cases of breast or ovarian cancer but with negative (wild-type) commercial genetic test results for BRCA1 and BRCA2 were screened by multiple DNA-based and 16551709 Human
pten endocrine tumor Almost two decades later, and after the first successful applications of positional cloning in Endocrine Genetics with the identification of RET, menin, PTEN and PRKAR1A in the various forms of multiple endocrine tumor syndromes, and a number of other gen 16574630 Human
pten leukaemia PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. 16633340 Mouse
pten lymphoid leukaemia Notably, the cell populations that expand in PTEN mutants match those that become dominant in the acute myeloid/lymphoid leukaemia that develops in the later stages of MPD. 16633340 Human
pten mpd Notably, the cell populations that expand in PTEN mutants match those that become dominant in the acute myeloid/lymphoid leukaemia that develops in the later stages of MPD. 16633340 Human
pten mcl Six MCL cases (5 with activated Akt and 1 with inactive Akt) and 3 of 4 cell lines showed loss of PTEN expression. 16645163 Human
pten tongue squamous cell carcinoma [Expression and significance of PTEN protein in tongue squamous cell carcinoma] PURPOSE: To study the expressions and clinical significance of PTEN protein in tongue squamous cell carcinoma (TSCC). 16685350 Human
pten tongue squamous cell carcinoma CONCLUSION: Expressions of PTEN is correlated with cervical lymphnode metastasis in tongue squamous cell carcinoma. 16685350 Human
pten histiocytic sarcoma The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. 16697958 Human
pten common cancers In summary, our results show that common variants in PTEN do not substantially influence risk of these two common cancers. 16702386 Human
pten neuromas Mucocutaneous Neuromas: An Underrecognized Manifestation of PTEN Hamartoma-Tumor Syndrome. 16702501 Human
pten medulloblastoma Phosphatidylinositol 3'-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN. 16707597 Human
pten medulloblastoma As the activation of PI3K/AKT signaling may be associated with alterations of the PTEN gene located at 10q23.3, a chromosomal region subject to frequent allelic losses in medulloblastoma, we screened PTEN for mutations and mRNA expression. 16707597 Human
pten medulloblastoma One medulloblastoma cell line was found to carry a truncating mutation in the PTEN coding sequence. 16707597 Human
pten medulloblastomas Even more important, PTEN mRNA and protein levels were found to be significantly lower in medulloblastomas compared with normal cerebellar tissue of different developmental stages. 16707597 Human
pten medulloblastoma CONCLUSIONS: We conclude that activation of the PI3K/AKT pathway constitutes an important step in the molecular pathogenesis of medulloblastoma and that dysregulation of PTEN may play a significant role in this context. 16707597 Human
pten endometrioid tumours Low-grade endometrioid carcinomas, however, are characterized by mutations in PTEN and CTNNB1, and microsatellite instability, and may arise from ovarian endometriosis or borderline endometrioid tumours. 16776856 Human
pten adrenal medulla tumors Akt1 deficiency had a profound effect on endometrium and prostate neoplasia, two types of human cancer, in which PTEN is frequently mutated, and also affected thyroid and adrenal medulla tumors and intestinal polyps. 16778075 Human
pten intestinal polyps Akt1 deficiency had a profound effect on endometrium and prostate neoplasia, two types of human cancer, in which PTEN is frequently mutated, and also affected thyroid and adrenal medulla tumors and intestinal polyps. 16778075 Human
pten cervical adenocarcinoma Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray. 16803514 Human
pten cervical adenocarcinomas We examined expression of PTEN in a series of cervical adenocarcinomas and precursors, using tissue microarray (TMA) technology. 16803514 Human
pten adenocarcinoma in situ There were no significant differences in distribution or intensity of PTEN expression between adenocarcinoma in situ and subtypes of invasive adenocarcinoma. 16803514 Human
pten cervical adenocarcinoma There is, however, evidence of altered distribution and intensity of PTEN expression in cervical adenocarcinoma cells. 16803514 Human
pten ovarian adenocarcinomas Genetic aberrations, such as loss of heterozygosity (LOH) and mutations leading to functional inactivation of the PTEN tumor suppressor gene, located on chromosome 10q23.3, have been shown to be associated with approximately one third of ovarian adenocarc 16810057 Human
pten ovarian adenocarcinomas In addition, microsatellite instability (MSI) leading to the functional inactivation of the PTEN gene has also been reported for ovarian adenocarcinomas with frequencies varying from 6 to 37%. 16810057 Human
pten metastatic melanoma We report significant positional PTEN promoter methylation in 62% of circulating DNA isolated from sera of patients with metastatic melanoma. 16818626 Human
pten embryonal carcinoma Suppression of PTEN expression during aggregation with retinoic acid in P19 mouse embryonal carcinoma cells. 16842746 Mouse
pten squamous cell carcinoma Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse. 16849541 Mouse
pten skin tumor Our previous studies have shown that coordinated deletion of the Smad4 and PTEN genes results in accelerated hair loss and skin tumor formation in mice. 16849541 Mouse
pten low-grade tumors The overexpression of cyclin D1 was higher in the low-grade tumors with negative PTEN expression than tumors with positive PTEN expression. 16884382 Human
pten cutaneous lipomas The BRRS is a dominant autosomal disorder characterized by cutaneous lipomas, macrocephaly, intestinal polyps, and developmental delay associated with PTEN gene mutations. 16952599 Human
pten intestinal polyps The BRRS is a dominant autosomal disorder characterized by cutaneous lipomas, macrocephaly, intestinal polyps, and developmental delay associated with PTEN gene mutations. 16952599 Human
pten extrapulmonary small cell cancers One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell cancers) were analysed for PTEN/MMAC1 homozygous deletions and five (8%) SCL 9794233 Human
pten salivary adenoid cystic carcinoma (sacc) [The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance] PURPOSE: To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma ( 16400482 Human
pten salivary adenoid cystic carcinoma [The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance] PURPOSE: To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma ( 16400482 Human
pten salivary adenoid cystic carcinoma RESULTS: The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01). 16400482 Human
pten progressive prostate cancer The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. 16402365 Human
pten progressive prostate cancer Taken together, these data show that bi-allelic deletion is a major mechanism of PTEN inactivation in locally progressive prostate cancer. 16402365 Human
pten canine mammary tumors CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that a decreased level of PTEN gene expression (compared with unaffected mammary gland tissue) is associated with malignancy in canine mammary tumors. 16426222 Dog
pten lymph node metastases This model harboring the Fgf8b transgene and haploinsufficiency in Pten, both in a prostate epithelium-specific manner, yielded prostatic adenocarcinoma with readily detectable lymph node metastases, whereas single models with each of the defects were sho 16489020 Human
pten ptc Twenty-six % of informative benign tumors (four follicular adenomas and three Hürthle cell adenomas) and only 3 of 49 (6.1%) informative malignant tumors (one PTC, one follicular carcinoma, and one anaplastic carcinoma) showed evidence of hemizygous dele 9354427 Human
pten small cell lung cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
pten hnscc We sequenced the entire coding region of the PTEN/MMAC1 gene in the remaining tumors displaying loss of heterozygosity and found one terminating mutation in a HNSCC sample. 9458098 Human
pten inherited cancer syndromes PTEN and inherited hamartoma-cancer syndromes. 9662392 Human
mmac1 small cell lung cancers We searched for genetic alterations of the PTEN/MMAC1 gene in 39 primary head and neck cancers (HNSCCs), 42 primary non-small cell lung cancers (NSCLCs), 80 pancreatic cancer xenografts, and 37 cell lines and xenografts from colon, lung, and gastric cance 9458098 Human
mmac1 hnscc We sequenced the entire coding region of the PTEN/MMAC1 gene in the remaining tumors displaying loss of heterozygosity and found one terminating mutation in a HNSCC sample. 9458098 Human
pten anaplastic ependymoma PTEN mutation and EGFR overexpression are rare in medulloblastoma, anaplastic oligodendroglioma, and anaplastic ependymoma, so the EGFR or PTEN targeted antitumor approaches may be useful in glioblastoma multiformes but the other 3 tumors. 17236582 Human
pten anaplastic oligodendroglioma PTEN mutation and EGFR overexpression are rare in medulloblastoma, anaplastic oligodendroglioma, and anaplastic ependymoma, so the EGFR or PTEN targeted antitumor approaches may be useful in glioblastoma multiformes but the other 3 tumors. 17236582 Human
pten anaplastic oligodendrogliomas METHODS: Using immunohistochemistry to detect the expression of EGFR and PTEN and adopting confocal technology to verify their location in the specimens of 25 respectively glioblastoma multiformes, medulloblastomas, anaplastic oligodendrogliomas, and anap 17236582 Human
pten anaplastic ependymomas METHODS: Using immunohistochemistry to detect the expression of EGFR and PTEN and adopting confocal technology to verify their location in the specimens of 25 respectively glioblastoma multiformes, medulloblastomas, anaplastic oligodendrogliomas, and anap 17236582 Human
phosphatase and tensin homolog brain tumors [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] OBJECTIVE: To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brai 17236582 Human
phosphatase and tensin homolog malignancy [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] OBJECTIVE: To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brai 17236582 Human
pten brain tumors [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] OBJECTIVE: To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brai 17236582 Human
pten malignancy [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] OBJECTIVE: To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brai 17236582 Human
phosphatase and tensin homolog intestinal polyps In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement. 17237784 Mouse
pten benign ovarian tumors METHODS: We examined the promoter methylation status of 9 tumor suppressor genes (RARbeta2, TMS1, RIZ1, P15, P16, PTEN, MINT31, APC and HIC1) in 89 ovarian cancers, 16 borderline ovarian tumors, 19 benign ovarian tumors, 16 normal ovarian tissue and 5 ova 17177027 Human
pten b16 melanoma After optimizing conditions for DNA delivery to the lungs of mice using the combination of polymeric micelles with Lipofectin and LacZ DNA, we used the Lipofectin/polymeric micelle system to deliver the tumor suppressor gene PTEN to the lungs of C57BL/6 m 17122804 Human
pten liver metastasis MVD was positively correlated with depth of invasion, venous invasion, lymph node metastasis and liver metastasis of tumours (p<0.05), whereas it was negatively correlated with PTEN expression (p<0.05). 16698949 Human
pten intestinal-type carcinomas Expression of FHIT, PTEN, Ki-67, caspase-3, mutant p53 and EMPPRIN was higher in intestinal-type carcinomas than in diffuse-type carcinomas (p<0.05). 16714395 Human
pten intestinal-type gastric carcinomas CONCLUSION: Intestinal-type gastric carcinomas with a more favourable prognosis frequently show high levels of proliferation and apoptosis, and always accompany strong expression of FHIT, PTEN and mutant p53 and EMMPRIN. 16714395 Human
pten papillary thyroid cancer For example, methylation of PTEN and RASSF1A genes occurs mostly in follicular thyroid cancer, and its tumorigenic role may be related to the phosphatidylinositol 3-kinase/Akt signaling pathway, whereas methylation of genes for tissue inhibitor of metallo 16946009 Human
pten follicular thyroid cancer For example, methylation of PTEN and RASSF1A genes occurs mostly in follicular thyroid cancer, and its tumorigenic role may be related to the phosphatidylinositol 3-kinase/Akt signaling pathway, whereas methylation of genes for tissue inhibitor of metallo 16946009 Human
pten leiomyoma The purpose of this study was to analyze the level of total PTEN and phosphoPTEN parallel to phosphoAkt in leiomyoma and adjacent myometrium during menstrual cycle and at menopause. 17097286 Human
pten leiomyoma The expression of total PTEN in leiomyoma and myometrium did not change throughout the experiments. 17097286 Human
pten leiomyoma Our results suggest that the altered phosphorylation of PTEN protein and the consequent activation of survival signals may contribute to the pathomechanism of leiomyoma. 17097286 Human
pten neuroblastic tumors We screened the 10q locus for loss of heterozygosity and the promoter methylation status of PTEN, MGMT, MXI1, and FGFR2 in neuroblastic tumors and neuroblastoma cell lines. 17350460 Human
pten acute leukemia [Expression of PTEN mRNA, hTERT and DNA-PKcs in bone marrow cells of children with acute leukemia] 17349160 Human
pten large cell carcinomas Immunohistochemically, PTEN expression gradually decreased from small cell carcinomas (SCCs), through large cell carcinomas (LCCs) and adenocarcinomas (ADs) to squamous (SQ) cell carcinomas (p <0.05), whereas FHIT was more highly expressed in ADs and LCCs 17348444 Human
pten small cell carcinomas Immunohistochemically, PTEN expression gradually decreased from small cell carcinomas (SCCs), through large cell carcinomas (LCCs) and adenocarcinomas (ADs) to squamous (SQ) cell carcinomas (p <0.05), whereas FHIT was more highly expressed in ADs and LCCs 17348444 Human
pten laryngeal papillomas The expression rates of PTEN protein in vocal cord polyps,adult laryngeal papillomas, atypical hyperplasia of vocal cord and laryngeal carcinoma were 100% ,92. 86% ,75. 00%, 56. 96% respectively . 17345711 Human
pten laryngeal papillomas METHODS: Formalin-fixed and paraffin-embedded tissues from 79 cases of laryngeal carcinoma, 16 cases of atypical hyperplasia of vocal fold,14 cases of adult laryngeal papillomas and 27 cases of vocal cord polyps were evaluated for the expression of Skp2, 17345711 Human
pten gangliocytoma Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. 17208451 Human
pten lung tumors Loss of PTEN or overexpression of pAKT predicts for an aggressive subset of lung tumors that have a poor prognosis. 17342327 Human
pten hnscc CCI-779, an mTOR inhibitor, arrested growth of a phosphatase and tensin homologue deleted on chromosome 10 (PTEN) abnormal HNSCC cell line FaDu, inhibiting phosphorylation of 4E-binding protein 1, resulting in increased association with eIF4E and inhibiti 17332346 Human
pten serous carcinomas There were 12 clear cell, 26 endometrioid, and 51 serous carcinomas evaluated by direct DNA sequencing for mutations in p53, PIK3CA, PTEN, BRAF, and CTNNB1. 17258789 Human
pten low-grade tumors PIK3CA mutations are associated with high-grade tumors, whereas PTEN and CTNNB1 mutations are associated with low-grade tumors. 17258789 Human
pten diffuse astrocytomas Some form of p53 mutation was found in three diffuse astrocytomas, in three anaplastic astrocytomas, and in six glioblastomas examined; PTEN mutations were detected only in two glioblastomas. 17327574 Human
pten cyst We show that PTEN localizes to the apical plasma membrane during epithelial morphogenesis to mediate the enrichment of PtdIns(4,5)P2 at this domain during cyst development in three-dimensional culture. 17254974 Human
pten non-small-cell lung cancer In these specimens, we measured the expression of RRM1 and two other proteins that are relevant to non-small-cell lung cancer: the excision repair cross-complementation group 1 (ERCC1) protein and the phosphatase and tensin homologue (PTEN). 17314339 Human
pten dysplastic nevi RESULTS: Both benign and dysplastic nevi showed strong cytoplasmic staining with PTEN, which was subsequently less in melanomas and completely lost in the metastatic lesions. 17302605 Human
pten dysplastic nevi OBJECTIVE: To investigate the expression pattern of PI3K in benign and dysplastic nevi, primary melanomas, and metastatic melanomas and the role of PTEN and PI3K in melanocytic tumor progression. 17302605 Human
pten kidney cancer Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. 17300726 Human
pten breast and ovarian cancer BRCA1 and BRCA2 mutations confer very high risks of breast and ovarian cancer. p53 and PTEN mutations lead to very high breast cancer risks associated with rare cancer syndromes. 17292821 Human
pten oligoastrocytoma Herein, we report on comparative genomic hybridization (CGH) and immunohistochemical (IHC) assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas (10 WHO grade II, 3 WHO grade III), one oligoastrocytoma (WHO grade III) and 23 high-gr 17390041 Human
pten intestinal polyps In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement. 17237784 Mouse
pten inflammatory breast cancers Moreover, patients with ErbB2-overexpressing inflammatory breast cancers responded to lapatinib monotherapy regardless of PTEN status. 17283152 Human
pten follicular adenomas Although complete loss of Pten was not sufficient to cause invasive tumors, over two thirds of the mutant females developed follicular adenomas by 10 months of age, showing that loss of Pten renders the thyroid highly susceptible to neoplastic transformat 17283127 Mouse
pten follicular adenomas Cowden Disease patients, who harbor germ-line PTEN mutations, often display thyroid abnormalities, including multinodular goiter and follicular adenomas, and are at increased risk of thyroid cancer. 17283127 Human
pten follicular adenomas Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. 17283127 Mouse
pten cowden syndrome The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. 17218261 Human
pten cowden syndrome A lysine mutant of PTEN, K289E associated with Cowden syndrome, retains catalytic activity but fails to accumulate in nuclei of patient tissue due to an import defect. 17218261 Human
pten primary tumors A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the P13-K/AKT pathway, is found associated with primary tumors. 17218262 Human
pten prostate tumors Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss of the PTEN tumor suppressor in glioblastoma and prostate tumors. 17372210 Human
pten carcinogenesis CONCLUSION: The abnormal expression of Survivin and PTEN gene may be related to carcinogenesis, tumor progress and prognosis. 17357516 Human
phosphatase and tensin homolog precancerous lesions [Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions] OBJECTIVE: To study the expression of S phase kinase associated protein 2 (Skp2), phosphatase and tensin homolog deleted on chromosome ten (PTEN) in hum 17345711 Human
pten precancerous lesions [Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions] OBJECTIVE: To study the expression of S phase kinase associated protein 2 (Skp2), phosphatase and tensin homolog deleted on chromosome ten (PTEN) in hum 17345711 Human
pten lymph node metastasis In Study II, 25 of the 42 patients (59%) with lymph node metastasis had complete loss of PTEN expression in both the neoplastic glands of the prostate and the invasive prostate cancer cells in the lymph node, and of these 13 (52%) exhibited already loss o 17163422 Human
phosphatase and tensin homolog leukemogenesis Recently, two publications by Yilmaz and colleagues and Zhang and colleagues demonstrated that the loss of the tumour suppressor phosphatase and tensin homolog (PTEN) in mice disturbed the maintenance of quiescent HSCs and promoted leukemogenesis. 16996801 Mouse
pten tumorigenesis CONCLUSIONS: Loss of PTEN function by mutational or other mechanisms is an early event in endometrial tumorigenesis that may occur in response to known endocrine risk factors and offers an informative immunohistochemical biomarker for premalignant disease 10841828 Human
pten renal carcinomas PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines. 11146448 Human
pten renal carcinoma To investigate the potential role of the PTEN gene in renal tumorigenesis, we searched for abnormalities of the gene in 68 primary renal-cell carcinomas (RCCs) as well as in 17 renal carcinoma-derived cell lines, using DNA-SSCP, sequencing and microsatell 11146448 Human
pten renal carcinomas To investigate the potential role of the PTEN gene in renal tumorigenesis, we searched for abnormalities of the gene in 68 primary renal-cell carcinomas (RCCs) as well as in 17 renal carcinoma-derived cell lines, using DNA-SSCP, sequencing and microsatell 11146448 Human
pten ptc Transient expression of PTEN in seven thyroid cancer cell lines resulted in G(1) arrest in two well differentiated papillary thyroid cancer lines (PTCs) and both G(1) arrest and cell death in the remaining five lines, including three FTCs, one poorly diff 11159944 Human
pten adenocarcinoma Analysis of prostate cancer progression in transgenic adenocarcinoma of mouse prostate mice bred to Pten(+/-) heterozygous mice, coupled with analysis of the Pten gene and protein in the resulting tumors, reveals that haploinsufficiency of the Pten gene p 11553783 Mouse
pten hnpcc Immunohistochemical analysis revealed 68% (28/41) of the HNPCC-related ECs with absent or weak PTEN expression. 11854177 Human
pten hnpcc Furthermore, we have shown that somatic PTEN mutation, especially frameshift, is a consequence of profound MMR deficiency in HNPCC-related ECs. 11854177 Human
pten hereditary tumor syndrome Germline mutations in the PTEN/MMAC1/TEP1 tumor suppressor gene cause Cowden syndrome (CS), a hereditary hamartoma-tumor syndrome with an increased risk of breast, thyroid, and endometrial cancers, and seemingly unrelated developmental disorders, such as 11986403 Human
pten solid tumors Initial work on cancer cell lines had suggested that PTEN caused every type of cancer because it was reported that a relatively high frequency of a variety of cancer cell lines, whether derived from solid tumors or hematological malignancies, had homozygo 12060605 Human
pten hepatocarcinogenesis These results demonstrate that downregulation of PTEN in the tumor is an important step in HCV-positive cirrhotic hepatocarcinogenesis and might result in concomitant upregulation of iNOS and COX II in the surrounding liver in favor of tumor promotion. 12115563 Human
pten thyroid adenomas Paradoxically, somatic intragenic PTEN mutations were rare in uncultured primary epithelial thyroid tumors, although hemizygous deletion occurred in 10-20% of thyroid adenomas and carcinomas. 12119278 Human
pten leukemogenesis Together, our results have established the role of PTEN, but not SHIP and SHIP2, in negatively regulating the PI3K/Akt cascade and in myeloma leukemogenesis. 12149650 Mouse
pten hnpcc We have demonstrated that somatic inactivation of PTEN is involved in both sporadic endometrial cancers and HNPCC-related endometrial cancers but with different mutational spectra and different relationships to MSI. 12163369 Human
pten ilc PTEN mutations were detected in ILC (truncating mutations) in around 2% of the tumors. 12203362 Human
pten myeloma These results indicate that PTEN-deficient myeloma cells are remarkably sensitive to mTOR inhibition. 12208757 Human
pten fibrosarcomas Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas. 12461751 Human
pten fibrosarcomas Subsequently, 22 markers from this region (including the intragenic Pten marker) were used to study the occurrence of allelic imbalance in distal RNO1 in fibrosarcomas that had been induced by DMBA in F1(BNxLE) rats. 12461751 Human
pten fibrosarcomas The analysis revealed that allelic imbalance was common in the vicinity of Pten, and there was loss or reduction of one of the Pten alleles in more than 60% of the fibrosarcomas. 12461751 Rat
pten fibrosarcomas However, no mutations were detected in the genomic sequence of Pten exons 5 to 9 in any of the fibrosarcomas, and normal mRNA transcripts were expressed in all tumors. 12461751 Rat
pten fibrosarcomas Thus, based on the targeted selection for loss of Pten observed in some of these tumors and the absence of inactivation of the remaining allele, we suggest that haploinsufficiency of Pten may be an important factor in rat DMBA-induced fibrosarcomas. 12461751 Rat
pten ptc In the case of thyroid epithelial neoplasia, tumor markers such as PTEN/MMAC1/TEP1, telomerase, RET/PTC, b-catenine, PAX8/PPAR(1, ciclooxygenase, thyroid stimulating hormonal receptor (TSHR), and thyro-globulin are being investigated. 12975039 Human
pten rms Consistent with this finding, transfection of wild-type PTEN into RMS and mouse myoblast C2C12 cells resulted in reduced Akt phosphorylation on Ser473, but not on Thr308. 14603261 Mouse
pten rms Our data suggest that Ser473 may be a key target residue for PTEN to modulate the effects of IGF-II on activating the PI3K/Akt pathway in RMS cells. 14603261 Human
pten precancerous lesions OBJECTIVES: Loss of PTEN tumor suppressor gene function characterizes most (63%) endometrial precancerous lesions (endometrial intraepithelial neoplasia, EIN) and up to 83% of endometrioid endometrial cancers. 14984979 Human
pten neuroblastoma Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines. 14999773 Human
pten neuroblastomas From our work, we can conclude that PTEN and DMBT1 seem to contribute to the development of a small fraction of neuroblastomas, and that promoter hypermethylation might have a role in DMBT1 gene silencing. 14999773 Human
pten c-cell hyperplasia CONCLUSIONS: PTEN-associated tumor syndromes should be considered in the differential diagnosis of C-cell hyperplasia of the thyroid. 15067177 Human
pten precancerous lesion Loss of PTEN staining was found in 3 cases, suggesting a precancerous lesion. 15163017 Human
pten acute t-cell leukemias Taken altogether, our data demonstrate that the PI3'-kinase/AKT pathway plays a major role in the growth and survival of PTEN-null T-ALL cells, and identify this cascade as promising target for therapeutic intervention in acute T-cell leukemias. 15240138 Human
pten t-all Taken altogether, our data demonstrate that the PI3'-kinase/AKT pathway plays a major role in the growth and survival of PTEN-null T-ALL cells, and identify this cascade as promising target for therapeutic intervention in acute T-cell leukemias. 15240138 Human
pten skin carcinoma Mitogen-activated protein kinase (MAPK) is consistently activated in the tumors with H-ras mutations, but is strongly down-regulated in Pten-/- tumors, suggesting that this pathway is dispensable for skin carcinoma formation. 15289454 Human
pten lung cancer Aerosol containing glucosylated PEI and recombinant plasmid pcDNA3.0-PTEN complex was delivered into K-ras null lung cancer model mice through a nose-only inhalation system. 15520204 Human
pten oncogenes Promising approaches and molecular markers include gene expression profiles, DNA ploidy, loss of heterozygosity and chromosomal aberrations as detected by CGH and FISH (1q, 17p, 17q), as well as oncogenes/ tumor suppressor genes and their proteins (TP53, 15624758 Human
pten precancerous lesions Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions. 15633233 Human
pten precancerous lesions AIM: To investigate the loss of heterozygosity (LOH) and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions. 15633233 Human
pten precancerous lesions RESULTS: LOH rate found in respectively atrophic gastritis was 10% (3/30), intestinal metaplasia 10% (3/30), atypical hyperplasia 13.3% (4/30), early stage gastric cancer 20% (6/30), and advanced stage gastric cancer 33.3% (9/30), None of the precancerous 15633233 Human
pten precancerous lesions CONCLUSION: LOH of PTEN gene appears in precancerous lesions, and PTEN mutations are restricted to advanced gastric cancer, LOH and mutation of PTEN gene are closely related to the infiltration and metastasis of gastric cancer. 15633233 Human
pten ptc H4/PTEN products were found by nested RT-PCR in 4/14 normal thyroid tissues (28%) and 14/18 PTC (78%) (P<0.01). 15680400 Human
pten adenoma Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations: high-grade serous and possibly endometrioid carcinomas most probably arise from surface epithelial inclusion glands wit 15761464 Human
pten tcc The objective of this study was to investigate the PTEN expression profile in superficial noninvasive papillary transitional cell carcinoma (TCC) versus invasive TCC and compared the results with pathological and clinical parameters. 16123561 Human
pten tcc Regarding the correlation between tumor stage and the PTEN expression, with the exception of patient 23 all patients who displayed a reduction in PTEN expression had muscle-invasive TCC. 16123561 Human
pten adenomas By 80 weeks of age, 100% of Pten-deficient livers showed adenomas and 66% had hepatocellular carcinomas. 16214396 Human
pten atll This down-regulation of PTEN was found to be essential for the formation of ATLL-type nuclear lobules. 16217039 Human
pten leukemogenesis PTEN gene may play a role in leukemogenesis. 16383243 Human
pten hl Akt phosphorylation was not associated with loss of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) expression, but with its phosphorylation in HL-cell lines, suggesting that its biological function is impaired. 16412023 Human
pten metaplasia METHODS: Immunohistochemical analysis was performed on 138 gastric carcinoma specimens, their paired adjacent mucosa specimens, 102 paired lymphatic metastatic carcinoma tissue specimens, 30 dysplasia specimens, 30 intestinal metaplasia specimens, 10 chro 16425372 Human
pten metastatic carcinoma METHODS: Immunohistochemical analysis was performed on 138 gastric carcinoma specimens, their paired adjacent mucosa specimens, 102 paired lymphatic metastatic carcinoma tissue specimens, 30 dysplasia specimens, 30 intestinal metaplasia specimens, 10 chro 16425372 Human
pten papillomas Moreover, in all PTEN-null tumors, levels of ras(Ha)-associated total ERK protein became reduced, whereas phosphorylated ERK and cyclin D1 were lowered in late-stage papillomas returning to elevated levels, alongside increased cyclin E2 expression, in TPA 16452183 Human
pten pancreatic neoplasms [Molecular mechanism in pathogenesis of pancreatic neoplasms: p-Akt, PTEN] 16457218 Human
pten leukaemia Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. 16598206 Human
pten leukaemia In contrast to leukaemia-initiating cells, HSCs were therefore unable to maintain themselves without Pten. 16598206 Human
pten tumorigenesis Pten, tumorigenesis, and stem cell self-renewal. 16630811 Human
pten leukemia (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms. 16630811 Human
pten tumor (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms. 16630811 Human
pten mpd Mice with PTEN-mutant bone marrow also have an increased representation of myeloid and T-lymphoid lineages and develop myeloproliferative disorder (MPD). 16633340 Mouse
pten malignant transformation These data indicate that UVA has carcinogenic potential in human keratinocytes and that the increased AKT signaling and decreased PTEN expression may contribute to this malignant transformation. 16682958 Human
pten borderline tumors Low-grade EC that developed in borderline tumors had PTEN and/or K-RAS mutation (4/5, 80%), while high-grade EC had TP53 mutations only. 16793127 Human
pten endometrioid tumors CONCLUSION: Our results suggest that PTEN mutations may play a role in a development of low-grade endometrioid tumors. 16793127 Human
pten lymphomagenesis We now show that reduced dosage of PTEN, a negative regulator of PI(3)K signaling, is sufficient to activate Akt, but has only a modest effect on lymphomagenesis in the same model. 16885364 Human
pten lymphomas Nonetheless, loss of even one PTEN allele resulted in lymphomas that were resistant to conventional chemotherapy yet sensitive to rapamycin/chemotherapy combinations. 16885364 Mouse
pten lymphomas These effects could be recapitulated by using RNA interference to suppress PTEN expression in lymphomas, which were previously established in the absence of PI(3)K lesions. 16885364 Human
pten high-grade prostatic intraepithelial neoplasias Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. 16938570 Human
pten tcc In early bladder cancers, PTEN expression was repressed in 42% of superficial papillary TCC but in only 8% of cases of carcinoma in situ (CIS). 16951148 Human
pten tcc Thus, PTEN deficiency may contribute to bladder cancer both by initiating superficial papillary TCC and by promoting the progression of CIS to advanced invasive and metastatic forms. 16951148 Human
pten schwannomas METHODS: The methylation status of 16 tumor-related genes including RASSF1A, RAR-B, VHL, PTEN, HMLH1, RB1, TP16, CASP8, ER, TIMP3, MGMT, DAPK, TP73, GSTP1, TP14, and THBS1 was examined in a series of 22 vestibular schwannomas.The bisulfite modification of 16983315 Human
pten leukemogenesis Recently, two publications by Yilmaz and colleagues and Zhang and colleagues demonstrated that the loss of the tumour suppressor phosphatase and tensin homolog (PTEN) in mice disturbed the maintenance of quiescent HSCs and promoted leukemogenesis. 16996801 Mouse
pten benign brain tumor RESULTS: PTEN mRNA levels were significantly lower in the glioma tissues than in the benign brain tumors and tumor-adjacent normal tissues, whereas there were no statistical differences between benign brain tumor and the tumor-adjacent normal tissues. 17000554 Human
pten benign brain tumors RESULTS: PTEN mRNA levels were significantly lower in the glioma tissues than in the benign brain tumors and tumor-adjacent normal tissues, whereas there were no statistical differences between benign brain tumor and the tumor-adjacent normal tissues. 17000554 Human
pten intraepithelial neoplasia In this report, we have examined the efficacy of 1alpha,25-dihydroxyvitamin D(3) (1,25 D(3)) as a chemopreventive agent using Nkx3.1; Pten mutant mice, which recapitulate stages of prostate carcinogenesis from prostate intraepithelial neoplasia (PIN) to a 17020998 Human
pten hamartoma syndromes The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway. 17028174 Human
pten precancerous lesions [Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and their correlations] OBJECTIVE: To detect the expression of PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and precancerous lesions and analyze thei 17067457 Human
mmac1 transitional carcinoma Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens. 11108659 Human
mmac1 tcc In the present study, we examined whether MMAC1 is a target for inactivation by mutations and deletions in bladder TCC cell lines and specimens. 11108659 Human
mmac1 tcc These results suggest that MMAC1 is not the primary target for inactivation in bladder TCC and that another gene, in close proximity to the MMAC1 locus, within this region of frequent allelic losses, may be the target for inactivation. 11108659 Human

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