IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene S1PR3 Ensembl ENSG00000213694 Chromosome 9 Start 90796182 End 90809744
Description Sphingosine 1-phosphate receptor 3 (S1P receptor 3)(S1P3)(Sphingosine 1-phosphate receptor Edg-3)(S1P receptor Edg-3)(Endothelial differentiation G-protein coupled receptor 3) [Source:UniProtKB/Swiss-Prot;Acc:Q99500]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3167
     Entrez Gene : 1903
     UCSC : uc004aqe.2
     GeneCards : 3167
     RefSeq : NM_005226
     CCDS : CCDS6680.1
     Uniprot : Q99500
     Interpro : Q99500
     OMIM : 601965
     GeneTests : S1PR3
     CGAP : S1PR3
     PMID : 8878560

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  228176_at  -0.44  4.38e-5  1.49e-4  -0.27  1.56e-2  2.46e-2
 HG_U133_Plus2  231741_at  0.83  1.42e-5  5.27e-5  0.11  6.15e-1  6.68e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 228176_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 231741_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
s1p receptor edg3 hepatoma We observed that S1P treatment significantly increased proliferation of HTC4 hepatoma cells stably transfected with human S1P receptor Edg3 or Edg5, which was attributable to stimulation of cell growth and inhibition of apoptosis caused by serum starvatio 10617617 Human
edg-3 lymphoblastoma Mechanisms of suppression of apoptosis by LPA and S1P were studied in the Tsup-1 cultured line of human T lymphoblastoma cells, which express Edg-2 and Edg-4 GPCRs for LPA and Edg-3 and Edg-5 GPCRs for S1P. 9973477 Human
edg3 hepatoma When H218 and Edg3 were stably expressed in rat HTC4 hepatoma cells, S1P induced Ca2+ responses with nanomolar EC50 values. 10220556 Human
edg-3 human breast cancer Cultured lines of human breast cancer cells (BCCs) express Edg-3 > Edg-4 > Edg-5 > or = Edg-2, without detectable Edg-1, by both assessment of mRNA and Western blots with rabbit and monoclonal mouse anti-Edg R antibodies. 10493533 Human
edg-3 leukemia Downregulation of mRNA expression of Edg-3, a putative sphingosine 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells. 9878524 Human
edg-3 leukemia We measured the mRNA expression of the recently identified putative sphingosine 1-phosphate (S1P) receptors, i.e., Edg-1, AGR16/H218, and Edg-3, in HL-60 leukemia cells. 9878524 Human
edg-3 leukemia Thus, Edg-3, whose mRNA expression is downregulated during cell differentiation, may be responsible for the S1P-induced Ca2+ response in HL-60 leukemia cells. 9878524 Human
edg-3 breast cancer Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. 12577307 Human
s1p3 breast cancer Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. 12577307 Human
edg-3 human breast cancer The findings that 1-alpha, 25-dihydroxy-vitamin D(3) (VD3) and all-trans retinoic acid (RA) differentially alter expression of the predominant S1P(3) (Edg-3) R and S1P(2) (Edg-5) R in human breast cancer cells (BCCs) permitted analyses of their individual 12577307 Human
s1p3 glioblastomas Moreover, S1P1, S1P3 and S1P2 receptors are expressed in the majority of human glioblastomas as determined by reverse transcriptase-polymerase chain reaction analysis. 12175535 Human
s1p3 astrocytomas Astrocytomas of various histologic grades expressed three types of sphingosine-1-phosphate receptors, S1P1, S1P2, and S1P3; however, no significant correlation with histologic grade or patient survival was detected. 16106218 Human

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