IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CKS2 Ensembl ENSG00000123975 Chromosome 9 Start 91115933 End 91121437
Description Cyclin-dependent kinases regulatory subunit 2 (CKS-2) [Source:UniProtKB/Swiss-Prot;Acc:P33552]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2000
     Entrez Gene : 1164
     UCSC : uc004aqh.2
     GeneCards : 2000
     RefSeq : NM_001827
     CCDS : CCDS6682.1
     Uniprot : P33552
     Interpro : P33552
     OMIM : 116901
     GeneTests : CKS2
     CGAP : CKS2
     PMID : 2227411

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40690_at  0.65  3.65e-3  9.80e-3  1.57  3.12e-9  3.13e-8
 HG_U133A  204170_s_at  1.29  5.39e-30  8.36e-29  1.20  1.69e-37  3.16e-37
 HG_U133_Plus2  204170_s_at  1.06  9.22e-15  1.21e-13  1.49  4.58e-21  7.16e-20
 Stanford  18224  0.65  4.60e-2  1.47e-1  1.47  2.19e-4  4.76e-3
 Stanford  21328  0.97  1.13e-2  7.01e-2  1.73  2.13e-4  4.67e-3
 Agilent_HS_21.6K  5831  0.47  4.44e-6  8.78e-5  0.70  4.01e-8  9.97e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204170_s_at  0.50  2.25e-1  8.44e-1  0.28  2.35e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40690_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204170_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204170_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18224    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21328    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5831    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ckshs2 lymphoid malignancy Among 45 patients presenting acute or chronic lymphoid malignancy, ckshs1 and ckshs2 mRNAs varied in a similar way and were significantly correlated to cell proliferation (p < 0.0001). 10360827 Human
ckshs2 acute lymphoblastic leukemia (all) When analysis was restricted solely to acute lymphoblastic leukemia (ALL) this correlation was still found and ckshs1 and ckshs2 were significantly more expressed in T-cell ALL than in B-cell-lineage ALL. 10360827 Human
cks2 cancer The localization of CKS2 to 9q22 places it very near to a putative tumour suppressor locus suggested to be responsible for susceptibility to the Basal Cell Nervus Syndrome (BCNS or Gorlin's syndrome) familial cancer disorder. 8697818 Human
cks2 tumour The localization of CKS2 to 9q22 places it very near to a putative tumour suppressor locus suggested to be responsible for susceptibility to the Basal Cell Nervus Syndrome (BCNS or Gorlin's syndrome) familial cancer disorder. 8697818 Human
cks2 tumour It is unlikely that CKS2 is the BCNS tumour suppressor gene. 8697818 Human
cks2 neoplasia To investigate whether the CKS genes may be altered in human neoplasia, we mapped the chromosome locations of CKS1 and CKS2 by fluorescence in situ hybridization (FISH). 8697818 Human
cks2 familial cancer The localization of CKS2 to 9q22 places it very near to a putative tumour suppressor locus suggested to be responsible for susceptibility to the Basal Cell Nervus Syndrome (BCNS or Gorlin's syndrome) familial cancer disorder. 8697818 Human
cks2 tumors Subsequent quantitative PCR experiments confirmed that PRDX4, CKS2, MAGED2, and an EST (GenBank accession number BF696304) were expressed at significantly higher levels in tumors with metastasis. 14719106 Human
cks2 metastasis Subsequent quantitative PCR experiments confirmed that PRDX4, CKS2, MAGED2, and an EST (GenBank accession number BF696304) were expressed at significantly higher levels in tumors with metastasis. 14719106 Human
cks2 tumors Several genes like RARRES1, RARRES3, CTGF, CKS2, CCNA2, IGFBP3, UBE2C, CCL2 or ITM2B that were previously found to be deregulated in advanced tumors exhibited opposite expression changes after ATRA treatment. 15897880 Human

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