IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GADD45G Ensembl ENSG00000130222 Chromosome 9 Start 91409748 End 91411283
Description Growth arrest and DNA-damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6)(DNA-damage-inducible transcript 2)(DDIT-2) [Source:UniProtKB/Swiss-Prot;Acc:O95257]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4097
     Entrez Gene : 10912
     UCSC : uc004aqq.2
     GeneCards : 4097
     RefSeq : NM_006705
     CCDS : CCDS6686.1
     Uniprot : O95257
     Interpro : O95257
     OMIM : 604949
     GeneTests : GADD45G
     CGAP : GADD45G
     PMID : 9827804

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39154_at  0.02  9.24e-1  9.45e-1  -1.21  4.76e-6  2.58e-5
 HG_U133A  204121_at  -0.02  8.17e-1  8.45e-1  0.27  7.13e-4  7.97e-4
 HG_U133_Plus2  204121_at  -0.09  4.73e-1  5.61e-1  -0.94  5.15e-7  1.57e-6
 Stanford  22217  -0.73  5.64e-2  1.69e-1  -0.38  5.56e-1  7.57e-1
 Agilent_HS_21.6K  16643  -0.14  2.66e-2  9.32e-2  -0.19  3.57e-3  1.55e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204121_at  0.30  4.08e-1  9.03e-1  0.02  9.51e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39154_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204121_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204121_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22217    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16643    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cr6 lung carcinoma Thus, to further explore the effects of these genes on cell growth and cell viability, either in the presence or absence of extrinsic stress, we have established M1 myeloblastic leukemia and H1299 lung carcinoma cell lines, where high level ectopic expres 11251170 NA
cr6 myeloblastic leukemia Thus, to further explore the effects of these genes on cell growth and cell viability, either in the presence or absence of extrinsic stress, we have established M1 myeloblastic leukemia and H1299 lung carcinoma cell lines, where high level ectopic expres 11251170 NA
gadd45gamma pituitary adenomas Loss of expression of the growth inhibitory gene GADD45gamma, in human pituitary adenomas, is associated with CpG island methylation. 14647444 NA
gadd45gamma pituitary adenomas In a search for novel genes, and employing cDNA-representational difference analysis, the gene encoding GADD45gamma was recently isolated and identified as being under-represented in pituitary adenomas. 14647444 NA
gadd45gamma pituitary adenomas In this study, we further confirm this initial report that the majority of pituitary adenomas (22 of 33; 67%) do not express GADD45gamma as determined by RT-PCR analysis. 14647444 NA
gadd45gamma tumours In marked contrast, epigenetic change, namely methylation of the GADD45gamma genes CpG island, was a frequent finding (19 of 33 adenoma; 58%) and was significantly associated with tumours in which GADD45gamma transcript was not expressed (18 of 22; 82%; P 14647444 NA
gadd45gamma adenoma In marked contrast, epigenetic change, namely methylation of the GADD45gamma genes CpG island, was a frequent finding (19 of 33 adenoma; 58%) and was significantly associated with tumours in which GADD45gamma transcript was not expressed (18 of 22; 82%; P 14647444 NA
gadd45gamma primary tumours In common with the primary tumours, methylation-associated gene silencing of the GADD45gamma gene was also found in the pituitary tumour cell line AtT20. 14647444 NA
gadd45gamma tumour In common with the primary tumours, methylation-associated gene silencing of the GADD45gamma gene was also found in the pituitary tumour cell line AtT20. 14647444 NA
gadd45gamma tumours These findings show that silencing of the GADD45gamma gene in pituitary tumours is primarily associated with methylation of the genes CpG island. 14647444 NA
gadd45gamma tumour Silencing of GADD45gamma, a negative regulator of cell growth, is most likely responsible for conferring a selective growth advantage during tumour evolution and outgrowth. 14647444 NA
cr6 retinoblastoma In cycling retinoblastoma protein-negative (pRb-) cells, ectopic CR6 expression blocked G2/M transition, but did not prevent G1/S transition so that endoreduplication resulted. 10597261 NA
cr6 human lung carcinoma Nevertheless, CR6, like MyD118 and Gadd45, suppressed colony formation of human lung carcinoma H1299 cells. 10490824 NA
gadd45gamma anaplastic thyroid cancer Gadd45gamma expression is reduced in anaplastic thyroid cancer and its reexpression results in apoptosis. 12915687 NA
gadd45gamma anaplastic cancer In this study we found that Gadd45gamma RNA was present at significantly lower levels in anaplastic cancer cells, compared with normal primary cultured thyrocytes. 12915687 NA
gadd45gamma anaplastic thyroid carcinoma In addition, the adenovirus-mediated reexpression of Gadd45gamma significantly inhibited the proliferation of anaplastic thyroid carcinoma cells, ARO, FRO, and NPA cells, which was attributed to apoptosis. 12915687 NA
gadd45gamma tumor Furthermore, the adenovirus-mediated delivery of Gadd45gamma gene in anaplastic thyroid cancer resulted in the inhibition of tumor growth in vivo. 12915687 NA
gadd45gamma anaplastic thyroid cancer This in vitro and in vivo activity of the adenovirus-mediated transduction of CR6/Gadd45gamma, on anaplastic thyroid cancer cell growth suppression, was reminiscent of the effects of p53. 12915687 NA
cr6 anaplastic thyroid cancer This in vitro and in vivo activity of the adenovirus-mediated transduction of CR6/Gadd45gamma, on anaplastic thyroid cancer cell growth suppression, was reminiscent of the effects of p53. 12915687 NA
gadd45gamma anaplastic thyroid cancer This study demonstrates that the Gadd45gamma gene has potential use as a candidate gene for gene therapy in anaplastic thyroid cancer. 12915687 NA
gadd45gamma prostate cancer Gadd45gamma is androgen-responsive and growth-inhibitory in prostate cancer cells. 15062559 NA
gadd45gamma human prostate cancer In this study, we showed that GADD45gamma was transiently up-regulated by androgens in the androgen-responsive human prostate cancer cell line LNCaP. 15062559 NA
gadd45gamma human prostate cancer The above observations provide evidence that GADD45gamma is an androgen-responsive gene with growth-inhibitory activity in human prostate cancer cells. 15062559 NA

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