IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NFIL3 Ensembl ENSG00000165030 Chromosome 9 Start 93211148 End 93225965
Description Nuclear factor interleukin-3-regulated protein (E4 promoter binding-protein 4)(Interleukin-3 promoter transcriptional activator)(Transcriptional activator NF-IL3A)(Interleukin-3 binding-protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q16649]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7787
     Entrez Gene : 4783
     UCSC : uc004arh.2
     GeneCards : 7787
     RefSeq : NM_005384
     CCDS : CCDS6690.1
     Uniprot : Q16649
     Interpro : Q16649
     OMIM : 605327
     GeneTests : NFIL3
     CGAP : NFIL3
     PMID : 7565758

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37544_at  -0.82  3.90e-9  4.31e-8  -0.54  8.09e-3  1.92e-2
 HG_U133A  203574_at  -0.63  1.31e-14  6.87e-14  -3.75  4.81e-82  2.04e-81
 HG_U133_Plus2  203574_at  -1.12  7.64e-24  2.71e-22  -0.80  1.44e-9  6.04e-9
 Stanford  284  -0.58  7.91e-2  2.12e-1  -0.59  9.11e-2  2.56e-1
 Agilent_HS_21.6K  9714  -0.47  3.31e-8  1.27e-6  -0.36  8.09e-5  6.67e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203574_at  0.09  6.78e-1  9.66e-1  -0.12  4.03e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37544_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203574_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203574_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 284    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9714    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nfil3 ovarian tumors Expression of six of them (PINK1, EGR2, HCLS1, DUSP1, BPOZ, and NFIL3) was decreased in ovarian tumors compared with corresponding normal tissues. 11494141 Human
e4bp4 human hepatoma Overexpression of E4BP4 represses the stimulating activity of box alpha in the upstream regulatory sequence of the core promoter and the second enhancer in differentiated human hepatoma cell lines. 10074173 Human
e4bp4 human hepatoma A low abundance of E4BP4 protein and mRNA in differentiated human hepatoma cell lines is detected, and E4BP4 is not a major component of box alpha binding proteins in untransfected differentiated human hepatoma cell lines. 10074173 Human
nfil3 leukemia Our results implicate NFIL3/E4BP4 (nuclear factor regulated by IL-3/adenovirus E4 promoter binding protein) in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E 9122243 Human
e4bp4 leukemia Our results implicate NFIL3/E4BP4 (nuclear factor regulated by IL-3/adenovirus E4 promoter binding protein) in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E 9122243 Human

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