IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPTLC1 Ensembl ENSG00000090054 Chromosome 9 Start 93833248 End 93917511
Description Serine palmitoyltransferase 1 (EC 2.3.1.50)(Serine-palmitoyl-CoA transferase 1)(SPT 1)(SPT1)(Long chain base biosynthesis protein 1)(LCB 1) [Source:UniProtKB/Swiss-Prot;Acc:O15269]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11277
     Entrez Gene : 10558
     UCSC : uc004arl.1
     GeneCards : 11277
     RefSeq : NM_006415
     CCDS : CCDS6692.1
     Uniprot : O15269
     Interpro : O15269
     OMIM : 605712
     GeneTests : SPTLC1
     CGAP : SPTLC1
     PMID : 9363775

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38818_at  -0.33  5.20e-4  1.77e-3  -0.21  9.48e-2  1.57e-1
 HG_U133A  202277_at  -0.08  1.49e-1  1.87e-1  0.48  6.02e-12  7.77e-12
 HG_U133A  202278_s_at  0.82  1.41e-13  6.79e-13  2.17  4.45e-46  9.49e-46
 HG_U133_Plus2  1554053_at  -0.31  2.49e-2  4.58e-2  -0.45  5.59e-3  9.53e-3
 HG_U133_Plus2  202277_at  -0.04  4.52e-1  5.41e-1  -0.02  7.65e-1  8.03e-1
 HG_U133_Plus2  202278_s_at  -0.24  2.97e-1  3.84e-1  -0.59  2.45e-2  3.72e-2
 Stanford  8641  0.37  1.96e-1  3.85e-1  0.28  1.99e-1  4.24e-1
 Stanford  22276  -0.37  1.77e-1  3.60e-1  -0.18  6.65e-1  8.27e-1
 Agilent_HS_21.6K  4519  -0.09  1.39e-1  2.94e-1  -0.03  6.32e-1  7.54e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202277_at  -0.29  1.88e-1  8.25e-1  0.04  8.04e-1  1.00e+0
 HG_U133A  202278_s_at  -0.47  7.15e-2  7.34e-1  -0.50  6.03e-2  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38818_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202277_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202278_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554053_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202277_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202278_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8641    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22276    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4519    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sptlc1 palmar-plantar keratosis These families comprised six multigenerational families, including two previously reported families not linked to the SPTLC1 locus on chromosome 9 and one multigenerational family with a complicated hereditary sensory neuropathy syndrome with associated p 12207934 Human
spt1 carcinoma In addition, we observed SPT1 and SPT2 immunoreactivity in reactive stromal fibroblasts surrounding the carcinoma cells of some of the tumors. 12754283 Human
spt1 tumors In addition, we observed SPT1 and SPT2 immunoreactivity in reactive stromal fibroblasts surrounding the carcinoma cells of some of the tumors. 12754283 Human
sptlc1 palmar plantar keratosis These families comprised six multigenerational families, including two previously reported families not linked to the SPTLC1 locus on chromosome 9 and one multigenerational family with a complicated hereditary sensory neuropathy syndrome with associated p 12207934 Human
spt1 glioma In the present study, based on evidence that indicates subunit 1 of serine palmitoyltransferase, SPT1, interacts with Hsp90, both ligand-induced Cyp1A1 transactivation and capacity for proliferation were evaluated using the wild type Glioma LN18 human bra 16968971 Human
spt1 brain cancer In the present study, based on evidence that indicates subunit 1 of serine palmitoyltransferase, SPT1, interacts with Hsp90, both ligand-induced Cyp1A1 transactivation and capacity for proliferation were evaluated using the wild type Glioma LN18 human bra 16968971 Human
spt1 glioma Although all the Glioma cell lines exhibited mitogenic proliferative response in dose response assay with the potent Cyp1A1 inducers 3-MC, 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and benzo [k] fluoranthene, BKF, only the recombinant cell line designat 16968971 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.