IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NOL8 Ensembl ENSG00000198000 Chromosome 9 Start 94099461 End 94127659
Description Nucleolar protein 8 (Nucleolar protein Nop132) [Source:UniProtKB/Swiss-Prot;Acc:Q76FK4]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 23387
     Entrez Gene : 55035
     UCSC : uc004arv.2
     GeneCards : 23387
     RefSeq : NM_017948
     CCDS : CCDS47993.1
     Uniprot : Q7L3E2
     Interpro : Q7L3E2
     OMIM : 611534
     GeneTests : NOL8
     CGAP : NOL8
     PMID : 12477932

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218244_at  0.11  4.46e-1  5.01e-1  -1.99  5.87e-64  1.70e-63
 HG_U133_Plus2  218244_at  -0.31  4.66e-4  1.30e-3  -0.22  6.25e-2  8.78e-2
 Agilent_HS_21.6K  15182  0.31  7.07e-7  1.82e-5  0.35  2.06e-5  2.09e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218244_at  0.10  8.91e-1  9.93e-1  -0.50  3.21e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 218244_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218244_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15182    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nol8 diffuse-type gastric cancer Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. 15132771 Human
nol8 cancers Among 153 genes whose expression levels were elevated in cancers compared to non-cancerous mucosae, we focused on a gene termed NOL8 that encodes a putative 150-kDa protein with an RNA-recognition motif (RRM) domain in its amino-acid terminal region. 15132771 Human
nol8 intestinal-type gastric cancers Comparison of expression profiles between diffuse-type and intestinal-type gastric cancers showed that NOL8 was specifically up-regulated in diffuse-type cancers. 15132771 Human
nol8 cancers Comparison of expression profiles between diffuse-type and intestinal-type gastric cancers showed that NOL8 was specifically up-regulated in diffuse-type cancers. 15132771 Human
nol8 diffuse-type gastric cancer Furthermore, transfection of short-interfering RNA (siRNA) specific to NOL8 into three diffuse-type gastric cancer cells, St-4, MKN45 and TMK-1, effectively reduced expression of this gene and induced apoptosis in these cells. 15132771 Human

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