IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CTSL2 Ensembl ENSG00000136943 Chromosome 9 Start 98834760 End 98841413
Description Cathepsin L2 Precursor (EC 3.4.22.43)(Cathepsin V)(Cathepsin U) [Source:UniProtKB/Swiss-Prot;Acc:O60911]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2538
     Entrez Gene : 1515
     UCSC : uc004awt.2
     GeneCards : 2538
     RefSeq : NM_001333
     CCDS : CCDS6723.1
     Uniprot : O60911
     Interpro : O60911
     OMIM : 603308
     GeneTests : CTSL2
     CGAP : CTSL2
     PMID : 9563472

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40717_at  0.15  4.83e-1  5.88e-1  1.67  5.94e-8  4.75e-7
 HG_U133A  210074_at  0.57  1.45e-5  3.31e-5  -0.71  1.40e-11  1.80e-11
 HG_U133_Plus2  210074_at  1.16  3.15e-11  2.67e-10  2.81  1.72e-36  1.82e-34
 Agilent_HS_21.6K  15494  0.42  2.36e-2  8.56e-2  1.18  2.05e-9  7.84e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210074_at  0.25  6.20e-1  9.54e-1  -0.15  6.71e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40717_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210074_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210074_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15494    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cathepsin l2 tumor Among the potential target proteinase of SCC antigen-1, immunoblotting analyses revealed that cathepsin L2 was remarkably overexpressed in tumor tissue, while cathepsin L was expressed in both normal and tumor tissues. 12874860 Human
cathepsin l2 colorectal carcinomas Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. 9563472 Human
cathepsin l2 human tumors Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. 9563472 Human
cathepsin l2 breast carcinomas Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. 9563472 Human
cathepsin l2 renal carcinomas Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas. 9563472 Human
cathepsin l2 tumors Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas. 9563472 Human
cathepsin l2 breast cancer Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas. 9563472 Human

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