IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FOXE1 Ensembl ENSG00000178919 Chromosome 9 Start 99655358 End 99658807
Description Forkhead box protein E1 (Thyroid transcription factor 2)(TTF-2)(Forkhead-related protein FKHL15)(Forkhead box protein E2)(HNF-3/fork head-like protein 5)(HFKL5)(HFKH4) [Source:UniProtKB/Swiss-Prot;Acc:O00358]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3806
     Entrez Gene : 2304
     UCSC : uc004axu.2
     GeneCards : 3806
     RefSeq : NM_004473
     CCDS : CCDS35078.1
     Uniprot : O00358
     Interpro : O00358
     OMIM : 602617
     GeneTests : FOXE1
     CGAP : FOXE1
     PMID : 9169137

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31353_f_at  0.33  2.04e-4  7.71e-4  0.24  8.17e-2  1.38e-1
 HG_U95  31354_r_at  0.25  3.96e-3  1.05e-2  0.46  6.15e-4  2.02e-3
 HG_U95  36370_at  0.54  1.94e-2  4.14e-2  1.89  2.63e-5  1.20e-4
 HG_U133A  206912_at  0.48  1.34e-2  2.06e-2  0.60  2.56e-4  2.89e-4
 HG_U133A  208239_at  -0.48  8.34e-5  1.75e-4  0.37  9.29e-3  1.01e-2
 HG_U133_Plus2  206912_at  1.18  2.72e-5  9.61e-5  5.03  1.86e-30  9.15e-29
 HG_U133_Plus2  208239_at  0.26  1.56e-1  2.24e-1  -0.08  6.36e-1  6.87e-1
 Agilent_HS_21.6K  13045  0.08  3.61e-2  1.16e-1  0.33  9.06e-4  4.99e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206912_at  1.02  1.06e-1  7.80e-1  0.17  7.76e-1  1.00e+0
 HG_U133A  208239_at  -0.32  4.64e-1  9.20e-1  0.07  8.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31353_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 31354_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36370_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206912_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208239_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206912_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208239_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13045    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ttf-2 anaplastic thyroid carcinomas However, most poorly differentiated and anaplastic thyroid carcinomas have lost the ability to express the TG gene expression accompanied by loss of transcription factors [thyroid transcription factor-1 (TTF-1), TTF-2, or Pax-8] interacting with the TG pr 11325833 Human
ttf-2 papillary thyroid carcinoma Using a chimeric construct containing the 5'-flanking region of the rat TG gene between -826 and +39 bp and the luciferase gene, TG promoter activity was detected in a normal rat thyroid cell line (FRTL-5), but not in a dedifferentiated line of thyro 11325833 Human
ttf-2 hemangioma The following topics are addressed: molecular mutations causing central hypothyroidism (isolated autosomal recessive TRH deficiency; autosomal recessive TRH-receptor inactivating mutations; TSH beta-subunit bio-inactivating mutations; Pit-1 mutations; Pro 11508826 Human
ttf-2 follicular adenoma In the benign lesions, TTF-2 transcripts were detected either by RT-PCR or ISH in 8 of 8 Graves disease; 3 of 7 Hashimoto's; 2 of 2 follicular hyperplasia; 15 of 21 follicular adenoma; 11 of 13 multinodular goiters and 0 of 1 hyalinizing trabecular a 11762722 Human
ttf-2 follicular hyperplasia In the benign lesions, TTF-2 transcripts were detected either by RT-PCR or ISH in 8 of 8 Graves disease; 3 of 7 Hashimoto's; 2 of 2 follicular hyperplasia; 15 of 21 follicular adenoma; 11 of 13 multinodular goiters and 0 of 1 hyalinizing trabecular a 11762722 Human
ttf-2 hyalinizing trabecular adenoma In the benign lesions, TTF-2 transcripts were detected either by RT-PCR or ISH in 8 of 8 Graves disease; 3 of 7 Hashimoto's; 2 of 2 follicular hyperplasia; 15 of 21 follicular adenoma; 11 of 13 multinodular goiters and 0 of 1 hyalinizing trabecular a 11762722 Human
ttf-2 papillary cancers In the malignant thyroid lesions, TTF-2 transcripts were detected in 8 of 18 follicular cancers; 0 of 2 anaplastic carcinoma, and 11 of 17 papillary cancers. 11762722 Human
ttf-2 anaplastic carcinoma In the malignant thyroid lesions, TTF-2 transcripts were detected in 8 of 18 follicular cancers; 0 of 2 anaplastic carcinoma, and 11 of 17 papillary cancers. 11762722 Human
ttf-2 follicular cancers In the malignant thyroid lesions, TTF-2 transcripts were detected in 8 of 18 follicular cancers; 0 of 2 anaplastic carcinoma, and 11 of 17 papillary cancers. 11762722 Human
fkhl15 cancer predisposition syndrome The map position of FKHL15 on 9q22 places the gene within the candidate regions for the cancer predisposition syndrome multiple self-healing squamous epitheliomata and the degenerative neurological disorder hereditary sensory neuropathy type I. 9169137 Human
foxe1 basal-cell carcinoma FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. 15140221 Human
foxe1 basal-cell carcinoma (bcc) FOXE1 expression is also found in basal keratinocytes of the human epidermis and basal cell carcinoma (BCC). 15140221 Human
foxe1 pancreatic cancers These genes include UCHL1 (methylated in 100% of 42 pancreatic cancers), NPTX2 (98%), SARP2 (95%), CLDN5 (93%), reprimo (86%), LHX1 (76%), WNT7A (71%), FOXE1 (69%), TJP2 (64%), CDH3 (19%), and ST14 (10%). 12839967 Human
foxe1 squamous-cell carcinoma The Foxe1 protein is also expressed in human and mouse basal cell carcinoma in which hedgehog signaling is constitutively activated, whereas it is undetectable in normal epidermis and squamous cell carcinoma. 15367491 Human
foxe1 basal-cell carcinoma The Foxe1 protein is also expressed in human and mouse basal cell carcinoma in which hedgehog signaling is constitutively activated, whereas it is undetectable in normal epidermis and squamous cell carcinoma. 15367491 Human

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