IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HEMGN Ensembl ENSG00000136929 Chromosome 9 Start 99728894 End 99746959
Description Hemogen (Hemopoietic gene protein)(Negative differentiation regulator protein)(Erythroid differentiation-associated gene protein)(EDAG-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXL5]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 17509
     Entrez Gene : 55363
     UCSC : uc004axy.2
     GeneCards : 17509
     RefSeq : NM_018437
     CCDS : CCDS6731.1
     Uniprot : Q9BXL5
     Interpro : Q9BXL5
     OMIM : 610715
     GeneTests : HEMGN
     CGAP : HEMGN

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  223669_at  -0.79  1.50e-4  4.61e-4  -0.86  5.78e-4  1.16e-3
 HG_U133_Plus2  223670_s_at  0.19  2.82e-1  3.68e-1  0.45  4.01e-2  5.85e-2
 Agilent_HS_21.6K  1772  -0.17  7.89e-2  2.00e-1  -0.17  1.08e-1  2.19e-1
 Agilent_HS_21.6K  14943  0.21  7.59e-2  1.95e-1  0.23  3.46e-2  9.34e-2

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 223669_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223670_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1772    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14943    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
edag neoplasms Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. 11404085 Human
hemogen neoplasms Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. 11404085 Human
edag leukemia We also identified a human homologue of Hemogen, named EDAG, which was mapped to chromosome 9q22, a leukemia breakpoint. 11404085 Human
hemogen leukemia We also identified a human homologue of Hemogen, named EDAG, which was mapped to chromosome 9q22, a leukemia breakpoint. 11404085 Human
edag neoplasms Taken together, these data are consistent with Hemogen and EDAG playing an important role in hematopoietic development and neoplasms. 11404085 Human
hemogen neoplasms Taken together, these data are consistent with Hemogen and EDAG playing an important role in hematopoietic development and neoplasms. 11404085 Human
edag hematological neoplasms Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. 11404085 Human
edag aml High expression of EDAG and its significance in AML. 15920494 Human
edag-1 tumor Overexpression of EDAG-1 in NIH3T3 cells resulted in loss of cell contact inhibition, anchorage-independent growth in soft agar and tumor formation in nude mice. 11958143 Mouse
edag-1 tumors These results suggest that EDAG-1 is a transforming gene and may be associated with the development of tumors, especially in hematopoietic system. 11958143 Mouse
edag-1 lymphoma [Expression of EDAG-1 gene in human leukemia and lymphoma cell lines.] BACKGROUND & OBJECTIVE: Embryonic development associated gene 1 (EDAG-1), located at chromosome 9q22, is specially expressed in hematopoietic cells, and related to the regulation of he 15522166 Human
edag-1 human leukemia [Expression of EDAG-1 gene in human leukemia and lymphoma cell lines.] BACKGROUND & OBJECTIVE: Embryonic development associated gene 1 (EDAG-1), located at chromosome 9q22, is specially expressed in hematopoietic cells, and related to the regulation of he 15522166 Human
edag-1 leukemia RESULTS: EDAG-1 mRNA and protein were highly expressed in erythroleukemia cell lines (K-562, HEL), megakaryoblast leukemia cell lines (DAMI, MEG-01), and T cell leukemia cell line (Jurkat), while no gene mutation was found in coding region, no amplificati 15522166 Human
edag-1 t-cell leukemia RESULTS: EDAG-1 mRNA and protein were highly expressed in erythroleukemia cell lines (K-562, HEL), megakaryoblast leukemia cell lines (DAMI, MEG-01), and T cell leukemia cell line (Jurkat), while no gene mutation was found in coding region, no amplificati 15522166 Human
edag-1 erythroleukemia RESULTS: EDAG-1 mRNA and protein were highly expressed in erythroleukemia cell lines (K-562, HEL), megakaryoblast leukemia cell lines (DAMI, MEG-01), and T cell leukemia cell line (Jurkat), while no gene mutation was found in coding region, no amplificati 15522166 Human
edag-1 leukemia CONCLUSION: EDAG-1 may relate with pathogenesis of erythroleukemia and megakaryoblast leukemia; its coding region may have no relation with the mechanism of its activation. 15522166 Human
edag-1 erythroleukemia CONCLUSION: EDAG-1 may relate with pathogenesis of erythroleukemia and megakaryoblast leukemia; its coding region may have no relation with the mechanism of its activation. 15522166 Human
edag-1 leukemia This study was designed to explore relationship between pathogenesis of leukemia, lymphoma and EDAG-1 through analyzing the structure of EDAG-1 coding region, and its expression in these cell lines. 15522166 NA
edag-1 lymphoma This study was designed to explore relationship between pathogenesis of leukemia, lymphoma and EDAG-1 through analyzing the structure of EDAG-1 coding region, and its expression in these cell lines. 15522166 NA
hemgn leukemia Finally, fluorescence in situ hybridization demonstrates that HEMGN is localized to chromosome 4 A5-B2 in mouse and to chromosome 9q22 in human, which is a region known to harbor a cluster of leukemia breakpoints. 14648837 Human
hemogen hematological neoplasms Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. 11404085 Human

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